September 13-16, 2009
San Diego Marriott La Jolla
La Jolla, California
Ronald M. Evans, The Salk Institute, La Jolla, CA
Reuben J. Shaw, The Salk Institute, La Jolla, CA
M. Celeste Simon, University of Pennsylvania, Philadelphia, PA
One of the first identified biochemical hallmarks of tumor cells was a shift in glucose metabolism from oxidative phosphorylation to aerobic glycolysis (the "Warburg effect"). We now know that much of this metabolic conversion is controlled by specific transcriptional programs activated in response to mutations in tumor suppressor and oncogenes. Further study of mitogenic signaling pathways have revealed a number of essential and conserved cellular functions that couple the cell growth machinery to glucose and lipid metabolism, coupling proliferation of cells and organisms to the nutrient status in their environment. At this AACR Special Conference, we focused on these connections and new therapeutic approaches that derive from our understanding of key intervention points in these metabolic and growth control pathways.
Over 350 researchers from 15 different countries participated in this AACR Special Conference on Metabolism and Cancer. The program featured sessions on the role of mTOR, AMPK, and Akt in signaling control of growth and metabolism, the transcriptional control of metabolism, the importance of mitochondria in metabolism, cancer, and apoptosis, as well as glucose uptake and glycolysis. The conference opened with keynote talks from Craig B. Thompson of the University of Pennsylvania and Lewis C. Cantley of the Harvard Medical School. In addition to the plenary sessions and keynote talks, over 100 abstracts were presented in poster sessions.
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Please visit the AACR Meetings & Workshops Calendar for a complete list of upcoming programs.