Poster Session A

Poster Session A
Friday, March 4
12:40 p.m.-3:40 p.m.

In alphabetical order, not board assignment order

• A subset of stem-like human prostate tumor-initiating cells manifest constitutive NF-kB signaling. Vinagolu K. Rajasekhar1, 4, Lorenz Studer1, William Gerald2, Nicholas D. Socci3, and Howard I. Scher4. 1Stem Cell Center, 2Pathology, 3Computational Biology Center, 4Department of Medicine (Genitourinary Oncology Service), Memorial Sloan-Kettering Cancer Center, New York, NY
• Analysis of androgen receptor function in prostate epithelial stem cells. Chee Wai Chua, Xi Wang, Ming Lei, Sarah B. Carner, Michael M. Shen. Columbia University Medical Center, New York, NY
• Analysis of ROS regulation in primitive human mammary subpopulations identifies committed luminal progenitors as sites of chronic oxidative stress and therapeutic resistance. Nagarajan Kannan, Peter Eirew, Maisam Makarem, Long Nguyen, Connie Eaves. Terry Fox Laboratory, British Columbia Cancer Agency, Vancouver, BC, Canada
• Barrier to autointegration factor 1 (Banf1) is required to maintain the self-renewal of both mouse and human embryonic stem cells. Jesse L. Cox1, Sunil K. Mallanna1, Briana D. Ormsbee1, Michelle Desler1, Matthew S. Wiebe2, Angie Rizzino1. 1University of Nebraska Medical Center, Omaha, NE, 2University of Nebraska at Lincoln, Lincoln, NE.
• Cancer stem cell profiles of clonal luminal and EMT PyMT cell lines. Lesley G. Ellies. University of California, San Diego, La Jolla, CA
• CD133(-) cells, derived from a single human colon cancer cell line, are more resistant to 5-fluorouracil (FU) than CD133(+) cells, dependent on the β1-integrin signaling. Kumiko Hongo1, Nelson H. Tsuno2, Eiji Sunami1, Joji Kitayama1, Koki Takahashi2, Hirokazu Nagawa1. 1Department of Surgical Oncology, The University of Tokyo, Tokyo, Japan, 2Department of Transfusion Medicine, The University of Tokyo, Tokyo, Japan
• Characterization of the cell cycle profile of human mammary stem and progenitor cells. Peter Eirew1, John Stingl2, Afshin Raouf3, Gulisa Turashvili1, Sam Aparicio1, Joanne Emerman4, Connie J. Eaves1. 1BC Cancer Agency, Vancouver, BC, Canada, 2CRUK Cambridge Research Institute, Cambridge, England, 3University of Manitoba, Winnipeg, MB, Canada, 4University of British Columbia, Vancouver, BC, Canada
• Characterization of tumour-initiating cells in head and neck squamous cell carcinoma. Christina Karamboulas1, Keira Peireira2, Elzbieta Hyatt3, Laurie Ailles1. 1Ontario Cancer Institute, Toronto, Ontario, Canada, 2University of Toronto, Toronto, ON, Canada, 3University Health Network, Toronto, ON, Canada
• Deciphering the convergence of melanoma tumorigenesis and embryonic neural crest development in vivo. Caleb M. Bailey, Jason A. Morrison, Joseph Steen, Paul M. Kulesa. Stowers Institute for Medical Research, Kansas City, MO
• Decursin inhibits early vasculogenesis in tumor progression by suppression of endothelial progenitor cell differentiation and function. Suk Yun Jung1, Jin Hwa Choi1, Sang Mo Kwon2, You Mie Lee1. 1Kyungpook National University, Daegu, Korea (Rep.), 2Pusan National University, Pusan, Korea (Rep.)
• Dedifferentiation of lung epithelial stem cells by downregulation of Runx3 is causally associated with the preneoplastic stage of lung adenocarcinoma. Suk-Chul Bae1, You-Soub Lee1, Han-Sung Jung2. 1Chungbuk National University, Cheongju, Korea (Rep.), 2Yonsei University, Seoul, Korea (Rep.)
