Abstracts

ABSTRACT SUBMISSION

Abstract submissions are no longer being accepted for this conference. The abstract submission deadline was Thursday, September 6.

REVIEW AND NOTIFICATION

Only those abstracts that have been reviewed and selected by the conference co-chairpersons may be presented. Abstracts selected for presentation during the conference will be printed electronically from submitted material. Every effort will be made to reproduce the content of the abstracts as submitted, except in certain circumstances where changes may be made to comply with AACR style. Please be sure to carefully check your abstract for content errors, spelling, names, etc. before submitting. The AACR does not proofread for or correct spelling, typographical, grammatical or scientific errors, nor can changes be made once the abstract is submitted.

SCHEDULE OF POSTER PRESENTATIONS

All accepted abstracts will be presented as posters on Monday, November 12, from 5:00 p.m.-7:30 p.m. Abstract titles and poster presenters are listed below (in alphabetical order, not board assignment order).

A genetic risk predictor for breast cancer using a combination of low-penetrance polymorphisms in a Japanese population. Hidemi Ito, Aichi Cancer Center Research Institute, Nagoya, Japan
A genome-wide association study identifies two new susceptibility loci for lung adenocarcinoma in the Japanese population. Kouya Shiraishi, National Cancer Center Research Institute, Tokyo, Japan
A pilot gene-environment-wide interaction study (GEWIS) of neurocognitive impairment in childhood medulloblastoma survivors. Philip Lupo, Baylor College of Medicine, Houston, TX
A review of the gene-environment interaction literature in cancer: What do we know? Armen Ghazarian, National Cancer Institute, Division of Cancer Control and Population Sciences, Bethesda, MD
Alterations in serum immunoglobulin levels in workers occupationally exposed to trichloroethylene. Bryan Bassig, National Cancer Institute, Bethesda, MD
Analgesic use in relation to sex hormone and prolactin concentrations in premenopausal women. Renee Fortner, Harvard School of Public Health, Boston, MA
Arsenic exposure in pregnancy increases the risk of adverse birth outcomes of newborns in Taiwan. Shu-Li Wang, Division of Environmental Health and Occupational Medicine, National Health Research Institutes, Zhunan, Miaoli, Taiwan
Assessment of two-way interactions in breast cancer susceptibility between 72,611 SNPs in 88,911 women: A study by the Breast Cancer Association Consortium (BCAC). Roger Milne, Spanish National Cancer Research Centre (CNIO), Madrid, Spain
Association of Polymorphisms in MCP-1 and CCR2 Genes with the Risk of Cancer: A Meta-analysis. Jeongseon Kim, National Cancer Center, Goyang, Korea (Rep.)
Associations between breast cancer survival and SNPs identified through GWAS meta-analyses for metabolic and cardiovascular diseases/traits. Laure Dossus, INSERM U1018, Villejuif, France
Associations between breast cancer susceptibility markers and terminal duct lobular unit involution in normal breast tissues among women from the Susan G. Komen for the Cure® Tissue Bank. Jonine Figueroa, National Cancer Institute, Bethesda, MD
Beta-diversity metrics of the upper digestive tract microbiome are associated with body mass index. Shih-Wen Lin, National Cancer Institute, Bethesda, MD
Beyond GWAS: The prognostic significance of promoter DNA methylation in patients with neuroblastoma. Lesley Ashton, Children's Cancer Institute Australia, Randwick, Australia
Blood leukocyte DNA methylation and colorectal cancer among male smokers in Finland. Ying Gao, National Cancer Institute, Rockville, MD
Body mass index and type 2 diabetes genetic risk scores and endometrial cancer risk among women of European ancestry. Jennifer Prescott, Brigham and Women's Hospital, Boston, MA
Cadmium exposure is associated with epigenetic changes in highly exposed subjects in Mae Sot, Thailand: A potential mechanism for cadmium carcinogenesis. Laura Rozek, University of Michigan, Ann Arbor, MI
Characterization of SNPs associated with prostate cancer in men of Ashkenazic descent from the set of GWAS identified SNPs: impact of cancer family history. Ilir Agalliu, Albert Einstein College of Medicine, Bronx, NY
Circulating concentrations and dietary intake of vitamin D in relation to pancreatic cancer risk in European populations: Preliminary results of a nested case-control study. Franzel van Duijnhoven, National Institute for Public Health and the Environment (RIVM), Bilthoven, The Netherlands
Circulating prolactin levels and mammographic density in the Nurses Health Studies. Megan Rice, Harvard School of Public Health, Boston, MA
Combined effects of low-penetrance variants on breast cancer risk: Results from the Seoul Breast Cancer Study. Hyuna Sung, Seoul National University, Seoul, Korea (Rep.)
Common genetic polymorphisms of catechol-O-methyltransferase (COMT) and colorectal cancer survival. Michael Passarelli, Fred Hutchinson Cancer Research Center, Seattle, WA
Contributions of Cancer Epidemiology Consortia to Genome-Wide Association Studies of Common and Rare Cancers. Daniela Seminara, National Cancer Institute, Bethesda, MD
