| MONDAY, NOVEMBER 17 |
PLENARY SESSION 1: MOLECULAR TARGETS IN CANCER PREVENTION
Chairperson: Phillip A. Dennis, National Cancer Institute, Bethesda, MD
7:45 a.m.-9:45 a.m.
Genetic Opportunities for Colon Cancer Prevention
Sanford D. Markowitz, Case Western Reserve University, Cleveland, OH
Studies on Tumor- and Metastasis-initiating Cells in the Lung: Novel Targets for Lung Cancer Prevention?
Jonathan M. Kurie, UT M.D. Anderson Cancer Center, Houston, TX
Progress in the Targeted Prevention of Lung Cancer
Fadlo R. Khuri, Emory University Winship Cancer Institute, Atlanta, GA
The Role of Regulatory T Cells in K-Ras Driven Lung Cancer
Phillip A. Dennis
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CONCURRENT SESSIONS
10:00 a.m.-11:45 a.m.
- SESSION 1: PROSTATE CANCER PREVENTION
Chairperson: William G. Nelson, V, Sidney Kimmel Comprehensive Cancer Center, Baltimore, MD
Genetic and Epigenetic Changes in Prostate Cancer as Targets for Prevention
William G. Nelson, V
The Prostate Cancer Prevention Trial: An Update on Pathology
M. Scott Lucia, University of Colorado Denver School of Medicine, Aurora, CO
Prostate Cancer Risk Reduction Through Lifestyle: New Insights from the Prostate Cancer Prevention Trial
Alan Kristal, Fred Hutchinson Cancer Research Center, Seattle, WA
*A Randomized Factorial Trial of Vitamins E and C in the Prevention of Cancer in Men: The Physicians' Health Study II
Howard Sesso, Brigham and Women's Hospital, Boston, MA
- SESSION 2: OVARIAN CANCER RISK REDUCTION
Chairperson: Karen A. Johnson, National Cancer Institute, Bethesda, MA
BRCA-associated Risk for Ovarian/Primary Peritoneal Carcinoma: The Role of Prophylactic Salpingo-oophorectomy
Timothy R. Rebbeck, University of Pennsylvania Cancer Center, Philadelphia, PA
Ovarian Cancer Risk Management Following Breast/Ovarian Cancer Gene Testing
Marc D. Schwartz, Lombardi Comprehensive Cancer Center at Georgetown University, Washington, DC
Prospects for Targeted Reduction of Ovarian Cancer Risk
Karen A. Johnson
*Investigation of Mismatch Repair Deficiency in Ovarian Cancers
Tuya Pal, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL
- SESSION 3: HEMATOLOGIC MALIGNANCIES
Chairperson: Nikhil C. Munshi, Dana-Farber Cancer Institute, Boston, MA
Molecular Determinants and Progression Risk in MGUS
Nikhil C. Munshi
Immune Surveillance in MGUS: A Balance between Immune Effector and Regulatory T Cells?
Qing Yi, UT M. D. Anderson Cancer Center, Houston, TX
Therapeutic Interventions to Prevent Progression of MGUS to Multiple Myeloma
Shaji Kumar, Mayo Clinic, Rochester, MN
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SPECIAL SESSION: ACHIEVING THE POTENTIAL OF CHEMOPREVENTION RISK REDUCTION
Chairpersons: Ernest T. Hawk, UT M.D. Anderson Cancer Center, Houston, TX and Frank L. Meyskens, Jr., University of California at Irvine, Orange, CA
12:00 p.m.-1:00 p.m.
How Health Communications Turned Cardiovascular Prevention into a Reality
Lisa Sparks, Chapman University, Orange, CA
Incenting Investment in Risk Reduction
Gerard T. Kennealey, Oncology Drug Development, Wilmington, DE
Chemoprevention: Poised for Success
Peter Greenwald, National Cancer Institute, Bethesda, MD
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CONCURRENT SESSIONS
1:00 p.m.-2:45 p.m.
