American Association for Cancer Research

Poster Session A

Poster Session A
Sunday, February 28
8:15 p.m.-10:15 p.m.

Subject to change (in alphabetical order, not board assignment order)

  • 17-β-estrodiol antagonizes TGF-β induced EMT through ERα in mammary epithelial cells. Tian Maozhen, William P. Schiemann. University of Colorado Denver, Aurora, CO.
  • Alterations in the expression of miRNAs by natural agents lead to the reversal of EMT, resulting in decreased aggressiveness of pancreatic cancer cells. Yiwei Li, Timothy G. VandenBoom, II, Dejuan Kong, Zhiwei Wang, Shadan Ali, Philip A. Philip, Fazlul H. Sarkar. Wayne State University, Detroit, MI.
  • An alternative isoform of the metastasis susceptibility gene Brd4 promotes EMT and metastatic progression. Jude Alsarraj, Renard W. Walker, Nigel P. S. Crawford, Joshua D. Webster, R. Mark Simpson, Keiko Ozato, Kent W. Hunter. NIH, Bethesda, MD.
  • Analysis of expression of transcriptional regulators of epithelial to mesenchymal transition in lung tumor tissues of various stages. Bruce Huang, Mary Litzinger, Duane Hamilton, Romaine Fernando, Jeffrey Schlom, Claudia Palena. NCI, Bethesda, MD.
  • Analysis of intranuclear entropy changes during EMT activation. John H. Frenster. Stanford University, Stanford, CA.
  • Axl is an essential epithelial to mesenchymal transition -induced regulator of breast cancer metastasis and patient survival. Crina Tiron1, Christine Gjerdrum1, Torill Høiby1, Ingunn Stefansson2, Hallvard Haugen1, Sandal Tone1, Emmet McCormack1, Bjørn Tore Gjertsen1, David Micklem1, Lars Akslen2, Carlotta Galckin3, James B. Lorens1. 1University of Bergen, Bergen, Norway, 2Haukeland University Hospital, Bergen, Norway, 3Beckman Center, City of Hope, Duarte, CA.
  • Circulating tumor cells from patients with metastatic breast and prostate cancer express vimentin and n-cadherin. Andrew J. Armstrong1, Sebastian Oltean2, Gabor Kemeny1, James Turnbull1, Christina Herold3, Paul Kelly Marcom1, Daniel J. George1, Mariano Garcia-Blanco1. 1Duke University, Durham, NC, 2University of Bristol, Bristol, United Kingdom, 3Beth Israel Medical Center, Boston, MA.
  • Comparison of in vitro and in vivo epithelial to mesenchymal transition following inducible expression of Snail or Zeb-1 in a human non-small cell lung cancer line. Joseph S. Krueger1, Gretchen M. Argast2, Krista Campbell1, Stacia Silva1, Matthew O'Connor2, G. David Young1, Regina Sennello1, Stuart Thomson2, David Epstein2, Robert C. Wild1, Julie Kan2, Maryland Rosenfeld-Franklin1. 1OSI Pharmaceuticals, Boulder, CO, 2OSI Pharmaceuticals, Farmingdale, NY.
  • Comparison of TGF-β1-induced EMT in benign and transformed prostate epithelial cells. Eva Lincova, Zuzana Pernicova, Eva Slavickova, Kristyna Adamcova, Alois Kozubik, Karel Soucek. Institute of Biophysics, Academy of Sciences of the Czech Republic, Brno, Czech Republic.
  • Cooperativity between Pten loss and K-ras activation in promoting EMT and metastasis in murine prostate cancer. David J Mulholland, Naoko Kobayashi, Mai Johnston, Zhaoying Sun, Ashkan Morim, Lily Wu, Jiaoti Huang, Hong Wu. UCLA School of Medicine, Los Angeles, CA.
  • Decreased expression of microRNA-199b increases protein levels of SET (protein phosphatase 2A inhibitor) in human choriocarcinoma. Angel Chao, Yun-Shien Lee, Tzu-Hao Wang, Chyong-Huey Lai. Chang Gung Memorial Hospital, Taoyuan, Taiwan.
