American Association for Cancer Research

Poster Session B

Poster Session B
Friday, October 29
5:00 p.m.-7:00 p.m.

In alphabetical order, not board assignment order

  • 15-hydroxyprostaglandin dehydrogenase is a possible early detection marker in colon cancer: Analysis of prostaglandin pathway in human tissue. Seung-Jae Myung, Dong-Hoon Yang, In-Wha Kim, Yeon-Mi Ryu, Sun-Mi Lee, Kyung Jo Kim, Byong Duk Ye, Jeong-Sik Byeon, Suk-Kyun Yang, Jin-Ho Kim. Asan Medical Center, Univ of Ulsan, Seoul, Republic of Korea.
  • A genetic model for early-onset breast and colon cancer in African Americans. Phillip Buckhaults1, Christopher Farrell2, Brent Wilkerson3, Jie Huang1, Greg Rempala1, Randal Croshaw4, Amy Messersmith5, Kim Creek5, Ervin Shaw6, Bill Butler7. 1The Medical College of Georgia Cancer Center, Augusta, GA, 2Presbyterian College, Newberry, SC, 3University of California Davis, Davis, CA, Allegheny General Hospital, Pittsburgh PA, 5The University of South Carolina, Columbia, SC, 6Lexington Regional Medical Center, Lexington, SC, 7South Carolina Oncology Associates, Columbia, SC.
  • A new long-range PCR-based method to analyze PMS2 gene. Felipe C. Silva, Bianca C G Lisboa, Dirce M. Carraro, Benedito M. Rossi, Fabio O. Ferreira. Hospital AC Camargo, São Paulo, Brazil.
  • A superficial colon tumor model involving subcutaneous colon translocation and orthotopic transplantation of green ?uorescent protein-expressing human colon tumor. Heiying Jin. National Center of Colorectal Surgery, The 3rd affiliated Hospital of Nanjing University of Traditional Chinese Medicine, Nanjing, China.
  • Activation of Akt contributes to the tumorigenicity of colon cancer. Shu Zheng. Cancer Institute of Zhejiang University, Hangzhou, China.
  • An unappreciated role for EGFR-RasGEF signals in colorectal cancer with oncogenic K-RasG12V? Philippe Depeille1, Robert Van De Ven1, Robert S. Warren2, Jeroen Roose1. 1UCSF Department of Anatomy, San Francisco, CA, 2UCSF Department of Surgery, San Francisco, CA.
  • Caveolin-1is transcriptionally induced by activating K-RAS mutations in colorectal cancer and regulates K-RAS-dependent migration of colorectal cancer cells. Natalia Ignatenko1, Upal Basu Roy2, Rebecca Henkhaus3, Eugene Gerner1. 1University of Arizona, Tucson, AZ, 2NYU Medical Center, New York, NY, 3Kansas University, Lawrence, KS.
  • Characteristic pit pattern identifies the precursor of colorectal cancer derived from sessile serrated adenoma. Tomoaki Kimura1, Hiro-o Yamano1, Kenjiro Yoshikawa1, Taku Harada1, Ryo Takagi1, Taro Abe1, Koujiro Tokutake1, Ryo Suzuki1, Masayo Okunomiya1, Michiko Nakaoka1, Tamotsu Sugai2, Eiichiro Yamamoto3, Seikou Kamimae3, Hiromu Suzuki3, Minoru Toyota3. 1Akita Red Cross Hospital, Akita, Japan, 2Iwate Medical University, Morioka, Japan, 3Sapporo Medical University, Sapporo, Japan.
  • Colon cancer growth is inhibited by a novel FAK autophosphorylation inhibitor. Melissa D. Heffler, Ya Li Zhao, Ravindra Pandey, William G. Cance, Vita M. Golubovskaya, Kelli M. Bullard Dunn. Roswell Park Cancer Institute, Buffalo, NY.
  • Colonic crypt morphogenesis after injury by the mesenchymal niche. Hiroyuki Miyoshi, Thaddeus S. Stappenbeck. Washington University School of Medicine, St. Louis, MO.
  • Different subgroups of colorectal cancer with CpG island methylator phenotype arise from genetically and epigenetically distinct early lesions. Minoru Toyota1, Eiichiro Yamamoto1, Hiromu Suzuki1, Tomoaki Kimura2, Hiro-o Yamano2. 1Sapporo Medical University, Sappporo, Japan, 2Akita Red Cross Hospital, Akita, Japan.
  • Differential expression of CD133 based on microsatellite instability status in human colon cancer. Ji-hee Kwon, Jae Jun Park, Sun-Hee Oh, Tae Il Kim. Yonsei University College of Medicine, Seoul, Republic of Korea.
