Pediatric Cancer Predisposition and Surveillance

In October of 2016, the Pediatric Cancer Working Group of the American Association for Cancer Research hosted a special workshop on pediatric cancer predisposition and surveillance. This meeting convened experts from various childhood cancer predisposition centers around the world to review the state of pediatric predisposition science and identify opportunities by which the AACR may accelerate progress in the field. The need for this workshop was based on evidence from recent pediatric studies that suggest that at least 10 percent of pediatric cancer patients harbor a germline mutation in a cancer predisposition gene, and surveillance and early detection of cancer in these patients may result in improved outcomes. Following this workshop, the participants wrote 18 position articles with surveillance recommendations for the major cancer predisposition syndromes likely to be encountered in children and adolescents.

These recommendations will be freely available upon publication in Clinical Cancer Research beginning June 1, 2017.  

The first article in the collection, which provides an overview of this initiative, and the editorial schedule are available for download.

To access other articles in the collection, visit

The following institutions have established centers dedicated to determining and managing hereditary cancer risks and were represented at the AACR Childhood Cancer Predisposition Workshop.

United States

Aflac Cancer and Blood Disorders Center, Atlanta, Georgia
Baylor College of Medicine and Texas Children's Hospital, Houston, Texas
Children's Hospital Colorado, Aurora, Colorado
Children's Hospital of Philadelphia, Philadelphia, Pennsylvania
Dana-Farber Cancer Institute and Boston Children's Hospital, Boston, Massachusetts
Memorial Sloan Kettering Cancer Center, New York, New York 
National Cancer Institute, Rockville, Maryland
St. Jude Children's Research Hospital, Memphis, Tennessee
St. Louis Children’s Hospital, St. Louis, Missouri
University of Chicago Medicine Comer Children's Hospital, Chicago, Illinois
University of California, Los Angeles, Los Angeles, California
University of Michigan, Ann Arbor, Michigan
University of Pennsylvania Abramson Cancer Center, Philadelphia, Pennsylvania
University of Texas Health Science Center at San Antonio, San Antonio, Texas
University of Texas MD Anderson Cancer Center, Houston, Texas
University of Utah Huntsman Cancer Institute, Salt Lake City, Utah


Centre for Cancer Biology, Adelaide, South Australia
Royal Children’s Hospital Melbourne, Parkville, Victoria


McGill University, Montreal, Quebec
The Hospital for Sick Children, Toronto, Ontario


Institut Curie, Paris, France
Rouen University Hospital, Rouen, France


German Cancer Research Center, Heidelberg, Germany
Hannover Medical School, Hannover, Germany


Sheba Medical Center, Ramat Gan, Israel


Saga Medical Center Koseikan, Saga, Japan


Princess Maxima Center for Pediatric Oncology, Utrecht, Netherlands


Sant Joan de Déu-Barcelona Children's Hospital, Barcelona, Spain

United Kingdom

Manchester Centre for Genomic Medicine, Manchester, UK 
The Royal Marsden NHS Foundation Trust, London, England
University of Cambridge, Cambridge, UK