  • Defining the role of ZEB1 in the molecular pathogenesis of lung cancer. Jill E. Larsen, Mitsuo Sato, James P. Sullivan, Luc Girard, Yang Xie, Jerry W. Shay, John D. Minna. UT Southwestern Medical Center, Dallas, TX.
  • Development of a novel NIR molecular imaging probe for the noninvasive assessment of in vivo EMT. Joseph E. Bugaj, Joseph Krueger, Krista Campbell, Robert Wild. OSI Pharmaceuticals, Boulder, CO.
  • Dicer1 is targeted by two EMT-associated microRNAs in breast cancer. Dawn R. Cochrane, Erin McKinsey, Jennifer K. Richer. University of Colorado, Aurora, CO.
  • Differentiation induces downregulation of MET receptor expression and inhibits metastatic abilities of rhabdomyosarcoma cells in vitro and in vivo. Katarzyna Miekus, Ewa Lukasiewicz, Grazyna Drabik, Marcin Majka. Jagiellonian University Medical College, Kraków, Poland.
  • Does EMT occur in circulating tumor cells in head and neck cancer patients? Priya Balasubramanian, Jas C. Lang, Amit Agrawal, Kris R. Jatana, Enver Ozer, Schuller David, Ted N. Teknos, Maryam B. Lustberg, Jeffrey J. Chalmers. The Ohio State University, Columbus, OH.
  • Dynamic regulation of CD24 and the invasive, CD44posCD24neg phenotype in breast cancer cell lines. Matthew J. Meyer, Jodie M. Fleming, Mustapha A. Ali, Mitchell W. Pesesky, Erika Ginsburg, Barbara K. Vonderhaar. National Institutes of Health/National Cancer Institute/Mammary Biology and Tumorigenesis Laboratory, Bethesda, MD.
  • EMT and invasion is induced by TGF-beta and EGF through a c-raf-dependent mechanism in early-stage prostate cancer cells. Michael D. Amatangelo1, Goodyear Shaun2, Mark E. Stearns1. 1Drexel University College of Medicine, Philadelphia, PA, 2University of Pennsylvania, Philadelphia, PA.
  • EMT and metastasis in a murine model of NSCLC is dependent upon the Notch ligand Jagged2 activation of a GATA3-miR-200 feedback loop. Don L. Gibbons1, Yanan Yang1, Young-Ho Ahn1, Chad Creighton2, Alex Pertsemlidis3, Gregory Phil4, Wei Lin1, Zain H. Rizvi1, Jon Kurie1. 1UT M. D. Anderson Cancer Center, Houston, TX, 2Baylor College of Medicine, Houston, TX, 3University of Texas Southwestern, Dallas, TX, 4Hanson Institute, Adelaide, Australia.
  • EMT status dictates the radiosensitivity of NSCLC cells. Raymond E. Meyn Jr.1, Anupama Munshi1, John V. Heymach1, Yuhui Yuan1, Kevin Coombes1, Jing Wang1, Li Shen1, John Yordy1, Michael Story2, Kian K. Ang1. 1UT M. D. Anderson Cancer Center, Houston, TX, 2UT Southwestern, Dallas, TX.
  • Epithelial to mesenchymal transition and mesenchymal-to-epithelial transition in a syngenic mouse model of postoperative peritoneal dissemination. Sachiko Matsuzaki, Claude Darcha, Elodie Maleysson, Michel Canis, Gérard Mage. CHU Clermont-Ferrand, Clermont-Ferrand, France.
  • Epithelial-mesenchymal transition generates ovarian cancer stem cells with metastatic potential. Gang Yin, Vinicius Craveiro, Jennie Holmberg, Han-Hsuan Fu, Ayesha Alvero, Gil Mor. Yale University, New Haven, CT.