  • Docking-specific forms of the Met oncoprotein: Powerful tools for dissecting the individual roles of proximal binding partners of receptor tyrosine kinases in intestinal epithelial cell transformation. Veronique Pomerleau1, Walid Chababi1, Jimmy Bernier1, Melissa Landry1, Dominique Arsenault2, Claire M. Dubois2, Caroline Saucier1. 1Dept. of Anatomy and Cell Biology, FMSS, Université de Sherbrooke, Sherbrooke, Quebec, Canada, 2Immunology Division, FMSS, Université de Sherbrooke, Sherbrooke, Quebec, Canada.
  • Evaluation of drug response and comparative proteomic analysis of cultivated colorectal cancer tissue slices. Florian T. Unger, Agnieszka Harasym, Hartmut Juhl, Kerstin A. David, Jana Krüger, Cordula Rosenbrock. Indivumed GmbH, Hamburg, Germany.
  • Frequent spindle-assembly checkpoint kinase TTK mutations in microsatellite-unstable colorectal cancer. Iina Niittymäki1, Alexandra Gylfe1, Leena Laine2, Marko Laakso1, Heli Lehtonen1, Johanna Sirkiä1, Jaana Tolvanen1, Kari Nousiainen1, Jeroen Pouwels2, Heikki Järvinen3, Kyösti Nuorva4, Jukka-Pekka Mecklin4, Markus Mäkinen5, Ari Ristimäki1, Torben F. Orntoft6, Sampsa Hautaniemi1, Auli Karhu1, Marko J. Kallio2, Lauri A. Aaltonen1. 1University of Helsinki, Helsinki, Finland, 2VTT Technical Research Centre of Finland, Turku, Finland, 3Helsinki University Hospital, Helsinki, Finland, 4Jyväskylä Central Hospital, Jyväskylä, Finland, 5Oulu University Hospital, Oulu, Finland, 6Aarhus University Hospital, Aarhus, Denmark.
  • Gene expression signature as a predictor of recurrence in colorectal cancer. Ryo Matoba1, Motohiko Tanino1, Ichiro Takemasa2, Kenichi Matsubara1. 1DNA Chip Research Inc., Yokohama, Japan, 2Osaka University, Suita, Osaka, Japan.
  • Genome-wide molecular and functional analysis identified LNX2 as a novel candidate gene involved in colorectal carcinogenesis. Jordi Camps1, Amanda B. Hummon1, Jason Pitt2, Chanelle M. Case1, Marian Grade1,3, Tamara L. Jones2, Georg Emons1,3, Quang T. Nguyen1, B. Michael Ghadimi3, Michael J. Difilippantonio1, Tim Beissbarth3, Natasha J. Caplen2, Thomas Ried1. 1Cancer Genomics Section and 2Gene Silencing Section, Genetics Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA, and 3Department of General and Visceral Surgery, University Medicine Göttingen, Göttingen, Germany.
  • Identification of integrated genomic alterations during the progression of colorectal tumors. Eiicihro Yamamoto1, Hiromu Suzuki1, Hiroo Yamano2, Tomoaki Kimura2, Tamotu Sugai3, Yasuhisa Shinomura1, Minoru Toyota1. 1Sapporo Medical University, Sapporo, Japan, 2Akita Red Cross Hospital, Akita, Japan, 3Iwate Medical University, Morioka, Japan.
  • Involvement of the canonical Wnt signaling pathway in the APC/MSI double-negative feedback loop. Erick Spears, Kristi Neufeld. The University of Kansas, Lawrence, KS.
  • Mitochondrial DNA damage as a biomarker of colorectal cancer susceptibility. Carlos A. Torres-Ramos1, Sylvette Ayala-Torres1, Sharon Fonseca-Williams1, Marcia R. Cruz-Correa1, Randa El-Zein2. 1University of Puerto Rico Medical Sciences Campus, San Juan, Puerto Rico, 2University of Texas MD Anderson Cancer Center, Houston, TX.
  • Molecular characterization and genomic profiling of a spontaneously transformed murine model for human colon cancer. Nicole E. McNeil, Hesed M. Padilla-Nash, Quang Tri Nguyen, Thomas Ried. National Cancer Institute, National Institutes of Health, Bethesda, MD.
  • Omics analysis for biomarker discovery associated with metastasis using paired primary and metastatic colorectal cancer cell lines. Ja-Lok Ku, Park Jae-Gahb. Laboratory of Cell Biology, Cancer Research Institute, Seoul National University College of Medicine, Seoul, Republic of Korea.
