Sir Michael R. Stratton, MBBS, PhD
Director, Wellcome Trust Sanger Institute, Cambridge, United Kingdom
An internationally acclaimed expert in cancer genetics and genomics, Dr. Stratton’s groundbreaking discoveries have revolutionized our understanding of cancer susceptibility as well as the role of individual genes in driving cancer. His pioneering research in these areas has had a major impact on the approaches taken to prevent and treat several types of cancer.
Early in his career, Dr. Stratton successfully mapped and identified the breast cancer susceptibility gene BRCA2, a breakthrough that directly transformed the lives of thousands of women in families with a history of breast cancer. Along with the rise of human genome sequencing, Dr. Stratton shifted his interests from genetic cancer susceptibility to understanding the role of somatic genetic aberrations in cancer, and concordantly initiated the Cancer Genome Project at the Wellcome Trust Sanger Institute.
Through his genome-wide sequencing studies, Dr. Stratton has identified numerous susceptibility genes and somatic mutations that drive a variety of human cancers, including specific mutations in the BRAF gene that have been linked to 60 percent of malignant melanomas. This remarkable discovery has since led to the development of BRAF inhibitors, which provide hope for many patients with melanoma. More recently, Dr. Stratton has employed powerful second-generation sequencing techniques to define the complex patterns of gene rearrangements and point mutations that exist in solid tumor genomes. These studies continue to lead to new insights into the process of human carcinogenesis.
2013 AACR Distinguished Lectureship in Breast Cancer Research2013 Knight Bachelor of the British Empire, Queen’s Birthday Honours2013 AACR-G.H.A. Clowes Memorial Award2012 Ernst W. Bertner Award, MD Anderson Cancer Center2010 C. Chester Stock Award Lectureship, Memorial Sloan-Kettering Cancer Center2010 Lila Gruber Award for Cancer Research, American Academy of Dermatology2008 Elected Fellow, The Royal Society, London2008 Biomedicum Helsinki Medal2002 Lennox K. Black International Prize for Excellence in Biomedical Research2001 Tom Connors Award Lectureship, British Association for Cancer Research1999 Elected Fellow, Academy of Medical Sciences, London (hon)1991 Fellow, Royal College of Pathologists1989 PhD, Institute of Cancer Research, London1982 MBBS, Guys Hospital, London