MONDAY, APRIL 16
7:00 a.m. to 8:00 a.m.
Breast Cancer: A Model for Translational Research in Solid Tumors, Martin D. Abeloff, Sidney Kimmel Comprehensive Cancer Center, Baltimore, MD
Chromatin and Cancer, Moshe Yaniv, Institut Pasteur, Paris, France
Combinatorial Cancer Immnunotherapy, Glenn Dranoff, Dana-Farber Cancer Institute, Boston, MA
From Surrogates to Mechanistic Kinase Biomarkers at the Single Cell Level in the Immune System and Hematological Cancers, Garry P. Nolan, Stanford School of Medicine, Palo Alto, CA
Inflammation and Cancer, William G. Nelson, V, Sidney Kimmel Comprehensive Cancer Center, Baltimore, MD
Integrating Chemical and Biological Etiologies to Effect Cancer Prevention, John D. Groopman, Johns Hopkins University, Baltimore, MD
Molecular Control of Apoptosis and Its Role in Tumorigenesis and Cancer Therapy, Andreas Strasser, The Walter and Eliza Hall Institute, Parkville, Australia
Mouse Models of Human Cancer, Dean W. Felsher, Stanford University School of Medicine, Stanford, CA
Mutations in Cancer Genomes, P. Andrew Futreal, Wellcome Trust Sanger Institute, Hinxton, United Kingdom
Optical and Magnetic Resonance Molecular Imaging, Umar Mahmood, Massachusetts General Hospital, Boston, MA
Ras Oncogene Signaling Networks, Julian Downward, Cancer Research UK, London, United Kingdom
Regulation of Stem Cell Functions, Connie J. Eaves, BC Cancer Research Center, Vancouver, BC, Canada
Spotlight on Molecular Profiling in Cancer Pharmacology and Therapeutics, John N. Weinstein, National Cancer Institute, Bethesda, MD
Centennial Lecture
Targeting PI3K in Cancer, Lewis C. Cantley, Beth Israel Deaconess Medical Center, Boston, MA
Targeting the WNT Pathway in Cancer, Paul G. Polakis, Genentech, Inc., South San Francisco, CA
The Benefits of Retaining p53 Activity, Moshe Oren, The Weizmann Institute of Science, Rehovot, Israel
Translational Cancer Medicine, Gordon B. Mills, UT M.D. Anderson Cancer Center, Houston, TX
Centennial Lecture
What Is the Potential Future for Angiogenesis-based Biomarkers?, Judah Folkman, Harvard Medical School, Boston, MA
Zebrafish, A. Thomas Look, Dana-Farber Cancer Institute, Boston, MA
TUESDAY, APRIL 17
7:00 a.m. to 8:00 a.m.
Building Successful Bioventures in Cancer, Geoffrey Duyk, Texas Pacific Group Ventures, San Francisco, CA
Centennial Lecture
Cancer-initiating Cells: From Leukemia to Solid Tumors, John E. Dick, University Health Network, Toronto, ON, Canada
Clinical Trials in Special Populations, Alex A. Adjei, Roswell Park Cancer Institute, Buffalo, NY
Design and Analysis of Genome-wide Association Studies, John S. Witte, University of California, San Francisco, CA
Early Detection Biomarker Discovery, Amanda Paulovich, Fred Hutchinson Cancer Research Center, Seattle, WA
Inherited Predisposition Syndromes in Pediatric Cancers, Kevin M. Shannon, University of California, San Francisco, CA
Metabolism and Cancer, Reuben J. Shaw, The Salk Institute for Biological Studies, La Jolla, CA
Myc in Breast Cancer Progression, Olufunmilayo I. Olopade, University of Chicago Medical Center, Chicago, IL
Oncogene-induced Senescence: In Vitro Tool or In Vivo Reality?, Daniel S. Peeper, The Netherlands Cancer Institute, Amsterdam, The Netherlands
Progress in Metronomic Antiangiogenic Chemotherapy, Robert S. Kerbel, Sunnybrook Health Sciences Center, Toronto, ON, Canada
Targeting p53 and the NF-kb, Andrei V. Gudkov, The Cleveland Clinic, Cleveland, OH
Centennial Lecture
The Multifactorial Nature of Resistance to Microtubule-stabilizing Drugs, Susan Band Horwitz, Albert Einstein College of Medicine, Bronx, NY
The Role of Intercellular Communication in Regulating the Development of Squamous Cell Carcinomas, Fiona M. Watt, Cancer Research UK, London, United Kingdom
The Shp2/Ras/Erk Pathway in Human Disease, Benjamin G. Neel, Beth Israel Deaconess Medical Center, Boston, MA
Tissue Recombinant Models of Cancer, Simon W. Hayward, Vanderbilt University Medical Center, Nashville, TN
Transcription Control in Cancer, Frank J. Rauscher III, The Wistar Institute, Philadelphia, PA
Viruses: Powerful Agents with Which to Understand and Treat Cancer, Clodagh C. O’Shea, UCSF Comprehensive Cancer Center, San Francisco, CA
WEDNESDAY, APRIL 18
7:00 a.m. to 8:00 a.m.
Ashkenazi Jews and Cancer Predisposition: A Model for Genomic Association Studies, Kenneth Offit, Memorial Sloan-Kettering Cancer Center, New York, NY
Combining Targeted Viral Replication and Gene/Immune Therapy of Cancer: Cancer Terminator Viruses, Paul B. Fisher, Columbia University, New York, NY
Computational Biology and Cancer, John Quackenbush, Dana-Farber Cancer Institute, Boston, MA
Endogenous Hormones and Breast Cancer Risk, Susan E. Hankinson, Brigham and Women’s Hospital, Boston, MA
Epigenome Technology, Peter W. Laird, USC/Norris Comprehensive Cancer Center, Los Angeles, CA
Functional Genomic Approaches to Identify Cancer Targets, William C. Hahn, Dana-Farber Cancer Institute, Boston, MA
Gain of Function in Mutants of Phosphatidylinositol 3-Kinase (PI3K), Peter K. Vogt, The Scripps Research Institute, La Jolla, CA
Glioblastoma Oncogenomics, Kenneth D. Aldape, UT M.D. Anderson Cancer Center, Houston, TX
How the Bcl2-Regulated Cell Death Switch Operates and Features in Tumor Development and Therapy, Jerry M. Adams, The Walter and Eliza Hall Institute, Parkville, Australia
Licensing Early-Stage Compounds: Preclinical Data in Context, Presenter to be announced
Models of Pediatric Malignancies in Drug Development, Peter J. Houghton, St. Jude Children’s Research Hospital, Memphis, TN
Centennial Lecture
Proliferation, Invasion, Genetic Instability and Malignant Progression, George F. Vande Woude, Van Andel Research Institute, Grand Rapids, MI
Stem Cells and Cancer Stem Cells in Solid Tumors Catriona H. M. Jamieson, Moores UCSD Cancer Center, La Jolla, CA
Telomeres, Victoria Lundblad, The Salk Institute for Biological Studies, La Jolla, CA
The Role of Chemokines in Tumor Formation, Angiogenesis, and Metastasis, Ann Richmond, Vanderbilt-Ingram Cancer Center, Nashville, TN
Centennial Lecture
Transcription and DNA Repair: Recent Developments Relevant to Cancer, Philip C. Hanawalt, Stanford University, Stanford, CA
Unfolded Protein Stress Response and Cancer, David Ron, NYU Medical Center, New York, NY