Dr. Kyprianou is professor of urology, molecular biochemistry, pathology and toxicology in the department of surgery and holds the James F. Hardymon chair in urology research at the University of Kentucky College of Medicine, Lexington, Ky. Dr. Kyprianou received her undergraduate and graduate education at the University of London and the University of Leeds, and completed her doctoral studies at the University of Wales College of Medicine in the United Kingdom (Ph.D. 1986). She completed fellowships in molecular oncology at Johns Hopkins University School of Medicine and in molecular biology at the Imperial Cancer Research Fund in London, England.
Dr. Kyprianou's research interests focus on the deregulation of apoptosis and growth factor signaling pathways in benign and malignant prostate, development of molecular therapeutics (via tumor selective apoptosis-targeting) for castration-resistant prostate tumors, and development of novel biomarkers of prostate and bladder cancer progression. She has made seminal contributions to the hormone-dependent apoptosis signaling mechanisms during tumorigenesis and has published more than 150 peer-reviewed original articles and reviews on molecular pathogenesis of cancer and therapeutic targeting of metastatic prostate cancer. Her book/monograph entitled “Molecular Exploitation of Apoptosis Pathways in Prostate Cancer” was recently published by Imperial College press (London).
Dr. Kyprianou served as a member and chair of several grant review advisory panels at the National Institutes of Health (NIDDK, NCI), the Department of Defense for the Congressionally Directed Programs in prostate and breast cancer, the American Cancer Society (ACS) and the American Urological Association (AUA) Research Foundation. She is active nationally and internationally in several leadership positions including serving as the president of the Society for Basic Urologic Research (2004-2006), a board member of the International Prostate Health Council and a member of the AUA Research Council. Dr. Kyprianou served as the chair of the Integration Panel for the congressionally directed Prostate Cancer Research Programs in the Department of Defense (PCRP) and she was the co-chair of the Innovative Minds in Prostate Cancer Today (IMPaCT) meeting in 2011.
Dr. Kyprianou has received several awards and honors including the Woman in Urology Award from the Society for Basic Urologic Research/American Urological Association (2006), the Distinguished Mentor Award from the American Urological Association Foundation (2008), “In the Know” Award from the Prostate Network, USA (2009) and the Dominique Chopin Distinguished Award in Urology from the EAU/ESUR (2010). She is currently on the editorial board of several journals, including Cancer Research, British Journal of Pharmacology, The Prostate, APOPTOSIS and PLoS One. Dr. Kyprianou is an advocate of academic mentoring, funding and training opportunities for young investigators in translational research.