American Association for Cancer Research

Poster Session A

Poster Session A
Thursday, October 28
12:30 p.m.-2:30 p.m.

In alphabetical order, not board assignment order

  • A let-7 microRNA SNP in the KRAS 3’UTR as an independent prognostic factor in early-stage colorectal cancer. Trupti Paranjape1, Kim M. Smits2, Sunitha Nallur1, Kim A.D. Wouters2, Matty P. Weijenberg2, Leo J. Schouten2, Fred Bosman2, Piet A. van den Brandt2, Joanne B. Weidhaas1, Manon van Engeland2. 1Yale School of Medicine, New Haven, CT, 2Maastricht University Medical Center, Maastricht, The Netherlands.
  • A novel antibody that can detect a serum biomarker: Utility for detection and prognosis in colorectal and pancreatic cancer. Janos Luka1, Mark Semenuk1, Ibrahim Sbeitan2, Mary Thomas2, Robert Washington1, Philip Arlen1, Andrew Bristol1. 1Neogenix Oncology, Inc., Rockville, MD, 2Conemaugh Cancer Center, Johnstown, PA.
  • A study to analyze biological role of growth hormone/insulin-like growth factor-1 on colonic mucosa in acromegaly. Kim Vaiphei, Pinaki Dutta, Rakesh Kochhar, Anil Bhansali.
  • β-catenin negatively regulates 15-prostaglandin dehydrogenase expression in intestinal epithelial cells: Implications for intestinal epithelial homeostasis and colorectal cancer prevention. Helena J.M. Smartt, Catherine Cherry, Catherine A. Wallam, Ann C. Williams, Christos Paraskeva. University of Bristol, Bristol, Avon, United Kingdom.
  • Beta-arrestin-2 is involved in early adenoma development during intestinal tumorigenesis. Caroline Bonnans1, Maud Flaceliere1, Jean-Pierre Desvignes1, Julie Pannequin1, Dany Severac1, Frédéric Bibeau2, Emeric Dubois1, Virgine Escriou3, Philippe Crespy1, Laurent Journot1, Frédéric Hollande1, Dominique Joubert1, Christelle Dantec1. 1Institute of Functional Genomics, Montpellier, France, 2Centre Régional de Lutte Contre le Cancer Val d'Aurelle-Paul Lamarque, Montpellier, France, 3INSERM U640, CNRS UMR8151, Université Paris Descartes, Paris, France.
  • Butyrylated high amylose maize starch provides dose-related reduction in colorectal cancer risk in genotoxin-treated rats. Shusuke Toden, Benjamin L. Scherer, Emma-Jane L. Watson, Jessica G. Southwood, David L. Topping, Trevor J. Lockett, Julie M. Clarke. CSIRO Food and Nutritional Sciences, Adelaide, SA, Australia.
  • CD95 stimulates cell protrusion and invasion by phospholipase C-dependent activation of the cofilin pathway. Ernst JA Steller1, Laila Ritsma2, Inne HM Borel Rinkes1, Jacco van Rheenen2, Onno Kranenburg1. 1Department of Surgery, University Medical Centre Utrecht, Utrecht, The Netherlands, 2Hubrecht Institute, KNAW & University Medical Centre Utrecht, Utrecht, The Netherlands.
  • Changes in TRPV6 transcription during HT-29 colon cancer cell line differentiation. M. Ashraf H. Chowdhury, Jodie Robinson, Gregory R. Monteith, Sarah J. Roberts-Thomson. University of Queensland, Brisbane, Qld, Australia.
  • Differentiated colorectal cancer cells protect tumor-initiating cells form irinotecan. Benjamin L. Emmink1, Winan J. van Houdt1, Rob G. Vries2, Frederik J.H. Hoogwater1, Connie J. Jimenez3, Hans Clevers2, Inne H.M Borel Rinkes1, Onno Kranenburg1. 1Department of Surgery, University Medical Center Utrecht, Utrecht, The Netherlands, 2Hubrecht Institute KNAW & University Medical Center Utrecht, Utrecht, The Netherlands, 3VUmc Cancer Center Amsterdam, VU University Medical Center, Amsterdam, The Netherlands.
