February 28 - March 2, 2010
Westin Arlington Gateway Hotel
John S. Condeelis, Albert Einstein College of Medicine, Bronx, NY
David M. Epstein, OSI Pharmaceuticals, Inc., Farmingdale, NY
Robert A. Weinberg, Whitehead Institute for Biomedical Research, Cambridge, MA
Epithelial to mesenchymal transition (EMT) is a physiological transcriptional reprogramming event used in normal organ development, and is characterized by the combined loss of epithelial cell junctions and cell polarity, and the gain of a mesenchymal phenotype. This reprogramming event allows for organ development through de-differentiation of normal epithelial cells, their migration through an extracellular matrix, and finally re-differentiation, homotypic adhesion and organ growth. EMT and mesenchymal to epithelial transition (MET) processes are now recognized in cancer progression. Understanding EMT/MET at the molecular level promises new insights into mechanisms of progression, detection of metastases, and therapeutic intervention. Over 200 researchers attended this conference which featured keynote talks by Jean Paul Thiery (Institute of Molecular and Cell Biology) and Eric G. Neilson (Vanderbilt University) as well as six plenary sessions and two poster sessions comprised of over 100 proffered paper presentations.
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Please visit the AACR Meetings & Workshops Calendar for a complete list of upcoming programs.