American Association for Cancer Research

Poster Session C

Poster Session C
Sunday, February 24
5:00 p.m.-7:00 p.m.

(In board assignment order, subject to change)


    TUMOR MICROENVIRONMENT

  • (C001) CCL5/CCR5 axis promotes VEGF production in human osteosarcoma cells, Shih-Wei Wang1; Shih-Chia Liu2; Chih-Hsin Tang3;
  • (C002) Involvement of serotonin receptor type 4 (5-HTR4) in estrogen receptor beta (ERβ) expression and cancer development through peritumoral mast cells in human prostate cancer tissue , Yasuhiro Nakamura; Kazue Ise; Keely McNamara; Hironobu Sasano;
  • (C003) Metabolic interaction between cancer cells and stroma according to the molecular subtypes of breast cancer, Junjeong Choi1; Ja Seung Koo2;
  • (C004) Cancer-associated Orthotopic Myofibroblasts Stimulates the Motility of Gastric Carcinoma Cells, Masakazu Yashiro; Yuhiko Fuyuhiro; Tsuyoshi Hasegawa; Naoki Aomatsu; Toshiki Hirakawa; Tatsunari Fukuoka; Tamami Morisaki; Haruhito Kinoshita; Noashi Kubo; Masaichi Ohira; Kosei Hirakawa;
  • (C005) Hyaluronidase1 activity and secretion are regulated by C-mannosylation, Siro Simizu; Yuki Goto; Yuki Niwa; Kazuo Umezawa;
  • (C006) Surfactant protein A suppresses lung cancer progression by regulating tumor-associated macrophage polarization, Sawaka Yukishige1; Hisatsugu Goto1; Atsushi Mitsuhashi1; Takuya Kuramoto1; Sho Tabata1; Masaki Hanibuchi1; Soji Kakiuchi1; Atsuro Saijyo1; Yoshinori Aono1; Hisanori Uehara1; Seiji Yano2; Julie G. Ledford3; Saburo Sone1;
  • (C007) BMP-9/ALK-1 signals inhibit proliferation of lymphatic endothelial cells and reprogram them to blood vascular endothelial cells through down-regulation of Prox1 expression, Yasuhiro Yoshimatsu; Yuichi Akatsu; Luna Taguchi; Tomoko Yamazaki; Hiroshi I. Suzuki; Akihiro Katsura; Yuka Suzuki; Yasuyuki Morishita; Kohei Miyazono; Tetsuro Watabe;
  • (C008) Tryptophan metabolite, kynurenine, secreted from cancer-associated fibroblasts as an oncometabolite in breast cancer progression, Jing-Yi Chen; Wen-Chun Hung;
  • (C009) TGF-beta blockade improves the distribution and efficacy of therapeutics in breast carcinoma by normalizing tumor blood vessels and interstitial matrix , Jieqiong Liu; Shan Liao; Benjamin Diop-Frimpong; Wei Chen; Shom Goel; Kamila Naxerova; Marek Ancukiewicz; Yves Boucher; Rakesh Jain; Lei Xu;
  • (C010) Action mechanism of vascular endothelial growth factor (VEGF) induction by thymosin β4 , Jin-Ok Jo; Yun-Jeong Kang; Mee Sun Ock; Hee-Jae Cha;
  • (C011) A Novel Anticancer Strategy to Attenuate Cancer Cells? Tolerance to Poor Oxygen and Glucose Supply; Antiausterity Strategy, Hiroyasu Esumi; Satoshi Owada; Yuko Shimada; Chika Miyoshi; Rumi Fujioka; Katsuya Tsuchihara; Akihiro Sato;
  • (C012) The Relationship of myeloma cells, stromal Cells and Monocytes Under Bone Marrow Microenvironment, Hiroshi Ikeda; Yasushi Sasaki;
  • (C013) Critical roles of NF-κB activation in breast cancer development, Jun-ichiro Inoue;
