American Association for Cancer Research

Poster Session A

Poster Session A
Sunday, February 28
7:30 p.m.-10:00 p.m.

In alphabetical order, not board assignment order

  • A small-molecule telomerase activator prevents the development of lung fibrosis in bleomycin mouse model. P.Davy1, C. Jourdan Le Saux1,2 , C. Brampton1, R. Tressler3, Calvin Harley3, R. Allsopp1. 1University of Hawaii John A. Burns School of Medicine, Honolulu, HI, 2UT Health Science Center at San Antonio, San Antonio, TX, 3Geron Corp., Menlo Park, CA.
  • ALT-immortalized human cells are critically dependent on the Fanconi anemia protein FANCD2 to limit BLM-dependent recombination and amplification of telomeric repeat DNA. Heather Root, Andrew Larsen, David Bazett-Jones, M. Stephen Meyn. Hospital for Sick Children, Toronto, ON, Canada.
  • Analysis of replication timing using a single-seeded telomere in human cells. Yugo Hirai, Michihito Wakai, Fuyuki Ishikawa. Kyoto University, Kyoto, Japan.
  • Androgen receptor interacts with telomeric proteins in prostate cancer cells. Sahn-ho Kim, Michelle Richardon, Kannagi Chinnakannu, V. Uma Bai, Evelyn R. Barrack, G. Prem-Veer Reddy. Henry Ford Hospital, Detroit, MI.
  • Behavior of telomeric transcript generated from human artificial chromosome (HAC). Michihito Wakai1, Yugo Hirai1, Satoshi Abe2, Yasuhiro Kazuki2, Akira Nabetani1, Mitsuo Oshimura2, Fuyuki Ishikawa1. 1Kyoto University, Kyoto, Japan, 2Tottori University, Yonago, Japan.
  • DNA base modifications at human telomeres. Phillip G. Smiraldo1, Yong Zhao1, Jinyong Kim1, Ilan Vidavsky2, Michael L. Gross2, Jerry W. Shay1, Woodring E. Wright1. 1UT Southwestern Medical Center, Dallas, TX, 2Washington University, St. Louis, MO.
  • Dyskeratosis congenita-associated TINF2 mutations affect TRF1 levels and sister telomere cohesion. Ghadir Sasa1, Silvia Canudas2, Albert Ribes-Zamora1, Susan Smith2, Alison A. Bertuch1. 1Baylor College of Medicine, Houston, TX, 2The Skirball Institute, NYU School of Medicine, New York, NY.
  • Embryonic stem cells and ALT cancer cells share key chromatin players and a common pathway in the regulation of telomere chromatin integrity. Lee H. Wong, James McGhie, Melissa Anderson, Soyeon Ahn, Jeffrey Mann, Andy Choo. Murdoch Childrens Research Institute, Parkville, VIC, Australia.
  • Enzymatic requirements of human telomerase for telomere homeostasis and cellular immortalization. Yasmin D’Souza, Chantal Autexier. McGill University, Lady Davis Institute of the Jewish General Hospital, Montréal, QC, Canada.
  • Epigenetic plasticity of hTERT gene promoter determines retinoid capacity to repress telomerase in maturation-resistant acute promyelocytic leukemia cells. Evelyne Segal-Bendirdjian1, Abdulkader Azouz1, Ying-Li Wu2, Josette Hillion1, Ilona Tarkanyi3, Aida Karniguian1, Mustapha Chehna4, Michel Lanotte1, Guo-Qiang Chen2, Janos Aradi3. 1INSERM UMR-S 1007, Paris Descartes University, Paris, France, 2Shanghai Jiaotong University School of Medicine, Shanghai, China, 3University of Debrecen, Debrecen, Hungary, 4University of Aleppo, Aleppo, Syrian Arab Republic.
  • Evaluation of telomere genetic variants in prostate cancer risk and biochemical failure. Shannon M. Lynch, Bao-Li Chang, Amy Walker, S. Bruce Malkowicz, Charnita Zeigler-Johnson, Timothy R. Rebbeck. University of Pennsylvania, Philadelphia, PA.
