Poster Session B

Poster Session B
Tuesday, February 1
11:30 a.m.-1:30 p.m.

In alphabetical order, not board assignment order

• 3-Methylindole is as mutagenic as the prototype cigarette smoke mutagens B(a)P and NNK. Jessica M. Weems, Garold S. Yost. University of Utah, Salt Lake City, UT.
• Alkyl hydroperoxide reductase is required for survival under oxidative stresses and colonization of Helicobacter cinaedi in BALB/c and BALB/c-IL10 null mice. Nisanart Charoenlap, Zeli Shen, Megan E. McBee, Suresh Muthupalani, Gerold N. Wogan, James G. Fox, David B. Schauer. Massachusetts Institute of Technology, Cambridge, MA.
• Calcium inhibition of porcine leukocyte 12-lipoxygenase via the N-terminal domain. Maureen N. Gibbs, Shu Xu, Allan M. Sharp, Max O. Funk. University of Toledo, Toledo, OH.
• Carboplatin microdosing as a strategy for understanding and possibly predicting chemoresistance in bladder and lung cancer patients. Paul T. Henderson¹, Laurel Beckett¹, David Gandara¹, Ralph W. de Vere White¹, Kenneth W. Turteltaub², Chong-Xian Pan¹, Sisi Wang¹, Tao Li¹, Miaoling He¹, Hongyong Zhang¹, Michael Malfatti², Peter P. Grimminger³, Kathleen D. Danenberg⁴. ¹University of California Davis Medical Center, Sacramento, CA, ²Lawrence Livermore National Laboratory, Livermore, CA, ³University of Southern California/Norris Comprehensive Cancer Center, Los Angeles, CA, ⁴Response Genetics, Inc., Los Angeles, CA.
• Cell-based and biochemical assay tools for the discovery of JAK inhibitors. Stephen A. Fakhoury, Laurie Reichling, Steve Riddle, Kun Bi, Thomas Machleidt, Tina Hallis. Life Technologies, Madison, WI.
• COX-2-mediated formation of eicosanoids and DNA-reactive bifunctional electrophiles. Xiaojing Liu, Suhong Zhang, Clementina Mesaros, Ian A. Blair. University of Pennsylvania, Philadelphia, PA.
• Cyclooxygenase-2-mediated formation of antiproliferative oxidized lipids. Nathaniel W. Snyder, Xiaojing Liu, Suhong Zhang, Jasbir S. Arora, Sumit J. Shah, Ian A. Blair. University of Pennsylvania, Philadelphia, PA.
• Design of second-generation silicon derivatives of indomethacin as inhibitors of inflammation and tumor growth: Iterative chemical design in pursuit of optimal bioactivity. Uzma I. Zakai¹, Stephen Gately², Robert West¹. ¹University of Wisconsin, Madison, WI, ²Silamed, Inc., Scottsdale, AZ.
• Detection of M1dG and 6-oxo-M1dG from urine and feces in rats. Sarah C. Shuck, Phil J. Kingsley, Dapo Akingbade, Larry J. Marnett. Vanderbilt University, Nashville, TN.
• Direct link between inflammation-induced developmental phases of immune dysfunction and tumor growth and angiogenesis in experimental models of ocular inflammatory diseases. Mahin Khatami. National Cancer Institute, Bethesda, MD.
• Drug targeting to eliminate breast and brain tumors. Phyllis Langone¹, Gina Marie Curcio¹, Ravinder Kodela², Khosrow Kashfi², Sukanta Dolai¹, Krishnaswami Raja¹, Probal Banerjee¹. ¹The College of Staten Island, City University of New York, Staten Island, NY, ²City University of New York Medical School, New York, NY.
• Environmentally induced oxidative stress: TCDD- and benzo[a]pyrene-mediated arachidonic acid metabolism in H358 human lung cells. Stacy Lynn Gelhaus, Ian A. Blair. University of Pennsylvania, Philadelphia, PA.
• Formation, replication, and repair of bulky oxidatively induced DNA lesions. Yinsheng Wang, Jin Wang, Bifeng Yuan, Changjun You. University of California, Riverside, CA.
• Hydrogen sulfide-releasing NSAIDs for prevention and treatment of colon and breast cancers. Mitali Chattopadhyay¹, Ravinder Kodela¹, Probal Banerjee², Daniel Boring³, James A. Crowell³, Khosrow Kashfi¹. ¹City University of New York Medical School, New York, NY, ²The College of Staten Island, City University of New York, Staten Island, NY, ³DCP-National Cancer Institute, Bethesda, MD.
