Andrew Z. Fire, PhD
Departments of Pathology and Genetics, George D. Smith Professor in Molecular and Genetic Medicine, Stanford University School of Medicine, Stanford, California
Internationally recognized for his pioneering research on the regulation of genes in Caenorhabditis elegans, Dr. Fire was awarded the 2006 Nobel Prize in Physiology or Medicine, along with Dr. Craig C. Mello, for their contributions to the understanding of RNA interference, a fundamental mechanism of selective gene silencing. In a series of key experiments, Dr. Fire demonstrated that double-stranded RNA molecules can selectively suppress the activity of matching target genes.
This groundbreaking work has since been exploited by countless researchers, allowing them to better understand gene function in both normal and cancerous cells. Similarly, new technologies stemming from Dr. Fire’s discovery have contributed to opening up numerous opportunities in drug discovery, diagnostics, and treatment for a variety of human diseases, including cancer. Dr. Fire’s current research is focused on understanding the molecular machinery that controls RNA interference and response to foreign genetic information.
2006 Nobel Prize in Physiology or Medicine2006 Paul Ehrlilch and Ludwig Darmstaedter Prize, Paul Ehrlich Foundation2005 Canada Gairdner International Award2005 Lewis S. Rosenstiel Award for Distinguished Work in Basic Medical Science2005 Massry Prize, University of Southern California2004 Elected Member, National Academy of Sciences, Washington, DC2004 Elected Fellow, American Academy of Arts and Sciences2004 Heineken Prize for Biochemistry and Biophysics, Royal Netherlands Academy of Sciences, Amsterdam2004 Warren Triennenial Prize, Massachusetts General Hospital2003 Passano Award2003 National Academy of Sciences Award in Molecular Biology2002 Genetics Society of America Medal2002 Myenburg Prize, German Cancer Research Center1983 PhD, Massachusetts Institute of Technology