  • Frequency and potential clinical relevance of telomerase complex mutations in esophageal cancer. Yuwei Zhang1, Rodrigo Calado2, Javier Cabrera-Perez2, Mahadev Rao1, Robert Taylor Ripley1, Nathan R. Peterson2, Nassar K. Altorki3, Alan G. Casson4, David G. Beer5, Curtis C. Harris1, Neal S. Young2, David S. Schrump1. 1National Cancer Institute, Bethesda, MD, 2 National Heart, Lung and Blood Institute, Bethesda, MD, 3Weill-Cornell Medical Center, New York, NY, 4Royal University Hospital, Saskatoon, Canada, 5University of Michigan Medical Center, Ann Arbor, MI.
  • Genome-wide human shRNA screening to dissect pathways involved in telomerase actions. Hirotoshi Hoshiyama, Jun Tang, Jin-yong Kim, Jerry W. Shay, Woodring E. Wright. UT Southwestern Medical Center, Dallas, TX.
  • Greater variability in telomeres in cancer cells and shorter telomeres in cancer-associated stromal cells are associated with a higher risk of prostate cancer death in surgically treated men. Ghil Suk Yoon1, Thomas Lee2, Christopher M. Heaphy2, Edward Giovannucci3, Lorelei A. Mucci3, Stacey A. Kenfield3, Meir J. Stampfer3, Walter C. Willett3, Jessica L. Hicks2, Angelo M. De Marzo2, Elizabeth A. Platz4, Alan K. Meeker2. 1Kyungpook National University, Daegu, Republic of Korea, 2Johns Hopkins University School of Medicine, Baltimore, MD, 3Harvard School of Public Health, Boston, MA, 4Johns Hopkins Bloomberg School of Public Health, Baltimore, MD.
  • HPV E6 protein interacts physically and functionally with the cellular telomerase complex. Xuefeng Liu, Aleksandra Dakic, Yiyu Zhang, Yuhai Dai, Renxiang Chen, Richard Schlegel. Georgetown University, Washington, DC.
  • Identification of genetic changes in cancer cells induced by telomere shortening by bioinformatic networks of miRNA and proteomic profiling. Orit Uziel1, Nir Yosef2, Roded Sharan2, Eytan Rupin2, Einat Beery1, Jardena Nordenberg1, Meir Lahav1. 1FMRC, Beilinson Medical Center, Petah-Tikvah, Israel, 2Tel Aviv University, Tel-Aviv, Israel.
  • In vitro analysis of Ku’s ability to simultaneously bind telomere ends and TLC1. Sandra M. L. Indiviglio, Alison A. Bertuch. Baylor College of Medicine, Houston, TX.
  • Interaction of MUS81 and BLM is required for telomere recombination. Sicong Zeng, Tao Xiang, Tej Pandita, Susana Gonzalo, Qin Yang. Washington University, St. Louis, MO.
  • Ku’s direct association with telomeric ends is required for normal telomere structure and function. Christopher R. Lopez, Albert Ribes-Zamora, Christopher L. Williams, Svasti Haricharan, Alison A. Bertuch. Baylor College of Medicine, Houston, TX.
  • Mammalian telomere end processing is delayed following telomere replication. Tracy T. Chow, Yong Zhao, Jerry W. Shay, Woodring E. Wright. UT Southwestern Medical Center, Dallas, TX.
  • Possible association between telomere erosion and disease severity in Alzheimer disease. Yusuke Takata1, Masayuki Kikukawa1, Haruo Hanyu1, Hirofumi Sakurai1, Takahiko Umahara1, Shunichi Koyama1, Soichiro Shimizu1, Toshihiko Iwamoto1, Kazuma Ohyashiki2, Junko H. Ohyashiki3. 1Geriatric Medicine, Tokyo Medical University, Tokyo, Japan, 2Internal Medicine, Division of Hematology, Tokyo Medical University, Tokyo, Japan, 3Intractable Diseases Research Center, Tokyo Medical University, Tokyo, Japan.
  • Posttranscriptional regulation of telomerase reverse transcriptase expression in human T cell activation. Jie An, Nanping Weng. National Institute on Aging, Baltimore, MD.
  • Prostate cancer progenitor cells have high telomerase activity and are inhibited in vitro and in vivo by telomerase interference. Tong Xu, Lina Wang, Amir Goldkorn. University of Southern California, Keck School of Medicine, Norris Comprehensive Cancer Center, Los Angeles, CA.
