Program

TUESDAY, NOVEMBER 27

EDUCATIONAL WORKSHOPS
12:30 p.m.-2:30 p.m.

Research Methods in Cancer Disparities
Chairperson: Otis W. Brawley, Emory University Winship Cancer Institute, Atlanta, GA


• Measuring health disparities: Individual and neighborhood effects
  Chloe Bird, Rand Corporation, Santa Monica, CA
• Investigating health disparities using clinical trials
  James Dignam, University of Chicago Medical Center, Chicago, IL
• Defining the Problem: Comparisons of Populations
  Otis W. Brawley
• How to Use Genomic Markers in Disparities Studies
  Jill Barnholtz-Sloan, Case Comprehensive Cancer Center, Cleveland, OH

Biomarkers/Genetics
Chairperson: Rick A. Kittles, University of Chicago, Chicago, IL


• The implications of population structure on cancer genetic studies in recently admixed populations
  Rick A. Kittles
• Whole genome admixture mapping
  Matthew L. Freedman, Dana-Farber Cancer Institute, Boston, MA
• The use of multiple biomarkers to detect prostate cancer in African-American men
  Walter Rayford, University of Tennessee, Memphis, TN

EDUCATIONAL WORKSHOPS
2:45 p.m.-4:45 p.m.

Cancer Health Care Communications
Chairperson: Steven R. Patierno, George Washington University School of Medicine, Washington, DC


• Beyond access: Communication inequality and its implications for health disparities
  K. Vish Viswanath, Dana-Farber Cancer Institute, Boston, MA
• Unintended effects of emphasizing disparities in cancer communication
  Matthew Kreuter, St. Louis University, St. Louis, MO
• Ethnic tailoring in cancer communications
  Kenneth A. Resnicow, University of Michigan, Ann Arbor, MI
• Native American cancer communication: What works and what doesn't
  Linda Burhansstipanov, Native American Cancer Initiatives, Inc., Pine Grove, CO

Systems Biology
Chairperson: Frederic M. Waldman, University of California Comprehensive Cancer Center, San Francisco, CA


• Systems biology approaches
  Frederic M. Waldman
• Applying the concepts of systems biology to improve and make broadly accessible in vitro diagnostics
  James R. Heath, California Institute of Technology, Pasadena, CA
• Computational systems biology approaches to elucidating functional mechanisms underpinning molecular profiles of cancers
  Yves A. Lussier, University of Chicago, Chicago, IL
• The cancer Biomedical Informatics Grid™ (caBIG™): Enabling integrative cancer research
  Leslie K. Derr, National Cancer Institute, Center for Bioinformatics, Bethesda, MD

OPENING PLENARY SESSION
5:30 p.m.-7:00 p.m.

Introductory Remarks
Olufunmilayo I. Olopade, University of Chicago Medical Center, Chicago, IL

Welcome
Margaret A. Foti, American Association for Cancer Research, Philadelphia, PA

Introductory Remarks
John D. Carpten, Translational Genomics Research Institute, Phoenix, AZ

Keynote Lecture
Genomics, cancer and health disparities
Francis S. Collins, National Human Genome Research Institute, Bethesda, MD

OPENING RECEPTION
7:00 p.m.-9:00 p.m.

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WEDNESDAY, NOVEMBER 28

PLENARY SESSION: STAGE/GRADE CANCER PATTERNS ACROSS POPULATIONS
8:00 a.m.-10:00 a.m.
Chairperson: Maria Elena Martinez, Arizona Cancer Center, Tucson, AZ

Stage-grade escalation of breast and prostate cancer in African Americans
Steven R. Patierno, The George Washington Cancer Institute, George Washington University School of Medicine, Washington, DC

Regional variations in cancer incidence in American Indians and Alaska Natives
David Espey, Centers for Disease Control, Albuquerque, NM
Discussant, Judith S. Kaur, Mayo Clinic College of Medicine, Rochester, MN

Cancer in U.S. Hispanic populations: Patterns, trends, and clinical issues
Holly L. Howe, North Central Cancer Registries, Springfield, IL
Discussant, Maria Elena Martinez

Hormone receptor status/stage and breast cancer patterns in Asian Americans
Anna H. T. Wu, University of Southern California, Norris Comprehensive Cancer Center, Los Angeles, CA

PLENARY SESSION: CANCER PREVENTION, CONTROL, AND EARLY DETECTION
10:30 a.m.-12:30 p.m.
Chairperson: Lucile L. Adams-Campbell, Howard University Cancer Center, Washington, DC

Obesity and colon polyps in the Black Women’s Health Study: An opportunity for prevention
Lucile L. Adams-Campbell

A population health approach to thinking about and addressing disparities related to breast cancer prevention and risk
Richard B. Warnecke, University of Illinois, Chicago, IL

Diet and breast cancer in the Black Women's Health Study
Tanya Agurs-Collins, National Cancer Institute, Bethesda, MD

The role of obesity and energy balance in cancer prevention
Kathryn H. Schmitz, University of Pennsylvania, Philadelphia, PA

CONCURRENT SESSIONS
2:00 p.m.-4:30 p.m.

