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FINDING CURES TOGETHER<sup>SM</sup>

TME at the Annual Meeting


The Annual Meeting is an extraordinary venue that fosters scientific discussions and helps build bridges across various disciplines. We encourage all meeting attendees to take advantage of the opportunities presented at the meeting to learn about the latest breakthroughs in the tumor microenvironment, attend sessions outside your own areas of expertise and network with other scientists and clinicians interested in all areas of cancer research.

The AACR Annual Meeting 2016 was held in New Orleans, Louisiana, from April 16-20.

The Tumor Microenvironment Working Group (TME) hosted a variety of sessions and events at the Annual Meeting, including:

TME Town Hall Meeting and Reception 

Insights into the Tumor Microenvironment from Intravital Imaging
Sunday, April 17, 2016, 6 - 8 p.m.
New Orleans Marriott, Mardi Gras Ballroom D-E

Chairperson: Morag Park, PhD, Canadian Institutes of Health Research, McGill University, Montréal, Québec, Canada
Chairperson-elect: Johanna A. Joyce, PhD, Memorial Sloan Kettering Cancer Center, New York, New York

This event provided an opportunity for all interested attendees to hear insights from our colleagues on the tumor microenvironment in relation to intravital imaging. In addition to the presentations, guests learned about other important TME initiatives, met members of the working group and steering committee, and  investigated the opportunity to join the TME Working Group. A networking reception followed.

Speakers:

Andrew J. EwaldPhD, Johns Hopkins Kimmel Comprehensive Cancer Center, Baltimore, Maryland
Reciprocal interactions between the cancer cell and the tumor microenvironment during metastasis

Mikala Egeblad, PhD, Cold Spring Harbor Laboratory, Cold Spring Harbor, New York
Heterogeneity of innate immune cell behavior and function in primary and metastatic tumors revealed by intravital imaging

Erik Sahai, PhD, The Francis Crick Institute, Cancer Research UK, London, United Kingdom
Heterotypic tumor-stroma cell-cell contacts: a new mechanism of cross-talk

Joint Cancer Immunology / Tumor Microenvironment (TME) Working Groups Evening Scientific Session 

Immunoregulatory Mechanisms in the Tumor Microenvironment
Monday, April 18, 2016
6 - 8 p.m.
New Orleans Marriott, Bissonet Room

Reprogramming immune-inhibitory signals in the tumor microenvironment is likely to be one of the pivotal approaches to improve the success of cancer immune therapy. However, to achieve this goal, the field needs to understand the numerous cellular and molecular mechanisms that are engaged in the process that defines the tumor microenvironment. The chairpersons of the Cancer Immunology (CIMM) and the Tumor Microenvironment (TME) Working Groups invited all interested guests to attend this evening scientific session, "Immunoregulatory Mechanisms in the Tumor Microenvironment," to hear the perspective of leaders in this field.

Chairpersons:
Pamela S. Ohashi, PhD, FRSC, Princess Margaret Cancer Center, University of Toronto, Toronto, Ontario, Canada (CIMM chairperson)

Morag Park, PhD, Canadian Institutes of Health Research, McGill University, Montréal, Québec, Canada (TME chairperson)

Speakers:
Jérôme Galon, PhD, Cordeliers Research Center, Paris, France
From genomics to immune landscape in human tumors

Jeffrey W. Pollard, PhD, FRSE, MRC and University of Edinburgh Centre for Reproductive Health, Queen's Medical Research Institute, Edinburgh, United Kingdom
Tumor associated macrophages: from mechanism to therapy

Weiping Zou, MD, PhD, University of Michigan, Ann Arbor, Michigan
Cancer epigenetics and immunotherapy

TME session with early-career investigators: 
Careers in TME Research 

Monday, April 18, 2016, noon -1 p.m.
AACRcentral Amphitheater, Exhibit Hall H, Booth #1230 

This networking session provided an opportunity for early-career investigators to interact with the TME Working Group leadership and other experts in the field of the tumor microenvironment, and to learn about career challenges and opportunities in TME research. This informative discussion provided ample time for comments and questions.

Moderators:
Valerie S. LeBleu, MD, UT MD Anderson Cancer Center, Houston, Texas
Sandra S. McAllister, PhD, Harvard Medical School, Boston, Massachusetts

Panelists/Speakers
:

Cyrus M. Ghajar, PhD, Fred Hutchinson Cancer Research Center, Seattle, Washington
Katherine N. Weilbaecher, MD, Washington University of St. Louis, St. Louis, Missouri
Shelia M. Violette, PhD
, Biogen, Cambridge, Massachusetts

The following tumor-microenvironment-related sessions were held at the Ernest N. Morial Convention Center; this list may not be all-inclusive:

Education and Methods Workshops 

Cancer Metabolism and Immunometabolism: Metabolic Decisions in Oncology
Saturday, April 16, 2016, 8 – 10 a.m., Room 265

Metabolic Interplay Between Tumor and Microenvironment
Saturday, Apr 16, 2016, 10:15 a.m. - 12:15 p.m., New Orleans Theater C    