  • Frequent overexpression of GEF-H1 promotes EMT and enhances cell motility in hepatocellular carcinoma. Ibis K-C Cheng, Arthur K-K Ching, Paul B-S Lai, Nathalie Wong. The Chinese University of Hong Kong, Hong Kong, China.
  • Hypoxia-induced epithelial to mesenchymal transition and tumor progression. Mazen Sidani, Ying Wei, David Jablons, Harold Chapman. University of California, San Francisco, CA.
  • Invasion and lymphatic dissemination of airway epithelial cells in a mouse model of chronic allergic airway inflammation. Jill R. Johnson, Tove Berg, Abraham B. Roos, Magnus Nord, Jonas Fuxe. Karolinska Institute, Stockholm, Sweden.
  • Lkb1-deficient metastases activate EMT-associated gene signatures. Julian Carretero1, Takeshi Shimamura2, Angel Ortega1, William Kim3, Geoffrey I. Shapiro2, Kwok K. Wong2. 1University of Valencia, Burjassot, Valencia, Spain, 2Dana-Farber Cancer Institute, Boston, MA, 3The University of North Carolina at Chapel Hill, Chapel Hill, NC.
  • Manipulation of epithelial-mesenchymal plasticity controls sensitivity to erlotinib in the H358 lung tumor model. Gretchen M. Argast1, Peter Mercado1, Matthew O'Connor1, Iain J. Mulford1, Jonathan A. Pachter1, David M. Epstein1, Stuart Thomson1, Julie L.C. Kan2. 1OSI Pharmaceuticals, Farmingdale, NY, 2Pfizer, La Jolla, CA.
  • Mesenchymal markers are present on circulating tumor cells in breast cancer. Maryam B. Lustberg, Priya Balasubramanian, Jas C. Lang, Sarah Carothers, Michael Berger, Amy S. Ruppert, Ewa Mrozek, Bhuvaneswari Ramaswamy, Rachel C. Layman, Jeffrey J. Chalmers, Charles L. Shapiro. The Ohio State University, Columbus, OH.
  • Molecular characterization of the claudin-low intrinsic subtype of breast cancer. Aleix Prat1, Joel S. Parker1, Cheng Fan1, Olga Karginova1, Chad Livasy1, Jason Herschkowitz2, He Xiaping1, Charles M. Perou1. 1University of North Carolina, Chapel Hill, NC, 2Baylor College of Medicine, Houston, TX.
  • Multiple growth factors induce epithelial-mesenchymal transition in novel liver cancer cell lines. Olorunseun Olatunji Ogunwobi, Lucy Zhang, Chen Liu. University of Florida, Gainesville, FL.
  • Overexpression of BOP1 promotes epithelial-mesenchymal transition in hepatocellular carcinoma. C.C. Lau, K.Y. Chung, Arthur K.K. Ching, Ibis K.C. Cheng, Paul B.S. Lai, Nathalie Wong. The Chinese University of Hong Kong, Hong Kong, China.
  • Prognostic significance of miR-200 family in bladder cancer progression. Michael Williams1, Alexandru Floares2, Woonyoung Choi1, Arlene Siefker-Radtke1, David McConkey1, Colin Dinney1, Liana Adam1. 1UT M. D. Anderson Cancer Center, Houston, TX, 2IOCN, Cluj-Napoca, Romania.
  • Role of co-repressor protein KAP1 in regulation of epithelial-mesenchymal transition. Joseph Addison, Renata Galeeva, Alexey Ivanov. West Virginia University, Morgantown, WV.
  • Role of EGFR pathway regulation in EMT of inflammatory breast cancer. Naoto T. Ueno1,2,3, Gabriel N. Hortobagyi3, Massimo Cristofanilli1,3, Dongwei Zhang1,2,3. 1Morgan Welch Inflammatory Breast Cancer Program, 2Breast Cancer Translational Research Laboratory, 3UT M. D. Anderson Cancer Center, Houston, TX.
  • Role of transcription factor SNAI1 in metastatic behavior of rhabdomyosarcoma. Katarzyna Miekus, Miroslawa Wilusz, Wojciech Bobela, Marcin Majka. Jagiellonian University Medical College, Kraków, Poland.
