American Association for Cancer Research

Endogenous Small Molecules that Regulate Signaling Pathways in Cancer Cells


A major goal in cancer biology is to understand the molecules that drive the growth and spread of cancer cells. This understanding is essential for developing targeted therapies that kill cancer cells while minimizing damage to normal cells. Rohatgi will focus on endogenous small molecules in cells that play a role in the signaling processes that cause cancer. Using an integrative strategy combining tools from cell biology and chemistry, he will identify small molecules that regulate the Hedgehog signaling pathway, which drives the development of a large number of adult and childhood cancers. Drugs that interfere with the function of this pathway hold promise for future cancer treatments.


Rajat Rohatgi, M.D., Ph.D., assistant professor in the Department of Medicine and Oncology at the Stanford University School of Medicine

Updated: Dec. 3, 2009