  • (C014) Significance of carbonic anhydrase 9 for neoadjuvant chemotherapy in breast cancer, Aomatsu Naoki; Yashiro Masakazu; Kashiwagi Shinichiro; Kinoshita Haruhito; Morisaki Tamami; Fukuoka Tatsunari; Hirakawa Toshiki; Hasegawa Tsuyoshi; Noda Satoru; Kawajiri Hidemi; Takashima Tsutomu; Onoda Naoyoshi; Ishikawa Tetsuro; Hirakawa Kosei;
  • (C015) Cancer-associated Fibroblasts Might Sustain the Stemness of Scirrhous Gastric Cancer Cells by TGFb Signalings, Tsuyoshi Hasegawa; Masakazu Yashiro; Haruhito Kinoshita; Tamami Morisaki; Naoki Aomatsu; Toshiki Hirakawa; Tatsunari Fukuoka; Katsunobu Sakurai; Takahiro Toyokawa; Naoshi Kubo; Hiroaki Tanaka; Kazuya Muguruma; Masaichi Ohira; Kosei Hirakawa;
  • (C016) Acquired resistance to anti-VEGF therapy via angiogenic switch in orthotopically implanted human malignant pleural mesothelioma in SCID mice, Atsushi Mitsuhashi1; Hisatsugu Goto1; Trung The Van1; Takuya Kuramoto1; Sho Tabata1; Masaki Hanibuchi1; Soji Kakiuchi1; Atsuro Saijo1; Yoshinori Aono1; Hisanori Uehara1; Seiji Yano2; Saburo Sone1; Yasuhiko Nishioka1;
  • (C017) Exercise Alter Breast Cancer Phenotype Through Distinct Reductions in Host-Derived Proinflammatory Growth Factor Ligands, Oliver Glass1; Brant A. Inman1; Kerry S. Courneya2; John R. Mackey2; Erik Nelson1; Zachary Hartman1; Lee Jones1;
  • (C018) Interaction between peritoneal mesothelial cells and ovarian cancer cells in peritoneal dissemination, Hiroko Mitsui; Kiyosumi Shibata; Shiro Suzuki; Tomokazu Umezu; Mika Mizuno; Hiroaki Kajiyama; Fumitaka Kikkawa;
  • (C019) The distribution of Wnt-expressing mesenchymal cells during colonic wound repair, Hiroyuki Miyoshi; Thaddeus S. Stappenbeck;
  • (C020) Constitutive activation of hypoxic response in newly established mtDNA-deficient-cell line with highly tumorigenesis, Masaru Koido; Naomi Haga; Sakae Saito; Yoshinori Tsukumo; Satomi Tsukahara; Shigeo Sato; Akihiro Tomida;
  • (C021) The expression pattern of MyD88 in rectal cancer in association with microscopic abscess formation., Masanori Uno; Toshio Kokuryo; Yukihiro Yokoyama; Keisuke Uehara; Yuichiro Yoshioka; Masato Nagino;
  • (C022) Selective DDS with engineered anaerobic Bifidobacterium longum, targeting the hypoxic microenvironment of solid tumors , Shun'ichiro Taniguchi1; Yuko Shimatani-Shibata2; Hitomi Shimizu2; Takayuki Sasaki2; Minoru Fujimori3; Minoru Okabe2;
  • (C023) Enhancement malignant transformation of endometrial cancer cells by mutual interaction with mesenchymal stem cells through TGF-beta and SDF-1 signaling pathways, Ding Dah-Ching; Chu Tang-Yuan;
  • (C024) TGF-beta modulates ovarian cancer progression by regulating CAF-derived protein expression levels, Tsz-Lun Yeung1; Cecilia S. Leung1; Kwong-Kwok Wong1; Michael J. Birrer2; Samuel C. Mok1;