Gene-Environment Interactions in Cancer Disparities
Chairperson: Timothy R. Rebbeck, University of Pennsylvania, Philadelphia, PA


• Ethnic variation in drug response
  Richard M. Weinshilboum, Mayo Clinic, Rochester, MN
• Nutrigenomics and health disparities
  Katherine Tucker, Tufts University, Boston, MA
• Multilevel analysis of gene-environment interactions in cancer disparities
  Timothy R. Rebbeck
• Genetic and behavioral risk factors for prostate cancer in African-Americans
  Wenndy Hernandez, University of Chicago, Chicago, IL
• Gene expression profiling reveals tumor immunobiological differences in prostate cancer between African-American and European-American men
  Tiffany Wallace, National Cancer Institute, Bethesda, MD

Tobacco-Related Health Disparities
Chairperson: Beverly D. Lyn-Cook, FDA-National Center for Toxicological Research, Jefferson, AR


• Smoking as a modulator of cancer biomarkers: Variation among ethnic groups
  Beverly D. Lyn-Cook
• Genetics and smoking cessation: Improving outcomes among those at risk
  Robert A. Schnoll, University of Pennsylvania, Philadelphia, PA
• Naltrexone and smoking cessation in an ethnically diverse cohort
  Andrea King, University of Chicago, Chicago, IL
• Eliminating tobacco-related health disparities: Research progress and challenges
  Pebbles Fagan, National Cancer Institute, Bethesda, MD
• Smoking prevalence of Asian Americans: Does living in an ethnic enclave matter?
  Diane S. Lauderdale, University of Chicago, Chicago, IL
• Health professionals’ advice to quit smoking. Does race and gender of smokers matter?
  Yan Wang, University of Maryland School of Medicine, Baltimore, MD

Molecular Etiology of Cancers with Disparate Incidence Rates Across Populations
Chairperson: John D. Carpten, Translational Genomics Research Institute, Phoenix, AZ


• Population differences in disease incidence and outcome for multiple myeloma
  John D. Carpten
• Acute promyelocytic leukemia in Latino populations
  Dan Douer, USC/Norris Cancer Center, Los Angeles, CA
• Disparities in gastric cancer treatment from an Asian perspective
  Atsushi Ohtsu, National Cancer Center Hospital East, Kashiwa, Japan
• Recurrent gene fusions in prostate cancer:  ETV1 class of fusions
  Saravana Mohan Dhanasekaran, University of Michigan Comprehensive Cancer Center, Ann Arbor, MI
• Gene expression analysis of African-American and European-American breast tumors
  Damali N. Martin, National Cancer Institute, Bethesda, MD
• Early onset breast cancer genomics and tumor biology in Alabama women
  Tyesha L. Farmer, University of Alabama, Birmingham, AL

POSTER SESSION A
4:30 p.m.-7:00 p.m.

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THURSDAY, NOVEMBER 29

FORUM: CURRENT AND FUTURE FUNDING OPPORTUNITIES FOR CANCER HEALTH DISPARITIES RESEARCH
7:00 a.m.-8:00 a.m.
Moderator: Sanya A. Springfield, Center to Reduce Health Care Disparities, National Cancer Institute, Bethesda, MD

Panelists:
• Shelia McClure, Research Centers in Minority Institutions Program, National Center for Research Resources, National Institutes of Health, Bethesda, MD
• Shobha Srinivasan, Division of Cancer Control and Population Sciences, National Institutes of Health, Bethesda, MD
• Nathaniel Stinson, National Center on Minority Health and Health Disparities, National Institutes of Health, Bethesda, MD

PLENARY SESSION: BIOLOGICAL MECHANISMS OF DISPARITIES
8:00 a.m.-10:00 a.m.
Chairperson: Olufunmilayo I. Olopade, University of Chicago Medical Center, Chicago, IL

