Poster Session A

Poster Session A
Monday, October 17
12:30 p.m.-3:00 p.m.

In alphabetical order, not board assignment order

• 2-Deoxy-D-glucose differentially regulates autophagy under normoxic and hypoxic conditions, Haibin Xi, University of Miami School of Medicine, Miami, FL
• A Computational Simulation of Nuclear Transport of NF-κB in three-dimensional model including Rel-A Phosphorylation, Daisuke Oshima, Division of Mathematical Oncology, The Institute of Medical Science, The University of Tokyo, Tokyo, Japan
• A histone lysine demethylase cooperates with pyruvate kinase M2 to promote hypoxia-inducible factor 1-dependent metabolic reprogramming, Weibo LUO, The Johns Hopkins University, Baltimore, MD
• A novel Noxa/Mcl-1L containing macromolecular complex in leukemia cells and how it controls oxidative stress, Ameeta Kelekar, University of Minnesota, Minneapolis, MN
• A novel role for Aldolase A in prostate cancer cell metastasis, Rana Awwad, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA
• ABCA1 and LDL-Receptor expression in mantle cell lymphoma renders cells sensitive to the anti-apoptotic and growth promoting effects of HDL and LDL derived cholesterol, Richard Jones, MD Anderson Cancer Center, Houston, TX
• Aberrant activation of mTORC1 is sufficient to cause hepatocellular carcinoma, Suchithra Menon, Harvard School of Public Health, Boston, MA
• Adipocytes promote ovarian cancer metastasis through secretion of cytokines and provide energy for rapid tumor growth, Ernst Lengyel, University of Chicago, Chicago, IL
• Adjacent tumors cohabiting the same tissue respond differentially to dietary restriction, Nada Kalaany, Children's Hospital Boston, Boston, MA
• AMPK alpha 2 Promotes Tumor Cell Survival in Models of Breast Cancer Dormancy, Kathryn Phoenix, University of Connecticut Health Center, Farmington, CT
• AMPK regulates metabolism and survival in response to ionizing radiation, Vanessa Zannella, Ontario Cancer Institute and Campbell Family Institute for Cancer Research, Toronto, ON Canada
• Antiproliferative actions of metformin are influenced by energy source, Shiva Javeshghani, McGill University, Montreal, QC Canada
• Autophagy facilitates glycolysis during Ras, but not Myc, transformation, Srirupa Roy, University of California San Francisco, San Francisco, CA
• Bioenergetics in lung cancer cells: Metabolic reprogramming induced by sodium butyrate, Nivea Amoedo, Instituto de Bioquímica Medica, UFRJ, Rio De Janeiro, Brazil
• Breast Cancer cells utilize lactate as energy during nutrient stress, Jennifer Molina, University of Texas MD Anderson Cancer Center, Houston, TX
• Cdc42 activity regulates insulin response and animal metabolism, Matthew Grogg, Cincinnati Children's Hospital Medical Center, Cincinnati, OH
• Cell metabolism and signaling are key factors in carcinoma invasiveness: An experimental and computational approach, Carlos Carmona-Fontaine, Computational Biology Department, Memorial Sloan-Kettering Cancer Center, New York, NY
• CHAF1A links hypoxia and differentiation in high risk neuroblastoma, Eveline Barbieri, Texas Children's Cancer Center and Baylor College of Medicine, Houston, TX
• Chemoprevention with the metabolism modifying drugs dichloroacetate and metformin in Trp53+/- mice, Anneke Blackburn, Australian National University, Canberra, ACT Australia
• Colon cancer cell lines differ in their requirement for glucose and are more dependent on glucose than glutamine as an energy source, Michael Lea, UMDNJ - New Jersey Medical School, Newark, NJ
• Crosstalk between MAPK and Notch signaling regulates proliferation in papillary thyroid cancer, Alex Yamashita, Institute of Biomedical Sciences - University of Sao Paulo, São Paul, Brazil
• Deleterious mitochondrial mutations are critical early events in the development of colorectal tumors, Tatianna Larman, Harvard Medical School Department of Genetics, Boston, MA
• Deletion of Hypoxia Inducible Factor-1α (HIF-1α) In Stromal Fibroblasts Induces Vascular Normalization and Promotes Mammary Tumor Progression, Jung-whan Kim, University of California, San Diego, La Jolla, CA
• Discovery of metabolites in ovarian cancer, Jonathan McDunn, Metabolon, Inc, Durham, NC
• DNA Damage-Induced ONR Is Crucial for p53 Stabilization and Increased Apoptosis, Hyunkyung Kim, Seoul National University, Seoul, Korea (Rep.)
