American Association for Cancer Research

FY2009 AACR Testimony

 

Written Testimony

from the

American Association for Cancer Research (AACR)

 

Submitted to U.S. House and Senate Appropriations Committees

April 28, 2008

 

Submitted by: Margaret Foti, Ph.D., M.D. (h.c.), Chief Executive Officer
American Association for Cancer Research, 615 Chestnut Street, 17th Floor
Philadelphia, PA 19106; (215) 440-9300/fax (215) 440-9313

 

Executive Summary

 

The American Association for Cancer Research (AACR) would like to thank members for their support of National Institutes of Health (NIH) and National Cancer Institute (NCI) research on the biology, treatment and prevention of the more than 200 diseases called cancer. The AACR, with more than 26,000 members worldwide, represents and supports scientists by publishing respected, peer-reviewed scientific journals, hosting international scientific conferences and awarding millions of dollars in research grants. Together, we have made great strides in the war on cancer, but much remains to be done. One in four deaths in America this year will be caused by cancer. Cancer-related deaths will increase dramatically as the baby boom generation ages, and we must be prepared to prevent, treat and manage the impending wave of new cancers.

Cancer is no longer a death sentence thanks to decades of research and development made possible by strong commitments from Congress and the American people, but now that commitment is wavering. After expanding capacity during the NIH budget doubling, researchers at hospitals and universities across the country now face shrinking budgets. Promising young researchers, unable to secure grants, turn to other careers. This disruption of the research pipeline will slow the development of new treatments and set back America's biomedical leadership for decades to come.

We are at the vanguard of a revolution in health care, where personalized treatment will improve health, reduce harmful side effects and lower costs. We have the opportunity to build upon our previous investments and accelerate the research process. Now is the time to face the nation's growing health care needs, reaffirm our role as world leaders in science, and renew our commitment to the research and development that brings hope to millions of suffering Americans. The AACR urges the U.S. Senate to support the following appropriations funding levels for cancer research in FY2009:

  • $32.1 billion for the National Institutes of Health, a 10.24 percent increase over FY2008.
  • At least $5.3 billion for the National Cancer Institute (the NCI Professional Judgment budget required to maintain current services), a 9.5 percent increase over FY2008.

The American Association for Cancer Research recognizes and expresses its thanks to the United States Congress for its longstanding support and commitment to funding cancer research. The completion of the five-year doubling of the budget of the National Institutes of Health (NIH) in 2003 was a stunning accomplishment that is already showing impressive returns and benefits to patients with cancer. Recently, however, budgets for cancer research have declined; this commitment appears to be wavering. Budget doubling enabled a significant expansion of infrastructure and scientific opportunities. Budget cuts prevent us from capitalizing on them.

Unquestionably, the nation's investment in cancer research is having a remarkable impact. Cancer death rates have been declining for over a decade, and the total number of annual cancer deaths declined in 2003 and 2004. This progress occurred in spite of an aging population and the fact that more than three-quarters of all cancers are diagnosed in individuals aged 55 and older. Yet this good news will not continue without sustained and substantial federal funding for critical cancer research priorities. Indeed, cancer deaths are again on the rise as the population ages. The American Association for Cancer Research joins the 95 Senators who voted in favor of the Specter/Harkin budget amendment in urging the United States Senate to support the following appropriations funding levels for cancer research in FY2009:

  • $32.1 billion for the National Institutes of Health, a 10.24 percent increase over FY2008.
  • At least $5.3 billion for the National Cancer Institute (the NCI Professional Judgment budget required to maintain current services), a 9.5 percent increase over FY2008.

AACR: Fostering a Century of Research Progress

The American Association for Cancer Research has been moving cancer research forward since its founding 101 years ago in 1907. The AACR and its more than 26,000 members worldwide strive tirelessly to carry out its important mission to prevent and cure cancer through research, education and communication. It does so by:

  • Fostering research in cancer and related biomedical science;
  • Accelerating the dissemination of new research findings among scientists and others dedicated to the conquest of cancer;
  • Promoting science education and training; and
  • Advancing the understanding of cancer etiology, prevention, diagnosis and treatment throughout the world.

Facing An Impending Cancer "Tsunami"

Over the past century, enormous progress has been made toward the conquest of the nation's second most lethal disease (after heart disease). Thanks to discoveries and developments in prevention, early detection and more effective treatments, many of the more than 200 diseases called cancer have been cured or converted into manageable chronic conditions while preserving quality of life. The five-year survival rate for all cancers has improved over the past 30 years to more than 65 percent. The completion of the doubling of the NIH budget in 2003 is bearing fruit as many new and promising discoveries are unearthed and their potential realized. However, there is much left to be done, especially for the most lethal and rarer forms of the disease.