• DeltaNp63 regulates mammary stem cell activity through induction of BMP7 and activation of canonical BMP signaling. Amanda L. Balboni, Pratima Cherukuri, Justine Hutchinson, Sierra Kent, Andrew DeCastro, James DiRenzo. Dartmouth College, Hanover, NH
• Detailed flow cytometry analysis of human breast with focus on normal breast stem cells. Hazem Ghebeh, Ghida Majed Sleiman, Eman Barhoush, Pulicat Manogaran, Amer Al-Mazrou, Asma Tulbah, Khalid Al-Faqeeh, Chaker N. Adra. Stem Cell Therapy Program, King Faisal Specialist Hospital & Research Center, Riyadh, Saudi Arabia
• Detection of ALDH-expressing normal stem and progenitor cells, and cancer cell lines using ALDEFLUOR®. Tracy Lee1, Ning Yuan1, Ravenska Wagey1, Terry E. Thomas1, Allen C. Eaves2, Albertus W. Wognum1. 1StemCell Technologies Inc., Vancouver, British Columbia, Canada, 2Terry Fox Laboratory, Vancouver, BC, Canada
• Disulfiram as a novel cytotoxic drug in glioblastoma multiforme cell lines. Sarah Brown, Peng Liu, John L. Darling, Weiguang Wang. University of Wolverhampton, Wolverhampton, England
• DNp63, a p53 family member, induces mammary stem cell quiescence through the Notch signaling pathway: Implications for Breast Cancer Chemo-resistance. Sierra Kent, Pratima Cherukuri, James DiRenzo. Dartmouth College, Hanover, NH
• Effect of the assay environment on colony formation by human bone marrow mesenchymal stem cells expanded under normal and low oxygen conditions. Ludmila Kharazi, Alexander Kharazi. Stemedica Cell Technologies, San Diego, CA
• EMT-Inducible NQO1 expression underlies a role for quinone-directed treatment of NQO1 expressing cancer stem cells. Erik A. Bey, Lei Jiang, Yonglong Zou, Malina Patel, David A. Boothman. University of Texas Southwestern Medical Center at Dallas, Dallas, TX
• Enhanced malignancy of human neuroblastoma stem cells caused by increased wild-type N-ras activation results from neurofibromin downregulation. Dan Han, Barbara A. Spengler, Robert A. Ross. Fordham University, Bronx, NY
• Enrichment of tumor initiating cells in primary human esophageal adenocarcinoma xenografts through the use of chemotherapy. Lorin Dodbiba1, Jennifer Teichman1, Aliya Ramjaun2, Yumeng Li2, Bin Sun2, Zhuo Chen2, Geoffrey Liu3, Laurie Ailles3. 1University of Toronto, Toronto, ON, Canada, 2University Health Network, Toronto, ON, Canada, 3Ontario Cancer Institute, University of Toronto, Toronto, ON, Canada
• Evaluating the expression of self renewal genes (Oct4, Nanog, Sox2, Nucleostemin, Zfx, Bmi, Dppa4, Esrrb, Tbx3 and Tcl1) in colon, bladder and prostate cancers and cancer cell lines. Sabrieh Amini1, Fardin Fathi2, Kazem Parivar3. 1Islamic Azad University- Sanandaj Branch, Sanandaj, Islamic Republic of Iran, 2Kurdistan University of Medical Sciences, Sanandaj, Iran, Islamic Republic Of, 3Science and Research Branch, Islamic Azad University, Tehran, Iran, Tehran, Islamic Republic of Iran
• Evidence for quantitative but not qualitative differences in the cells in human cord blood and mobilized peripheral blood that rapidly produce mature platelets and granulocytes using a NOD/SCID-IL-2Rγc-/- mouse xenograft model. Alice M.S. Cheung, Donna Leung, Connie J. Eaves. Terry Fox Laboratory, BC Cancer Agency, Vancouver, BC, Canada
• Evidence that AS1411, an anti-cancer aptamer, targets cancer stem cells. Enid Choi1, Kavitha Yaddanapudi1, Ewa Zuba-Surma2, Mariusz Ratajczak1, Paula Bates1. 1University of Louisville, Louisville, KY, 2Jagiellonian University, Krakow, Poland
• Gene expression profiling of liver cancer stem cells in human liver cancer with Illumina sequencing. D.W. Ho, Z.F. Yang, S.C.T. Lam, C.K. Lau, W.C. Yu, S.T. Fan. The University of Hong Kong, Hong Kong, Hong Kong, China
• Genetic manipulation of human pluripotent stem cells before and during their differentiation into hematopoietic cells. Melanie D. Kardel, Connie J. Eaves. Terry Fox Laboratory, BC Cancer Agency, Vancouver, BC, Canada
• Hedgehog signaling specifies positional identity and fate in adult neural stem cells. Rebecca A. Ihrie1, Jugal K. Shah1, Corey C. Harwell1, Cristina D. Guinto1, Melissa Lezameta2, Arnold R. Kriegstein1, Arturo Alvarez-Buylla1. 1University of California - San Francisco, San Francisco, CA, 2Instituto Cavanilles de Biodiversitat i Biologia Evolutiva, Valencia, Spain
• Hierarchy independent plasticity in the phenotype of acute myeloid leukemia stem cells. Kenneth Demire Gibbs Jr., Astraea Jager, Yury Goltsev, Chase E. Richard, Garry P. Nolan. Stanford School of Medicine, Stanford, CA
• High-throughput characterization of single hematopoietic stem cells under static and dynamic conditions using microfluidic cell culture arrays. Véronique Lecault1, Sanja Sekulovic2, James M. Piret1, David J.F.P. Knapp2, Stefan Wohrer2, Ivan Sloma2, Michael VanInsberghe3, William Bowden1, Connie J. Eaves2, R. Keith Humphries2, Carl L. Hansen3. 1Michael Smith Laboratories, University of British Columbia, Vancouver, BC, Canada, 2Terry Fox Laboratory, BC Cancer Agency, Vancouver, BC, Canada, 3Centre for High-Throughput Biology, University of British Columbia, Vancouver, BC, Canada
• Hypoxia up-regulates Nodal expression via the HIF-1 pathway in poorly metastatic cancer cells. Meghan Taylor, Padmalaya Das, Michael Jewer, Dylan Dieters-Castator, Logan Walsh, Daniela Quail, Lynne-Marie Postovit. University of Western Ontario, London, ON, Canada
• ID4 regulates chemoresistance and brain cancer stemness by derepressing miR-9*-mediated suppression of SOX2. Hye Mi Jeon1, Young Wo Sohn1, Se Young Oh1, Soonhag Kim2, Hynggee Kim1. 1School of Life Sciences and Biotechnology, Korea University, Seoul, Korea (Rep.), 2Department of Applied Bioscience, CHA Stem Cell Institute, CHA University, Seoul, Korea (Rep.)
