Poster Session B

Poster Session B
Tuesday, October 18
5:00 p.m.-7:30 p.m.

In alphabetical order, not board assignment order

• 2-Deoxyglucose-induced toxicity is regulated by Bcl-2 family members and is enhanced by antagonizing Bcl-2 in lymphoma cell lines, Oksana Zagorodna, University of Iowa, Iowa City, IA
• A biochemical analysis of IDH1 neomorphic mutations, Benjamin Schwartz, GlaxoSmithKline, Collegeville, PA
• A metabolic approach to ovarian cancer. Biological insights on altered choline kinase activity and expression: Possible prognostic and therapeutic implications, Marina Bagnoli, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy
• A new perspective for LKB1 as pediatric MLL-rearranged B-ALL cells survival promoter, Luisa Galla, Oncohematology Laboratory, University of Padua, Padova, Italy
• A novel Fumarate Hydratase (FH)-deficient primary tumor cell line (UOK268) provides a model for the metabolic investigation of early HLRCC-associated cancer, Youfeng Yang, National Cancer Institute, Bethesda, MD
• A systems approach to predicting cell type-specific cancer therapies through metabolic network analysis, Edik Blais, University of Virginia, Charlottesville, VA
• ABT-737 synergizes with Pseudomonas exotoxin immunotoxins., Antonella Antignani, NCI, NIH, Bethesda, MD
• Acquisition of anoikis resistance promotes the increase of syndecan-4 expression in endothelial cells in culture, Carla Lopes, Federal University of São Paulo, São Paulo, Brazil
• Activated KRAS- and BRAF-induced transformation of pancreatic epithelial cells involves MEK/ERK-stimulated IGF1R Signaling, Victoria Appleman, University of Massachusetts Medical School, Worcester, MA
• Adenylate Kinase 4 Is a Novel Cancer Metabolism-Associated Biomarker That Promotes Tumor Metastasis through ATF3-depedent Regulation of MMP2, Yi-Hua Jan, Genomics Research Center, Academia Sinica, Taipei, Taiwan
• Alteration of monounsaturated fatty acid metabolism induces cell death through ER stress in colon cancer cells, Anne-Sophie PIERRE, INSERM U866 "Lipides Nutrition Cancer", Université de Bourgogne, Dijon, France
• Alterations of the aerobic mitochondrial energy metabolism in brain tumors, Rene Feichtinger, Paracelsus Medical University, Department of Pediatrics, Salzburg, Austria
• Anti-glycolytic therapy combined with an image-guided minimally invasive delivery strategy for the treatment of breast cancer, Manon Buijs, Johns Hopkins, Baltimore, MD
• Blockade of fatty acid synthase induces lysosomal-autophagosomal proteolysis of phosphatidylinositol-3 kinase signaling proteins in ovarian cancer, Thomas Grunt, Ludwig Boltzmann Cluster Oncology & Comprehensive Cancer Center, Medical University, Vienna, Austria
• C/EBPα protects hepatocellular carcinoma cells from glucose starvation induced cell death through activation of glutamine and lipid metabolism, Guo-Dong Lu, National University of Singapore, Singapore, Singapore
• Cationic triterpenoids disrupt mitochondrial function of breast cancer cells, Teresa Serafim, Center for Neurosciences and Cell Biology, Coimbra, Portugal
• Changes to cellular NAD⁺/NADH levels via NAMPT knockdown modulates tumor progression in breast cancer, Sarah LeBoeuf, The Scripps Research Institute, La Jolla, CA
• Changing the metabolism of cancer cells with PKM2 activators – a path to a cancer metabolism drug, Vered Behar, Dynamix Pharmaceuticals, Rehovot, Israel
• Choline kinase α as a novel tumor marker and a molecular target in cancer therapy, Juan Carlos Lacal, Instituto de Investigaciones Biomédicas, CSIC, Madrid, Spain
• Comparative Analyses of Metabolomics and Phospho-Proteomics Reveal Discriminatory Metabolic Profiles in Lung, Prostate, and Pancreas Tumors, Yoshiaki Ohashi, Human Metabolome Technologies, Inc., Yamagata, Japan