  • Oncogenic actions of HDGF (hepatoma-derived growth factor) in colorectal cancer: implication for tumor biology/ patient prognosis and modulation by butyrate. Ralph Melcher1, Theodor Kudlich1, Michael Scheurlen1, Wolfgang Scheppach2, Anika Grell1, Tilmann Neun1, Maike Wilk1, Hardi Luehrs1, Dorothee Rogoll1. 1Department of Medicine II, University Hospital of Wuerzburg, Wuerzburg, Germany, 2Department of Medicine (Gastroenterology/ Rheumatology), Juliusspital Wuerzburg, Wuerzburg, Germany.
  • Peritumoral/pericryptal myofibroblast-induced activation of Calgranulin A/B in tumor microenvironment of colon cancer. Sun-Hee Oh, Ji-hee Kwon, Jae Hak Kim, Tae Il Kim. Yonsei University College of Medicine, Seoul, Republic of Korea.
  • PKCα signaling regulates inhibitor of differentiation (Id) proteins in the intestinal epithelium. Fang Hao, Marybeth A. Pysz, Kristin N. Haas, Kathryn J. Curry, Steven J. Seedhouse, Thomas Vollmer, Adrian R. Black, Jennifer D. Black. Roswell Park Cancer Institute, Buffalo, NY.
  • Prospective clinical validation of a biomarker, methylated SEPT9 DNA, for colorectal cancer detection in plasma of average risk men and women over the age of 50. Joseph Romangnuolo1, Timothy R. Church2, Michael Wandell3, Catherine Lofton-Day4, Steven J. Mongin2, Matthias Burger5, Shannon R. Payne4, Esmeralda Heiden5, Brent A. Blumenstein6, Thomas Rösch7, Neal Osborn8, Dale Snover9, Robert Day10 and David Ransohoff11. 1GI and Hepatology Research, Medical University of South Carolina, Charleston, SC; 2School of Public Health, University of Minnesota, Minneapolis, MN; 3Formerly Epigenomics, Inc. Seattle, WA; 4 Epigenomics, Inc. Seattle, WA; 5Epigenomics, AG, Berlin, DE; 6TriArc, Washington, D.C.; Bloomington, MN; 7Clinic for Interdisciplinary Endoscopy, University Hospital Hamburg-Eppendorf, Hamburg, DE; 8Atlanta Gastroenterology Associates, Atlanta, GA; 9Department of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, MN; 10Fred Hutchinson Cancer Research Center, Seattle, WA; 11School of Medicine, University of North Carolina, Chapel Hill, NC.
  • Proteome analysis strategies for discovery of novel, low-abundance serological colon cancer biomarkers. Wona Joo, Hsin-Yao Tang, Tony Chang-Wong, Dorothee Herlyn, David W. Speicher. The Wistar Institute, Philadelphia, PA.
  • Regulation of EGFR expression by the BAG-1:NF-κB p50 homodimeric complex: Implications for colorectal carcinogenesis. Bettina C. Urban, Samantha Southern, Tracey Collard, Chris Paraskeva, Ann C. Williams. University of Bristol, Bristol, United Kingdom.
  • Role of angiogenesis in the premalignant microcirculatory augmentation in colon carcinogenesis. Ashiish K. Tiwari1, Susan Crawford1, Andrew Radosevich2, Ramesh Wali1, Yolada Stypula2, Nikhil Mutyal2, Sarah Ruderman2, Andrew Gomes2, Dhananjay Kunte1, Mart DelaCuz1, Vadim Backman2, Hemant Roy1. 1NorthShore University HealthSystems, Evanston, IL, 2Northwestern University, Evanston, IL.
  • Suppressive effects of γ-secretase inhibitor on azoxymethane-induced colon carcinogenesis in mice. Shingo Miyamoto, Masako Nakanishi, Daniel W. Rosenberg. University of Connecticut Health Center, Farmington, CT.
  • Systematic analysis of low-penetrance loci in colorectal cancer. Alexandra Gylfe1, Iina Niittymäki1, Sari Tuupanen1, Jian Yan2, Yilong Li1, Jukka-Pekka Mecklin3, Heikki Järvinen4, Ian P.M. Tomlinson5, Richard S. Houlston6, Auli Karhu1, Jussi Taipale2, Lauri A. Aaltonen1. 1University of Helsinki, Helsinki, Finland, 2Karolinska Insitutet, Stockholm, Sweden, 3Jyväskylä Central Hospital, Jyväskylä, Finland, 4Helsinki University Hospital, Helsinki, Finland, 5Wellcome Trust Centre for Human Genetics, Oxford, United Kingdom, 6Institute of Cancer Research, Sutton, United Kingdom.
  • The combination of PF03084014 (a γ-secretase inhibitor) and Irinotecan reduces ALDH+ tumor-initiating cells and recurrence in tumors with elevated notch pathway. Rebecca W. Powell, Wells Messersmith, Marileila Garcia, Aik Choon Tan, Basel Touban, Todd Pitts, Arvind Dasari, John J. Arcaroli. University of Colorado Denver AMC, Aurora, CO.
