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FINDING CURES TOGETHER<sup>SM</sup>

TME at the Annual Meeting

The Annual Meeting is an extraordinary venue that fosters scientific discussions and helps build bridges across various disciplines. We encourage all meeting attendees to take advantage of the opportunities presented at the meeting to learn about the latest breakthroughs in the tumor microenvironment, attend sessions outside your own areas of expertise and network with other scientists and clinicians interested in all areas of cancer research.

The AACR Annual Meeting 2015 was held in Philadelphia, Pennsylvania, from April 18-22.

The Tumor Microenvironment Working Group (TME) hosted a variety of sessions and events at the Annual Meeting, including:

TME Town Hall Meeting and Reception 

The Future of Cancer Science
Tuesday, April 21, 2015, 6:30 p.m. - 8:30 p.m.
Philadelphia Marriott Downtown Hotel, Grand Ballroom, Salons C-D

Chairperson: Raghu Kalluri, MD, PhD, UT MD Anderson Cancer Center, Houston, Texas
Chairperson-Elect: Morag Park, PhD, Canadian Institutes of Health Research, McGill University, Montréal, Québec, Canada

This was an opportunity for all interested to hear an update from our colleagues on The Future of Cancer Science. In addition to the presentations, guests learned  about other important TME initiatives, met members of the working group and steering committee, and investigated the opportunity to join the TME Working Group. A networking reception followed.

Speakers:

Sunil R. Hingorani, MD, PhD, Fred Hutchinson Cancer Research Center, and the University of Washington School of Medicine, Seattle, Washington
Stromal re-engineering to treat cancer

Valerie LeBleu, PhD, UT MD Anderson Cancer Center, Houston, Texas
Targeting vascular pericytes in hypoxic tumors increases lung metastasis via angiopoietin-2

Johanna A. Joyce, PhD Memorial Sloan Kettering Cancer Center, New York, New York
Exploring and exploiting the tumor microenvironment

Joint Cancer Immunology / Tumor Microenvironment (TME) Working Groups Evening Scientific Session 

The TME: Impact on Immunotherapeutic Responses
Monday, April 20, 2015
6 - 8 p.m.
Philadelphia Marriott Downtown, Grand Ballroom, Salon H

The emerging success of tumor immunotherapy heralds a new chapter in the treatment of advanced cancers. This session, "The TME: Impact on Immunotherapeutic Responses", discussed how the TME modulates the local and systemic immune response and how immune based interventions can redefine the TME. The Chairpersons of the Cancer Immunology (CIMM) and Tumor Microenvironment (TME) Working Groups invited all Annual Meeting registrants to attend this evening scientific session to hear leaders from both fields present the most current information on this topic.

Chairpersons:

Nina Bhardwaj, MD, PhD, Icahn School of Medicine at Mt. Sinai Medical Center, New York, New York, CIMM Chairperson

Raghu Kalluri, MD, PhD, UT MD Anderson Cancer Center, Houston, Texas, TME Chairperson

Speakers:

Raghu Kalluri, MD, PhD, UT MD Anderson Cancer Center, Houston, Texas
Functional Role of Stroma and Tumor Immunity in Pancreas Cancer

Tak W. Mak, PhD, Campbell Family Institute for Breast Cancer Research, Toronto, Ontario, Canada
The Role of TOSO in CLL Progression and Immunotherapy

Nina Bhardwaj, MD, PhD, Icahn School of Medicine at Mt. Sinai Medical Center, New York, New York
Modulation of Innate Immune Function by the TME

TME activity with early-career scientists:
TME Career Opportunities  and Challenges for Young Investigators

Monday, April 20, 2015, 12:30-2:00 p.m.
AACRcentral Amphitheater  

This networking session provided an opportunity for early-career investigators to interact with the TME Working Group Leadership, experts in the field of the tumor microenvironment, to learn about career challenges and opportunities. This informative discussion also provided ample time for comments and questions.

Panelists/Speakers:

Raghu Kalluri, MD, PhD, UT MD Anderson Cancer Center, Houston, Texas

Mary Helen Barcellos-Hoff, PhD, New York University School of Medicine, New York, New York

Morag Park, PhD, Canadian Institutes of Health, McGill University, Montréal, Québec, Canada


Other TME-Related Content (held at the Pennsylvania Convention Center, unless otherwise noted; this list may not be all-inclusive of the sessions offered):

Educational Sessions

Imaging the Tumour Niche and Therapeutic Responses
Saturday, Apr 18, 2015, 8:00 AM -10:00 AM, Room 103   

Therapeutic Targeting and Monitoring Tumor Microenvironments
Saturday, Apr 18, 2015, 8:00 AM -10:00 AM, Terrace Ballroom IV (400 Level)   

Detecting Treatment Response and Investigating the Tumor Microenvironment Using Magnetic Resonance Imaging
Saturday, Apr 18, 2015, 10:15 AM -12:15 PM, Terrace Ballroom IV (400 Level)