• DNA Methylation of the Obesity gene (lep) promoter in cancer cells, Sagarika Kanjilal, Penn State university, University Park, PA
• Dysregulated mTORC1 renders cells dependent on serum lipids for survival under tumor-like stress, Regina Young, AFCRI, Perelman School of Medicine at The University of Pennsylvania, Philadelphia, PA
• Dysregulation of c-terminal ezrin phosphorylation prevents metastasis and alters cellular metabolism in osteosarcoma, Ling Ren, National Institutes of Health, Bethesda, MD
• Effects of high-fat diet feeding on mammary tumor growth and metastasis in an ER-negative mouse model, Linda Vona-Davis, West Virginia University, Morgantown, WV
• Effects of the western-type diet on protein expression levels and tumorigenesis in normal colon mucosa of the Mlh1+/- mice, Denis Dermadi Bebek, Department of Biosciences, Faculty of Biological and Environmental Sciences, University of Helsinki, Helsinki, Finland
• Efficacy and limitation of targeting HIF1α against heptocellular carcinoma, Zhi Xie, Oncology Research Unit, Pfizer Inc., San Diego, CA
• Efficacy of metformin and mechanisms of action in KRAS-driven mouse models of lung tumorigenesis, Brendan Quinn, National Cancer Institute, Bethesda, MD
• Elucidation of cancer cell metabolism by non-targeted metabolic profiling, Yaguang Si, Agios Pharmaceuticals, Cambridge, MA
• Erastin prevents closure of voltage dependent anion channels (VDAC) and mitochondrial depolarization induced by free tubulin in HepG2 cells, Eduardo Maldonado, Department of Pharmaceutical & Biomedical Sciences, Medical University of South Carolina, Charleston, SC
• FGFR3 stimulates de novo lipogenesis to promote bladder tumor growth, Jing Qing, Genentech, South San Francisco, CA
• Functional redundancy in the last step of the human proline biosynthesis, Jessica De Ingeniis, Sanford-Burnham Medical Research Institute, San Diego, CA
• GAPDH as a molecular target within the cancer energy metabolism network, Manali Phadke, Temple University, Philadelphia, PA
• Glucose restriction induces proteasome-independent degradation of p53 mutants leading to activation of autophagy and to cell death., Maria Laura Avantaggiati, Georgetown University, Washington, DC
• Glutaminase C and kidney-type glutaminase are distinct enzymes regarding its catalytic properties: implications for cancer development, Andre L. B. Ambrosio, Laboratório Nacional de Biociências, Campinas, SP Brazil
• Hexokinase 2 is required Ras-mediated tumorigenesis, Krushna Patra, University of Illinois at Chicago, Chicago, IL
• HypoxCR2: a novel fluorescence protein reporter system to envisage differential response of cancer cells to metabolic therapy in the tumor microenvironment, Peng Sun*, Johns Hopkins, Baltimore, MD
• Hypoxia inducible factor (HIF2a) is sufficient for induction of reductive glutamine metabolism in renal cell carcinoma cells, Paulo Gameiro, Massachusetts General Hospital Cancer Center, Charlestown, MA
• Hypoxia-induced methylation of a pontin chromatin-remodeling factor, Hi-Jai Shin, Seoul National University, Seoul, Korea (Rep.)
• Impact of managing diet-induced obesity with anti-obesity drug on progression of melanoma, Manoj Bhat, National Centre for Cell Science, Pune, Maharashtra India
• Inducing pseudo-Warburg effect in yeast S. cerevisiae, Matic Legiša, National Institute of Chemistry, Ljubljana, Slovenia
• Inhibition of PKM2 by reactive oxygen species contributes to cellular antioxidant responses, Dimitrios Anastasiou, Harvard Medical School, Boston, MA
• Investigation of genetic polymorphisms of the XPD and CCND1 genes in Turkish malignant melanoma patients, Semra Demokan, Istanbul University, Oncology Institute, Istanbul, Capa Turkey
• Lactate dehydrogenase A alters morphology and inhibits migration of basal-like breast cancer cells, Jennifer Dennison, MD Anderson Cancer Center, Houston, TX
• Lipid profiles and prostate cancer severity in a hospital-based cohort, Mieke Van Hemelrijck, King's college London, London, England
• Loss of dystroglycan reduces autophagic flux in prostate cancer, Michael Miller, University of Iowa, Iowa City, IA
• Loss of the tumor suppressor Hace1 leads to glutamine addiction, Naniye Cetinbas, Department of Pathology & Laboratory Medicine, University of British Columbia, Vancouver, BC Canada
• Lysophophatidic acid is a novel regulator of de novo lipogenesis in ovarian cancer, Abir Mukherjee, Virginia Commonwealth University, Richmond, VA
• Metabolic effects of ALDH1L1 evoke cell cycle arrest, apoptosis and inhibition of motility, Natalia Oleinik, Medical University of South Carolina, Charleston, SC
• Metabolic pathways synthetically lethal with the Warburg effect, Daciana Margineantu, Fred Hutchinson Cancer Research Center, Seattle, WA
• Metabolic reprogramming of liver cancer metabolism by the MYC oncogene, Asha Balakrishnan, University of California, San Francisco, San Francisco, CA
• Metabolic switch upon depletion of mutant K-Ras in tumor cells promotes ROS production and cellular senescence, Cheng-Chung Tsao, Oncology Research Unit, Pfizer Inc., Pearl River, NY
• Metabolism and inflammatory breast cancer: Characterizing metabolic changes in breast cancer cells, Lauren Van Wassenhove, University of Michigan, Ann Arbor, MI
• Metformin induces cellular stress as a component of its anti-neoplastic activity in breast carcinoma cells, Brittany Singleton, Xavier University of Louisiana, New Orleans, LA
• Methionyl-tRNA synthetase regulates translation and tumor suppressor activity of AIMP3 via general control nonrepressed 2-mediated phosphorylation, Nam Hoon Kwon, Medicinal Bioconvergence Research Center, Seoul National University, Seoul, Korea (Rep.)
