Poster Session B

Poster Session B
Saturday, March 5
5:00 p.m.-8:00 p.m.

In alphabetical order, not board assignment order

• A JAK2 activating mutation subverts hematopoietic stem cells by increasing proliferation, survival, and differentiation while compromising overall long-term self-renewal activity. David G. Kent, Juan Li, Anthony R. Green. Cambridge Institute for Medical Research, Cambridge, Cambridgeshire, England
• A polymeric nanoparticle formulation of curcumin inhibits growth, clonogenicity and stem-like fraction in malignant brain tumors. Kah Jing Lim, Savita Bisht, Eli E. Bar, Anirban Maitra, Charles G. Eberhart. The Johns Hopkins University, Baltimore, MD
• Antagonistic pleiotropy: The role of senescence in cancer and aging. Charusheila Ramkumar, Rachel Gerstein, Hong Zhang. UMass Medical School, Worcester, MA
• Bmi-1 epigenetic control of proliferation and growth arrest of neural stem cells by switching on and off CDK inhibitors. JeeSun Kim, Paul K.Y. Wong. The University of Texas MD Anderson Cancer Center, Smithville, TX
• Breast cancer stem cells and distinct tumor initiating cells are linked by EMT. Jochen Maurer, David Castro, Robert Oshima. SBMRI, La Jolla, CA
• Characterization of mammary stem cell activity and expression profiles during embryonic development. Jennifer C. Lin1, Dannielle D. Engle2, Benjamin T. Spike1, Samantha K. Cheung1, Justin La1, Geoffrey Wahl1. 1The Salk Institute, La Jolla, CA, 2University of California, San Diego, CA
• Characterization of the appearance and properties of mouse mammary epithelial stem and progenitor cells during development. Maisam Makarem, Nagarajan Kannan, Peter Eirew, Connie J. Eaves. BC Cancer Research Center, Vancouver, BC, Canada
• Characterization of the epigenetic modification patterns of pluripotent stem cell genes in human cancers. Xiao Qi Wang, Ray K Ng, Xiaoyan Ming, Wu Zhang, Lin Chen, Ronnie TP Poon, Sheung Tat Fan. The University of Hong Kong, Hong Kong, China
• Cyclooxygenase-2 promotes breast cancer progression by induction and sustenance of tumor-initiating cells. Mousumi Majumder, Postovit Lynn-Marie, Elena Tutunea Fatan, Eloy Jose Torres-Garcia, Peeyush K. Lala. The University of Western Ontario, London, ON, Canada
• Defining the limits of embryonic pluripotency. Anestis Tsakiridis1, Rodrigo Osorno1, Noemi Cambray1, Constantinos Economou1, Ronald Wilkie1, Paul J. Scotting2, Ian Chambers1, Valerie Wilson1. 1MRC Centre for Regenerative Medicine, University of Edinburgh, Edinburgh, Scotland, 2Children's Brain Tumor Research Centre, University of Nottingham, Nottingham, England
• Defining the origins of Ras/p53 mediated squamous cell carcinoma. Andrew C. White, Kathy Tran, Joan Khuu, William E. Lowry. UCLA, Los Angeles, CA
• Development of multiplexed single cell expression and genotyping assays to assess intercellular variability, sample heterogeneity and clonality in AML and CML patient samples. Amy L. Paguirigan, Jerald R. Radich. Fred Hutchinson Cancer Research Center, Seattle, WA
• Differential expression and tissue distribution of miR-21 and miR-302 in FFPE samples of esophageal cancer. Nazila Nouraee1, Mojtaba Tabrizi1, Mohammad Vasei2, Shahryar Semnani3, Seyed Javad Mowla1. 1Tarbiat Modares University, Tehran, Islamic Republic of Iran, 2Pathology laboratory, Shariati Hospital, Tehran, Islamic Republic of Iran, 3Golestan Research Center of Gastroenterology and Hepatology, Gorgan, Golestan, Islamic Republic of Iran
• Disulfiram – an old antialcoholism drug targeting breast cancer stem cells. Peng Liu1, Sarah Brown1, Angel L. Armesilla1, John L. Darling1, James Cassidy2, Weiguang Wang1. 1University of Wolverhampton, Wolverhampton, England, 2University of Glasgow, Glasgow, Scotland