  • (C025) Leptin up-regulates matrix metalloproteinase-1 in ovarian cancer cells in the omental tumor microenvironment, Chi Lam Au Yeung; Ngai Na Co; Tetsushi Tsuruga; Tsz-Lun Yeung; Cecilia S Leung; Prahlad Ram; Samuel C Mok;
  • (C026) Cancer associated fibroblast derived MFAP5 as a potential target of antiangiogenic therapy in ovarian cancer, Cecilia S. Leung1; Tsz-Lun Yeung1; Kwong-Kwok Wong1; Michael J. Birrer2; Samuel C. Mok1;
  • (C027) Immunity, proliferation and molecular subtype interactions in breast cancer prognosis revealed by meta-analysis of tumor expression profiles, Srikanth Nagalla1; Jeff W. Chou2; Jimmy Ruiz1; Jonas Bergh3; Christos Sotiriou4; Michael A. Black5; Lance D. Miller6;
  • (C028) Identification of exosomal microRNAs involved in stromal-epithelial interaction in ovarian cancer by next generation sequencing., Tetsushi Tsuruga; Chi Lam Au Yeung; Sze L Leung; Tsz-Lun Yeung; Kwong K Wong; Rosemarie Schmandt; Co Ngai Na; Karen H Lu; Samuel Mok;
  • (C029) Targeting a novel Matrixmetalloprotease signaling system in lung cancer with cell penetrating pepducin , Lidija Covic; Jaroslaw Cisowski; Caitlin Foley; Nga Nguyen; John Yang; Larry H. Brinckerhoff; Athan Kuliopulos;
  • (C030) Convergent signaling in the regulatuion of malignant mesothelioma growth through CTGF expression: TGF-β signaling and defects in the Hippo signaling pathway , Makiko Fujii1; Takeshi Toyoda2; Hayao Nakanishi1; Ichidai Tanaka1; Yutaka Kondo1; Hirotaka Osada1; Yoshitaka Sekido1;
  • (C031) Control of pancreatic cancer and metastasis by cytochrome P450-derived eicosanoids, Jessica A. Casper1; Diane R. Bielenberg1; Jennifer Chang2; Emily R. Greene1; Bruce D. Hammock3; Darryl C. Zeldin2; Mark W. Kieran4; Dipak Panigrahy1;
  • (C032) Repression of miR-126 and up-regulation of ADM in the stromal endothelium confers angiogenesis of cervical cancer, Tang-Yuan Chu; Tien-Hung Huang;
  • (C033) Roles of signaling and transcriptional networks during TGF-β-induced endothelial-to-mesenchymal transition (EndMT), Tetsuro Watabe; Hajime Mihira; Takashi Kokudo; Yuichi Akatsu; Akihiro Katsura; Yasuhiro Yoshimatsu; Kohei Miyazono;
  • (C034) CXCR2 plays critical roles in inflammation-associated cancer through trafficking of myeloid-derived suppressor cells (MDSCs) , Raymond N. DuBois1; Hiroshi Katoh2; Dingzhi Wang2;
  • (C035) Permanent alteration of systemic environment: Behind the sciences of tumor relapse., Dilini Gunasekera1; Kayla Minser1; Mary M. Zheng1; Kyle Bemis1; Mukti R. Parikh1; Zhifang Zhang2; John E. Shively2; Julia Kirshner1;
  • (C036) Deletion of macrophage COX-2 reduces mammary tumorigenesis: An altered tumor-associated macrophage phenotype?, Edward P. Chen; Nune Markosyan; Lewis A. Chodosh; Garret A. FitzGerald; Emer M. Smyth;
  • (C037) Mathematical model Predicts IDH-1 Mutation and Malignant Progression in Contrast-Enhancing Gliomas, Anne Baldock1; Kevin Yagle2; Sunyoung Ahn2; Donald Born2; Paul Swanson2; Russell Rockne1; Kristin Swanson1;
