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FINDING CURES TOGETHER<sup>SM</sup>

AACR G.H.A. Clowes Memorial Award Recipients

This award recognizes outstanding recent accomplishments in basic cancer research.

58th Award Recipient
Scott W. Lowe, PhD
Chair, Cancer Biology and Genetics Programs
Memorial Sloan Kettering Cancer Center
New York, New York

Dr. Lowe delivered his award lecture titled “Cancer Drivers and Dependencies” at the AACR Annual Meeting 2018 in Chicago, Illinois. The award presentation and lecture were held Monday, April 16, 2018, at the McCormick Place North/South Convention Center.

This award was established in 1961 by AACR and Lilly Oncology to honor Dr. G.H.A. Clowes, a founding member of AACR and past research director at Lilly Oncology. The award recognizes an individual that has had outstanding recent accomplishments in the field of basic cancer research.

Scott W. Lowe, PhD, is honored for his visionary research on the mechanisms of tumor suppression, including discovering the process of oncogene-induced senescence and defining how senescence may influence therapeutic response. He is also recognized for his contributions to the understanding of p53 biology and for developing RNAi screens for target validation and drug discovery involving the p53 signaling axis.

Dr. Lowe received his bachelor’s degree from the University of Wisconsin-Madison and his PhD from the Massachusetts Institute of Technology. He initiated his independent research at Cold Spring Harbor Laboratory, where his group made important contributions to our understanding of the p53 tumor suppressor network, as well as the processes of multi-step carcinogenesis, cellular senescence, and tumor-cell drug resistance.

At Memorial Sloan Kettering Cancer Canter, Dr. Lowe’s laboratory applies mouse models, functional genomics and cancer genomics in a coordinated effort to identify cancer drivers and dependencies. These efforts have revealed fundamental insights into cancer mechanisms and identified potential therapeutic targets.

Dr. Lowe’s work has been recognized by several awards, including a Sidney Kimmel Scholar Award, a Rita Allen Scholar Award, the Outstanding Achievement Award in Cancer Research from the American Association for Cancer Research, the Paul Marks Prize, and the Alfred G. Knudsen Award. He has also been elected to the American Academy of Arts and Sciences, the National Academy of Sciences, and in 2014, served as chairperson of the AACR Annual Meeting Program Committee.

 2018 AACR Clowes Award Presentation.jpg

Award Recipients

  • 2017: Riccardo Dalla-Favera
  • 2016: Vishva M. Dixit
  • 2015: Owen N. Witte
  • 2014: James P. Allison
  • 2013: Michael R. Stratton
  • 2012: Alan D. D'Andrea
  • 2011: Yosef Shiloh
  • 2010: Titia de Lange
  • 2009: Joan Massagué
  • 2008: John E. Dick 
  • 2007: Michael B. Kastan 
  • 2006: Carlo M. Croce
  • 2005: David M. Livingston
  • 2004: Frederick W. Alt
  • 2003: Ronald A. DePinho
  • 2002: Frank McCormick
  • 2001: Stephen J. Elledge
  • 2000: Elizabeth H. Blackburn
  • 1999: Mina J. Bissell
  • 1998: Arnold J. Levine
  • 1997: Stanley J. Korsmeyer
  • 1996: Robert A. Weinberg
  • 1995: Bert Vogelstein
  • 1994: Mary-Claire King
  • 1993: Stuart H. Yuspa
  • 1992: June L. Biedler
  • 1991: Michael H. Wigler
  • 1990: Erkki Ruoslahti
  • 1989: Janet D. Rowley
  • 1988: Isaiah J. Fidler
  • 1987: I. Bernard Weinstein
  • 1986: Hidesaburo Hanafusa
  • 1985: Judah Folkman
  • 1984: Emmanuel Farber
  • 1983: Peter N. Magee
  • 1982: George Weber
  • 1981: Allan H. Conney
  • 1980: Lloyd J. Old
  • 1979: Roswell K. Boutwell
  • 1978: Torbjorn Caspersson
  • 1977: Ludwik Gross
  • 1976: Henry S. Kaplan
  • 1975: Elwood V. Jensen
  • 1974: Howard M. Temin
  • 1973: Wallace P. Rowe
  • 1972: Sidney Weinhouse
  • 1971: Howard E. Skipper
  • 1970: Charles Heidelberger
  • 1969: James A. Miller
  • 1968: George H. Hitchings
  • 1967: George Klein
  • 1966: Joseph W. Beard
  • 1965: Lloyd W. Law
  • 1964: Van R. Potter
  • 1963: Peyton Rous
  • 1962: Jacob Furth
  • 1961: Renato Dulbecco