  • Discovery of autoantibody targets in colorectal cancer by using phage microarrays. Ignacio Casal1, Ingrid Babel1, Rodrigo Barderas1, Ramon Diaz-Uriarte2, Victor Moreno3, Ramon Salazar3, Gabriel Capellá3. 1Centro de Investigaciones Biológicas, Madrid, Spain, 2CNIO, Madrid, Spain, 3IDIBELL-ICO, Barcelona, Spain.
  • Do genotypes and haplotypes in cell cycle genes modulate the risk of colorectal and pancreatic cancers? P. Vodicka1,, A. Naccarati1, B. Pardini1, V. Polakova1, Z. Smerhovsky2, R. Kumar3, L. Vodickova1,2. 1 Inst. Exper. Medicine, Acad. Sci. Czech Rep., Prague, Czech Republic; 2 Natl. Inst. Publ. Health, Prague, Czech Republic; 3 German Cancer Research Center, Heidelberg, Germany.
  • Enteric bacterial protein AvrA activates intestinal beta-catenin signaling. Rong Lu, Shaoping Wu, Xingyin Liu, Yong-guo Zhang, Jun Sun. University of Rochester, Rochester, NY.
  • Frameshift mutations of vacuolar protein sorting genes in gastric and colorectal cancers with microsatellite instability. Changhyeok An1, Yoori kim2, Hoshik kim2, Sungsoo Kim1, namjin yoo2, sughyung Lee2. 1Uijeongbu ST. Mary's Hosiptal, Uijeongbu, Kyeonggi, Republic of Korea, 2Catholic University of Korea, Seoul, Republic of Korea.
  • From cancerous stem cells to goblet cells: A therapeutic approach for colon cancer. Julie M. Chandler, Eric Lagasse. University of Pittsburgh, Pittsburgh, PA.
  • From human cancer genome to flies: Multigenic models of metastatic colon cancer is drosophila. Erdem Bangi, Ross Cagan. Mount Sinai Medical Center, New York, NY.
  • Functional characterization of KIAA1199: Towards a novel biomarker of colorectal neoplasia. Amit Tiwari, Josef Jiricny, Giancarlo Marra. Institute of Molecular Cancer Research, University of Zurich, Zurich, Switzerland.
  • Global proteomic analysis of SW620 human colon cancer cells treated with 5-fluorouracil. Kerry M. Bauer, Paul A. Lambert, Amanda B. Hummon. University of Notre Dame, Notre Dame, IN.
  • Identification of prion protein as a cell surface candidate biomarker for colorectal adenoma-to-carcinoma progression. Meike de Wit, Connie R. Jimenez, Beatriz Carvalho, Jeroen A.M. Belien, Pien M. Delis-van Diemen, Sandra Mongera, Sander Piersma, Gerrit A. Meijer, Remond J.A. Fijneman. VU University Medical Center, Amsterdam, The Netherlands.
  • Inefficient recovery of colorectal cancer cells from a normoxic G2 cell cycle arrest induced by the hypoxia-activated prodrug Tirapazamine. Klaas M. Govaert1, Maarten W. Nijkamp1, Andrew I. Minchinton2, Onno Kranenburg1, Inne H.M. Borel Rinkes1. 1University Medical Center Utrecht, Utrecht, The Netherlands, 2British Columbia Cancer Research Centre, Vancouver, BC, Canada.
  • Inhibiting c-Src kinase activity increases 5-fluorouracil-mediated apoptosis in HT29 colon cancer cells and activates the tumor suppressor protein prostate apoptosis response protein-4 (Par-4). Christina Leah B. Kline, Rosalyn B. Irby. Penn State College of Medicine, Hershey, PA.
  • Insulin-like growth factor-2 mRNA-binding protein-1 (IMP-1) modulates colon cancer cell survival through a novel proapoptotic protein and is interrelated with K-RAS. Perry S. Mongroo1, Jiri Kalabis1, Catrina E. King1, Cameron N. Johnstone1, Mark J. Bowser1, Miriam Cuatrecasas2, Antoni Castells2, Anil K. Rustgi1. 1University of Pennsylvania, Philadelphia, PA, 2University of Barcelona, Barcelona, Catalonia, Spain.
