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The AACR Annual Meeting once again highlighted the latest and most exciting discoveries in every area of cancer research and provided a unique opportunity for investigators from all over the world to meet and forge collaborations. With the accelerating pace of discoveries in the basic, translational, and clinical sciences, due in large part to the advent of new technologies, cancer researchers are making rapid progress that is having significant patient benefit. It is clear that in the near future even greater opportunities for the prevention, management, and cures for all types of cancer will abound.