Tumor Heterogeneity
Saturday, April 16, 2016, 3:15 - 5:15 p.m., New Orleans Theater A

Forum

Should Tumor Heterogeneity Guide Therapy?
Monday, April 18, 2016, 5 - 6:30 p.m., New Orleans Theater C          

Major Symposia

Inflammation and Cancer: Targeting the Myeloid Microenvironment
Sunday, April 17, 2016, 2:15 - 4:00 p.m., Room 293

Microenvironment and Cancer Stemness
Monday, April 18, 2016, 1 - 2:45 p.m., New Orleans Theater C

Pre-Metastatic Niches, Exosomes, and Tumor-Secreted Factors
Wednesday, April 20, 2016, 10:15 a.m. - noon, Room 393

Contribution of the Microenvironment to Therapy-Induced Resistance in Cancer
Tuesday, April 19, 2016, 10:30 a.m. - 12:15 p.m., Room 293

Tumor Evolution Within the Host Microenvironment
Tuesday, April 19, 2016, 1 - 2:45 p.m., New Orleans Theater B         

Meet-the-Expert

Regulation of Disseminated Tumor Cell Dormancy by Distant Microenvironments
Wednesday, April 20, 2016, 7 - 8 a.m., Room 265

Cellular Plasticity, Cellular Heterogeneity and Single Cell Sequencing
Sunday, April 17, 2016, 7 - 8 a.m., Room 288      

Minisymposia

Tumor-supporting Microenvironment
Tuesday, April 19, 2016, 3 - 5 p.m., Room 393

Mechanism and Dynamics of Cancer Metastasis
Tuesday, April 19, 2016, 3 - 5 p.m., Room 393

Plenary

Tumor Heterogeneity, Clonal Evolution, and Therapeutic Response
Tuesday, April 19, 2016, 8:15 - 10:15 a.m., Hall F

Posters

Cell Adhesion and Tumor Treatment
Wednesday, April 20, 2016, 8 a.m. - noon, Section 28

Biomarkers and Profiling of Metastasis
Monday, April 18, 2016, 8 a.m. - noon, Section 28      

Imaging and Therapeutics of Metastasis
Tuesday, April 19, 2016, 1 - 5 p.m., Section 30

Metastasis-Promoting and -Suppressing Genes
Monday, April 18, 2016, 8 a.m. - noon, Section 31

Epithelial-Mesenchymal Transition in Metastasis
Monday, April 18, 2016, 8 a.m. - noon, Section 30

Regulators of Epithelial-Mesenchymal Transition and Metastasis
Monday, April 18, 2016, 8 a.m. - noon, Section 33

Antiangiogenic Therapy: Inhibitors and Resistance
Tuesday, April 19, 2016, 8 a.m. - noon, Section 28

Tumor Angiogenesis: Mediators and Mechanisms
Tuesday, April 19, 2016, 8 a.m. - noon, Section 34

Tumor Angiogenesis: Host Interactions and the Tumor Microenvironment
Tuesday, April 19, 2016, 8 a.m. - noon, Section 33

Cellular and Molecular Mediators of Metastasis
Monday, April 18, 2016, 8 a.m. - noon, Section 29

Immunomodulation and Immunotherapy
Wednesday, April 20, 2016, 8 a.m. - noon, Section 31      

Targeting the Microenvironment
Sunday, April 17, 2016, 1 - 5 p.m., Section 33      

Hematological Microenvironment
Tuesday, April 19, 2016, 8 a.m. - noon, Section 29      

Host-Tumor Interactions
Tuesday, April 19, 2016, 1 - 5 p.m., Section 29      

Pro-Tumorigenic Microenvironment
Sunday, April 17, 2016, 1 - 5 p.m., Section 32      

Extracellular Microenvironment
Wednesday, April 20, 2016, 8 a.m. - noon, Section 30      

Immune Cell Activity
Tuesday, April 19, 2016, 1 - 5 p.m., Section 31      

Molecular Regulation of Tumor Invasion
Sunday, April 17, 2016, 1 - 5 p.m., Section 31      

Cellular and Molecular Dynamics of Cancer Migration and Invasion
Wednesday, April 20, 2016, 8 a.m. - noon, Section 29      

Clonal Heterogeneity and Evolution
Monday, April 18, 2016, 1 - 5 p.m., Section 28      

Intratumor Heterogeneity and Treatment Responses
Monday, April 18, 2016, 1 - 5 p.m., Section 29      

Recent Advances in Organ Site Research

Targeting Stromal Fibroblasts in Pancreatic Cancer: Controversy or Consensus?
Monday, April 18, 2016, 10:30 a.m. - 12:15 p.m., Room 293

Recent Advances in Prevention Research

Cancer Prevention through Modulation of the Tumor Microenvironment
Wednesday, April 20, 2016, 10:15 a.m. - noon, Room 271

Check the Cancer Immunology Working Group webpage for other sessions of interest, and be sure to visit the AACR Annual Meeting homepage for more information about many other sessions and to access the online itinerary planner.