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FINDING CURES TOGETHER<sup>SM</sup>

TME at the Annual Meeting

The Annual Meeting is an extraordinary venue that fosters scientific discussions and helps build bridges across various disciplines. We encourage all meeting attendees to take advantage of the opportunities presented at the meeting to learn about the latest breakthroughs in the tumor microenvironment, attend sessions outside your own areas of expertise and network with other scientists and clinicians interested in all areas of cancer research.

The AACR Annual Meeting 2014 was held in San Diego, CA, from April 5-9.

The Tumor Microenvironment Working Group (TME) hosted a variety of sessions and events at the Annual Meeting, including:

TME Town Meeting and Reception: Modeling the Microenvironment

Sunday, April 6, 2014, 6:30 p.m. - 8:30 p.m.
San Diego Marriott Marquis and Marina, Marina Ballroom G

Chairperson: Mary Helen Barcellos-Hoff, Ph.D., New York University School of Medicine, New York, NY
Chairperson-Elect: Raghu Kalluri, M.D., Ph.D., UT MD Anderson Cancer Center, Houston, TX

This was an opportunity for all interested to hear an update from our colleagues on Modeling the Microenvironment. In addition to the presentations, guests learned about other important TME initiatives, met members of the working group and steering committee, and took advantage of the opportunity to join the TME Working Group. A networking reception followed.

Speakers:

Kenneth J. Pienta, Johns Hopkins University Brady Urology Institute, Baltimore, MD
Of niche construction and ecological inheritance: applying the science of ecology to cancer

Katarzyna A. Rejniak, Moffitt Cancer Center & Research Institute, Tampa, FL
M for microenvironment modeling: mathematics, morphology, mechanics and mice

Raghu Kalluri, UT MD Anderson Cancer Center, Houston, TX
Functional Auditing of Tissue Microenvironment in Pancreas Cancer

Joint Cancer Immunology (CIMM)/Tumor Microenvironment (TME) Working Group Evening Scientific Session: Collaboration of TME and Immune Responses in Irradiated Tumors 

Monday, April 7, 2014
6:00-8:00 p.m.
San Diego Marriott Marquis and Marina, Marriott Hall, Salon 4

Tumor microenvironment and immunology are at an exciting crossroads. This jointly-sponsored session, "Collaboration of TME and Immune Responses in Irradiated Tumors", discussed tumor response to targeted radiotherapy mediated by the immune system. The Chairpersons of the Cancer Immunology (CIMM) and Tumor Microenvironment (TME) Working Groups invited all Working Group members as well as all other interested Annual Meeting registrants to attend this evening scientific session to hear leaders from both fields present the most current information on this topic.

Chairpersons:
Robert Vonderheide, M.D., DPhil., Abramson Family Research Cancer Institute of the University of Pennsylvania, Philadelphia, PA

Mary Helen Barcellos-Hoff, Ph.D, New York University School of Medicine, New York, NY

Speakers
:
Silvia Formenti, New York University, New York, NY
Radiation and Immunotherapy - the Role of the Tumor Microenvironment

Charles G. Drake, Johns Hopkins Kimmel Comprehensive Cancer Center, Baltimore, MD
Effects of Radiation Therapy on Treg Infiltration of Tumors

Andy J. Minn, M.D., Ph.D., Abramson Family Research Cancer Institute of the University of Pennsylvania, Philadelphia, PA
Insights into combining immune checkpoint blockade with radiation to treat metastatic melanoma

Other TME-Related Content: (to be held at the San Diego Convention Center)

Current Concepts
Quantitative Models of Tumor Heterogeneity: From Clonal Diversity to Epigenetic Drift to the Microenvironment
Monday, April 8, 2014, 11:00 a.m. - 1:00 p.m.; Room 11

Exosomes and Microvesicles in Cancer
Tuesday, April 8, 2014, 1:00 p.m. - 3:00 p.m.; Room 11

Fora
Plasticity vs. Hierarchy in Tumors
Monday, April 7, 2014, 5:00 p.m. - 6:30 p.m.; Room 31A-C

Targeting Autophagy in Cancer: Promise or Peril?
Monday, April 7, 2014; 5:00 p.m. - 6:30 p.m.; Room 5

