American Association for Cancer Research

Cancer Susceptibility and Cancer Susceptibility Syndromes

March 1 - 5, 2006
Sheraton Maui Resort
Maui, Hawaii

Pier Paolo Pandolfi, Memorial Sloan-Kettering Cancer Center, New York, NY
Alan D. D'Andrea, Dana-Farber Cancer Institute, Boston, MA

Chromosome instability is a common feature of most human cancers and promotes cancer progression and accounts, at least in part, for the hypersensitivity of cancers to chemotherapy and radiation. The systematic characterization of inherited human chromosome breakage disorders and families with cancer susceptibility has led to the elucidation of a complex network of cancer proteins and tumor suppressors which function in the DNA damage response. The primary focus of this conference was to explore the cooperation of these proteins in telomere length maintenance, checkpoint responses, and DNA repair. Also discussed was how mechanisms of control of mRNA/Protein Translation, when deregulated, lead to tumorigenesis. Cancer susceptibility syndromes, which are due to mutations in key regulators, of these pathways were also addressed.

Over 150 participants gathered in Hawaii for this exciting program. Of those, nearly half of the attendees submitted abstracts for presentation during the informal poster sessions. Researchers from academia and industry representing over a dozen countries participated in the conference.

*(Adobe Acrobat Reader required)

Please visit the AACR Meeting Calendar for a complete list of upcoming programs.