  • Investigation into the role of a TNF family member APRIL in colorectal cancer. Valeria VL Lascano1, Leticia Fernandez2, Marco Guadagnoli1, Fiona Kimberley1, Michael Hahne2, Medema Jan Paul1. 1Academic Medical Center, Amsterdam, Nord Holland, The Netherlands, 2Institut de Génétique Moléculaire de Montpellier, Montpellier, France.
  • LIN28B fosters colon cancer migration, invasion, and tumorigenicity through let-7-dependent and -independent mechanisms. Catrina King1, Louise Wang1, Perry Mongroo1, Cameron Johnstone2, Anil Rustgi1. 1The University of Pennsylvania, Philadelphia, PA, 2Peter MacCallum Cancer Centre, East Melbourne, Vic, Austria.
  • Long constitutional telomere length and colorectal cancer. Lisa A. Boardman1, Ruth A. Johnson1, Halcyon Skinner2, Songwon Seo2, Ronald Gangnon2, Kristin Litzelman2, Stephen Thibodeau1, Julie Cunningham1, Gloria Petersen1, David Rider1. 1Mayo Clinic College of Medicine, Rochester, MN, 2University of Wisconsin, Madison, WI.
  • Loss of DNA mismatch repair in planarian adult stem cells provides an in vivo survival advantage. Jessica P. Hollenbach, Brenton R. Graveley, Christopher D. Heinen.
  • Loss of Notch signaling fosters Barrett’s esophagus development in c-myc-Cdx1 expressing esophageal cells. Maria E. Vega, Anil K. Rustgi, Douglas B. Stairs, Shinya Ohashi, Mitsuteru Natsuizaka, Hiro Nakagawa. University of Pennsylvania, Philadelphia, PA.
  • mir-21 causes resistance to 5-fluorouracil by inducing MSH2-MSH6 downregulation in colon cancer. Nicola Valeri, Pierluigi Gasparini, Chiara Braconi, Francesca Lovat, Alessio Paone, Muller Fabbri, Gerard Nuovo, Carlo Croce. The Ohio State University, Columbus, OH.
  • Molecular signature of Egyptian colorectal cancers. Taina T. Nieminen1, Soheir Shoman2, Saad Eissa2, Päivi Peltomäki1, Wael M. Abdel-Rahman3. 1University of Helsinki, Helsinki, Finland, 2National Cancer Institute, Cairo University, Cairo, Egypt, 3Sharjah Medical Research Institute, Sharjah, United Arab Emirates.
  • Next generation stool DNA testing for detection of colorectal neoplasia: Early marker evaluation. David A. Ahlquist1, Hongzhi Zou2, Michael Domanico2, Douglas W. Mahoney1, Graham Lidgard2. 1Mayo Clinic, Rochester, MN, 2Exact Sciences, Madison, WI.
  • Novel small molecule drugs targeting the main autophosphorylation site (Y397) of focal adhesion kinase are effective colon cancer therapeutics. Vita M. Golubovskaya1, Sheila Figel1, Baotran T. Ho1, Christopher P. Johnson1, Kristiana T. Ferguson1, Carl Nyberg2, David Ostrov2, Irwin H. Gelman1, William G. Cance1. 1Roswell Park Cancer Institute, Buffalo, NY, 2University of Florida, Gainesville, FL.
  • Pathway profiling of laser capture microdissected colorectal cancer reveals the presence of early markers of aggressiveness. Alessandra Silvestri1, Claudio Belluco1, Valery Calvert2, Jianghong Deng2, Enzo Mammano3, Francesco De Marchi1, Alfonso Colombatti1, Donato Nitti3, Lance Liotta2, Emanuel Petricoin2, Mariaelena Pierobon2. 1CRO-IRCCS, National Cancer Institute, Aviano, Italy, 2George Mason University, Manassas, VA, 3University of Padova, Padova, Italy.
  • Phosphorylation of vasodilator-stimulated phosphoprotein at Ser157 and Ser239 regulates intestinal cancer cell proliferation. Mehboob Ali, Joshua Pelta-Heller, Gianmario Pitari. Department of Pharmacology and Experimental Therapeutics, Thomas Jefferson University, Philadelphia, Pennsylvania.