Is the Stroma Tumor Suppressive or Tumor Promoting?
Saturday, Apr 18, 2015, 10:15 AM -12:15 PM, Room 103   

Therapeutic Targeting the Diverse Immune Inhibitory Pathways in the Tumor Microenvironment
Saturday, Apr 18, 2015, 3:15 PM - 5:15 PM, Terrace Ballroom II-III (400 Level)   

Methods Workshops

Extracellular Vesicles in Cancer: Isolation and Function
Saturday, Apr 18, 2015, 3:15 PM - 5:15 PM, Room 119   

Award Lectures

Eighteenth Annual AACR-Women in Cancer Research Charlotte Friend Memorial Lectureship
Saturday, Apr 18, 2015, 5:30 PM - 6:45 PM, Terrace Ballroom II-III (400 Level)   

Major Symposia

Antiangiogenesis Revisited
Monday, Apr 20, 2015, 1:00 PM - 3:00 PM, Room 115   

Tumor Microenvironment
Monday, Apr 20, 2015, 1:00 PM - 3:00 PM, Terrace Ballroom II-III (400 Level)    

Minisymposia

Signaling of the Microenvironment Regulates Tumor Progression
Sunday, Apr 19, 2015, 3:15 PM - 5:15 PM, Room 113

Epigenetic and Metabolic Regulation in the Microenvironment
Monday, Apr 20, 2015, 3:00 PM - 5:00 PM, Room 114

Poster Sessions

Tumor Microenvironment/Innate Immune Activators
Sunday, Apr 19, 2015, 1:00 PM - 5:00 PM, Section 13

Role of the Microenvironment and Tumor Metabolism in Therapeutic Response
Wednesday, Apr 22, 2015, 8:00 AM -12:00 PM, Section 34

Crosstalk of the Microenvironment and the Tumor Clone
Sunday, Apr 19, 2015, 1:00 PM - 5:00 PM, Section 17

Cytokines and Chemokines and the Microenvironment
Sunday, Apr 19, 2015, 1:00 PM - 5:00 PM, Section 18

Immune Regulation in the Microenvironment
Sunday, Apr 19, 2015, 1:00 PM - 5:00 PM, Section 19

Therapeutic Targeting of the Microenvironment
Monday, Apr 20, 2015, 8:00 AM -12:00 PM, Section 20

The Immune Microenvironment
Monday, Apr 20, 2015, 1:00 PM - 5:00 PM, Section 18

Tumor-Microenvironment Interactions
Monday, Apr 20, 2015, 1:00 PM - 5:00 PM, Section 19

Dynamic Regulation of the Tumor Microenvironment
Tuesday, Apr 21, 2015, 8:00 AM -12:00 PM, Section 14

Biomarkers and Clinical Implications of the Tumor Microenvironment
Wednesday, Apr 22, 2015, 8:00 AM -12:00 PM, Section 14

Angiogenesis Inhibitors
Monday, Apr 20, 2015, 8:00 AM -12:00 PM, Section 14

Molecular Mechanisms of Angiogenesis
Tuesday, Apr 21, 2015, 1:00 PM - 5:00 PM, Section 19

Hormonal Regulation of Tumor Growth and Metastasis
Tuesday, Apr 21, 2015, 8:00 AM -12:00 PM, Section 26

Metastasis-Promoting Genes
Monday, Apr 20, 2015, 1:00 PM - 5:00 PM, Section 15

Metastasis-Suppressing Genes
Tuesday, Apr 21, 2015, 8:00 AM -12:00 PM, Section 16

Tumor Metastasis
Wednesday, Apr 22, 2015, 8:00 AM -12:00 PM, Section 19

Tumor-Host Interactions
Wednesday, Apr 22, 2015, 8:00 AM -12:00 PM, Section 20   

Recent Advances in Diagnostics and Therapeutics Research

Biomarkers of Antiangiogenic Therapy: Are We Lost in Translation?
Sunday, Apr 19, 2015, 1:00 PM - 3:00 PM, Room 114   

Recent Advances in Organ Site Research

Pancreatic Cancer: The Promise and Pitfalls of Targeting the Stroma
Tuesday, Apr 21, 2015, 1:00 PM - 3:00 PM, Room 114   

Special Session 

TME career opportunities and challenges for young investigators
Monday, Apr 20, 2015, 12:30 PM - 2:00 PM, AACRcentral, Booth #725, AACR Amphitheater, Halls B-E   

Joint Cancer Immunology (CIMM)/Tumor Microenvironment (TME) Working Groups Evening Scientific Session
Monday, Apr 20, 2015, 6:00 PM - 8:00 PM, Philadelphia Marriott Downtown, Grand Ballroom Salon H (Level 5)

Be sure to check out these immunology sessions, you may also find interesting.