• Identification of CD44R1 as a marker for gastric cancer stem cells. Eileen Teng1, Shing Leng Chan1, Wen Min Lau1, Hui Shan Chong1, Kirsten Anne Pagaduan Lopez1, Amy YL Tay2, Manuel Salto-Tellez3, Ting Ting Wang1, Asim Shabbir2, Jimmy BY So2. 1Cancer Science Institute of Singapore, Singapore, Singapore, 2Department of Surgery, National University of Singapore, Singapore, Singapore, 3Department of Pathology, National University of Singapore, Singapore, Singapore
• Identifying stem cells and their progenitors in the bovine mammary gland. Gat Rauner, Itamar Barash. ARO, The Volcani Center, Bet-Dagan, Israel
• In vitro and in vivo interaction of cdk6 and Eya2 indicate potential crosstalk between the cell cycle and developmental pathways. Jennifer I. Crary1, Martha J. Grossel1, Philip W. Hinds2. 1Connecticut College, New London, CT, 2Tufts Medical Center, Boston, MA
• In vitro screening of aldehyde dehydrogenase substrates suitable for in vivo imaging of cancer stem cells. Saga Johansson, Alan Cuthbertson, Matthew Morrison, Ian Wilson. GE Healthcare, Amersham, England
• Inhibition of glioma cell proliferation and tumor development by Sox21. Demet Caglayan, Marianne Kastemar, Bengt Westermark, Maria Ferletta. Uppsala University, Uppsala, Sweden
• Limiting levels of telomerase in human hematopoietic stem cells. Geraldine Aubert*1, Gabriela M. Baerlocher*2, Irma Vulto1, Steven S. Poon1, Peter M. Lansdorp1. 1Terry Fox Laboratory, BC Cancer Agency, Vancouver, BC, Canada, 2Department of Hematology and Department of Clinical Research, Bern, Switzerland
• Lymphoid-deficient hematopoietic stem cells appear in mice before birth and expand rapidly and preferentially over the next 4-5 weeks. Claudia Benz, Copley Michael, David Kent, Keegan Rowe, Adrian Cortes, Nima Aghaeepour, Ryan Brinkman, Connie J. Eaves. BC Cancer Agency, Vancouver, BC, Canada
• Ovarian cancer frequently generates in aged chickens (Gallus domesticus): the possible animal model for ovarian cancer. Jung Kyu Choi, Jong IL Ahn, Jong Heum Park, Gwonhwa Song, Jae Yong Han, Dae Yong Kim, Jeong Mook Lim. Seoul National University, Seoul, Korea (Rep.)
