Colorectal Cancer: Biology to Therapy
October 27-30, 2010
Loews Philadelphia Hotel
Philadelphia, Pennsylvania
CHAIRPERSONS:
Anil K. Rustgi, Abramson Cancer Center, University of Pennsylvania, Philadelphia, PA
Joanna L. Groden, Ohio State University College of Medicine, Columbus, OH
Richard M. Goldberg, University of North Carolina, Chapel Hill, NC
Information on registration, abstract submission, accommodations, etc. will be available in mid-2010.
Colorectal cancer constitutes one of the most common cancers in the United States and worldwide. Significant advances have been made in recent years, yet challenges and opportunities remain. This conference will convene internationally renowned scientists to provide state-of-the art talks in critical areas of relevance to colorectal cancer: stem cell and regenerative biology, regulation of the genome, genetics of susceptibility, inflammation and the tumor microenvironment, mouse models, advances in diagnostics, and clinical trials/experimental therapeutics. There will be opportunities for oral presentations by attendees, selected on a competitive basis. Additionally, there will be poster sessions as well as career development sessions targeting new investigators, trainees, women, and underrepresented minorities. The target audience is broad based to include scientists, physicians, trainees, and allied health personnel.
Program as of February 4, 2010
| WEDNESDAY, OCTOBER 27 |
Opening Session
7:00 p.m.-8:00 p.m.
Welcome and Opening Remarks
Anil K. Rustgi, Abramson Cancer Center, University of Pennsylvania, Philadelphia, PA
Colorectal cancer genomes and their implications for basic and applied research
Bert Vogelstein, Johns Hopkins University, Baltimore, MD
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Welcome Reception
8:00 p.m.-9:30 p.m.
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| THURSDAY, OCTOBER 28 |
Continental Breakfast
7:00 a.m.-8:00 a.m.
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Session 1: Intestinal Stem Cells
8:00 a.m.-10:00 a.m.
Targeting dormant drug-resistant cancer stem cells
Linheng Li, Stowers Institute for Medical Research, Kansas City, MO
In vitro analysis of intestinal stem cells
Calvin J. Kuo, Stanford University, Stanford, CA
Relationship of progenitors within the stem cell niche
Melissa Hirose Wong, Oregon Health and Science University, Portland, OR
Short talks from proffered papers
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Break
10:00 a.m.-10:30 a.m.
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Session 2: Regulation of the Genome
10:30 a.m.-12:30 p.m.
Dampening of TGFbeta responses by Myc-regulated microRNAs: Implications for colon cancer angiogenesis
Andrei Thomas-Tikhonenko, University of Pennsylvania, Philadelphia, PA
DNA mismatch repair and colorectal cancer: Understanding pathogenic variants using yeast as a model system
Alison Gammie, Princeton University, Princeton, NJ
Causes and consequences of microRNA dysregulation in cancer
Carlo M. Croce, Ohio State University Comprehensive Cancer Center, Columbus, OH
Integrative systems biology of colorectal cancer genomics: Unraveling the dominant oncogenic mechanisms
Bruce J. Aronow, Cincinnati Children's Hospital Medical Center, Cincinnati, OH
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Poster Session A and Lunch
12:30 p.m.-2:30 p.m.
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Session 3: Genetics of Susceptibility
2:30 p.m.-4:30 p.m.
Intermediate-penetrance genes in the predisposition to colorectal cancer
Albert de la Chapelle, Ohio State University Comprehensive Cancer Center, Columbus, OH
DNA repair and susceptibility to colon cancer
Joanna L. Groden, Ohio State University College of Medicine, Columbus, OH
Title to be announced
Charles S. Fuchs, Dana-Farber Cancer Institute, Boston, MA
Short talks from proffered papers
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| FRIDAY, OCTOBER 29 |
Continental Breakfast
7:00 a.m.-8:00 a.m.
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Session 4: Inflammation and Tumor Microenvironment
8:00 a.m.-10:00 a.m.
Title to be announced
Michael Karin, University of California, San Diego, La Jolla, CA
Gastrointestinal cancer and the tumor microenvironment
Timothy C. Wang, Columbia University Medical Center, New York, NY
Inflammation and cancer: Impact of COX-2 and other inflammatory mediators
Raymond N. DuBois, UT M. D. Anderson Cancer Center, Houston, TX
Short talks from proffered papers
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Break
10:00 a.m.-10:30 a.m.
|
Session 5: Mouse Models of Intestinal Cancer
10:30 a.m.-12:30 p.m.
Inactivation of CCR1 suppresses colon cancer metastasis by blocking accumulation of immature myeloid cells
Makoto Mark Taketo, Kyoto University Graduate School of Medicine, Kyoto, Japan
Mechanisms of crypt fission
Thaddeus S. Stappenbeck, Washington University School of Medicine, St. Louis, MO
Host genetic factors controlling development of flat colonic adenomas
David W. Threadgill, North Carolina State University, Raleigh, NC
Short talks from proffered papers
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Mentoring Groups / Lunch on Own
12:30 p.m.-2:30 p.m.
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Session 6: Advances in Diagnostics
2:30 p.m.-4:30 p.m.
Genetic opportunities for preventing death from colon cancer
Sanford D. Markowitz, Case Western Reserve University, Cleveland, OH
Early detection of colorectal cancer using stool DNA: Is it ready for prime time?
Nita Ahuja, Johns Hopkins Medical Institutes, Baltimore, MD
DNA methylation markers: Implications for therapy?
Stephen B. Baylin, Johns Hopkins School of Medicine, Baltimore, MD
Short talks from proffered papers
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Poster Session and Reception
5:00 p.m.-7:00 p.m.
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| SATURDAY, OCTOBER 30 |
Continental Breakfast
7:00 a.m.-8:00 a.m.
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Session 7: Imaging of the GI Tract
8:00 a.m.-10:00 a.m.
Molecular imaging approaches to colorectal cancer
Umar Mahmood, Massachusetts General Hospital, Boston, MA
Advances in point of care microscopy
Christopher H. Contag, Stanford University School of Medicine, Stanford, CA
Imaging colon cancer targets for therapy
Wafik S. El-Deiry, University of Pennsylvania School of Medicine, Philadelphia, PA
Short talks from proffered papers
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Break
10:00 a.m.-10:30 a.m.
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Session 8: Clinical Trials and Experimental Therapeutics
10:30 a.m.-12:30 p.m.
Novel agent development in CRC: Approach to individualized therapy
S. Gail Eckhardt, University of Colorado Denver School of Medicine, Denver, CO
Managing the interface between chemotherapy and targeted therapy in patients with colorectal cancer
Richard M. Goldberg, University of North Carolina, Chapel Hill, NC
Efficacy and toxicity of VEGF inhibitors: Predictive markers and biological insights
Herbert I. Hurwitz, Duke University, Durham, NC
Short talks from proffered papers
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Departure
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