• Intake of meat mutagens and risk of non-Hodgkin lymphoma. Carrie R. Daniel¹, Amanda J. Cross¹, Yikyung Park¹, Albert R. Hollenbeck², Arthur Schatzkin¹, Rashmi Sinha¹. ¹DCEG-National Cancer Institute, Rockville, MD, ²AARP, Washington, DC.
• Molecular and chemical biological delineation of a novel cytokine-induced breast cancer metastasis. Xia Ding¹, Tianpa You², Zhiyong Wang², Xuebiao Yao³, Dongmei Wang², Phil Y. Yao⁴, Cibuzo Emenari³, Fengsong Wang², Xue Yu³, XuanNv Zhao², Felix Aikhionbare³, Zhen Guo². ¹Beijing University of Chinese Medicine, Beijing, China, ²Anhui Key Laboratory for Cellular Dynamics and Chemical Biology, Hefei, China, ³Morehouse School of Medicine, Atlanta, GA, ⁴Georgia Cancer Coalition, Atlanta, GA.
• Nitroxyl releasing NSAIDs: A new class of chemotherapeutic agents. Debashree Basudhar¹, Robert Cheng², Gaurav Bharadwaj¹, Lisa A. Ridnour², Yannan Liang¹, David A. Wink², Katrina M. Miranda¹. ¹University of Arizona, Tucson, AZ, ²National Cancer Institute, Bethesda, MD.
• Novel celecoxib derivatives that inhibit growth in MCF-7 human breast cancer cell line. Leyte L. Winfield. Spelman College, Atlanta, GA.
• Organ- and lesion-dependent biases in the spectrum of inflammation-induced DNA damage in colon and liver from Helicobacter hepaticus-infected Rag2-deficient mice. Aswin Mangerich, Peter C. Dedon, Wenjie Ye, Erin G. Prestwich, Pallavi Lonkar, Koli Taghizedeh, Cui Liang, John S. Wishnok, James G. Fox, Steven R. Tannenbaum. Massachusetts Institute of Technology, Cambridge, MA.
• Role of XRCC1 in response to nitric oxide-induced DNA damage. James T. Mutamba¹, Ying N. Chan¹, Xiao-hong Wang², Ying-Chih Lin², Robert W. Sobol², Bevin P. Engelward¹. ¹ Massachusetts Institute of Technology, Cambridge, MA, ²University of Pittsburgh Cancer Institute, Pittsburgh, PA.
• Signal integration from PI 3-kinases and phospholipase D regulates proinflammatory NADPH oxidase activity and extracellular reactive oxygen species production. Christian D. Ellson, Albert Hsu, Tanya Mitra, Michael B. Yaffe. Koch Institute at MIT, Cambridge, MA.
• Standardizing cancer biomarkers (CBs) criteria (data elements) as foundation of a database tracking and utilization for oncology community: M-CSF as a model marker (prototype). Mahin Khatami. National Cancer Institute, Bethesda, MD.
• The biological fate of strand breaks: Metabolism of oxidation products of 2'-deoxyribose in DNA. Watthanachai Jumpathong, Wan Simon Chan, Peter C. Dedon. Massachusetts Institute of Technology, Cambridge, MA.
• Therapeutic spin coupling to guanine by palladium-lipoic acid. Merrill Garnett, Chirakal V. Krishnan, Bill Jones. Garnett McKeen Lab, Inc., Bohemia, NY.
• Trastuzumab conjugated immunoliposome-loading glycosylated paclitaxel. Masaharu Murakami¹, Tomonari Kasai¹, Masashi Okada¹, Arun Vaidynath¹, Katsuhiko Mikuni², Naoyoshi Egashira³, Masaharu Seno¹, Hiroki Hamada⁴. ¹Okayama University, Okayama, Japan, ²Ensuiko Sugar Refining Co., Ltd., Yokohama, Japan, ³Prefectural University of Hiroshima, Shobara, Hiroshima, Japan, ⁴Okayama University of Science, Okayama, Japan.
• Treatment with 17β-estradiol prevents the development of cancer in chronically H. pylori-infected INS-GAS mice by modulating complement activity and decreasing neutrophilic infiltration. Alexander Sheh¹, Nicola M. Parry¹, Melissa W. Mobley¹, Amanda F. McCabe¹, Julia E. Rager², Arkadiusz R. Raczynski¹, Rebecca C. Fry², Timothy C. Wang³, James G. Fox¹. ¹Massachusetts Institute of Technology, Cambridge, MA, ²University of North Carolina, Chapel Hill, NC, ³Columbia University Medical Center, New York, NY.
• Tumor-recruited inflammatory neutrophils and their TIMP-free MMP-9 determine coordinately the levels of tumor angiogenesis and malignant cell dissemination. Elena I. Deryugina, Erin M. Bekes, Bernhard Schweighofer, Tatyana A. Kupriyanova, James P. Quigley. The Scripps Research Institute, La Jolla, CA.