We recognize that the underlying causes of the disease and its incidence have not been significantly altered. The fact remains that men have a 1 in 2 lifetime risk of developing cancer, while women have a 1 in 3 lifetime risk. The leading cancer sites in men are the prostate, lung and bronchus, and colon and rectum. For women, the leading cancer sites are breast, lung and bronchus, and colon and rectum. And cancer still accounts for 1 in 4 deaths, with more than 564,830 people expected to die from their cancer in 2006. Age is a major risk factor - this nation faces a virtual "cancer tsunami" as the baby boomer generation reaches age 65 in 2011. A renewed commitment to progress in cancer research through leadership and resources will be essential to dodge this cancer crisis.

Federal Investment for Local Benefit

Nearly 80 percent of the NCI budget is awarded to scientists who work at local hospitals and universities throughout the country. More than 5,400 research grants are funded at more than 150 cancer centers and specialized research facilities located in 49 states. Over half the states receive more than $15 million in grants and contracts to institutions located within their borders. Many AACR member scientists are engaged in this rewarding work. But too many of them have had their long-term research jeopardized by grant reductions caused by the flat and declining overall funding for the NCI since 2003. The AACR recommends, at a minimum, a 9.5 percent increase in funding for the National Cancer Institute to maintain its current services, and supports a 10.24 percent increase to enable the National Cancer Institute to expand its work on focused research questions.

Understanding the Causes and Mechanisms of Cancer

Basic research into the causes and mechanisms of cancer is at the heart of what the NCI and many of AACR's member scientists do. Basic research is the engine that drives scientific progress. The outcomes from this fundamental basic research - including laboratory and animal research in addition to population studies and the deployment of state-of-the-art technologies - will inform and drive the cancer research enterprise in ways and directions that will lead to unparalleled progress in the search for cures.  

Accelerating Progress in Cancer Prevention

Preventing cancer is far more cost-effective and desirable than treating it. The NCI uses multidisciplinary teams and a systems biology approach to identify early events and how to modify them. More than half of all cancers are related to modifiable behavioral factors, including tobacco use, diet, physical inactivity, sun exposure and failure to get cancer screenings. The NCI supports research to understand how people perceive risk, make health-related decisions and maintain healthy behavior. Prevention is the keystone to success in the battle against cancer.

Developing Effective and Efficient Treatments

The future of cancer care is all about developing individualized therapies tailored to the specific characteristics of a patient's cancer. Noteworthy recent advances in this area have included the development of oral versions of medicines that were formerly only available by injection, thus improving patients' quality of life, and the discovery of intraperitoneal (IP) chemotherapy - delivering drugs directly to the abdominal cavity - that can add more than a year to survival for some women with ovarian cancer.

Overcoming Cancer Health Disparities

Some minority and underserved population groups suffer disproportionately from cancer. Solving this issue will contribute significantly to reducing the cancer burden. Successful achievements in this important area include the development and dissemination of the patient navigator program that assists patients and caregivers to access and chart a course through the health care system, and the NCI Cancer Information Services Partnership Program that provides information and education about cancer in lay language to the medically underserved through community organizations.

AACR's Initiatives Augment Support for the NCI

The NCI is not working alone or in isolation in any of these key areas. NCI research scientists reach out to other organizations to further their work. The AACR is engaged in scores of initiatives that strengthen, support and facilitate the work of the NCI, including:

  • Sponsoring the largest meeting of cancer researchers in the world, with more than 17,000 scientists and 6,000 abstracts featuring the latest scientific advances;
  • Publishing more than 3,400 original research articles each year in six prestigious peer-reviewed scientific journals, including Cancer Research;
  • Sponsoring the annual International Conference on Frontiers of Cancer Prevention Research, the largest such prevention meeting of its kind in the world; and
  • Raising and distributing more than $5 million in awards and research grants.

Training and Career Development for the Next Generation of Researchers

Of critical importance to the viability of the long-term cancer research enterprise is supporting, fostering and mentoring the next generation of investigators. The NCI devotes approximately 4 percent of its budget to multiple strategies in training and career development, including sponsored traineeships, a Medical Scientist Training Program, special set-aside grant programs and bridge grants for early career cancer investigators. Increased funding for these foundational opportunities is essential to retain the scientific workforce that is needed to continue the fight against cancer.

Increase Research Funding Now

Remarkable progress is being made in cancer research, but much more remains to be done. Cancer costs the nation more than $209 billion in direct medical costs and lost productivity due to illness and premature death. Respected University of Chicago economists Kevin Murphy and Robert Topel have estimated that even a modest 1 percent reduction in mortality from cancer would be worth nearly $500 billion in social value. Investments in cancer research have huge potential returns. Thanks to successful past investments, promising research opportunities abound and must not be lost. To maintain our research momentum, the American Association for Cancer Research urges the United States Senate to support the following appropriations funding levels for cancer research in FY2009:

  • $32.1 billion for the National Institutes of Health, a 10.24 percent increase over FY2008.
  • At least $5.3 billion for the National Cancer Institute (the NCI Professional Judgment budget required to maintain current services), a 9.5 percent increase over FY2008.