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FINDING CURES TOGETHER<sup>SM</sup>

AACR Annual Meeting 2016

NextGen Stars

The NextGen Stars program provides an exciting opportunity to increase the visibility of early-career scientists at the AACR Annual Meeting and to support the professional development and advancement of those selected to speak. Three outstanding NextGen Stars will present their work in major sessions at the AACR Annual Meeting 2016. Selections were made through a competitive application process that was limited to AACR Associate Members and AACR Active Members who were at the junior faculty level (not higher than assistant professor or equivalent).

Congratulations to the 2016 NextGen Stars!

Margaret L. Hoang, Johns Hopkins Kimmel Comprehensive Cancer Center, Baltimore, Maryland
Accumulation of somatic mutations in normal and cancerous tissues with age

Major Symposium
Population Genetics Meets Single Cell Analysis
Tuesday, April 19, 2016, 1:00 p.m. - 2:45 p.m.
Room 354, Morial Convention Center


Genevieve Kendall, UT Southwestern Medical Center, Dallas, Texas
Zebrafish models of PAX3-FOXO1 pathogenesis reveal novel targets in human rhabdomyosarcoma

Major Symposium
Pediatric Cancers and Epigenetic Therapies: Promise and Challenges
Wednesday, April 20, 2016, 10:15 a.m. - 12:00 p.m.
Room 354, Morial Convention Center


John Paul Shen, University of California – San Diego, La Jolla, California
A network of deeply conserved synthetic-lethal interactions for exploration of precision cancer therapy

Major Symposium
Modeling the Interface between Cancer Genomics and Drugs
Wednesday, April 20, 2016, 10:15 a.m. - 12:00 p.m.
Room 243, Morial Convention Center

View the webcasts of the NextGen Stars' presentations from the AACR Annual Meeting 2015:

Christopher E. Barbieri, Weill Cornell Medical College of Cornell University, New York, New York
SPOP mutation is associated with genomic instability in prostate cancer
Presented in a Recent Advances in Diagnostics and Therapeutics Research session on Exploiting DNA Repair Deficiencies in Cancer.

Katherine B. Chiappinelli, Johns Hopkins School of Medicine, Baltimore, Maryland
Immunomodulatory and tumor cell killing effects of the demethylating agent 5-azacytidine in ovarian cancer
Presented in a Major Symposium on Epigenetic Mechanisms in Cancer Risk.

Ryan B. Corcoran, Massachusetts General Hospital Cancer Center, Boston, Massachusetts
Clinical acquired resistance to RAF inhibitor combinations in BRAF mutant colorectal cancer through MAPK pathway alterations
Presented in a Major Symposium on Mechanisms of Resistance: From Signaling Pathways to Stem Cells.

Courtney Hodges, Howard Hughes Medical Institute and Stanford University School of Medicine, Stanford, California
Chromatin accessibility underlies the tumor-suppression role of BAF (mSWI/SNF) complexes in many malignancies
Presented in a Recent Advances in Diagnostics and Therapeutics Research session on DNA Repair Pathways in Cancer: Basic Biology

Hongbo Pang, Sanford-Burnham Medical Research Institute, La Jolla, California
A novel endocytic and intercellular transport pathway for drug delivery across blood vessels and into nutrient-deprived tumor cells
Presented in a Recent Advances in Diagnostics and Therapeutics Research session on Novel Delivery Systems and/or Formulations in Cancer Treatment.

Rushika M. Perera, Massachusetts General Hospital Cancer Center, Harvard Medical School, Boston, Massachusetts
Transcriptional mechanisms for autophagy regulation and metabolic reprogramming in pancreatic cancer
Presented in a Recent Advances in Organ Site Research session on
Pancreatic Cancer in 2015: An Integrated View of a Complex Disease.

Catherine C. Smith, University of California, San Francisco, California
Polyclonal and heterogeneous resistance to targeted therapy in leukemia
Presented in a Major Symposium on Targeted Therapies in Hematologic Malignancies.

Surojit Sur, Ludwig Center at the Johns Hopkins Kimmel Cancer Center, Baltimore, Maryland
The Trojan Horse Strategy: Packaging chemotherapeutics can help alleviate toxicity
Presented in a Major Symposium on Applying Systems Biology in the Oncology Clinic.

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