  • Regulation of telomerase and ALT in esophageal squamous cell cancer and Barrett cancer. Angela Queisser1, Michaela Thaler1, Alexander von Werder1, Heike Kunert1, Hiroshi Nakagawa2, Oliver G. Opitz3. 1Institute of Molecular Medicine and Cell Research, Freiburg, Germany, 2Gastroenterology Division, University of Pennsylvania, Philadelphia, PA, 3Comprehensive Cancer Center Freiburg, Freiburg, Germany.
  • Reprogramming murine telomerase rapidly inhibits the growth of mouse cancer cells in vitro and in vivo. Tong Xu, Yucheng Xu, Chun-Peng Liao, Roy Lau, Amir Goldkorn. University of Southern California, Keck School of Medicine, Norris Comprehensive Cancer Center, Los Angeles, CA.
  • Role of mammalian RAP1 in telomere maintenance, subtelomeric gene silencing, and general transcriptional regulation. Paula Martinez, Maria Thanasoula, Rita Carlos, Agueda Tejera, Gonzalo Gomez, Stefan Schoeftner, Orlando Dominguez, David Pisano, Madalena Tarsounas, Maria Blasco. Spanish National Cancer Centre (CNIO), Madrid, Spain.
  • RTEL is required for genome stability and telomere maintenance. Evert-Jan Uringa1, Irma Vulto1, Julie Brind'Amour1, Kathleen Lisaingo1, Annie Moradian2, Mike Schertzer3, Alex Zelensky4, Jeroen Essers4, Gregg B. Morin2, Peter M. Lansdorp5. 1Terry Fox Laboratory, BC Cancer Research Centre, Vancouver, BC, Canada, 2Genome Sciences Centre, BC Cancer Research Centre, Vancouver, BC, Canada, 3Telomeres and Cancer Lab, Institut Curie, Paris, France, 4Cancer Genomics Center, Erasmus Medical Center, Rotterdam, The Netherlands, 5Terry Fox Laboratory, BC Cancer Research Centre and Department of Medicine, UBC, Vancouver, BC, Canada.
  • Screen a better G-quadruplex binder to human telomeres by a simple method. Ting-Yuan Tseng1, Wei-Chun Huang2, Chang-Ting Lin1, Cheng-Chung Chang2, Ta-Chau Chang2. 1Institute of Biophotonics, National Yang-Ming University, Taipei, Taiwan, 2IAMS, Academia Sinica, Taipei, Taiwan.
  • Self-complementary mutant telomeric repeats engage an alternative fusion pathway in human cancer cells. Bradley A. Stohr1, Lifeng Xu2, Elizabeth H. Blackburn1. 1University of California, San Francisco, CA, 2University of California, Davis, CA.
  • Sequence analysis of the shelterin telomere protection complex in dyskeratosis congenital. Sharon A. Savage1, Neelam Giri1, Kristen Pike2, Teri Plona2, Gabriela Baerlocher3, Peter M. Lansdorp4, Blanche P. Alter1. 1National Cancer Institute, Rockville, MD, 2SAIC-Frederick, National Cancer Institute, Frederick, MD, 3University Hospital Bern, Bern, Switzerland, 4British Columbia Cancer Research Center, Vancouver, BC, Canada.
  • Shorter telomeres promote chromosomal instability and predict progression to hematological malignancy in aplastic anemia. Rodrigo T. Calado1, James N. Cooper1, Elaine M. Sloand1, Phillip Scheinberg1, Hesed Padilla-Nash2, Thomas Ried2, Neal S. Young1. 1National Heart, Lung and Blood Institute, Bethesda, MD, 2National Cancer Institute, Bethesda, MD.
  • Significant telomere length heterogeneity in 52 breast cancer cell lines. Francesca Smylie Gazzaniga1, Imke Listerman1, Laura Heiser2, Jason Lukas1, Joe Gray2, Elizabeth Blackburn1. 1University of California, San Francisco, CA, 2Lawrence Berkeley National Laboratory, Berkeley, CA.
  • Stem cell depletion and cancer resistance in conditional TRF2-/- mice. Bojana Bojovic, David L. Crowe. University of Illinois, Chicago, IL.
  • Telomerase expression and activity correlates with pathobiological features of breast cancer cell lines. Imke Listerman1, Jason Lukas1, Laura Heiser2, Joe W. Gray2, Elizabeth H. Blackburn1. 1University of California, San Francisco, CA, 2Lawrence Berkeley National Laboratory, Berkeley, CA.