  • (C038) Mammary acini in collagen: Biophysical analysis of cell-substrate interactions, Michael W. Harman; Joyce Schroeder; Charles W. Wolgemuth;

    CANCER IMMUNOLOGY AND IMMUNOTHERAPY

  • (C039) Modulation of dendritic cell maturation: unmasking a novel role for the tumor suppressor p15Ink4b in immunity., Joanna Fares; Richard Koller; Rita Humeniuk; Linda Wolff; Juraj Bies;
  • (C040) Identification of a novel HLA-DR1-restricted dominant epitope recognized by HTLV-1 Tax-specific CD4+ T-cells augmenting HTLV-1-specific CTL expansion in ATL patients after allogeneic HSCT, Atsuhiko Hasegawa1; Yotaro Tamai1; Ayako Takamori1; Amane Sasada1; Ryuji Tanosaki2; Ilseung Choi3; Atae Utsunomiya4; Yasuhiro Maeda5; Yoshihisa Yamano6; Tetsuya Eto7; Ki-Ryang Koh8; Hirohisa Nakamae8; Youko Suehiro3; Koji Kato9; Shigeki Takemoto10; Jun Okamura3; Naokuni Uike3; Mari Kannagi1;
  • (C041) Antigen receptor gene-modified lymphocytes: Harnessing T cells for effective cancer treatment with novel vectors and manipulations, Hiroaki Ikeda1; Shinichi Kageyama1; Naoko Imai1; Yoshihiro Miyahara2; Mikiya Ishihara1; Ayumi Kawamura1; Makiko Yamane1; Daisuke Tomura3; Sachiko Okamoto3; Ikuei Nukaya3; Junichi Mineno3; Kazutoh Takesako3; Naoyuki Katayama4; Hiroshi Shiku1;
  • (C042) Expression of chemokine BRAK/CXCL14 suppresses tumor growth and metastasis NK cell dependently and increases survival rate of tumor-bearing mice, Ryu-Ichiro Hata1; Kazuhito Izukuri1; Yasumasa Kato2; Kazuyoshi Takeda3; Tohru Kiyono4; Naofumi Mukaida5; Masaru Taniguchi6;
  • (C043) The role of indoleamine 2,3 dioxygenase (IDO) and Programmed death-1 (PD-1) interaction in the head and neck cancer , Babak Baban; Mohamad Masoumy; Arina Ghaffari; Mei Zheng; Jun Yao Liu; Karolina Grochowska; Mahmood Mozaffari; Jeffrey R. Lee;
  • (C044) Bortezomib-induced ICAM-1 enhances the susceptibility to NK cell-mediated lysis of melanoma cells , Kim Jee-Eun; Kim Daejin;
  • (C045) Metronomic chemotherapy: schedule-dependent activation of innate immunity-induced tumor regression. , David J. Waxman; Chong-Sheng Chen; Junjie Wu; Joshua C. Doloff;
  • (C046) Phase II analysis of glioma patients treated with pritumumab, Mark C. Glassy;
  • (C047) Emulsion-type adjuvant contains CpG oligodeoxynucleotides enhances HPV E7-based immunotherapy, Ying-Chyi Song; Chih-Hsiang Leng; Ming-Hsi Huang; Shih-Jen Liu;
  • (C048) Imaging tumor-infiltrating macrophages as an early response marker of therapy-induced apoptosis, Qizhen Cao; Qian Huang; Marites Melancon; Chun Li;
  • (C049) TAMpering with efferocytosis in cancer, KhanhQuynh Nguyen; WenI Tsou; Sergei Kotenko; Raymond Birge;
  • (C050) Tumor infiltrating CD11b + immature Dendritic cells are associated with poor prognosis factor for gastric cancer, Yoshihiro Okita; Hiroaki Tanaka; Mao Watanabe; Mami Yoshii; Naoki Aomatsu; Tsuyoshi Hasegawa; Akihiro Murata; Tomohiro Lee; Kenjiro Kimura; Hisashi Nagahara; Amano Ryosuke; Eiji Noda; Naoshi Kubo; Kazuya Muguruma; Hiroshi Otani; Kiyoshi Maeda; Masaichi Ohira; Kosei Hirakawa;