• Drosophila Boi limits hedgehog levels to suppress follicle stem cell proliferation. Tiffiney R. Hartman1, Daniel Zinshteyn1, Heather K. Schofield1, Emmanuelle Nicolas1, Ami Okada2, Alana M. O'Reilly1. 1Fox Chase Cancer Center, Philadelphia, PA, 2Stanford University, Stanford, CA
• Effect of age and mutagen on the function and genetic integrity of murine mammary stem/progenitor cells. LuZhe Sun, Abhik Bandyopadhyay, Qiaoxiang Dong, I-Tien Yeh, Maryanne C. Herzig, Christi A. Walter. University of Texas Health Science Center at San Antonio, San Antonio, TX
• EGFRvIII, a tumor specific variant of the EGF receptor, can be used to identify and target glioblastoma cancer stem cells. Albert J. Wong, Siddhartha Mitra, Shuang-Yin Han, Catherine Del Vecchio, Stephen Skirboll, Marina Holgado-Madruga. Stanford University, Stanford, CA
• Epigenetic regulation of stemness and malignancy in Ewing Tumors. Stephanie Plehm, Stefan Burdach, Guenther HS Richter. Children’s Cancer Research Center, Technische Universitaet Muenchen, Munich, Germany
• Epithelial-Mesenchymal Transition Induces A Lgr5-positive tumorigenic subpopulation in Runx3-deficient mouse gastric epithelial cells. Huajing Wang1, Dominic C. Voom1, Yoshiaki Ito1, Tu Anh Pham Nguyen2, Jason W.K. Koo1, Yit Teng Hor1, Yeh-Shiu Chu2, Kosei ITO3, Hiroshi Fukamachi4, Shing Leng Chan1, Jean Paul Thiery2. 1Cancer Science Institute of Singapore, National University of Singapore, Singapore, Singapore, 2Institute of Molecular and Cell Biology, Singapore, Singapore, 3Graduate School of Biomedical Sciences, Nagasaki University, Nagasaki, Japan, 4Department of Molecular Oncology, Tokyo Medical and Dental University, Tokyo, Japan
• Expression and invasion-suppressive function of HOXB4 in ovarian cancer cells. Xin Zhang, Peter C.K. Leung, Christian Klausen. Child and Family Research Institute, Vancouver, BC, Canada
• Fgf9 is required for stem cell function and tissue homeostasis in the intestinal epithelium. Marc Leushacke, Ralf Spörle, Antje Brouwer-Lehmitz, Bernhard G. Herrmann, Markus Morkel. Max-Planck-Institute for Molecular Genetics, Berlin, Germany
• Flow sort array comparative genomic hybridization to assess tumor heterogeneity in glioblastoma. Daniel Stieber1, Elizabeth Lenkiewicz2, Lisa Evers2, Laurent Vallar3, Rolf Bjerkvig4, Mike Barrett2, Niclou P. Simone1. 1CRP-Santé, NorLux Neurooncology, Luxembourg, Luxembourg, 2TGEN, Scottsdale, AZ, 3CRP-Santé, Microarray Center, Luxembourg, Luxembourg, 4University of Bergen Department of Biomedicine, Bergen, Norway
• Gata3 prevents prostate cancer progression. Alana H.T. Nguyen1, Hervé Koumakpayi2, Katharina Haigh3, Marilène Paquet1, Pier Paolo Pandolfi4, Jody J. Haigh3, Anne-Marie Mes-Masson2, Fred Saad2, Maxime Bouchard1. 1McGill University, Montreal, QB, Canada, 2Université de Montréal, Montreal, QB, Canada, 3Ghent University, Ghent, Belgium, 4Harvard University, Boston, MA
• GATA6-mediated upregulation of LGR5 is essential for colorectal tumorigenesis. Shinnosuke Tsuji1, Hironobu Sugimasa1, Masaya Miyamoto1, Masaya Hiyoshi2, Joji Kitayama2, Yoshihiro Kawasaki1, Tetsu Akiyama1. 1Institute for Molecular and Cellular Biosciences, The University of Tokyo, Tokyo, Japan, 2Graduate school of Medicine, The University of Tokyo, Tokyo, Japan
• Id-1 regulates the self-renewal and differention of mouse mammary stem/progenitor cells. Dong-Hui Shin1, Jeong-Yeon Lee1, Seung Hyun Oh2, Ki-Seok Jang1, Su Chan Lee2, Hyun-Jun Kim1, Gu Kong1. 1College of Medicine, Seoul, Korea (Rep.), 2National Cancer Center, Goyang, Korea (Rep.)
