Program

Sunday, January 8

Keynote Presentation

8:00 p.m.-9:00 p.m.

Physiological and pathological functions of microRNAs
David Baltimore, California Institute of Technology, Pasadena, CA

Opening Reception

Monday, January 9

Continental Breakfast

7:00 a.m.-8:00 a.m.

Session 1: Long Noncoding RNAs

Session Chairperson: Jeannie T. Lee, Massachusetts General Hospital, Boston, MA
8:00 a.m.-10:00 a.m.

Navigating the balance of INK4/ARF expression in cancer: ncRNAs as sensors and regulators of transcription
Martin J. Walsh, Mount Sinai School of Medicine, New York, NY

Regulatory networks in onco-lncRNAomics: cis-regulation and non-conservation
Leonard Lipovich, Wayne State University School of Medicine, Detroit, MI

Linking RNA to human health and disease
John L. Rinn, Beth Israel Deaconess Medical Center, Boston, MA

BRAFV600E remodels the melanocyte transcriptome and induces BLNCR1 to regulate melanoma cell migration*
Ross J. Flockhart, Stanford University, Stanford, CA

Break

10:00 a.m.-10:15 a.m.

Session 2: Chromatin Modifications

Session Chairperson: Danesh Moazed, Harvard Medical School, Boston, MA
10:15 a.m.-12:15 p.m.

Mechanism of RNAi-mediated heterochromatin assembly
Danesh Moazed

Epigenetic genome control by heterochromatin machinery and noncoding RNAs
Shiv Grewal, National Cancer Institute, Bethesda, MD

Elucidation of enhancer-like RNAs
Ramin Shiekhattar, The Wistar Institute, Philadelphia, PA

Lunch on Own / Free Time

12:15 p.m.-2:30 p.m.

Session 3: miRNA Biology

Session Chairperson: David P. Bartel, Massachusetts Institute of Technology, Cambridge, MA
2:30 p.m.-4:30 p.m.

MicroRNAs and their regulatory targets
David P. Bartel, Massachusetts Institute of Technology, Cambridge, MA

Unraveling the complexities of p63 in cancer and stem cells
Elsa R. Flores, University of Texas MD Anderson Cancer Center, Houston, TX

microRNAs and control of metabolism
Markus Stoffel, Institute of Molecular Systems Biology, Zurich, Switzerland

Poster Session A / Reception

4:30 p.m.-6:30 p.m.

Dinner on Own / Evening Off

6:30 p.m.-

Tuesday, January 10

Continental Breakfast

7:00 a.m.-8:00 a.m.

Session 4: Biology of Long Noncoding RNAs

Session Chairperson: Jeannie T. Lee, Massachusetts General Hospital, Boston, MA
8:00 a.m.-10:00 a.m.

Spreading of X-chromosome inactivation via a hierarchy of defined polycomb stations
Jeannie T. Lee, Massachusetts General Hospital, Boston, MA

Control of gene expression in the nucleus by small RNAs
David R. Corey, UT Southwestern Medical Center, Dallas, TX

Small RNA pathways in germline
Alexei A. Aravin, California Institute of Technology, Pasadena, CA

Functional characterization of p53-regulated long intervening noncoding RNAs (lincRNAs)*
Nadya M. Dimitrova, David H. Koch Institute for Integrative Cancer Research at MIT, Cambridge, MA

Break

10:00 a.m.-10:15 a.m.

Session 5: miRNA Regulation in Development

Session Chairperson: Eric N. Olson, UT Southwestern Medical Center, Dallas, TX
10:15 a.m.-12:15 p.m.

MicroRNA control of muscle development and disease: From new biology to new therapeutics
Eric N. Olson

Long-term, efficient inhibition of miRNA function in mice using Tough Decoys delivered by Adeno-associated virus vectors
Philip D. Zamore, University of Massachusetts Medical School, Worcester, MA

microRNA regulation in stem cells and cancer
Richard I. Gregory, Children’s Hospital Boston/Harvard Medical School, Boston, MA

Poster Session B / Lunch

12:15 p.m.-2:30 p.m.

Session 6: miRNA Regulation in Cancer

Session Chairperson: Carlo M. Croce, The Ohio State University Comprehensive Cancer Center, Columbus, OH
2:30 p.m.-4:30 p.m.

microRNAs as therapeutic targets
Carlo M. Croce

MicroRNA reprogramming in cancer: Mechanisms and consequences
Joshua Mendell, University of Texas Southwestern Medical Center, Dallas, TX

The ceRNA hypothesis and the noncoding revolution in cancer research and therapy
Pier Paolo Pandolfi, Beth Israel Deaconess Medical Center, Boston, MA

Characterization of a novel pseudogene expressed antisense RNA that regulates PTEN expression*
Per Johnsson, Karolinska Institutet, Stockholm, Sweden

Dinner on Own / Evening off

4:30 p.m.-

Wednesday, January 11

Continental Breakfast

7:00 a.m.-8:00 a.m.

Session 7: RNA in Cancer and Disease

Session Chairperson: William C. Hahn, Dana-Farber Cancer Institute, Boston, MA
8:00 a.m.-10:00 a.m.

Functional genomics, small RNAs, and cancer
William C. Hahn

Mechanisms of miRNA mediated cellular reprogramming
Edward E. Morrisey, University of Pennsylvania, Philadelphia, PA

New therapeutic strategies for lymphomas inspired by functional and structural genomics
Louis M. Staudt, National Cancer Institute, Bethesda, MD

Molecular function of the RNA binding protein EWS in RNA processing*
Bethsaida I. Nieves, Stanford University School of Medicine, Stanford, CA

Break

10:00 a.m.-10:15 a.m.

Session 8: RNA Therapeutics

Session Chairperson: William C. Hahn, Dana-Farber Cancer Institute, Boston, MA
10:15 a.m.-12:15 p.m.

Targeting of microRNAs for therapeutics
Sakari Kauppinen, Santaris Pharma, Horsholm, Denmark

Long noncoding RNAs as drug targets
Claes R. Wahlestedt, University of Miami Miller School of Medicine, Miami, FL

Anti-miR therapeutics for cancer
Eric Marcusson, Regulus Therapeutics, San Diego, CA

Treatment of ovarian cancer with targeted tumor-penetrating siRNA nanocomplexes*
Yin Ren, David H. Koch Institute for Integrative Cancer Research at MIT, Cambridge, MA

Closing Remarks / Departure

12:15 p.m.