  • (C051) Exploration of the allele-specific protein isoforms of Prostate Stem Cell Antigen (PSCA) in bladder and gastric cancers: the road to a genotype-based immunotherapy, Wei Tang; Patricia Porter-Gill; Ludmila Prokunina-Olsson;
  • (C052) EGFR-TKIs (EGFR-tyrosin kinase inhibitors) enhance anti-tumor immune responses by acting on both non-small cell lung carcinoma cells and dendritic cells, Tomonori Yaguchi1; Ryosuke Satomi2; Asuka Kobayashi1; Kenji Morii1; Naoshi Kawamura1; Yutaka Kawakami1;
  • (C053) Identification of novel ovarian cancer-associated antigens and its epitopes for CTL using an HLA-modified cancer cell line., Eri Yamada1; Ayako Demachi-Okamura1; Shinji Kondo1; Hiroyuki Maki1; Rong Zhang1; Yasushi Uemura1; Shiro Suzuki2; Shiro Suzuki2; Kiyosumi Shibata2; Fumitaka Kikkawa2; Kiyotaka Kuzushima1;
  • (C054) Immnunological analysis in a phase II clinical trial of the GPC3 derived peptide vaccine for ovarian clear cell adenocarcinoma patients, Kiyosumi Shibata; Hiroko Mitusi; Ryuichiro Sekiya; KIkkawa Fumitaka;
  • (C055) The role of antigen presenting cells in Crohn?s disease, Takayuki Ogino; Junichi Nishimura; Mamoru Uemura; Naotsugu Haraguchi; Taishi Hata; Ichiro Takemasa; Tsunekazu Mizushima; Hirofumi Yamamoto; Yuichiro Doki; Masaki Mori;
  • (C056) Antitumor immunity induced by autologous hematopoietic stem cell transplantation is enhanced by a priming of the donor T lymphocytes to tumor-associated antigens, Kenta Narumi; Koji Suzuki; Reina Miyakawa; Kouichirou Aida; Teruhiko Yoshida; Kazunori Aoki;
  • (C057) Translational implications of small cell lung cancer-associated anti-ELAVL4 immune response for early detection and therapy
    , Mario A. Pulido1; Meleeneh Kazarian1; Stephen Liu1; Zhenxia Qin2; Jeffrey A. Tsou1; Diane Lee1; Eric Chung1; Yiwei Wang1; Michelle Gonzales1; Jose Rosa, Jr.1; Sam Wang1; Sunny Jones1; Rinse Klooster3; Jan J.G.M. Verschuuren3; Dana W. Aswad2; Ite Laird-Offringa1;
  • (C058) SNPs gene VEGF as prognostic biomarkers for DC-based immunotherapy , Yulia Khochenkova; George Chkadua; Evgenia Stepanova;

    PRECLINICAL MODELS

  • (C059) Animal models of fusion related sarcoma to explore tumorigenic mechanisms and novel therapeutics., Miwa Tanaka; Yukari Yamazaki; Yohei Kanno; Takuro Nakamura;
  • (C060) Ex-Vivo prostate cancer explant organ culture: an innovative model system for drug discovery and development in prostate cancer , Shilpa Gupta1; Lei Gu2; Zhiyong Liao2; Peter McCue2; Edouard J. Trabulsi2; Marja T. Nevalainen2;
  • (C061) The profile of regional and distant metastasis in experimental metastasis models and orthotopic nude mice model with 30 HNSCC cell lines, Daisuke Sano1; Takahashi Hideaki1; Hiroshi Hyakusoku1; Horii Chihiro1; Jeffrey N. Myers2;
  • (C062) Targeting mutant K-Ras and N-Ras in colorectal cancer, Kevin Haigis;