  • Silencing the early lung cancer marker hnRNP A2/B1 induces mesenchymal-epithelial transition (MET) in NSCLC cell lines A549 and H1703. Jordi Tauler, James L. Mulshine. Rush University Medical Center, Chicago, IL.
  • Slug is an essential mediator of Twist-induced epithelial-mesenchymal transition and promotes metastasis. Esmeralda Casas-Silva1, Andres Bendesky2, Cecily Wolfe3, Jing Yang1. 1University of California, San Diego, California, 2Rockefeller University, New York, New York, 3University of Hawaii at Manoa, Honolulu, Hawaii.
  • Snail-induced epigenetic regulation in epithelial-mesenchymal transition. Tong Lin, Jianrong Lu. University of Florida, Gainesville, FL.
  • TGF-β-induced EMT facilitates aberrant invasion to EGF: A unique look at the EMT phenotype. Michael K. Wendt, Jason A. Smith, William P. Schiemann. University of Colorado Denver, Anschutz Medical Campus, Aurora, CO.
  • TGFβ-induced tissue transglutaminase mediates epithelial-mesenchymal transition of ovarian cancer cells. Liyun Cao, Minghai Shao, Daniela Matei. Indiana University School of Medicine, Indianapolis, IN.
  • The effect of snail on cellular adhesion in prostate cancer cells. Corey L. Neal1, Tisheeka Graham2, Valerie Odero-Marah1. 1Clark Atlanta University, Atlanta, GA, 2Emory University, Atlanta, GA.
  • The EMT proteins Snail and Slug regulate unique and common gene targets in breast cancer cells. Archana Dhasarathy, Paul A. Wade. National Institute of Environmental Health Sciences, Research Triangle Park, NC.
  • The HBP1 transcriptional repressor regulates EMT and self-renewal properties: Potential insights into understanding a poor prognosis in breast cancer. Amy S. Yee, K. Eric Paulson, Mendel Roth, Scott Ezell, Hien Doan, Teeru Bihani. Tufts University School of Medicine, Boston, MA.
  • The reversal of epithelial to mesenchymal transition by an inducible miR-200 expression system inhibits liver cancer cell migration. Wei Ding, Carl B. Rountree. Penn State College of Medicine, Hershey, PA.
  • The role of microenvironment in mammary epithelial cell plasticity. Ana Luisa Correia1, Fernando Schmitt2, Mina Bissell1. 1Life Sciences Division, Lawrence Berkeley National Laboratory, Berkeley, CA, 2Institute of Molecular Pathology and Immunology of the University of Porto, Porto, Portugal.
  • The role of miR-146a in the mammary epithelial stem cell induction by EMT. Xianhui Wang, Jihe Zhao. Albany Medical College, Albany, NY.
  • The Six1 homeoprotein activates TGF-β signaling through upregulation of the TGF-β type I receptor and mediates the switch in TGF-β signaling from tumor suppressive to tumor promotional. Douglas S. Micalizzi, Chu-An Wang, William P. Schiemann, Heide L. Ford. University of Colorado at Denver, Aurora, CO.
  • The Src tyrosine kinase downregulates C/EBP delta protein expression via the SIAH2 E3 ubiquitin ligase to maintain motility of breast tumor cells. Tapasree Roy Sarkar1, Jun Wang1, Snehalata Pawar2, Shikha Sharan1, Esta Sterneck1. 1National Cancer Institute, Frederick, MD, 2University of Arkansas for Medical Sciences, Little Rock, AR.
  • Type I collagen-modulated expression of microRNAs. Cui Li, Hong T Nguyen, Joseph Lasky, Bin Shan. Tulane University School of Medicine, New Orleans, LA.
  • Vimentin induces changes in epithelial cell shape, motility and adhesion that accompany the epithelial to mesenchymal transition. Melissa G. Mendez, Robert D. Goldman. Feinberg School of Medicine, Northwestern University, Chicago, IL.