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FINDING CURES TOGETHER<sup>SM</sup>

AACR-Women in Cancer Research Charlotte Friend Memorial Lectureship Recipients

The WICR Friend Lectureship is presented to an outstanding scientist who has made meritorious contributions to the field of cancer research and who has, through leadership or by example, furthered the advancement of women in science.

Twenty-first Award Recipient
Dafna Bar-Sagi, PhD
Senior Vice President & Vice Dean for Science; Chief Scientific Officer
New York University Langone Medical Center
                           New York, NY

Dr. Bar-Sagi delivered her award lecture titled "Unravelling mechanisms of oncogenic Ras-mediated tumorigenesis" at the Annual Meeting 2018 in Chicago, IL. The award lecture was held Monday, April 16, 2018, in the McCormick Place North/South Convention Center. 

The AACR-Women in Cancer Research Charlotte Friend Memorial Lectureship was established in 1998 in honor of renowned virologist and discoverer of the Friend virus, Dr. Charlotte Friend, for her pioneering research on viruses, cell differentiation, and cancer. The lectureship recognizes an outstanding scientist who has made meritorious contributions to the field of cancer research and who has, through leadership or by example, furthered the advancement of women in science.

Dafna Bar-Sagi, PhD is honored as a world-renowned cancer biologist whose research has had a major impact on the understanding of mechanisms that control tumor initiation and progression. The focus of her work is the Ras oncogene and its role in the regulation of cell proliferation and survival, tumor immunity, cellular metabolism, and cell-to-cell signaling. Her laboratory is credited with identifying key molecular events that mediate Ras activation by extracellular signals and regulate its intracellular activity. She was also the first to show that oncogenic KRas is directly involved in conferring immune suppression – a discovery that establishes a new mechanistic paradigm for therapeutic interventions.

Currently, Dr. Bar-Sagi’s research is centered on the contribution of oncogenic Ras to the metabolic adaptation of tumor cells. Her efforts in this area have established a new paradigm for nutrient delivery into tumor cells involving the scavenging of extracellular protein by macropinocytosis. This nutrient delivery mechanism has broad implications for understanding the metabolic vulnerabilities of Ras-driven tumors.

Dr. Bar-Sagi is a pillar of the cancer research community and continues to work tirelessly to improve outcomes for women. She embodies the true meaning of being a role model for those who cross her path.

Dr. Bar-Sagi is the senior vice president and vice dean for science, chief scientific officer of NYU Langone Medical Center. She is also a Professor of Biochemistry and Molecular Pharmacology. After earning her undergraduate and master's degree in Biochemistry from Bar-Ilan University in Israel, Dr. Bar-Sagi completed a PhD in Cell Biology at the State University of New York, Stony Brook.

Dr. Bar-Sagi is the recipient of numerous honors and awards, including an NCI Outstanding Investigator Award and an NCI Merit Award. She has been a member of many advisory boards including the Board of Directors of the AACR, NCI Board of Directors, and the Pancreatic Cancer Action Network, and she has served on the editorial boards of multiple journals including Cancer Cell, Oncogene, and Molecular and Cellular Biology.

AACR WICR Lectureship Presentation.jpg

Award Recipients

  • 2017: Anne-Lise Børresen-Dale
  • 2016: Angelika Amon
  • 2015: Sara A. Courtneidge
  • 2014: Charis Eng
  • 2013: Guillermina Lozano
  • 2012: Lisa M. Coussens
  • 2011: Carol L. Prives
  • 2010: Elaine V. Fuchs
  • 2009: Jessica K. Tyler
  • 2008: Nancy E. Davidson 
  • 2007: Janet S. Butel  
  • 2006: Nancy Hopkins
  • 2005: Joan S. Brugge
  • 2004: Titia de Lange
  • 2003: Janet D. Rowley
  • 2002: Ellen S. Vitetta
  • 2001: Zena Werb
  • 2000: Leona D. Samson
  • 1999: Lorraine L. Gudas
  • 1998: Frances Visco

 

Prior to 1998, the lectureship was known as the WICR Keynote Lecture.

  • 1997: Mary-Claire King
  • 1996: Cora B. Marrett
  • 1995: Gertrude B. Elion
  • 1994: Mary Ellen Jones
  • 1993: Florence Haseltine