The Annual Meeting is an extraordinary venue that fosters scientific discussions and helps build bridges across various disciplines. We encourage all meeting attendees to take advantage of the opportunities presented at the meeting to learn about the latest breakthroughs in the tumor microenvironment, attend sessions outside your own areas of expertise and network with other scientists and clinicians interested in all areas of cancer research.
The AACR Annual Meeting 2017 was held in Washington, D.C., from April 1-5.
The Tumor Microenvironment Working Group (TME) hosted a variety of sessions and events at the Annual Meeting, including:
TME Town Hall Meeting and Reception
Microenvironmental Regulation of Metastasis
Tuesday, April 4, 2017, 6 - 8 p.m.
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Presentation by TME Chair-elect, Valerie M. Weaver, PhD, of TME Chair Award for Johanna A. Joyce, PhD, in absentia to Daniela F. Quail, PhD
Chairperson: Johanna A. Joyce, PhD, Ludwig Institute for Cancer Research, University of Lausanne, Switzerland (in absentia)
Chairperson-elect: Valerie M. Weaver, PhD, UCSF Medical Center, San Francisco, California
This event provided an opportunity for all interested attendees to hear insights from our colleagues on the tumor microenvironment in relation to metastasis regulation. In addition to the presentations, guests learned about other important TME initiatives, met members of the working group and steering committee, and investigated the opportunity to join the TME Working Group. A networking reception followed.
Yibin Kang, PhD, Princeton University, Princeton, New Jersey
Endothelial and osteoblastic niches in the seeding and treatment resistance of bone metastasis
Valerie M. Weaver, PhD, UCSF Medical Center, San Francisco, California
Spatial-mechanical regulation of tumor dormancy and metastases
Sandra S. McAllister, PhD, Harvard Medical School, Boston, Massachusetts
Systemic and microenvironmental determinants of cancer progression and metastasis
Joint Cancer Immunology / Tumor Microenvironment (TME) Working Groups Evening Scientific Session
Microenvironmental Regulation of Immunotherapy Efficacy in Cancer
Monday, April 3, 2017; 6 - 8 p.m.
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As the number of success stories for immunotherapies across a range of different cancers increases, there is a growing appreciation of the importance of the tumor microenvironment in regulating both the intrinsic response to immunotherapy, and contributing to acquired resistance. Thus, understanding the underlying mechanisms and co-targeting the microenvironment along with immunotherapies will be critical for broadening the impact of these strategies in patients. The chairpersons of the Cancer Immunology (CIMM) and the Tumor Microenvironment (TME) Working Groups organized an informative program in this evening scientific session to hear the perspective of leaders in this field.
Patrick Hwu, MD, UT MD Anderson Cancer Center, Houston, Texas (CIMM chairperson)
Valerie M. Weaver, PhD, University of California at San Francisco Medical Center,
San Francisco, California (TME chairperson-elect)
Judith A. Varner, PhD, Moores UCSD Cancer Center, San Diego, California
Targeting the molecular switch controlling immune suppression for cancer therapy
Andy J. Minn, MD, PhD, Abramson Family Cancer Research Institute, Philadelphia, Pennsylvania
Interferon signaling and resistance mechanisms to cancer immune checkpoint blockade
Stefani Spranger, PhD, University of Chicago, Chicago, Illinois
Impacts of tumor cell-intrinsic signaling on the induction and recruitment of anti-tumor effector T cells
TME Special Networking Session with Early-career Researchers
Perspectives of a Senior Principal Investigator and a Junior Investigator
Monday, April 3, 2017, noon -12:30 p.m.; AACRcentral Amphitheater
This networking session provided an opportunity for
early-career researchers to interact with the TME Working Group leadership and other
experts in the field of the tumor microenvironment, and to learn about career
challenges and opportunities in TME research. This informative discussion provided ample time for comments and questions.
The TME Working Group sincerely congratulates Dr. Bissell on being the recipient of this award for her many years of service to cancer research. Dr. Bissell was be presented with her award during the AACR Annual Meeting 2017's Opening Ceremony on Sunday, April 2, 8-9 a.m. Learn more about this award. Dr. Bissell was also the presenter at a "Meet-the-Expert" session on Saturday, April 1, 2017, 3:30-4:30 p.m.