• Identification of cancer stem-like cells in human esophageal epithelial and adenocarcinoma cell lines. Ronghua Zhao, Alan G. Casson. Department of Surgery, College of Medicine University of Saskatchewan, Saskatoon, SK, Canada
• Identification of miR-34a as a potent inhibitor of prostate cancer progenitor cells and metastasis by directly repressing CD44. Dean G. Tang. UT MD Anderson Cancer Center, Smithville, TX
• Immunohistochemical analyses of stress-induced phosphoprotein1 in ovarian cancer patients with low serum CA125. Tzu-Hao Wang1, Swei Hsueh2, Chun Hsueh2, Angel Chao1. 1Dept. Obs and Gyn. Chang Gung Memorial Hospital and Chang Gung University, Tao-Yuan, Taiwan, 2Dept. Clin Pathol. Chang Gung Memorial Hospital and Chang Gung University, Tao-Yuan, Taiwan
• Immunophenotypic diversity in acute myeloid leukemia as defined by 31-parameter single-cell mass cytometry. Erin F. Simonds1, Sean C. Bendall1, Michael D. Linderman1, Peng Qiu1, Zachary B. Bjonrson1, El-ad D. Amir2, Rachel Finck1, Sylvia K. Plevritis1, Dana Pe'er2, Garry P. Nolan1. 1Stanford University School of Medicine, Stanford, CA, 2Columbia University, New York, NY
• Isolation and characterization of ALDHhigh /ALDHlow/ ALDHneg cells from murine H-22 liver cancer. Yingxin Xu1, Yi Ding1, Wentao Liang1, Ning Ning1, Xiaohui Du1, Qiao Li2, Rong Li1. 1Institute of General Surgery, General Hospital of PLA, Beijing, China, 2University of Michigan Comprehensive Cancer Center, Ann Arbor, MI
• Isolation and characterization of SP cells from cervical cancer-derived cell lines. Jairo R. Villanueva-Toledo, Juan A. Ponciano-Gómez, Efraín Garrido. CINVESTAV-IPN, Mexico, DF, Mexico
• Lentiviral tracking of normal and malignant human mammary epithelial cell growth in an in vivo xenotransplant model. Long V. Nguyen, Nagarajan Kannan, Peter Eirew, Maisam Makarem, Connie J. Eaves. Terry Fox Laboratory, BC Cancer Agency, Vancouver, BC, Canada
• Microfluidic culture of isolated human embryonic stem cell colonies from single cell suspensions. Darek J. Sikorski1, Nicolas J. Caron2, Michael VanInsberghe1, Carl L. Hansen1, James M. Piret2. 1Centre for High-Throughput Biology, University of British Columbia, Vancouver, BC, Canada, 2Michael Smith Laboratories, University of British Columbia, Vancouver, BC, Canada
• Microfluidic single cell gene expression analysis. Adam K. White, Michael VanInsberghe, Oleh I. Petriv, Mani Hamidi, Darek Sikorski, Carl L. Hansen. University of British Columbia, Vancouver, BC, Canada
• miR-302, an ESC-specific microRNA, is expressed in a subpopulation of brain tumors and brain tumor cell lines. Mahshid Malakootian1, Mahmoud-Reza Rafiee2, Afsaneh Malekzadeh Shafaroudi2, Sara Rohban1, Hooshang Saberi3, Seyed Javad Mowla1. 1Tarbiat Modares University, Tehran, Islamic Republic of Iran, 2Nanomedicine and Tissue Engineering Center, Shahid Beheshti University of Medical Sciences, Tehran, Islamic Republic of Iran, 3Brain and Spinal Cord Injuries Repair Research Center, Tehran University of Medical Sciences, Tehran, Islamic Republic of Iran
• Modifiers of neurofibroma number and size implicate STAT3 signaling in NF1 peripheral nerve tumorigenesis. Jianqiang Wu1, Vincent Keng2, Edwin Jousma1, Deanna M. Patmore1, Anat O. Stemmer-Rachamimov3, David A. Largaespada2, Nancy Ratner1. 1Cincinnati Children’s Hospital Research Foundation, Cincinnati, OH, 2University of Minnesota, Minneapolis, MN, 3Massachusetts General Hospital and Harvard Medical School, Boston, MA
• Neovascularisation in tumor-derived cancer stem cells: Are current anti-angiogenic therapy trials facing serious challenge?  Hamid Reza Mirzaei. Department of Immunology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Isfahan, Islamic Republic of Iran
• Optimization of microRNA detection in FFPE samples of esophageal cancer. Nazila Nouraee1, Mojtaba Tabrizi1, Mohammad Vasei2, Shahriar Semnani3, Seyed Javad Mowla1. 1Tarbiat Modares University, Tehran, Tehran, Islamic Republic of Iran, 2Pathology laboratory, Shariati Hospital, Tehran, Islamic Republic of Iran, 3Golestan Research Center of Gastroenterology and Hepatology, Gorgan, Golestan, Islamic Republic of Iran
• Outgrowth of single cells in a tissue context driven by oncogene-induced cellular translocation. Cheuk T. Leung, Joan S. Brugge. Harvard Medical School, Boston, MA
• PAX6 controls the stem-like features of glioma cells and their response to radiation. Yuanjie Hu, Fengrong Yan, Charles L. Limoli, Mark E. Linskey, Yi-Hong Zhou. University of California, Irvine, Irvine, CA.
