Friday, June 21
7:00 a.m.-8:00 a.m.
Session 4: SWI/ SNF (BAF) Complexes
Session Chairperson: Charles W.M. Roberts, Dana-Farber Cancer Institute, Boston, MA
8:00 a.m.-10:00 a.m.
SWI/SNF (BAF) complexes in tumor suppression
Charles W.M. Roberts
Chromatin regulation: New concepts and methods
Gerald R. Crabtree, Stanford University, Stanford, CA
Histone variant H2A.Z sets the stage for ESC differentiation
Keji Zhao, National Institutes of Health, Bethesda, MD
CARM1 methylates BAF155 and perturbs chromatin remodeling machinery to enhance tumor progression*
Wei Xu, University of Wisconsin-Madison, Madison, WI
SNF5 is an essential executor of epigenetic regulation during differentiation*
Minmin Liu, USC Norris Comprehensive Cancer Center, Los Angeles, CA
10:00 a.m.-10:30 a.m.
Session 5: Chromatin Dynamics and Transcriptional Regulation
Session Chairperson: Peter A. Jones, USC Norris Comprehensive Cancer Center, Los Angeles, CA
10:30 a.m.-12:30 p.m.
Reactivating epigenetically silenced genes
Peter A. Jones
mSWI/SNF (BAF) complexes facilitate decatentation of DNA by topoisomerase II*
Emily Dykhuizen, Stanford University, Stanford, CA
Unraveling intricate relationship between chromatin remodeling, transcription, and cancer*
Michael Y. Tolstorukov, Massachusetts General Hospital, Boston, MA
Modulation of chromatin structure and transcription by the SWI/SNF complex in acute lymphoblastic leukemia*
Jennifer Wu, Dana-Farber Cancer Institute, Boston, MA
Doxorubicin enhances nucleosome turnover around active gene promoters*
Fan Yang, Fred Hutchinson Cancer Research Center, Seattle, WA
CHD5 is required for neurogenesis and has a dual role in facilitating gene expression and polycomb gene repression*
Adrian P. Bracken, Trinity College Dublin, Dublin, Ireland
Poster Session B / Lunch
12:30 p.m.-2:30 p.m.
Session 6: Reprogramming and Development
Session Chairperson: George Q. Daley, Boston Children's Hospital, Harvard Medical School, Boston, MA
2:30 p.m.-4:30 p.m.
The stem cell factor LIN28 in pediatric cancer
George Q. Daley
Genetic and epigenetic control of transcription in hematopoiesis
Stuart H. Orkin, Dana-Farber Cancer Institute, Boston, MA
In vivo RNAi screening for polycomb targets in glioblastoma
Maarten Van Lohuizen, Netherlands Cancer Institute, Amsterdam, The Netherlands
Comparison of the gene regulatory programs controlled by the mutually exclusive SWI/SNF subunits ARID1A and ARID2*
Jesse Raab, University of North Carolina at Chapel Hill, Chapel Hill, NC
Dissecting the role of histone variant macroH2A in breast cancer progression*
Alexandre Maia, Icahn School of Medicine at Mount Sinai, New York, NY
Panel Discussion: Inferring Mechanism from Human Genetics and Genomic Analysis of Cancer
Moderator: Gerald R. Crabtree, Stanford University, Stanford, CA
4:30 p.m.-5:30 p.m.
- Jesse J. Smith, Epizyme, Inc., Cambridge, MA
- Charles W.M. Roberts, Dana-Farber Cancer Institute, Boston, MA
- Bradley E. Bernstein, Massachusetts General Hospital, Boston, MA
- Additional panelist to be announced
Dinner on Own / Evening Off