Perspective on the descriptive epidemiology of breast cancer as a reflection of biological heterogeneity and racial disparity
William F. Anderson, National Cancer Institute, Rockville, MD

Epigenetic mechanisms and molecular classification of breast cancer
Olufunmilayo I. Olopade

Genetic determinants of tumor metastases
Kent W. Hunter, National Cancer Institute, Bethesda, MD

Clinical outcomes and minority patients
Lisa A. Newman, University of Michigan, Ann Arbor, MI

PLENARY SESSION: INTERVENTIONS TO REDUCE DISPARITIES: COMMUNITY PROGRAM OUTCOMES AND POTENTIAL IMPACT OF ADVANCING TECHNOLOGIES
10:30 a.m.-12:30 p.m.
Chairperson: Electra D. Paskett, The Ohio State University Comprehensive Cancer Center, Columbus, OH

Cervical cancer in underserved rural communities
Electra D. Paskett

Access to health care: Is it enough to reduce disparities in cancer prevention?
Karen M. Emmons, Dana-Farber Cancer Institute and Harvard School of Public Health, Boston, MA

Liver cancer control interventions for Asian Americans: A first community-based program project to reduce cancer health disparities
Moon S. Chen, UC Davis Cancer Center, Sacramento, CA

Virtual colonoscopy by teleradiology in an underserved Native American population
M. Peter Lance, Arizona Cancer Center, Tucson, AZ

FORUM: LEGISLATIVE ACTION NETWORK FOR CANCER HEALTH DISPARITIES
Moderator: Nicole Lurie, RAND Corporation, Santa Monica, CA
12:30 p.m.-2:00 p.m.

• Claudia R. Baquet, University of Maryland, Baltimore, MD
• Lovell A. Jones, UT M. D. Anderson Cancer Center, Intercultural Cancer Council, Houston, TX
• Additional panelists to be announced

CONCURRENT SESSIONS
2:00 p.m.-4:30 p.m.

Translational Models of Bio-behavioral Stress
Chairperson: Sarah Gehlert, University of Chicago, Chicago, IL


• A multi-informative, multi-level approach to understanding the role of stress in breast cancer disparities
  Sarah Gehlert
• A mouse model of breast cancer reveals social environment-tumor interactions
  Suzanne Conzen, University of Chicago, Chicago, IL
• Biobehavioral influences on tumor growth and immunity in ovarian cancer
  Susan K. Lutgendorf, University of Iowa, Iowa City, IA
• Profiling stress genes regulated by the oncoprotein LEDGFp75 in prostate cancer cells using real time PCR arrays
  Carlos A. Casiano, Loma Linda University School of Medicine, Loma Linda, CA
• Genetic variation influencing glucocorticoid-mediated induction of the SGK gene in different populations
  Anna Di Rienzo, University of Chicago, Chicago, IL

Using Genetics to Optimize Cancer Care
Chairperson: Cheryl L. Willman, University of New Mexico Cancer Center, Albuquerque, NM


• BRCA1 and BRCA2 mutation testing in minority populations enrolled in the Breast Cancer Family Registry
  Esther M. John, Northern California Cancer Center, Fremont, CA
• Hereditary breast cancer in an underserved population: Hispanic BRCA mutations
  Jeffrey N. Weitzel, City of Hope National Medical Center, Duarte, CA
• Tailoring prevention strategies in breast cancer: Genes, race, and healthcare delivery
  Katrina Armstrong, University of Pennsylvania, Philadelphia, PA
• Microsatellite instability in diverse populations
  Noralane M. Lindor, Mayo Clinic, Rochester, MN
• Prognostic importance of p53 codon 72 polymorphism differs with race in microsatellite stable colorectal adenocarcinoma
  Venkat R. Katkoori, University of Alabama, Birmingham, AL
• Estrogen receptor α (ER), BRCA1 and FANCF promoter methylation occur in distinct subsets of sporadic breast cancers
  Junhua Xu, University of Chicago, Chicago, IL

Carcinogenesis and DNA Repair Pathways
Chairperson: Eddie Reed, Centers for Disease Control and Prevention, Atlanta, GA


• Prognostic value of p53 in colorectal cancer varies with tumor location and patient race/ethnicity
  Upender Manne, University of Alabama, Birmingham, AL
• Prediction models of cancer risk in African-Americans and Whites
  Jennifer J. Hu, University of Miami, Miami, FL
• ERCC1, nucleotide excision repair, and cancer risk
  Eddie Reed
• DNA repair phenotypes and cancer risk
  Peter G. Shields, Lombardi Comprehensive Cancer Center at Georgetown University, Washington, DC
• Evaluating markers of microsatellite instability in an ethnically diverse patient cohort
  Brooke E. Sylvester, University of Chicago, Chicago, IL
• Characterization of mouse models for the human p53 codon 72 polymorphism
  Karla S. Fuller, UT M. D. Anderson Cancer Center, Smithville, TX

POSTER SESSION B
4:30 p.m.-7:00 p.m.

