American Association for Cancer Research

Press Releases: 2012

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Unexpected MEK1 Mutations Not Cause of Potent Melanoma Drug Resistance

April 1, 2012

CHICAGO — A genetic mutation in MEK1 does not prevent response to BRAF inhibitors in patients undergoing treatment for BRAF-mutated melanomas,...

AACR Board of Directors Pronounce Crisis in Cancer Research Funding its No. 1 Priority

April 1, 2012

CHICAGO — Leaders from the American Association for Cancer Research, which today opened its AACR Annual Meeting 2012 here, declared that the...

Older Patients With Certain Breast Cancer Subtype May Not Benefit From Radiation Therapy

April 1, 2012

CHICAGO — Local breast radiation therapy may not be necessary for women with the luminal A subtype of breast cancer, particularly those aged...

Long-term Use of Estrogen Hormone Therapy Linked to Higher Risk for Breast Cancer

April 1, 2012

CHICAGO — In a landmark study, researchers have linked the long-term use of estrogen plus progesterone and estrogen-only hormone therapy with a...

HPV Infection Lasts Longer in College-age African-American Women

April 1, 2012

CHICAGO — College-age African-American women have a more difficult time clearing human papillomavirus infection and are more likely to have an...

Link Between Inflammation and Breast Cancer Metastases Identified, May Be Treatable

April 1, 2012

CHICAGO — The incidence of breast cancer-associated metastasis was increased in animal models of the chronic inflammatory condition arthritis,...

Proteins Associated With Poor Prognosis in Hormone Receptor-positive Breast Cancer Identified

April 1, 2012

CHICAGO — Researchers have identified specific proteins involved in translation that when overexpressed or activated are associated with a...

Lack of Oxygen Influenced Tumor Behavior and Patient Outcome in Intermediate-risk Prostate Cancer

March 31, 2012

CHICAGO — Hypoxia, or a lack of oxygen, in prostate cancer tumors was associated with early biochemical relapse and local recurrence after...

EGFR Mutation Unique to Glioblastoma May Explain Lack of Response to Traditional EGFR Inhibitors

March 31, 2012

CHICAGO — The epidermal growth factor receptor mutations that occur in glioblastoma differ from those that occur in lung cancers — a...

Novel Technology Allows for Noninvasive Imaging of Prostate Cancer

March 31, 2012

CHICAGO — Use of a novel, noninvasive imaging tool allowed researchers to measure free prostate-specific antigen in prostate cancer models and...

Selumetinib Controlled Recurrent Low-grade Serous Ovarian Cancer

March 31, 2012

CHICAGO — Selumetinib, a small-molecule MEK inhibitor, demonstrated the ability to control low-grade serous ovarian or peritoneal cancer,...

Biomarker Identified in Relation to Drug Response in Refractory Urothelial Cancer

March 31, 2012

CHICAGO — The antiangiogenic drug pazopanib has demonstrated clinically meaningful activity in patients with refractory urothelial cancer,...

Oral Vitamin D Supplements Reduced Levels of Ki67 in Prostate Cancer Cells

March 31, 2012

CHICAGO — Higher oral doses of plain vitamin D raised levels of calcitriol in prostate tissue. Higher prostate levels of calcitriol, a hormone...

Early Clinical Data Show Galeterone Safe, Effective Against Prostate Cancer

March 31, 2012

CHICAGO — Patients with castration-resistant prostate cancer had limited side effects and in many cases a drop in prostate-specific antigen...

Combination Targeted Therapy Well Tolerated, Effective for Refractory Ewing’s Sarcoma Tumors

March 31, 2012

CHICAGO — A combination of targeted therapies may be effective against relapsed or recurrent Ewing’s sarcoma or desmoplastic...

Metformin Appeared to Slow Prostate Cancer Growth

March 31, 2012

CHICAGO — The use of metformin in men with prostate cancer before prostatectomy helped to reduce certain metabolic parameters and slow the...

Metformin May Protect Against Liver Cancer

March 31, 2012

PHILADELPHIA — Metformin, a widely used, well-tolerated drug prescribed for patients with diabetes, may protect against liver cancer, according...

Metformin May Lower Risk for Oral Cancer Development

March 31, 2012

PHILADELPHIA — New findings published in Cancer Prevention Research, a journal of the American Association for Cancer Research, suggest that...

Metformin May Improve Pancreatic Cancer Prognosis in Patients With Diabetes

March 31, 2012

PHILADELPHIA — Patients with diabetes and pancreatic cancer who are prescribed metformin may have improved survival compared with those not...

Metformin in Combination With Common Cancer Drug Increased BRAF-Mutant Melanoma Tumor Response

March 31, 2012

PHILADELPHIA — The combination of metformin, a commonly prescribed antidiabetic drug, and vascular endothelial growth factor-A inhibitors...

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