  • The dual PI3K/mTOR inhibitor NVP-BEZ235 inhibits tumor growth in a genetically engineered mouse model for sporadic colon cancer. Jatin Roper1, Michael P. Richardson1, Vivian L. Wang1, Larissa Georgeon Richard2, Erin M. Coffee1, Lydia Lee1, Wei Y. Chen1, Peng-Chieh Chen2, Eric S. Martin3, Roderick T. Bronson4, Raju Kucherlapati2, Kenneth E. Hung1. 1Tufts Medical Center, Boston, MA, 2Brigham and Women's Hospital, Boston, MA, 3Dana-Farber Cancer Institute, Boston, MA, 4Harvard Medical School, Boston, MA.
  • The effect of vitamin D receptor activation on β-catenin-regulated transcripts in mice with colonic inactivation of both APC alleles. Marsha DeSmet, James C. Fleet. Purdue University, West Lafayete, IN.
  • The TGFβ inhibitor Bambi promotes metastatic growth by overexpression at the invasive front of colorectal cancer metastases. Christoph Kahlert, Shamik Dutta, Juergen Weitz, Markus W. Buechler, Johannes Fritzmann, Moritz Koch. Heidelberg University Hospital, Heidelberg, Germany.
  • Timing matters: Resveratrol’s effect on Benzo(a)pyrene-induced colon tumors in Apcmin mice. Ashley Corrin Huderson1, Mohammad Niaz1, Mary K. Washington2, Aramandla Ramesh1. 1Meharry Medical College, Nashville, TN, 2Vanderbilt University, Nashville, TN.
  • TOP1 DNA aberrations in colorectal cancer. Maria Unni Rømer1, Niels Frank Jensen1, Signe Lykke Nielsen1, Sven Müller2, Kirsten Vang Nielsen2, Hans Jørgen Nielsen3, Nils Brünner1. 1Department of Veterinary Disease Biology, University of Copenhagen, Frederiksberg , Denmark, 2R&D, DAKO Denmark A/S, Glostrup, Denmark, 3Department of Surgical Gastroenterology, Hvidovre Hospital, Hvidovre, Denmark.
  • Tracking how stem cell overpopulation drives colon tumor development and cancer growth. Bruce M. Boman1, Tao Zhang2, Zenobia Cofer3, Juan Palazzo4, Jeremy Z. Fields5. 1Thomas Jefferson University, Philadelphia, PA, 2CA*TX, Inc, Gladwyne, PA, 3University of Delaware, Newark, DE, 4Center for Translational Cancer Research, Newark, DE, 5Helen F. Graham Cancer Center, Newark, DE.
  • Tumorigenic transcriptional pathways revealed by proteomic analyses of large colorectal adenomas. Robert W. Sprung, Jr., Misti A. Martinez, Kristin L. Carpenter, Robbert J. Slebos, Bing Zhang, Daniel C. Liebler. Vanderbilt University, Nashville, TN.
  • Unique gene expression signatures to analyze fluorouracil-induced cell death mechanism in colorectal cancer cell lines. Mohammad Azhar Aziz1, Janet A. Houghton2. 1King Abdullah International Medical Research Center, Riyadh, Saudi Arabia, 2The Cleveland Clinic, Cleveland, OH.
  • Using three-dimensional tissue culture models to study the role of Src family kinases in determining colonic epithelial cell polarity. Sabine Hellwig, Thomas E. Smithgall. University of Pittsburgh, Pittsburgh, PA.
  • Validation of multiplexed proximity ligation assays for in-solution protein biomarker research in combination with a pilot study of colorectal cancer detection. Stine Buch Thorsen1, Jan Stenvang1, Nils Brunner1, Nielsen Sander Birgitte1, Simon Fredriksson2, Martin Lundberg2, Erika Assarsson2, Andrea Villablanca2, Bonnie Tran2, Nick Gee3, Mick Knowles3, Mats Gustafsson4, Claes Andersson4, Bjorn Ekstrom2, Ib Jarle Christensen5, Hans-Jørgen Nielsen6. 1Copenhagen University, Faculty of Life Sciences, Dept. of Veterinary Disease Biology, Frederiksberg, Denmark, 2Olink Bioscience, Uppsala, Sweden, 3Innova Biosciences, Cambridge, United Kingdom, 4Uppsala University, Dept. of Medical Sciences, Uppsala, Sweden, 5The Finsen Laboratory, Rigshospitalet, Copenhagen, Denmark, 6Hvidovre Hospital, Dept. of Surgical Gastroenterology, Hvidovre, Denmark.
Poster Session A Poster Session B