• Ovulation-related homing and aggravation of primary fallopian tube cancer cells to ovarian stroma supporting an ectopic origin of serous carcinoma of the ovary. Tang-Yuan Chu1, Ching-Hua Yeh1, Chiu-Hua Chen1, Che-Fung Hsu1, Pao-Chu Chen1, Sung-Chao Chu2, Da-Ching Ding1. 1Buddhist Tzu Chi General Hospital, Hualien, Taiwan, 2Tzuchi University, Hualien, Taiwan
• P63 promotes reversible cell cycle arrest in mammary stem cells via global suppression of RNA Polymerase II activity and selective expression of anti-proliferative P53 targets. Justine Hutchinson, Sierra Kent, Pratima Cherukuri, James DiRenzo. Dartmouth Medical School, Hanover, NH
• Phosphorylation of ΔNp63α at serines 66 and 68 is associated with mammary stem cell quiescence. Andrew J. DeCastro, Pratima Cherukuri, Justine Hutchinson, Sierra Kent, Amanda Balboni, James DiRenzo. Dartmouth College, Hanover, NH
• Prognostic cancer stem cell marker profiles in aggressive metastatic colorectal cancer. Crystal Hessman, Eric Anderson, Melissa Wong. Oregon Health & Science University, Portland, OR
• Purification and interrogation of human prostate cancer cells-of-origin. Andrew S. Goldstein, Jiaoti Huang, Owen N. Witte. University of California, Los Angeles, Los Angeles, CA
• Regulation of ovarian cancer progression by microRNA-187 through targeting disabled homolog 2. Angel Chao, Tzu-Hao Wang, Chyong-Huey Lai. Chang Gung Memorial Hospital and Chang Gung University, Tao-Yuan, Taiwan
• Regulatory functions of microRNAs in stem-like populations from embryonal tumor cell lines. Judy C. Chang, Patricia C. Sanchez-Diaz, Anne Romeo, Gail E. Tomlinson, Yidong Chen, Jaclyn Y. Hung. University of Texas Health Science Center, San Antonio, TX
• Reprogramming the metastatic phenotype using embryonic neural crest microenvironmental signals. Jennifer C. Kasemeier-Kulesa, Paul M. Kulesa. Stowers Institute for Medical Research, Kansas City, MO
• Role of DEB-induced ROS production during the activation of cell survival pathways in prostate cancer cells. Lea A. Dixon, Eduardo Martinez-Ceballos. Southern University and A&M College, Baton Rouge, LA
• Src tyrosine kinase elicits an isoform-specific role of hepatocyte nuclear factor 4α in colon cancer. Karthikeyani Chellappa1, Jane R. Evans1, Charles Chan2, Owen F. Dent2, Stephen J. Clarke2, Mary C. Weiss3, Graham R. Robertson2, Frances M. Sladek1, Poonam J. Bajwa1, Lucy Jankova2, Jake M. Schnabl1, Eugene Bolotin1, Songqin Pan1, Yann Brelivet4, Nadege Briancon5, Caroline L-S Fung2. 1University of California, Riverside, Riverside, CA, 2Concord Hospital, Sydney, New South Wales, Australia, 3Pasteur Institute, Paris, France, vIGBMC, Illkirch, France, 5Harvard Medical School, Boston, MA
• Targeting of multiple HER-receptors stops growth and self-renewal of glioblastoma cancer stem cells. Paul A. Clark, Mari Iida, Deric L. Wheeler, H. Ian Robins, John S. Kuo. University of Wisconsin - Madison, Madison, WI
• TDP1 and PARP-1: Potential therapeutic targets for rhabdomyosarcoma? Hok Khim Fam1, Miraj Chowdhury1, Timothy J. Triche2, Catherine Pallen1, Cornelius F. Boerkoel1, Sheetal Bajaj2, Nichola Osborne1, Kunho Choi1, Cheryl Walton1, Guobin Sun1, Mason Bond1. 1University of British Columbia, Vancouver, BC, Canada, 2Children's Hospital Los Angeles, Los Angeles, CA
• Telomere regulation changes within different subpopulations in normal human mammary tissue. Nagarajan Kannan1, Nazmul Huda2, Hiromi Tanaka2, Connie J. Eaves1, David Gilley2. 1Terry Fox Laboratory, British Columbia Cancer Agency, Vancouver, BC, Canada, 2Indiana University School of Medicine, Department of Medical and Molecular Genetics, Indianapolis, IN
• The intergenic sequence of keratins 8 and 18 bi-directionally drives EGFP and Cre/Esr in the mouse as a new genetic tool for epithelial homeostasis and cancer. Chun-Ming Chen, Fang-Yi Su, Nai-Chen Chao, Li-Ru You. National Yang-Ming University, Taipei, Taiwan
• The study of Human Artificial Chromosome (HAC) with a conditional centromere. Indri Erliandri1, Haiqing Fu1, Kim Jung-Hyun1, Mirit Aladjem1, William Earnshaw2, Hiroshi Masumoto3, Larionov Vladimir1. 1The National Cancer Institute of NIH, Bethesda, Maryland, 2Wellcome Trust Centre for Cell Biology, University of Edinburg, Edinburg, Scotland, 3Laboratory of Cell Engineering, Kazusa DNA Research Institute, Chiba, Japan
• Validation of epithelial stem cells in human squamous esophagus and generation of a 3D organotypic model. Mariagnese Barbera1, Elaine Walker1, John Stingl2, David Doupe1, Philip Jones1, Rebecca Fitzgerald1. 1MRC Cancer Cell Unit, Hutchison/MRC Research Center, Cambridge, England, 2CRUK, Cambridge Research Institute, Cambridge, England