Raymond N. DuBois, MD, PhD
Dean, Medical University of South Carolina, Charleston, South Carolina
In ground-breaking research, Dr. DuBois elucidated the role of cyclooxygenase 2 (COX-2) in colon cancer and the contributions of the lipid metabolite prostaglandin E2 (PGE2) to tissue inflammation in the etiology of colon cancer. This research led to the finding that use of a COX-2 inhibitor reduced polyp formation in patients with familial adenomatous polyposis. His recent research has focused on molecules involved in tissue inflammation and epigenetic changes in colorectal cancer progression, showing that PGE2 induces DNA methylation in PGE2-treated colon cancer cells and mouse interstitial tissues, leading to selective silencing of tumor suppressor genes.
A physician scientist and administrator with expertise in basic, translational and clinical research, Dr. DuBois currently holds a joint appointment at the Mayo Clinic and is internationally renowned for his work in cancer prevention. Dr. DuBois’ current research at Arizona State University is focused on discovering combination therapies to advance the treatment of colorectal cancer.
2010 President, International Society for Gastrointestinal Cancer2008-2009 President, AACR2007-2012 Provost and Executive Vice President, University of Texas MD Anderson Cancer Center2005-2007 Director, Vanderbilt-Ingram Cancer Center2004 Elected Fellow, American Association for the Advancement of Science2004 Distinguished Achievement Award, American Gastroenterology Association2004 Dorothy P. Landon-AACR Cancer Research Prize2003-2006 Board of Directors, American Association for Cancer Research2002 AACR-Richard and Hinda Rosenthal Foundation Cancer Research Award2001-2007 Professor of Cancer Biology, Vanderbilt University Medical Center2000 President, Southern Society for Clinical Investigation2000 Outstanding Investigator Award, American Federation for Medical Research2000 Royal College of Physicians (by distinction), London, UK1998-2004 Director of Gastroenterology, Hepatology and Nutrition, Vanderbilt University Medical Center1985 MD, University of Texas Health Sciences Center1981 PhD University of Texas Southwestern Medical Center