  • (C063) Metabolic reprogramming for producing energy and reducing power in fumarate hydratase null cells from hereditary leiomyomatosis renal cell carcinoma (HLRCC), Youfeng Yang1; Andrew Lane2; Chris Ricketts1; ming-Hui Wei1; Lisa Pike3; Min Wu3; Tracey A. Rouault4; Laszlo Boros5; Teresa Fan2; Marston Linehan1;
  • (C064) The lineage-specific transcription factor ASCL1 defines a neuroendocrine subtype of non-small cell lung cancer (NSCLC-NE) with poor prognosis and distinct therapeutic targets., Alexander Augustyn1; Mark Borromeo1; Tao Wang1; Victoria Lee1; Christopher Tan1; Chunli Shao1; James P. Sullivan2; Luc Girard1; Carmen Behrens3; Ignacio Wistuba3; Yang Xie1; Jane Johnson1; Adi F. Gazdar1; John D. Minna1;
  • (C065) Epidermal hyperplasia and appendage abnormalities in mice lacking CD109, a negative regulator of TGF-β signaling, Shinji Mii1; Yoshiki Murakumo2; Naoya Asai1; Masato Asai1; Masahide Takahashi1;
  • (C066) Characterization of MYCN-driven human medulloblastoma primary cells, Yvan HT Chanthery; William A. Weiss;
  • (C067) Glioblastomas: Cell-of-origin, reprogramming and role of miRNAs, Dinorah Friedmann-Morvinski1; Eugene Ke1; Eric Bushong2; Oded Singer1; Thales Papagiannakopoulos3; Tomotoshi Marumoto4; Yasushi Soda1; Mark H. Ellisman2; Inder M. Verma1;
  • (C068) Tamoxifen chemoprevention abrogates luminal progenitor expansion an early step in mammary tumorigenesis in NRL-TGFalpha mice , Olga Zhdankin; Melanie Bomier; MingQian Duan; Ronald Regal; Jon Holy; Teresa Rose-Hellekant;
  • (C069) Discovery of gene expression patterns correlated with increased breast cancer risk using genetically engineered mouse models., Sarah A. Dabydeen1; Ariundelger Gantulga2; Keunsoo Kang3; Edgar S. Diaz-Cruz4; Sejong Oh2; Lothar Hennighausen3; Priscilla A. Furth5;
  • (C070) Radiosensitizing effect of CDK4/6 inhibitor in atypical teratoid/rhabdoid tumors, Maxwell W. Tom; Ilan Kolkowitz; Yuichiro Ihara; Anuradha Banerjee; Michael D. Prados; Daphne A. Haass-Kogan; Nalin Gupta; David C. James; Sabine Mueller; Rintaro Hashizume;
  • (C071) Cytobands 11E2 and 17q25 are linked to tumor aggressivenes, Alexandra Kuzyk; Sabine Mai;
  • (C072) Predicting pharmacologic response based on genetic aberrations in Asian oral cancer cell lines, Ivy Kim Ni Chiang1; Kalen Ray Dionne1; Pei San Yee2; Sok Ching Cheong3;
  • (C073) Establishment of a novel mice model for lung squamous cell carcinoma, Shotaro Yamano; Min Wei; Masaki Fujioka; Anna Kakehashi; Hideki Wanibuchi;
  • (C074) Development of columnar-lined esophagus with or without goblet cells in rat duodenogastroesophageal reflux models, Ken-ichi Mukaisho; Takanori Hattori; Hiroyuki Sugihara;
  • (C075) Investigating therapeutic strategies in small cell lung cancer using genetically engineered mouse models, Anna F. Farago; Thales Papagiannakopoulos; David McFadden; Rebecca Robbins; Tyler Jacks;
