AACR News
Below are highlights of peer-reviewed cancer research published in the May issues of Clinical Cancer Research and Cancer Research. Please check back for upcoming highlights from Cancer Epidemiology, Biomarkers and Prevention and Cancer Prevention Research.
- Men whose prostate cancer screenings show high grade prostatic intraepithelial neoplasia (HG-PIN) may find themselves in limbo, "stuck" between diagnoses - they are told prostate cancer has not yet developed, but it might, and they are advised to undergo repeated needle biopsies as a precaution. Learn More.
Source: Morote, J. PTOV1 Expression in Cancer Associated HG-PIN. Clinical Cancer Research
- Based on research using a new mouse model of gastritis and stomach cancer, researchers from the Massachusetts Institute of Technology (MIT) say that prompt treatment of Helicobacter pylori (H. pylori) infections reverses damage to the lining of the stomach that can lead to cancer. Learn More.
Source: Fox, J. H. pylori Eradication and Cancer Prevention in Mice. Cancer Research
- Scientists have discovered a cellular process that may contribute to the development of colon cancer stem cells. Researchers suggest a deregulation of two cellular mechanisms responsible for cell proliferation and DNA synthesis may lead to an increase in mutated cells resulting in colon cancer.
Source: Boman, B. How Dysregulated Colonic Crypt Dynamics Cause Stem Cell Overpopulation and Initiate Colon Cancer. Cancer Research
- Inhibition of the epidermal growth factor receptor (EGFR) in combination with conventional chemotherapy may improve treatment for soft tissue sarcoma. Researchers found that EGFR may inhibit the activation of certain pathways and increase apoptosis, or programmed cell death, potentially limiting soft tissue sarcoma activity.
Source: Lev, D (2008). Epidermal growth factor receptor (EGFR) blockade in combination with conventional chemotherapy inhibits soft tissue sarcoma (STS) cell growth in vitro and in vivo. Clinical Cancer Research