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FRIDAY, NOVEMBER 30

PLENARY SESSION: DISPARITIES IN CANCER SURVIVORSHIP: FROM DIAGNOSIS TO INTERVENTION
8:00 a.m.-10:00 a.m.
Chairperson: Mary J. Scroggins, In My Sister's Care, Washington, DC

Opening Comments
Mary Scroggins, In My Sister's Care, Washington, DC

Issues faced by survivors: Beyond the statistics
Jeanne Mandelblatt, Georgetown University, Washington, DC

Not done living
Bettye L. Green, Saint Joseph Regional Medical Center, South Bend, IN

Health-related outcomes in cancer survivors
Smita Bhatia, City of Hope National Medical, Duarte, CA

Keeping the faith: Surviving cancer in Appalachia
Delrita Gilliland, Southern Ohio Medical Center and Fight Cancer, Save Lives Coalition, Lucasville, OH

Question and answer session

PLENARY SESSION: TREATMENT
10:30 a.m.-12:30 p.m.
Chairperson: Alex A. Adjei, Roswell Park Cancer Institute, Buffalo, NY

Somatic cancer mutations across populations
Levi A. Garraway, Dana-Farber Cancer Institute, Boston, MA

Race, ethnicity, and response to anticancer agents
Alex A. Adjei

Racial and ethnic disparities in cancer treatment
Dawn Hershman, Columbia University, New York, NY

Racial variations in pharmacogenetics that impact treatment outcomes
William D. Figg, National Cancer Institute, Medical Oncology Branch, Bethesda, MD

CLOSING REMARKS
12:30 p.m.-1:00 p.m.

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SATURDAY, DECEMBER 1

PUBLIC FORUM
10:00 a.m.-12:00 p.m.
Sponsored by Susan G. Komen for the Cure, the lead supporter of The Science of Cancer Health Disparities in Racial/Ethnic Minorities and the Medically Underserved conference

Genetics and disparities
Tim Rebbeck, University of Pennsylvania School of Medicine, Philadelphia, PA
Hear about the controversies surrounding genetics and cancer. Will genetics be used as tool to increase disparities or will it be helpful in mapping out disease susceptibility?

Survivorship issues: How to cater programs to special populations
Rebecca Keen Fan Sze, Charles B. Wang Community Center, Inc., New York, NY
Hear the reasons why it is necessary to create programs for culturally specific populations. Learn how to develop these targeted programs.

Clinical trials and special populations
Otis Brawley, Emory University School of Medicine, Winship Cancer Institute at Grady, Atlanta, GA
Clinical trials have under-enrolled special populations such as patients from minority groups, women, the young, the elderly and diverse geographical locations. What makes a patient population a special population? Why are special populations often ignored in trials of new cancer treatments? What can go wrong when that happens? Discover the fundamentals of clinical trials and what the community can do to eliminate this disparity.

Health communication: Serving minority communities
Mary Jackson Scroggins, In My Sister's Care, Washington, DC
Linda Burhansstipanov, Native American Cancer Initiatives, Inc., Pine Grove, CO
Lina Jandorf, Mount Sinai School of Medicine, New York, NY
Retired Col. James Williams, Pennsylvania Prostate Cancer Coalition, Camp Hill, PA

Health communication informs and influences individuals and community decisions that enhance health. Health communication can contribute to cancer prevention and cancer awareness. Learn communication tools that may influence policies and programs, promote positive changes in the socioeconomic and physical environments and improve the delivery of public health and healthcare services.

This free exciting half-day program educates the community and lay public on cancer health disparities in racial/ethnic minorities and the medically underserved. This is an exceptional educational opportunity for everyone concerned about cancer. Internationally recognized experts in cancer health disparities research will come together in Atlanta to share the new discoveries about reducing cancer health disparities to save more lives.

• Discover what the community and the public can do to help reduce health disparities.
• Familiarize yourself with support services and advocacy organizations.

EXHIBITS
10:00 a.m.-1:00 p.m.