• Dichloroacetate (DCA), a metabolism modulator, sensitizes hepatocellular carcinoma cells to sorafenib-induced apoptosis through oxidative stress-independent JNK/c-Jun activation, Ying-Chun Shen, Graduate Institute of Toxicology, College of Medicine, National Taiwan University, Taipei, Taiwan
• Dichloroacetate reverses the Warburg effect, inhibiting growth and sensitizing breast cancer cells towards apoptosis, Bevan Gang, Molecular Genetics Group, The Australian National University, Canberra, ACT Australia
• Drug-induced autophagy in cancer cells has a distinct metabolic profile detected by nuclear magnetic resonance spectroscopy, Gigin Lin, The Institute of Cancer Research, Sutton, England
• Elucidating the new role of Notch3 signaling in cancer metabolic pathways, Alexander Stoeck, Johns Hopkins University, School of Medicine, Baltimore, MD
• Enhanced mitochondrial enzymatic activities by Palladium α-lipoic Acid complex, Chirakkal Krishnan, Department of Chemistry, Stony Brook University, Stony Brook, NY
• Enhancement of lung cancer therapy using ketogenic diet, Melissa Fath, University of Iowa, Iowa City, IA
• ErbB2-driven breast cancer cell invasion depends on a complex signaling network activating TF dependent cathepsin B and L expression, Bo Rafn, The Danish Cancer Society, Copenhagen, Denmark
• Establishment and Characterization of a Matched Model of Radiation Resistance in Head and Neck Cancer, Cristina Furdui, Wake Forest School of Medicine, Winston-Salem, NC
• Expression of Enzymes Related to Glycolytic Pathway as Biomarkers in Gastric Carcinoma, Hur Hoon, Department of Surgery, Ajou University Hospital, Suwon-Si, Korea (Rep.)
• GLUT4-Dependent Glucose Metabolism Maintains MCL-1 Expression and Myeloma Viability, Mala Shanmugam, Northwestern University, Chicago, IL
• Glutamine transporter SLC1A5 is a novel candidate biomarker for non-small cell lung cancer, Mohamed Hassanein, Division of Allergy, Pulmonary and Critical Care Medicine, Department of Medicine, Nashville, TN
• High Levels of Mitochondrial ATP5E Promote Tumor Metastasis and Poor Prognosis in Colon Cancer by Modulating AMPK-AKT-GSK3 Signaling Pathway to Induce SNAI1-mediated Downregulation of E-cadherin, Chien-Hsin Lee, Genomics Research Center, Academia Sinica, Taipei, Taiwan
• Human cancer cells with a mutation in the TCA cycle enzyme fumarate hydratase are dependent on mitochondrial metabolism and ROS for proliferation, Lucas Sullivan, Northwestern University Medical School, Chicago, IL
• Inactivation of mTORC1-S6K1 induces fatty acid oxidation and glucose-independent survival in BCR-ABL transformed cells, David Plas, University of Cincinnati, Cincinnati, OH
• Inhibiting ACCess: The role of dicholoroacetate (DCA) in inhibiting the fatty acid synthesis pathway in prostate cancer, Nadya Ogloff, Vancouver Prostate Centre, University of British Columbia, Vancouver, BC Canada
• Inhibition of Fatty Acid Synthase attenuates CD44-associated signaling and reduces metastasis in colorectal cancer, Yekaterina Zaytseva, University of Kentucky, Lexington, KY
• Inhibition of monocarboxylate transporter 4 (MCT4) preferentially targets stem-like cells in glioblastoma, Kah Suan Lim, Johns Hopkins University School of Medicine, Baltimore, MD
• Inhibition of phosphatidylcholine-specific phospholipase c induces changes in choline metabolism and downregulates her2 overexpression in ovarian cancer cells, Franca Podo, Istituto Superiore di Sanità, Roma, Italy
• Inhibition of PI3K/mTOR leads to adaptive resistance in matrix-attached cancer cells, Taru Muranen, Harvard Medical School, Boston, MA
• Investigation of a novel mode of Glutaminase C inhibition via the expansion of the structure-activity relationship surrounding the small molecule allosteric regulator 968, William Katt, Cornell University, Ithaca, NY
