Aaron J. Ciechanover, MD, D.Sc.
Distinguished Research Professor, Technion - Israel Institute of Technology, Haifa, Israel
The discovery that the destruction of proteins is as important as their synthesis for the maintenance of protein homeostasis in cells and the unraveling of the ubiquitin system that targets proteins for degradation led to the 2004 Nobel Prize in Chemistry for Dr. Ciechanover. His recent focus has been the involvement of the ubiquitin-protease system (UPS) in the pathogenesis of malignant transformation, especially via activation of NF-κB, the anti-apoptotic factor that is activated by the UPS, and evasion of apoptosis by malignant cells as they gradually develop resistance to genotoxic agents. Identifying irregularities in the UPS has proved critically important in cancer as well as neurodegenerative and immunologic diseases and has resulted already in the development of successful drugs to combat multiple myeloma.
Dr. Ciechanover’s ground-breaking work has opened up opportunities in drug discovery, diagnostics, and treatment. For this work, he has received numerous honors and dozens of honorary degrees in recognition of his contributions to many areas of science.
2011 Elected Foreign Member, Russian Academy of Sciences2008 Elected Foreign Fellow (Honorary), American Academy of Arts and Sciences2008 Elected Foreign Associate, Institute of Medicine 2007 Elected Foreign Associate, National Academy of Sciences, Washington, DC2007 Elected Member, Pontifical Academy of Sciences, the Vatican 2006 Sir Hans Krebs Medal, Federation of the European Biochemical Societies (FEBS)2005 Elected Foreign Member, American Philosophical Society2004 Nobel Prize in Chemistry 2004 Elected Member, Israeli Academy of Sciences and Humanities 2003 Israel Prize for Biology2000 Albert Lasker Award for Basic Medical Research1996 Elected Member, European Molecular Biology Organization (EMBO)1981 D.Sc., Technion-Israel Institute of Technology1974 MD, Hebrew University Medical School1970 M.Sc., Hebrew University Faculty of Natural Sciences