• Modulating metabolism in prostate cancer cell progression: PRKAB1 and PFKFB4, Susana Ros, Gene Expression Analysis Laboratory, Cancer Research UK London Research Institute, London, England
• mTOR links oncogenic signaling to tumor cell metabolism, Jessica Yecies, Harvard School of Public Health, Boston, MA
• Myc induction of hypoxic glutamine metabolism and a glucose-independent TCA cycle in human B lymphocytes, Anne Le, Johns Hopkins, Baltimore, MD
• NADH, the Warburg Effect, and Breast Cancer, Kevin Gardner, National Cancer Institute, Bethesda, MD
• Ngal (neutrophil gelatinase-associated lipocalin) transcription dependent on the tumor-associated cytochrome Pgrmc1, Shakeel Mir, University of Kentucky, Lexington, KY
• Novel pathway of survival under hypoxia involves induction of lipid uptake by HIF1α, Karim Bensaad, The Weatherall Institute of Molecular Medicine, University of Oxford, John Radcliffe Hospital, CRUK, Oxford, England
• Obesity-associated Flt3 mutations in Acute Promyelocytic Leukemia, Luca Mazzarella, European Institute of Oncology, Milan, Italy
• Oncogenic activation of Hippo-YAP pathway in hepatocellular carcinoma with stemness under hypoxia, JI SU KIM, Severance Biomedical Science Institute, Yonsei University College of Medicine, Seoul, Korea (Rep.)
• Pyruvate flux: A potential bio-marker for vascular targeting of tumors, Joanne Bluff, University of Sheffield, Sheffield, England
• Revealing metabolism of colon and stomach cancers using partial correlation coefficients, Mitsunori Kayano, University of Tokyo, Tokyo, Japan
• Reversible Lysine Acetylation/Deacetylation on AMPKα modulates its kinase activity and autophagy response under glucose deprivation, Yanhua Rao, Duke University, Durham, NC
• Role of autophagy in breast cancer metastasis, Rasika Rohatgi, University of Massachusetts Medical School, Worcester, MA
• Role of glycogen metabolism in cancer cell growth under hypoxia, Elena Favaro, Molecular Oncology Laboratories, Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, England
• Secondary active transport of glucose enhances the viability of ovarian cancer cells in high glucose environments, Lisa Kellenberger, University of Guelph, Guelph, ON Canada
• Stable isotope-resolved metabolomic investigations reveal anti-cancer mechanisms of Se agents and the failure of selenomethionine as a chemopreventive agent, Teresa Fan, University of Louisville, Louisville, KY
• StearoylCoA desaturase-5 (SCD5), a novel regulator of cell proliferation and differentiation in human cells, R. Igal, Rutgers University, New Brunswick, NJ
• Supplementation of isocaloric carbohydrate and fat restriction diet inhibits the B16F10 tumor growth in mouse xenograft model and regulates its underlying molecular signaling pathways, Min-Ah Choi, Yonsei University College of Medicine, Seoul, Korea (Rep.)
• Surveying the metabolic response to c-Myc overexpression using ¹³C flux analysis, Taylor Murphy, Vanderbilt University, Nashville, TN
• Targeting C4-demethylating genes in the cholesterol pathway sensitizes cancer cells to EGFR inhibitors via increased EGFR degradation, Igor Astsaturov, Fox Chase Cancer Center, Philadelphia, PA
• The Mevalonate Pathway Contributes to Cellular Transformation, Paul Sobol, Ontario Cancer Institute, Toronto, ON Canada
• The multifunctional protein E4F1 controls p53-associated functions in metabolism, laurent Le Cam, INSERM, Montpellier, France
• The role of the histone deacetylase SIRT6 in tumor metabolism, Raul Mostoslavsky, The Massachusetts General Hospital Cancer Center-Harvard Medical School, Boston, MA
• The Role of Vesicle-Trafficked MT1-MMP in ECM Degradation: A Computer Simulation, AYAKO WATANABE, Division of Mathematical Oncology, The Institute of Medical Science, The University of Tokyo, Tokyo, Japan
• The use of cholesterol-lowering ezetimibe for prostate cancer prevention in the Hi-Myc and PTEN transgenic mouse models, Elizabeth Masko, Duke University Medical Center, Durham, NC
• Validation of Acyl-Coenzyme a Binding Protein as Candidate Biomarker of Lung Cancer, Frederick Harris, Meharry Medical College, Nashville, TN