Educational Sessions and Methods Workshops
Evolving Tumor Cell Populations: Dealing with Diversity
Saturday, April 5, 2014, 8:00 a.m. - 10:00 a.m.; Room 11

Tumor Immunology and Immunotherapy for Non-Immunologists
Saturday, April 5, 2014, 8:00 a.m. - 10:00 a.m.; Ballroom 20D

Cancer Immunology for the Non-Immunologist - Tutorial
Saturday, April 5, 2014, 10:00 a.m. - 12:00 noon; Room 2

Intratumoral Heterogeneity and its Effects on Drug Response and Disease Relapse
Saturday, April 5, 2014, 10:15 a.m. - 12:15 p.m.; Room 7

The Complex Role of Autophagy in Cancer
Saturday, April 5, 2014, 10:15 a.m. - 12:15 p.m.; Room 30A-C

The Nature of Tumor Cell Death for the Control of Cancer: About Apoptosis, Necroptosis, Autophagy, Immunity and Metabolism
Saturday, April 5, 2014, 1:00 p.m. - 3:00 p.m.; Room 7

Phenotyping and Function of Solid Tumor Stroma
Saturday, April 5, 2014, 1:00 p.m. - 3:00 p.m.; Ballroom 20D

Spatial and Temporal Evolution of Carcinomas in Patients: Heterogeneity in Four Dimensions
Saturday, April 5, 2014, 3:15 p.m. - 5:15 p.m.; Room 25A-C

Stem Cells and Cancer
Saturday, April 5, 2014, 3:15 p.m. - 5:15 p.m.; Room 30A-C

Major Symposia
Cancer Cell Niche
Monday, April 7, 2014, 1:00 p.m. - 3:00 p.m.; Room 11

Novel Mechanisms of Metastasis
Monday, April 7, 2014; 1:00 p.m. - 3:00 p.m.; Ballroom 20D

Tumor Microenvironment: Composition and Consequence
Monday, April 7, 2014, 1:00 p.m. - 3:00 p.m.; Room 30A-C

Complexity in the Tumor Microenvironment
Tuesday, April 8, 2014, 10:30 a.m. - 12:30 p.m.; Ballroom 20D

Minisymposia
Molecular Profiling to Elucidate Tumor Heterogeneity and Clonal Evolution
Sunday, April 6, 2014, 3:15 p.m. - 5:15 p.m.; Room 5

Molecular Regulation of Tumor Metastasis
Sunday, April 6, 2013, 3:15 p.m. - 5:15 p.m.; Room 30A-C

Elucidation and Niche Targeting of Cancer Stem Cell Epigenetic and Metabolic Alterations
Tuesday, April 8, 2014, 3:00 p.m. - 5:00 p.m.; Room 6B

Stromal Importance in Modulating Tumor Progression
Tuesday, April 8, 2014, 3:00 p.m. - 5:00 p.m.; Room 33

Tumor Angiogenesis
Tuesday, April 8, 2014, 3:00 p.m. - 5:00 p.m.; Room 6B

Meet-the-Expert
How Tumor Cells Acquire Metastatic Traits
Saturday, April 5, 2014, 3:15 - 4:15 p.m.; Room 6CF

Targeting Physical Forces to Enhance Cancer Treatment
Sunday, April 6, 2014, 7:00 a.m. - 8:00 a.m.; Room 31A-C

Understanding Tumor Heterogeneity Using 40 Markers at Single Cell Resolution
Monday, April 7, 2014, 7:00 a.m. - 8:00 a.m.; Room 33A-C

Tumor-Host Dialogue During Progression and Therapeutic Resistance: A Perspective from the Vascular Niche
Tuesday, April 8, 2014, 7:00 a.m. - 8:00 a.m.; Room 31A-C

The Hypoxia Transcriptome and Antiangiogenesis Therapy - Synthetic Lethality Recruited for Therapeutic Effect
Tuesday, April 8, 2014, 7:00 a.m. - 8:00 a.m.; Room 33A-C

Inflammation and Cancer Progression: The Tumor Microenvironment
Wednesday, April 9, 2014, 7:00 a.m. - 8:00 a.m.; Room 30A-C