Dietary Supplement Use among German Colorectal Cancer Patients: the ColoCare Study. Petra Schrotz-King, Division of Preventive Oncology, National Center for Tumor Diseases (NCT), Heidelberg, Germany
Differential DNA methylation related to arsenic exposure and tobacco smoking. Maria Argos, The University of Chicago, Chicago, IL
Differential gene expression in adipose tissue of colorectal cancer patients dependent on disease stage. Dominique Scherer, German Cancer Research Center, Heidelberg, Germany
DNA Adductome: an ultimate exposome of human tissues. Haruhiko Sugimura, Hamamatsu University School of Medicine, Hamamatsu, Japan
DNA isolated from toenails: A new and valid source for high-throughput genotyping in large-scale epidemiological studies. Leo Schouten, Maastricht University, Maastricht, The Netherlands
Evaluation of bead-based assays of inflammation markers for epidemiologic studies. Elizabeth Poole, Harvard Medical School and Brigham and Women's Hospital, Boston, MA
Examining genetic markers of obesity and metabolism against prostate cancer risk using Metabochip. Jay Fowke, Vanderbilt University Medical Center, Nashville, TN
Exposure to heavy metals and polycyclic aromatic hydrocarbons and DNA damage in Taiwanese traffic conductors. Shu-Li Wang, Department of Public Health, National Defense Medical Center, Taipei, Taiwan
Fine mapping and in silico analysis of the 8q24.21 region for glioma identifies a low frequency risk variant insight into etiological basis of glioma. Yanhong Liu, Baylor College of Medicine, Houston, TX
Framework for post-GWAS functional annotation of regulatory regions associated with susceptibility loci for Colorectal Cancer. Stephanie Rosse, Fred Hutchinson Cancer Research Center, Seattle, WA
Functional DNA repair tests and their perspectives in molecular epidemiology (experience with subjects exposed to carcinogens and in cancer patients). Pavel Vodicka, Institute of Experimental Medicine, Academy of Science of the Czech Republic, Prague, Czech Republic
Gene expression induced by acrylamide and glycidamide in mammalian cells. Jorge Gaspar, Faculty of Medical Sciences, Universidade Nova de Lisboa, Lisbon, Portugal
Genetic Associations and Mechanisms in Oncology (GAME-ON): A network approach to post-GWAS research. Daniela Seminara, National Cancer Institute, Bethesda, MD
Genetic pathways related to vitamin-D and risk of pancreatic cancer. Hannah Arem, National Cancer Institute, Bethesda, MD
Genetic predictors of DNA repair capacity in melanoma patients – A genome-wide approach. Li-E Wang, The University of Texas MD Anderson Cancer Center, Houston, TX
Genetic variability in MRP4 (ABCC4), ibuprofen use, and colorectal cancer risk in the Colon Cancer Family Registry. Laura Heath, Fred Hutchinson Cancer Research Center, Seattle, WA
Genetic variation in prostaglandin synthesis and related pathways, NSAID use, and risk of colorectal cancer in the Colon Cancer Family Registry. Alexa Resler, Fred Hutchinson Cancer Research Center and University of Washington, Seattle, WA
Genetically-determined differences in arsenic metabolism efficiency influence risk for pre-malignant skin lesions in Bangladesh: Mendelian Randomization and gene-environment interaction. Brandon Pierce, University of Chicago, Chicago, IL
Human papillomavirus-16 DNA methylation in head and neck squamous cell carcinomas. Lauren Cole, Louisiana State University Health Sciences Center School of Public Health, New Orleans, LA
Innate Immunity Pathways and Breast Cancer Risk in African American and European American Women in the Women's Circle of Health Study (WCHS). Zhihong Gong, Roswell Park Cancer Institute, Buffalo, NY
Instrumental variable analysis on soluble receptor for advanced glycation end-products and risk of pancreatic cancer - A pilot study. Li Jiao, Baylor College of Medicine, Houston, TX
Interaction between Obesity and Variants in Angiogenesis-Related Genes and Prostate Cancer Aggressiveness. Ernest Amankwah, Moffitt Cancer Center, Tampa, FL
Interaction between Retinol Transporter Genes and Alcohol on the Risk of Head and Neck Cancer. Jeffrey Chang, National Institute of Cancer Research, National Health Research Institutes, Tainan, Taiwan
Lifestyle and dietary factors and antibody levels to oral bacteria in healthy individuals. Dominique Michaud, Brown University, Providence, RI
LINE-1 %5-methyl cytosine levels in pre-diagnostic leukocyte DNA and future bladder cancer risk among PLCO and ATBC cohort subjects. Gabriella Andreotti, NCI, Bethesda, MD
Metabolomic profile of bladder cancer according to GSTM1 copy number. André Amaral, Spanish National Cancer Research Center (CNIO), Madrid, Spain
Molecular epidemiology of Gc-globulin isotype, circulating 25(OH)D levels, and uptake of vitamin D metabolites in colon cancer cells.. Elizabeth Hibler, University of Arizona, Tucson, AZ
Molecular links between energy balance and colorectal cancer risk: A key role for methylation of insulin-like growth factor binding protein genes. Colinda Simons, Maastricht University, Maastricht, The Netherlands