  • (C076) Humanized GBM model and its utility in discovery of drug response biomarkers, Baoli Hu; Sujun Hua; Ronald DePinho; Y. Alan Wang;
  • (C077) Paradoxical acceleration of pancreatic tumorigenesis by Smoothened inhibition: the effect of stromal signalling on epithelial differentiation state, Paul E. Oberstein; Dafydd H. Thomas; Carmine F. Palermo; Stephen A. Sastra; Kenneth P. Olive;
  • (C078) Genetic strategy reveals murine adult neural stem cells and astrocytes are equally susceptible to transformation in vivo and converge on a common phenotype when targeted by the same driver mutations , Robert M. Bachoo; Tomoyuki Mashimo; Suraj Nannepaga; Shyam Sirasanagandla; Brian McEllin; Vamsidhara Vemireddy; Elizabeth A. Maher;

    TARGETED THERAPIES AND RESISTANCE

  • (C079) Involvement of Drp1-mediated mitochondrial fission in safingol-induced cell death, Masakazu Hamada; Ken Wakabayashi; Soichi Iwai; Yura Yoshiaki;
  • (C080) Targeting Anticancer Drug Delivery to Pancreatic Cancer Cells Using A Fucose-Bound Nanoparticle Approach, Rishu Takimoto; Makoto Yoshida; Yasushi Sato; Masahiro Hirakawa; Fumito Tamura; Tsutomu Sato; Satoshi Iyama; Takahiro Osuga; Koji Miyanishi; Kohichi Takada; Tsuyoshi Hayashi; Masayoshi Kobune; Junji Kato;
  • (C081) A Combination of the anti-fibroblast growth factor receptor 1 monoclonal antiboby and interferon-a/b suppresses human hepatic cancer cells in vitro and in vivo, Yasuo Kato1; Hiromi Hirata2; Masayuki Tsujisaki3; Toshio Matsune4; Shigeru Sasaki5; Yuji Hinoda6; Yasuhisa Shinomura5; Kohzoh Imai7;
  • (C082) Quantitative high-throughput efficacy profiling of approved oncology drugs in inflammatory breast cancer models of acquired drug resistance, Kevin P. Williams1; Shalonda M. Ingram1; Jennifer L. Allensworth2; Ginger R. Smith1; Amy J. Aldrich2; H. Kim Lyerly2; Jonathan Z. Sexton1; Gayathri R. Devi2;
  • (C083) Synthetic lethal interaction of combined BCL-XL and MEK inhibition promotes tumor regressions in KRAS-mutant cancer models, Ryan B. Corcoran1; Katherine Cheng2; Aaron Hata1; Anthony Faber1; Erin Coffee1; Patricia Greninger1; Ronald Brown1; Jason Godfrey1; Toshi Shioda1; Jeffrey Settleman3; Cyril Benes1; Mari Mino-Kenudson1; Kwok-Kin Wong2; Jeffrey A. Engelman1;
  • (C084) STAT3 inhibition induces tumor-specific growth inhibition in a wide range of cancer cells without growth suppression of normal hematopoietic cells., Fumihiko Hayakawa1; Keiki Sugimoto2; Singo Kurahashi1; Takumi Sumida2; Tomoki Naoe1;
  • (C085) Small Molecule Inhibitors of ubiquitin-proteasome dependent degradation of p27Kip1 identified by high throughput screening, Nobumoto Watanabe1; Li-Ching Ooi2; Hiroyuki Osada1;
  • (C086) Targeting Aggrus/podoplanin for suppressing the growth and metastasis of lung squamous cell carcinoma in vivo., Satoshi Takagi; Naoya Fujita;
  • (C087) An obatoclax derivative, SC-2001, induces autophagic cell death through SHP-1-mediated Mcl-1 ablation in hepatocellular carcinoma, Jung-Chen Su1; Kuen-Feng Chen2; Chung-Wai Shiau1;