Plenary Session
Cellular and Molecular Heterogeneity of Cancer
Wednesday, April 9, 2014, 8:00 a.m. - 10:00 a.m.; Ballroom 20A-D

Poster Sessions
Role of Tumor-associated Mesenchymes and Their Support of the Tumor Microenvironment
Sunday, April 6, 2014, 1:00 pm - 5:00 pm; Hall A-E, Poster Section 7

Pathway of Tumor Microenvironmental Modulation
Sunday, April 6, 2014, 1:00 pm - 5:00 pm; Hall A-E, Poster Section 6

Negative Modulators and Suppressors of Tumor Metastasis
Sunday, April 6, 2014, 1:00 pm - 5:00 pm; Hall A-E, Poster Section 5

Angiogenesis 1: Molecular and Cellular Mechanisms
Sunday, April 6, 2014, 1:00 pm - 5:00 pm; Hall A-E, Poster Section 1

Factors Influencing the Tumor Microenvironment
Monday, April 7, 2014, 8:00 am - 12:00 noon; Hall A-E, Poster Section 7

Angiogenesis 2: Novel Targets and Agents
Monday, April 7, 2014, 8:00 am - 12:00 noon; Hall A-E, Poster Section 2

Cells and Their Factors in the Tumor Microenvironment
Monday, April 7, 2014, 8:00 am - 12:00 noon; Hall A-E, Poster Section 4

Modeling Cancers in 3D Culture
Monday, April 7, 2014, 1:00 pm - 5:00 pm; Hall A-E, Poster Section 5

Inflammation and the Tumor Microenvironment
Monday, April 7, 2014, 8:00 am - 12:00 noon; Hall A-E, Poster Section 28

Impact of Tissue Context on Tumor Progression and Treatment
Monday, April 7, 2014, 1:00 pm - 5:00 pm; Hall A-E, Poster Section 3

Epithelial-Mesenchymal Transitions in Tumor Metastasis
Monday, April 7, 2014, 8:00 am - 12:00 noon; Hall A-E, Poster Section 6

Metastasis Regulating Genes
Monday, April 7, 2014, 1:00 pm - 5:00 pm; Hall A-E, Poster Section 4

Cell Plasticity in Tumor Metastasis
Monday, April 7, 2014, 8:00 am - 12:00 noon; Hall A-E, Poster Section 3

Positive Modulators of Tumor Metastasis
Monday, April 7, 2014, 1:00 pm - 5:00 pm; Hall A-E, Poster Section 8

Dynamic Interactions in the Tumor Microenvironment
Monday, April 7, 2014, 8:00 am - 12:00 noon; Hall A-E, Poster Section 5

Immune Modulation in the Tumor Microenvironment
Tuesday, April 8, 2014, 8:00 am - 12:00 noon; Hall A-E, Poster Section 26

Role of Microenvironment in Therapeutic Responses to Anticancer Drugs
Tuesday, April 8, 2014, 8:00 am - 12:00 noon; Hall A-E, Poster Section 34

Tumor-Stroma Interactions
Tuesday, April 8, 2014, 8:00 am - 12:00 noon; Hall A-E, Poster Section 24

Cancer Stem Cell Niche and Metastasis
Tuesday, April 8, 2014, 8:00 am - 12:00 noon; Hall A-E, Poster Section 3

Therapeutic Approaches for Metastatic Tumors
Tuesday, April 8, 2014, 1:00 pm - 5:00 pm; Hall A-E, Poster Section 7

Angiogenesis 3: Translation to Therapeutics
Tuesday, April 8, 2014, 8:00 am - 12:00 noon; Hall A-E, Poster Section 2

Microenvironmental Cues
Wednesday, April 9, 2014, 8:00 am - 12:00 noon; Hall A-E, Poster Section 3

Tumor Metastasis
Wednesday, April 9, 2014, 8:00 am - 12:00 noon; Hall A-E, Poster Section 6

Diversity of Microenvironmental Signaling
Wednesday, April 9, 2014, 8:00 am - 12:00 noon; Hall A-E, Poster Section 2

Tumor Microenvironment
Wednesday, April 9, 2014, 8:00 am - 12:00 noon; Hall A-E, Poster Section 7

Be sure to check out these immunology sessions, you may also find interesting.