Sunday, April 1
The Cancer Biology Revolution: From Concept to Clinic
Chairperson: Benjamin G. Neel, Ontario Cancer Institute, Princess Margaret Hospital, Toronto, ON, Canada
Emerging landscape of the tumor genome Elaine Mardis, Washington University School of Medicine, St. Louis, MO
The genetic basis for cancer therapeutics William R. Sellers, Novartis Institutes for BioMedical Research, Cambridge, MA
Mobilizing the immune system to treat cancer: New insights and opportunities James P. Allison, Memorial Sloan-Kettering Cancer Center, New York, NY
Human papillomavirus in the etiology and prevention of genital cancers Nubia Muñoz, Consultant, Lyon, France
Molecular mechanisms of epigenetic inheritance Danny F. Reinberg, NYU Langone Medical Center, New York, NY
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Monday, April 2
Tumor Heterogeneity: Challenges and Therapeutic Opportunities
Chairperson: Lisa M. Coussens, Knight Cancer Institute Oregon Health & Science University, Portland, OR
Normalizing tumor microenvironment to treat cancer Rakesh K. Jain, Massachusetts General Hospital, Boston, MA
Reprogramming immune microenvironments in solid tumors and therapy Lisa M. Coussens
Stem cells in self-renewal and cancer Hans Clevers, Hubrecht Institute, Utrecht, The Netherlands
Genomic mapping of cancer origins Richard J. Gilbertson, St. Jude Children’s Research Hospital, Memphis, TN
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Tuesday, April 3
Immune Therapies: The Future Is Now
Chairperson: Patrick Hwu, The University of Texas MD Anderson Cancer Center, Houston, TX
Targeted blockade of immune checkpoints in cancer therapy Suzanne L. Topalian, Johns Hopkins Kimmel Comprehensive Cancer Center, Baltimore, MD
Chimeric antigen receptor T-cells for leukemia and more? Carl H. June, Abramson Family Cancer Center Research Institute, University of Pennsylvania, Philadelphia, PA
Current status of recombinant pox-viral vaccines James L. Gulley, National Cancer Institute, Bethesda, MD
T-cell therapy Patrick Hwu
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Wednesday, April 4
Pathway-Targeted Therapeutics: Coming of Age
Chairperson: Charles L. Sawyers, Memorial Sloan-Kettering Cancer Center, New York, NY
Overcoming cancer drug resistance Charles L. Sawyers
Ras and Raf signaling: From biology to therapeutics Richard M. Marais, Institute of Cancer Research, London, United Kingdom
ALK in non-small cell lung cancer: Understanding sensitivity and resistance to ALK inhibition Alice T. Shaw, Massachusetts General Hospital and Harvard Medical School, Boston, MA
Cell signaling by receptor tyrosine kinases: From basic principles to cancer therapy Joseph Schlessinger, Yale University School of Medicine, New Haven, CT
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