New teaching tools for new epidemiologists. Matty Weijenberg, Dept. of Epidemiology, Maastricht Molecular Epidemiology Expertise group (M2E2), Maastricht University, Maastricht, The Netherlands
One-carbon metabolism pathway genes and colorectal cancer risk in the Women's Health Initiative (WHI). Elissa Brown, Fred Hutchinson Cancer Research Center, Seattle, WA
Pathway-based gene-environment interactions in ovarian cancer. Marieke Braem, Julius Center, University Medical Center Utrecht, Utrecht, The Netherlands
PER3 gene in association with plasma melatonin in Caucasian men. Fangyi Gu, National Cancer Institute, Rockville, MD
Polymorphisms in Chronic Inflammation Mediated Pathway Genes Associated with Risk of Postmenopausal Breast Cancer (PMBC). Xiaowei (Sherry) Yan, Geisinger Center for Health Research, Danville, PA
Pre-diagnostic serum levels of inflammation markers and risk of ovarian cancer in the Prostate, Lung, Colorectal and Ovarian Cancer Screening Trial: preliminary results.. Britton Trabert, Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, DHHS, Bethesda, MD
Pretreatment Levels of Circulating Th1 and Th2 Cytokines, and their Ratios, are Associated with ER-Negative and Triple Negative Breast Cancers. Chi-Chen Hong, Roswell Park Cancer Institute, Buffalo, NY
Prioritizing SNPs for gene-environment interaction studies. Matty Weijenberg, Dept. of Epidemiology, GROW - School for Oncology and Developmental Biology, Maastricht University, Maastricht, The Netherlands
Prospective study of LINE-1 hypomethylation in peripheral leukocyte DNA and colorectal cancer risk. Wen-Yi Huang, National Cancer Institute, National Institutes of Health, Bethesda, MD
Prostate cancer risk variants and disease progression in the NCI Breast and Prostate Cancer Cohort Consortium. Irene Shui, Harvard School of Public Health, Boston, MA
Relationship of mammographic density and gene expression analysis of normal breast tissue surrounding breast cancer. Xuezheng Sun, Department of Epidemiology, University of North Carolina, Chapel Hill, NC
Relationships between biomarkers of diet, one-carbon metabolism, and inflammation within the Women's Health Initiative observational study. Michael Paskow, Division of Preventative Oncology, National Center for Tumor Diseases/German Cancer Research Center, Heidelberg, Germany
SNP association mapping across the extended major histocompatibility complex and the risk of precursor B-cell acute lymphoblastic leukemia in children. Kevin Urayama, St. Luke's Life Science Institute, Tokyo, Japan
Soluble RAGE modestly inversely associated with liver cancer risk in male Finnish Smokers. Kristin Moy, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD
Telomere length and pancreatic cancer in the alpha-tocopherol beta-carotene cancer prevention (ATBC) study. Shannon Lynch, University of Pennsylvania, Philadelphia, PA
Telomere length in relation to the risk of Barrett's esophagus and esophageal adenocarcinoma. E. Christina Persson, National Cancer Institute, Bethesda, MD
The association between GWAS SNPs and mammographic density in Norwegian postmenopausal women stratified by non-genetic factors. Merete Ellingjord-Dale, Department of Nutrition, University of Oslo, Oslo, Norway
The association of genetic variants in dopamine regulators with indoor tanning and melanoma. Kristina Flores, University of New Mexico, Albuquerque, NM
The Colon Cancer Family Registry: a major resource for Post-GWAS gene-environment studies. Aung Win, University of Melbourne, Parkville, VIC, Australia
The effect of genetic variants on the relationship between statins and breast cancer in the Women's Health Initiative Observational Study. Cathryn Bock, Detroit Medical Center, Detroit, MI
The epidemiology of triple-negative breast cancer: A review. Leila Family, Gillings School of Global Public Health, Chapel Hill, NC
The relationship between abdominal fat distribution, vitamin D levels and physical activity in colorectal cancer patients: A pilot study. Jürgen Staffa, Department of Preventive Oncology, National Center for Tumor Diseases (NCT), Heidelberg, Germany
Thymidylate synthase polymorphisms and colorectal cancer risk and prognosis. Katharina Buck, Division of Preventive Oncology, National Center for Tumor Diseases (NCT) and German Cancer Research, Heidelberg, Germany
Using family-based genome-wide data to evaluate imprinting and maternal genetic effects: A pilot study of glioma risk. Philip Lupo, Baylor College of Medicine, Houston, TX
Value of bilateral breast cancer for identification of rare recessive at-risk alleles: evidence for the role of homozygous GEN1 c.2515_2519delAAGTT mutation. Ekaterina Kuligina, N.N. Petrov Institute of Oncology, St. Petersburg, Russian Federation
Variations in DNA repair gene expression and breast cancer risk in the New York site of the Breast Cancer Family Registry. Maya Kappil, Columbia University, New York, NY
Whole exome sequencing of aristolochic acid induced upper urothelial carcinomas. Thomas Rosenquist, Stony Brook University, Stony Brook, NY
Within-person reproducibility of urinary bisphenol A and phthalate metabolites among women in the Nurses’ Health Studies. Mary Townsend, Brigham and Women's Hospital, Boston, MA