  • Polarity regulator Cdc42 in intestinal epithelium morphogenesis and tumorigenesis. Nan Gao, Ryotaro Sakamori. Rutgers, The State University of New Jersey, Newark, NJ.
  • STAT3 as a novel cancer therapeutic target in colorectal cancer stem cells. Li Lin1, Chenglong Li2, Pui-Kai Li2, James Fuchs2, Jiayuh Lin1. 1Center for Childhood Cancer, The Research Institute at Nationwide Children’s Hospital, Columbus, Ohio, 2Division of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, The Ohio State University, Columbus, OH.
  • SYNE1 and FOXE1 are promising methylation markers for sensitive and specific detection of colorectal cancer in blood. Veerle Melotte1, Joo Mi Yi2, Kim Smits1, Kim AD Wouters1, Joost Louwagie3, Katja Bierau3, Jim Herman4, Stephen Baylin4, Adriaan de Bruïne1, Nita Ahuja4, Manon van Engeland1. 1Maastricht University, Maastricht, The Netherlands, 2Dept. of Oncology and Surgery The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, MD, 3Oncomethylome Sciences, Liege, Belgium, 4The Sidney Kimmel Comprehensive Cancer Center at the Johns Hopkins University School of Medicine, Baltimore, MD.
  • Synergistic killing of colorectal cancer cells by oxaliplatin and the BH3-mimetic ABT-737 requires induction of Noxa by wildtype p53 and oncogenic KRAS. Menno T. de Bruijn, Daniëlle A.E. Raats, Inne H.M. Borel Rinkes, Onno Kranenburg. Department of Surgery, University Medical Centre Utrecht, Utrecht, The Netherlands.
  • TagSNPs of the hypoxia inducible factor 1α gene and their relation with clinicopathological features, recurrence, metastasis, and survival in colorectal cancer patients from Newfoundland, Canada. Sevtap Savas, Angela Hyde, Jing Wang, Susan Stuckless, Yanqing Yi, William Pollett, Roger C. Green, Patrick Parfrey, Banfield H. Younghusband. Memorial University, St. John’s, NL, Canada.
  • The myeloid-derived suppressor cell is the only upregulated leukocyte in the colon in the absence of toll like receptor 4 in the interleukin 10 deficient mouse model of colitis-associated cancer. Manmish S. Bawa, Donna-Marie McCafferty, Kelvin Ng, Kevin Tse.
  • TNIK is a protein kinase essential for Wnt signaling and colorectal cancer growth. Tesshi Yamada, Miki Shitashige. National Cancer Center Research Institute, Tokyo, Japan.
  • Twist1 detection reveals a mesenchymal signature in microsatellite-stable colorectal cancers with worse prognosis. Giuseppe Celesti, Giuseppe Di Caro, Fabio Grizzi, Massimo Roncalli, Alberto Malesci, Paolo Bianchi, Luigi Laghi, Mariaroberta Tersigni, Antonio Sica.
  • Verification of the three-step model in assessing the pathogenicity of mismatch repair gene variants. Minttu Kansikas, Reetta Kariola, Minna Nyström. University of Helsinki, Helsinki, Finland.
  • Whole genomic sequencing of nine colorectal adenocarcinomas identifies a recurrent VTI1A-TCF7L2 fusion. Adam Bass1, Michael Lawrence2, Alex Ramos2, Lear Brace1, Kristian Cibulskis2, Carrie Sougnez2, Doug Voet2, Gordon Saksena2, Andrey Sivachenko2, Rui Jing2, Trevor Pugh2, Roel Verhaak2, Adam Boutin1, Jordi Barretina2, David Solit3, Evi Vakiani3, Derek Chiang4, Nicole Spardy1, William Hahn1, Yujin Hoshida2, Shuji Ogino1, Ronald DePinho1, Lynda Chin1, Levi Garraway1, Charles Fuchs1, Jose Baselga5, Josep Tabernero5, Stacey Gabriel2, Todd Golub2, Eric Lander2, Gad Getz2, Matthew Meyerson1.
Poster Session A Poster Session B