- SESSION 4: EARLY PHASE CLINICAL TRIALS OF CANCER PREVENTIVE AGENTS
Chairpersons: Eva Szabo, National Cancer Institute, Bethesda, MD, and H-H. Sherry Chow, University of Arizona, Tucson, AZ
Phase II Study of Genistein in Bladder Cancer
Edward Messing, University of Rochester, Rochester, NY
Presurgical Trials in Chemoprevention Drug Development
Howard H. Bailey, University of Wisconsin, Madison, WI
Phase 1b Sulindac Study for Women at High Risk for Breast Cancer
Patricia A. Thompson, University of Arizona, Tucson, AZ
Phase II Trial of Bexarotene in Women at High Risk of Breast Cancer: Comparison of Protein and RNA Biomarkers
Powel H. Brown, Baylor College of Medicine, Houston, TX
Commentary on Study Designs for Early Phase Breast Cancer Prevention Trials
H-H. Sherry Chow
Randomized Phase II Trial of Budesonide in High-Risk Population with Undetermined Lung Nodules Detected at Screening Low Dose CT Scan
Giulia Veronesi, European Institute of Oncology, Milan, Italy
Commentary on Study Designs for Early Phase Lung Cancer Prevention Trials
Eva Szabo
- SESSION 5: ER STRESS, AUTOPHAGY, PROTEIN HOMEOSTASIS, AND PROTEIN DEGRADATION
Chairperson: Vassiliki Karantza-Wadsworth, The Cancer Institute of New Jersey, New Brunswick, NJ
ER Stress, Protein Folding, and Oxidative Stress
Randal J. Kaufman, Howard Hughes Medical Institute, University of Michigan, Ann Arbor, MI
Autophagy and Mammary Tumorigenesis: Role of Metabolic and ER Stress Management
Vassiliki Karantza-Wadsworth
Modulating ER Stress-induced Autophagy to Cancer Control
Xiao-Ming Yin, University of Pittsburgh, Pittsburgh, PA
*A Novel Function of Poly(ADP-ribose) Polymerase-1 In Modulation of Autophagy and Necrosis Under Oxidative Stress
Han-Ming Shen, National University of Singapore, Singapore
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SESSION 6: ENERGY BALANCE AND PHYSICAL ACTIVITY
Chairperson: Lucile L. Adams-Campbell, Lombardi Comprehensive Cancer Center at Georgetown University, Washington, DC
Obesity, Physical Activity, and Colon Polyps: Black Women's Health Study
Lucile L. Adams-Campbell
Fitness versus Fatness in Breast Cancer Risk and Prognosis
Anne McTiernan, Fred Hutchinson Cancer Research Center, Seattle, WA
Pediatric Obesity Research: A Transdisciplinary Approach
Donna Spruijt-Metz, University of Southern California, Los Angeles, CA
*Physical Activity and Postmenopausal Breast Cancer: Effect Modifications by Hormone Receptor Status and Breast Cancer Risk Factors
Karen Steindorf, German Cancer Research Center, Heidelberg, Germany
*A Pooled Analysis of 14 Cohort Studies of Body Mass Index and Pancreatic Cancer Risk
Jeanine M. Genkinger, Lombardi Comprehensive Cancer Center at Georgetown University, Washington, DC
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PLENARY SESSION 2: INTERNATIONAL CANCER PREVENTION STRATEGIES
Chairperson: Christopher P. Wild, University of Leeds, Leeds, United Kingdom
3:00 p.m.-5:00 p.m.
Global Trends in Cancer Incidence: Priorities for Prevention
Michael J. Thun, American Cancer Society, Atlanta, GA
Foodborne Toxins in Developing Countries
Christopher P. Wild
Nutrition and Cancer - What Have We Learned So Far?
Elio Riboli, Imperial College, London, United Kingdom
Cancer Screening in Developing Countries
Rengaswamy Sankaranarayanan, International Agency for Research on Cancer, Lyon, France
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AACR-PREVENT CANCER FOUNDATION AWARD LECTURE
5:00 p.m.-6:00 p.m.
Optimizing Chemoprevention by Minimizing Risk-Benefit and Maximizing Risk-Reduction
Frank L. Meyskens, Jr., University of California at Irvine, Orange, CA
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BEHAVIORAL SCIENCE NETWORKING EVENT
6:00 p.m.–7:30 p.m.
Sponsored by the AACR Task Force on Behavioral Science and Cancer
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POSTER SESSION A
6:00 p.m.-8:30 p.m.
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