REGISTRATION AND ACCOMMODATIONS

Individuals planning on presenting an abstract at this conference are encouraged to register and make a room reservation at the conference hotel as early as possible. If an abstract is not accepted for presentation at the conference, the presenter may request a full refund of the registration fee and may cancel his/her room reservation at no charge up to four days before the scheduled arrival date. For additional information, please visit the registration and accommodations and travel webpages.

PRESENTATION AND PUBLICATION

Abstracts selected for presentation during the conference will be printed in the Conference Proceedings from submitted material. Every effort will be made to reproduce the content of the abstracts as submitted, except in certain circumstances where changes may be made to comply with AACR style. Abstract titles and authors will be posted on the AACR website before the conference begins (only titles and authors, no data will be posted online before or after the conference). For those abstracts that have been accepted for poster presentation, poster boards will be 4 feet high and 8 feet across (1.22m x 2.44m) and AACR will provide poster numbers and pushpins. See a sample poster layout. For programs that include short talks selected from the abstract submissions, instructions will be sent to the ABSTRACT PRESENTERS with the date, time, and format for those presentations.

REQUEST FOR WITHDRAWAL

Once an abstract has been submitted, it may be withdrawn only by written request from the ABSTRACT PRESENTER. The request may be sent by fax to (215) 599-0111 or email to programs@aacr.org and must be received at least 30 days prior to the start of the conference.