• PDAC reporter gene Rgs16 in screens for pancreatic cancer genes and drugs. Thomas M. Wilkie, Lee B. Rivera, Rolf A. Brekken. UT Southwestern Medical Center, Dallas, TX
• Resveratrol inhibits pancreatic cancer stem cell characteristics in human and KrasG12D transgenic mice: Molecular mechanisms. Sharmila Shankar1, Dara Nall1, Su-Ni Tang1, Daniel Meeker1, Jenna Passarini2, Jay Sharma2, Rakesh Srivastava1. 1University of Kansas Medical Center, Kansas City, KS, 2Celprogen, San Pedro, CA
• Sex hormones promote stemness characteristics in prostate cancer cells. Ji Zheng1, Elaine M. Hurt2, William Farrar1. 1National Cancer Institute, Frederick, MD, 2MedImmune, Gaithersburg, MD
• Sphingosine-1-phosphate: A potential therapeutic agent against human breast cancer. Jian Yang, Binbing Ling, Lifeng Chen, Jane Alcorn. University of Saskatchewan, Saskatoon, SK, Canada
• Targeting the growth of cancer stem cells as spheroids, in vitro, using chemo dietary agents and RNAi. Carla Kantara, Ixiu Ortiz, Shubhashish Sarkar, Robert Ullrich, Pomila Singh. University of Texas Medical Branch, Galveston, TX
• The embryonic protein, Nodal, promotes breast cancer angiogenesis and metastatic phenotypes. Daniela F. Quail1, Guihua Zhang1, Logan A. Walsh1, Heather Broughton2, David Hess2, Lynne-Marie Postovit1. 1University of Western Ontario, London, ON, Canada, 2Robarts Research Institute, London, ON, Canada
• The involvement of HMGA2 in mesenchymal oncogenesis. Jørn Henriksen1, Marianne Stabell1, Leonardo A. Meza-Zepeda1, Moustapha Kassem2, Ola Myklebost1. 1Norwegian Radium Hospital, Oslo, Norway, 2Odense University, Odense, Denmark
• The metabolic state of glioma stem cells and non-tumorigenic cells. Erina Vlashi, Chann Lagadec, Lorenza Della Donna, Frank Pajonk. David Geffen School of Medicine at UCLA, Los Angeles, CA
• The Ras related protein TC21 regulates TGFβ signaling in Nf1 tumors. Deanna M. Patmore, Sara Welch, Patricia Fulkerson, Jennifer J. Kordich, David Eaves, Timothy Cripe, Nancy Ratner. Cincinnati Children's Hospital Medical Center, Cincinnati, OH
• The role of stromal cells as a cancer stem cell niche in head and neck squamous cell carcinoma. Keira D. Pereira1, Christina Karamboulas2, Elzbieta Hyatt3, Joshua Paterson3, Laurie Ailles2. 1University of Toronto, Toronto, ON, Canada, 2Ontario Cancer Institute, Toronto, ON, Canada, 3University Health Network, Toronto, ON, Canada
• The role of young and aged niches on the progression of AML in mice. Virag Vas1, Maria Carolina Florian1, Bettina Überle1, Corinna Wandhoff1, Karin Dörr1, Anja Niebe1, Hartmut Geiger1,2. 1University of Ulm, Ulm, Germany, 2University of Cincinnati, Cincinnati, OH
• The tea type Brazilian herb prevent lung cancer induced by 4-nitroquinoline 1-oxide and glycerol in mice. Harukuni Tokuda1, Nobutaka Suzuki1, Akira Iida2. 1Kanazawa University, Kanazawa, Japan, 2Kinki Uiversity, Nara, Japan
• Trop2 regulates prostate stem cell self-renewal and transformation. Tanya I. Stoyanova, Andrew Goldstein, Owen Witte. UCLA, Los Angeles, CA
• Ubiquitin carboxy-terminal esterase L1 (UCHL1) in stem-like cancer cells of embryonal neural tumors. Anne Romeo, Judy C.Y. Chang, Patricia C. Sanchez-Diaz, Kihoon Yoon, Gail E. Tomlinson, Jaclyn Y. Hung. University of Texas Health Science Center, San Antonio, TX