American Association for Cancer Research

Program

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Chemical Systems Biology 2012

Program as of May 9

Wednesday, June 27

Welcome Reception

8:00 p.m.-9:30 p.m.

 

Thursday, June 28

Continental Breakfast

7:00 a.m.-8:00 a.m.

Session 1: Interrogating Pathways Using Small Molecules

Session Chairperson to be announced
8:00 a.m.-10:00 a.m.

Cancer dependencies defined by genomic alterations and targeted by small molecules
Stuart L. Schreiber, Broad Institute of MIT and Harvard, Cambridge, MA

Challenges in translating the cancer genome into impactful drugs
Markus M. Warmuth, H3 Biomedicine, Cambridge, MA

Accelerating natural product discovery with multivariate image-based screening
Scott Lokey, University of California, Santa Cruz, CA

Break

10:00 a.m.-10:30 a.m.

Session 2: Signaling Pathways

Session Chairperson: Scott Lokey, University of California, Santa Cruz, CA
10:30 a.m.-12:30 p.m.

Network biology and drug discovery
James J. Collins, Howard Hughes Medical Institute and Boston University, Boston, MA

Systems approaches to using and optimizing anti-cancer drugs
Michael B. Yaffe, MIT Koch Institute for Integrated Cancer Research, Cambridge, MA

Quantifying and perturbing protein dynamics in single cancer cells
Galit Lahav, Harvard Medical School, Boston, MA

Lunch on Own / Free Time

12:30 p.m.-1:30 p.m.

Poster Session A

1:30 p.m.-3:30 p.m.

Session 3: Synthetic Chemical Biology

Session Chairperson: Brent Stockwell, Columbia University, New York, NY
3:30 p.m.-5:30 p.m.

Designing biological systems to report on disease
Pamela A. Silver, Harvard Medical School, Boston, MA

Context and engineering of gene expression in bacteria and mammalian viruses
Adam Arkin, Virtual Institute of Microbial Stress and Survival, Berkeley, CA

Title to be announced
Christina D. Smolke, Stanford University, Stanford, CA

Evening Off / Dinner on Own

5:30 p.m.-

 

Friday, June 29

Continental Breakfast

7:00 a.m.-8:00 a.m.

Session 4: Genome-wide SH/siRNA Screening

Session Chairperson: Christina Smolke, Stanford University, Stanford, CA
8:00 a.m.-10:00 a.m.

Genetic strategies for next generation of breast cancer therapies
Jose M. Silva, Columbia University, New York, NY

Functional genomics to identify cancer targets and resistance
William C. Hahn, Dana-Farber Cancer Institute, Boston, MA

Title to be announced
Stephen J. Elledge, Harvard Medical School, Boston, MA

Break

10:00 a.m.-10:30 a.m.

Session 5: Systems Pharmacology and the LINCS Initiative

Session Chairperson: Jose M. Silva, Columbia University, New York, NY
10:30 a.m.-12:30 p.m.

Title to be announced
Todd R. Golub, Broad Institute of MIT and Harvard, Cambridge, MA

Interrogating gene regulatory networks to explore the boundary between chemistry and biology in cancer
Andrea Califano, Columbia University, New York, NY

Perturbed funtional genomics
Gordon B. Mills, University of Texas MD Anderson Cancer Center, Houston, TX

Lunch on Own / Free Time

12:30 p.m.-2:00 p.m.

Session 6: Sensing and Pertubing Pathways

Session Chairperson: Todd Golub, Broad Institute of MIT and Harvard, Cambridge, MA
2:00 p.m.-4:30 p.m.

Super-resolution fluorescence microscopy of cells and tissues
Xiaowei Zhuang, Harvard University and Howard Hughes Medical Institute, Cambridge, MA

TMP-Tag: A chemical surrogate to the fluorescent proteins for live cell imaging
Virginia Cornish, Columbia University, New York, NY

Probing cell death with small molecules
Brent R. Stockwell, Columbia University, New York, NY

Predicting drug response from cancer cell lines
Adam A. Margolin, Broad Institute of MIT and Harvard, Cambridge, MA

Poster Session B

4:30 p.m.-6:30 p.m.

Evening Off / Dinner on Own

6:30 p.m.-

 

Saturday, June 30

Continental Breakfast

7:00 a.m.-8:00 a.m.

Session 7: Chemical Biology and Cancer

Session Chairperson: Virginia Cornish, Columbia University, New York, NY
8:00 a.m.-10:00 a.m.

Chemical inhibition of bromodomains
James E. Bradner, Dana-Farber Cancer Institute, Boston, MA

Title to be announced
Leona D. Samson, Massachusetts Institute of Technology, Cambridge, MA

A genomics approach to discover small-molecule pertubagens of cancer cells
Kimberly Stegmaier, Dana-Farber Cancer Institute, Boston, MA

Break

10:00 a.m.-10:15 a.m.

Session 8: Integrative Chemical and Systems Biology

Session Chairperson: Kimberly Stegmaier, Dana-Farber Cancer Institute, Boston, MA
10:15 a.m.-12:15 p.m.

Small-molecule modulators of the Hedgehog signaling pathway
James K. Chen, Stanford University School of Medicine, Stanford, CA

Proteomic and knowledge-based identification of tumor suppressors and cancer targets
Peter Jackson, Genentech, Inc., South San Francisco, CA

General methods to conditionally regulate protein stability
Thomas J. Wandless, Stanford University, Stanford, CA

Closing Remarks and Departure

12:15 p.m.-12:30 p.m.