David Botstein, PhD
Anthony B. Evnin Professor of Genomics, Princeton University, Princeton, New Jersey; Chief Scientific Officer, Calico, San Francisco, California
As one of the principal scientists responsible for unlocking the human genome, Dr. Botstein has revolutionized our understanding of the genetic basis of human disease. In the early 1980s he proposed building a map of human disease genes using DNA polymorphisms, laying the groundwork for the new science of genomics and the foundation for what would later become the Human Genome Project. His techniques have been especially important for studying inherited diseases and have led to the identification of disease genes such as those responsible for Huntington’s disease and the BRCA1 gene.
In addition to his genomics work, Dr. Botstein contributed to the discovery of transposons in bacteria and the understanding of their physical and genetic properties. He developed methods to study the eukaryotic cytoskeleton in yeast to detect gene interactions and co-founded the Saccharomyces Genome Database. His laboratory has collaborated in applying microarray technology to study genome-wide gene expression patterns to define human tumor subtypes, while also developing the statistical methods and graphical interfaces now widely used to interpret genomic data.
A noted educator, Dr. Botstein has taught at the Massachusetts Institute of Technology, Stanford University, and directed the Lewis-Sigler Institute at Princeton. He is also credited with establishing a new introductory science curriculum at Princeton that combines biology, physics, chemistry, and computer science. More recently, he has helped fund innovative curricula in technology-advanced teaching laboratories at various institutions.
2014 AACR-Irving Weinstein Foundation Distinguished Lectureship2013 Breakthrough Prize in Life Sciences2012 Dan David Prize, Dan David Foundation, Tel Aviv University2010 Albany Medical Center Prize in Medicine and Biomedical Research2003 Peter and Patricia Gruber Foundation Award in Genetics1993 Elected Member, Institute of Medicine1992 Lewis S. Rosenstiel Award for Distinguished Work in Basic Medical Science1992 Dickson Prize in Medicine, University of Pittsburgh1989 Allen Award, American Society for Human Genetics1988 Genetics Society Medal1985 Elected Fellow, American Academy of Arts and Sciences1981 Elected Member, National Academy of Sciences, Washington, DC1978 Eli Lily Award in Microbiology and Immunology, American Society for Microbiology1967 PhD, University of Michigan