• Investigation of the melanoma genetic landscape identifies the glutamate pathway as a major player in the disease, Yardena Samuels, NIH, Bethesda, MD
• Linking lipid metabolism and cancer: The role of sterol regulatory element binding proteins in the hypoxic response of cancer cells, Caroline Lewis, Cancer Research UK London Research Institute, London, England
• Loss of TSC2 confers resistance to ceramide and nutrient stress, Aimee Edinger, University of California Irvine, Irvine, CA
• Luminal and HER2-enriched tumor cell lines show higher levels of oxidative phosphorylation and mitochondria than claudin-low and basal triple negative cell lines, Michelle Barbi de Moura, University of Pittsburgh, Pittsburgh, PA
• Metabolic capability to induce the Pasteur effect mediates sensitivity of human leukemic cells to metformin, Jean-Emmanuel Sarry, University of Pennsylvania, Philadelphia, PA
• Metabolic circuit disruption induces cell death in triple negative breast cancer cells, Fionnuala Morrish, Fred Hutchinson Cancer Research Center, Seattle, WA
• Metabolic response of Glioblastoma tumor cells to fenofibrate and activation of Foxo3a-Bim apoptotic pathway, Anna Wilk, Louisiana State University, Health Science Center, New Orleans, LA
• Metformin shifts cellular metabolism towards glucose fermentation and increases glutamine fueling of tricarboxylic acid cycle metabolites and fatty acids, Sarah-Maria Fendt*, Massachusetts Institute of Technology, Cambridge, MA
• Mitochondrial physiology in commercial breast cancer cell lines: Relevance for the development of mitochondrial-directed agents, Paulo Oliveira, Center for Neuroscience and Cell Biology, University of Coimbra, Coimbra, Portugal
• Mitochondrial quiescence, decreased apoptotic signaling and a blockade on autophagy may reduce sensitivity of p19 embryonal carcinoma stem cells to cell death, Ignacio Vega-Naredo, Center for Neuroscience and Cell Biology, University of Coimbra, Coimbra, Portugal
• mTOR S-nitrosylation decreases the viability of human cancer cells, Marilia Dias, UNICAMP, Campinas, Brazil
• Myc suppresses fatty acid oxidation and directly stimulates lipogenesis in human P493 B cells, Arvin Gouw, Johns Hopkins University School of Medicine, Baltimore, MD
• Non-invasive monitoring of apoptosis processes during breast cancer neoadjuvant chemotherapy by measuring deep tissue temperature using diffuse optical spectroscopic imaging, So Hyun Chung, University of Pennsylvania, Philadelphia, PA
• Obesity-induced inflammatory response enhances growth of prostate cancer xenografts, Guilherme Rocha, UNICAMP, Campinas, SP Brazil
• Oncogenic Kras inhibits mitochondrial metabolism by regulating the pyruvate dehydrogenase complex under conditions of nutrient stress, Diego Jaitin, Stanford University School of Medicine, Stanford, CA
• Percutaneous ablation using glyceraldehyde-3 phosphate dehydrogenase antagonists: Assessment of tumor response in a mouse model of human hepatocellular carcinoma, Shanmugasundaram Ganapathy-Kanniappan, Johns Hopkins University School of Medicine, Baltimore, MD
• PGC1α promotes tumor growth by inducing gene expression programs supporting lipogenesis, Geoffrey Girnun, University of Maryland, Baltimore, MD
• Potent anti-cancer agents, non-redox-active lipoate derivatives, have pervasive, catastrophic regulatory effects on cancer cell metabolism, Paul Bingham, Stony Brook University, Stony Brook, NY
• Pre-clinical targeting of the metabolic phenotype of lymphoma by AZD3965, a selective inhibitor of monocarboxylate transporter 1 (MCT1), Susan Critchlow, AstraZeneca, Alderley Edge, Cheshire England
• Regulation of mitochondrial respiration by 17β-estradiol through lactate dehydrogenase in MCF7 breast cancer cells, Bennett Van Houten, University of Pittsburgh, Pittsburgh, PA
