Program

OPENING KEYNOTE TALKS

7:00 p.m.-8:45 p.m.

Inflammation and Cancer: PGE2 Signaling and Epithelial Biology
Raymond N. DuBois, UT M.D. Anderson Cancer Center, Houston, TX

Tissue Structure, MMPs, and the Shape of Things to Come in Studying Breast Cancer
Mina J. Bissell, Lawrence Berkeley National Laboratory, Berkeley, CA

OPENING RECEPTION

8:30 p.m.-10:00 p.m.

SESSION 1: REACTIVE OXIDANTS / DNA DAMAGE

8:45 a.m.-10:30 a.m.

Oxidative Stress-induced Formation of Endogenous DNA-adducts
Ian A. Blair, University of Pennsylvania, Philadelphia, PA

Fen1 Mutations Result in Autoimmunity, Chronic Inflammation, and Cancers
Binghui Shen, City of Hope, Duarte, CA

Damaged Nucleotides and Nucleic Acids as Biomarkers of Inflammation
Peter C. Dedon, Massachusetts Institute of Technology, Cambridge, MA

* Riboflavin Kinase is a Novel TNF Receptor Binding Protein Required for TNF-induced ROS Production and Apoptosis
Martin Kronke, University of Cologne, Koeln, Germany

SESSION 2: PROTEIN MODIFICATIONS

10:45 a.m.-12:15 p.m.

Keap1: A Sensor for Cellular Responses to Inflammation
Thomas W. Kensler, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD

The Nrf2-Keap1 System and Cancer
Masayuki Yamamoto, Tohoku University Graduate School of Medicine, Sendai, Japan

Anti-inflammatory and Anti-oxidative Actions of New Synthetic Triterpenoids and Rexinoids
Karen Liby, Dartmouth Medical School, Hanover, NH

FREE TIME / LUNCH ON OWN

12:15 p.m.-4:00 p.m.

SESSION 3: EICOSANOIDS

4:00 p.m.-5:30 p.m.

The Prostaglandin-Aromatase Connection: Implications for Breast Carcinogenesis
Andrew J. Dannenberg, Weill Medical College of Cornell University, New York, NY

COX-2 As A Target for Diagnosis and Therapy
Lawrence J. Marnett, Vanderbilt University Medical Center, Nashville, TN

Roles of Prostaglandins in Enhancement of Tumor-associated Angiogenesis and Tumor Growth
Matsaka Majima, Kitasato University, Kanagawa, Japan

FREE TIME / DINNER ON OWN

5:30 p.m.-7:30 p.m.

POSTER SESSION A / DESSERT RECEPTION

7:30 p.m.-10:00 p.m.

SESSION 4: CYTOKINES AND CHEMOKINES I

9:00 a.m.-10:30 a.m.

An Extrinsic and An Intrinsic Pathway Connecting Inflammation and Cancer
Alberto Mantovanti, Istituto Clinico Humanitas, Rozzano, Italy

Title to be announced
Michael Karin, Moores UCSD Cancer Center, La Jolla, CA

Role of Receptor Activator of NF-κB Ligand (RANKL) in Tumorigenesis and Metastasis
Bill Dougall, Amgen, Inc., Seattle, WA

SESSION 5: CYTOKINES AND CHEMOKINES II

10:45 a.m.-12:15 p.m.

Targeting Cancer-Related Inflammation
Frances R. Balkwill, Barts & The London Queen Mary’s School of Medicine and Dentistry, London, England

The Switch from Tumor Immune Surveillance to Inflammation
Martin Oft, Schering-Plough Biopharma, Palo Alto, CA

Inhibiting Monocyte Chemoattractant Protein-1 (MCP-1, CCL2) as a Therapy for Prostate Cancer
Kenneth J. Pienta, University of Michigan, Ann Arbor, MI

POSTER SESSION B / LUNCH

12:15 p.m.-2:45 p.m.

DINNER ON OWN / FREE TIME

2:45 p.m.-7:30 p.m.

SESSION 6: GASTRIC CANCER

7:30 p.m.-9:15 p.m.

The Interplay between Ras Signaling, Inflammation, and Cancer
Dafna Bar-Sagi, New York University School of Medicine, New York, NY

K-Ras Oncogenes, Pancreatitis, and Pancreatic Cancer
Mariano Barbacid, Spanish National Cancer Center (CNIO), Madrid, Spain

Helicobacter, Heterologous Immunity, and Gastric Cancer
James G. Fox, Massachusetts Institute of Technology, Cambridge, MA

* Mechanism of H. pylori–induced Genetic Mutation in Gastric Carcinogenesis
Tsutomu Chiba, Kyoto University Graduate School of Medicine, Kyoto, Japan

SESSION 7: INNATE ADAPTIVE CELLS

9:00 a.m-11:00 a.m.

Tissue-Specific Mechanisms Regulating Inflammation-Associated Epithelial Carcinogenesis
Lisa M. Coussens, UCSF Comprehensive Cancer Center & Cancer Research Institute, San Francisco, CA

Inflammation-Facilitated Cross-Talk between Suppressor Cells and Macrophages Promotes Tumor Progression and Metastasis
Suzanne Ostrand-Rosenberg, University of Maryland, Baltimore, MD

NK Cells and Cancer
Lewis Lanier, University of California, San Francisco, CA

Human Anti-NeuSGc Antibodies in Inflammation-induced Carcinoma Progression
Ajit Varki, University of California at San Diego, La Jolla, CA

SESSION 8: STROMA / ANGIOGENESIS

11:30 a.m.-1:30 p.m.

TGF-beta Regulation of Carcinoma Metastasis
Harold L. Moses, Vanderbilt-Ingram Cancer Center, Nashville, TN

Role of Hypoxia in Inflammation and Tumor Progression
Randall S. Johnson, University of California at San Diego, La Jolla, CA

Cell Non-Autonomous Effects of the Tumor Suppressive Senescence Response
Judith Campisi, Lawrence Berkeley National Laboratory, Berkeley, CA

How the Inflammatory Microenvironment Regulates Tumor Progression
Zena Werb, University of California, San Francisco, CA

DEPARTURE