  • Telomerase mutations associated with hereditary cancer. Geraldine Aubert1, Mark Hills1, Cynthia Toze2, Irma Vulto1, Barb McGillivray3, Peter M. Lansdorp4. 1BC Cancer Agency, Terry Fox Laboratory, Vancouver, BC, Canada, 2Gordon & Leslie Diamond Health Care Center, Hematology, Vancouver, BC, Canada, 3BC Cancer Agency Hereditary Cancer Program, Vancouver, BC, Canada, 4BC Cancer Agency, Division of Hematology, Department of Medicine, Department of Medical Genetics UBC, Vancouver, BC, Canada.
  • Telomere lengths, pulmonary fibrosis, and telomerase (TERT) mutations. Alberto Diaz de Leon, Jennifer Cronkhite, Christine Kim Garcia. UT Southwestern Medical Center, Dallas, TX.
  • Telomere shortening in colorectal cancerogenesis: Relationship with genetic instability and tumor origin site. Enrica Rampazzo1, Roberta Bertorelle2, Laura Serra1, Liliana Terrin2, Salvatore Pucciarelli3, Paola Del Bianco2, Donato Nitti3, Anita De Rossi1. 1Section of Oncology, Department of Oncology and Surgical Sciences, University of Padova, Padova, Italy, 2IOV-IRCCS, Padova, Italy, 3Section of Surgery, Department of Oncology and Surgical Sciences, University of Padova, Padova, Italy.
  • Telomeres and telomerase in acute myeloid leukemia. Jessica M. Goldstrohm, Phuong N. Le, Susan M. Bailey. Colorado State University, Fort Collins, CO.
  • The Est3 protein of Saccharomyces cerevisiae stimulates telomerase catalytic activity through direct interaction with Est2p. Jennell M. Talley1, Diane C. DeZwaan2, Leslie D. Maness1, Brian C. Freeman2, Katherine L. Friedman1. 1Vanderbilt University, Nashville, TN, 2University of Illinois, Urbana-Champaign, IL.
  • The interaction of β-catenin and telomerase and its role during carcinogenesis. Falk Mancke1, Angela Queisser1, Heike Kunert1, Steffen Heeg2, Nina Hirt2, Frank Götschel1, Andreas Hecht1, Steve Artandi3, Oliver G. Opitz2. 1Institute of Molecular Medicine and Cell Research, Freiburg, Germany, 2Comprehensive Cancer Center Freiburg, Freiburg, Germany, 3Stanford School of Medicine, Stanford, CA.
  • The role of DNA repair in the sensitivity of telomeric regions to double-strand breaks in human cells. Avanti Kulkarni, Douglas Miller, Gloria Reynolds, John P. Murnane. University of California, San Francisco, CA.
  • The role of nucleolin in DNA double-strand break-induced damage response. Junya Kobayashi1, Ikue Hayashi2, Hiroko Fujimoto1, Kenshi Komatsu1. 1Kyoto University Radiation Biology Center, Kyoto, Japan, 2Hiroshima University, Hiroshima, Japan.
  • The role of short telomeres in initiation of colon cancer. Laila Bendix1, Jesper Graakjaer2, Lars Henrik Jensen2, Steen Koelvraa2. 1Copenhagen University, Copenhagen, Denmark, 2Vejle Hospital, Vejle, Denmark.
  • Transcriptional regulation of TINF2, a gene encoding for the telomere-associated protein TIN2, by Sp1 and NF-κB factors. Kathryn A. Carroll, Zhongtao Xin, Hinh Ly. Emory University, Atlanta, GA.
  • TRF1 mediates mitotic abnormalities induced by Aurora-A overexpression. Tomokazu Ohishi1, Toru Hirota2, Takashi Tsuruo1, Hiroyuki Seimiya1. 1Cancer Chemotherapy Center, Japanese Foundation for Cancer Research, Tokyo, Japan, 2Cancer Institute, Japanese Foundation for Cancer Research, Tokyo, Japan.
  • V-ATPase inhibitors, concanamycin B, and Bafilomycin induce the reduction of G-tail length and TRF2 foci. Ayuri Kojima1, Yuki Sudo1, Hiroyuki Seimiya2, Hidetoshi Tahara1. 1Hiroshima University, Hiroshima, Japan, 2Cancer Chemotherapy Center, Japanese Foundation for Cancer Research, Tokyo, Japan.