• Role of the Glutaminase II Pathway in Tumor Biology, Thambi Dorai, New York Medical College, Valhalla, NY
• Singleminded-2s (Sim2s) plays a unique role in mammary gland and breast cancer autophagy and metabolism homeostasis, Kelly Scribner, Texas A&M University, College Station, TX
• Succinate dehydrogenase, an iron-sulfur protein: From mitochondria to malignancy, Neetu Saxena, Eunice Kennedy Shriver National Institute of Child Health and Human Development, Bethesda, MD
• Sunitinib and SU11652 induce lysosomal membrane permeabilisation and revert multidrug resistance, Anne Marie Ellegaard, Danish Cancer Society, Copenhagen, Denmark
• Telomere-mediated senescence causes impaired insulin secretion in β-cells by limiting mitochondrial function and Ca²⁺ signaling, Mary Armanios, Johns Hopkins School of Medicine, Baltimore, MD
• The anti-malaria agent dihydroartemisinin inhibits growth and mTORC1 signaling in tumor cells, Yoshi Odaka, LSUHSC, Feist-Weiller Cancer Center, Shreveport, LA
• The endoplasmic reticulum acts as a sensor of glucose limitation during malignant transformation, Justine Lebeau, CRCL, Lyon, France
• The gluconeogenic pathway from glutamine is operative in cancer cells of non-gluconeogenic origin, Teresa Fan, University of Louisville, Louisville, KY
• The metabolic reprogramming of primary lymphocytes requires Myc but not Hif1α, Ruoning Wang, St Jude Children Research Hospital, Memphis, TN
• The mitochondrial citrate transporter, CIC, is necessary for mitochondrial homeostasis and promotes tumor proliferation, Maria Laura Avantaggiati, Georgetown University, Washington, DC
• The mitochondrial solute carrier SLC25A43 gene is frequently deleted in HER2-positive breast cancer and influences cell turnover and metabolism, Marike Gabrielson, Örebro University, Örebro, Sweden
• The oxidation of proline by proline oxidase provides a regulated source of ROS for mitochondria derived cellular signaling, Chad Hancock, NCI-Frederick, Frederick, MD
• The reprogramming of proline and glutamine metabolism contributes to the proliferative and metabolic responses to c-Myc, Wei Liu, National cancer institute, Frederick, MD
• The role of metabolic enzyme, Phosphoglucomutase 1 in cancer development, Hapiloe Maranyane, University of Cape Town, Cape Town, WC South Africa
• The role of PUMA in metabolic stress induced autophagy and mitochondrial morphology, Xiaobo Cao, Scott & White Memorial Hospital, Texas A&M Health Science Center, Temple, TX
• Therapeutic manipulation of metabolic pathways in cancer using bioactive constitutive agents in natural products, Dipali Sharma, Johns Hopkins University, Baltimore, MD
• TMBIM3/GRINA is a conserved Unfolded Protein Response (UPR) target gene that controls apoptosis through the modulation of ER calcium homeostasis, Diego Rojas-Rivera, University of Chile, Santiago, Chile
• Tumor cell death induced by inhibition of mitochondrial electron transport chain: Effect of 3-hydroxybakuchiol, Fabián Jaña, Department of Molecular and Clinical Pharmacology, ICBM, Faculty of Medicine, University of Chile, Santiago, Chile
• Tumor suppressor, BHD / FLCN controls energy homeostasis by modulating mitochondrial oxidative metabolism through PGC1α, Hisashi Hasumi, National Cancer Institute, Bethesda, MD
• Tyrosine phosphorylation of mitochondrial pyruvate dehydrogenase kinase 1 is important for cancer metabolism, Jing Chen, Winship Cancer Institute, Emory University, Atlanta, GA
• Voltage dependent anion channels (VDAC) modulate bioenergetics of HepG2 human hepatoma cells, Eduardo Maldonado, Department of Pharmaceutical & Biomedical Sciences, Medical University of South Carolina, Charleston, SC
• Wwox expression predicts tamoxifen response in randomized breast cancer patients, Anna Göthlin Eremo, Örebro University, Örebro, Sweden