  • (C088) Toll-like receptor 7 as a novel predictor of long-term survival in patients with perihilar cholangiocarcinoma, Shingo Oya; Toshio Kokuryo; Yukihiro Yokoyama; Masanori Uno; Tomoki Ebata; Tsuyoshi Igami; Gen Sugawara; Masato Nagino;
  • (C089) Translational genomics identifies promising targeted therapy for cholangiocarcinoma, Jesper B. Andersen; Gillen C. Matthew; Elizabeth A. Conner; Valentina M. factor; Snorri S. Thorgeirsson;
  • (C090) Targeting IGF-I receptor for human pancreatic carcinoma with k-ras mutation, Yasushi Adachi1; Hiroyuki Yamamoto1; Yasutaka Matsunaga1; Katsuhiko Nosho1; Hiroaki Taniguchi2; Hiromu Suzuki1; Yoshiaki Arimura1; Takao Endo3; Yasuo Kato3; Kohzoh Imai2; Yasuhisa Shinomura1;
  • (C091) Cyclooxygenase-2 Modulates VEGF-C-induced Proliferation and Chemoresistance in Acute Myeloid Leukemic Cells Involving Endothelin-1, Ming-Hsien Chien; Chia-Chi Ku;
  • (C092) Pentoxifylline Enhanced the Efficacy of Gemcitabine by Improving Drug Delivery via Modulating CTGF-mediated Fibrosis in Pancreatic Tumor Xenografts, Jung Ho Kim1; Won Sang Park2; Byung Cheol Shin3; Hyo-Jeong Kuh1;
  • (C093) Development of new androgen antagonists by in silico screening and natural product screening, Yasubumi Sakakibara; Masaya Imoto;
  • (C094) Ring Finger Protein 149 is an E3 ubiquitin ligase active on wild-type BRAF, Jai-Hee Moon; Jin-Sun Kim; Seung-Woo Hong; Seung-Mi Kim; Kyung-Ah Jung; Jae-Sik Shin; Eun Kyoung Choi; Chang-Kyu Lee; Kyu-pyo Kim; Yong Sang Hong; Jae-Lyun Lee; Jung Shin Lee; Dong-Hoon Jin; Tae Won Kim;
  • (C095) Dual roles of a cell adhesion molecule, CADM1, in human lung oncogenesis, Mika Sakurai-Yageta1; Takeshi Ito1; Hideki Kuwano1; Daisuke Matsubara1; Akiteru Goto2; Yoshinori Murakami1;
  • (C096) Combination therapy of new biological therapeutic drug, oncolytic herpes virus hrR3, with anti-angiogenesis drug, Bevacizumab, against human gastric cancer xenograft model., Hideki Kasuya; Tan Gewen; Tevfik Tolga Sahin; Kazuo Yamamura; Yasuhiro Kodera;
  • (C097) Vemurafenib promotes RAS wild-type tumor formation in a mouse model of HPV driven cSCC, Matthew Holderfield1; Edward Lorenzana1; Ben Weisburd1; Lisa Lomovasky1; Majid Ghoddusi1; Dylan Daniel1; Nancy Pryer1; Frank McCormick2; Darrin Stuart1;
  • (C098) USP1 inhibitors target ID1 degradation and promote differentiation in leukemic cells, Grace Hsieh1; Helena Mistry1; Min Huang1; Eunmi Park1; Gregory Cuny2; Sara Burhlage1; Nathanael Gray1; Richard Stone1; Kalindi Parmar1; Alan D'Andrea1;
  • (C099) Molecular networks of the EGFR-TKI resistant lung cancer -How to apply new technologies to bench-to-bed research, Takeshi Yoshida1; Guolin Zhang2; Yun Bai2; Bin Fang2; Bhupendra Rawal2; Kate J. Fisher2; Ann Chen2; Takafumi Okabe1; Isamu Okamoto1; Kazuhiko Nakagawa1; Eric B. Haura2;
  • (C100) Targeting medulloblastoma tumor-propagating cells through inhibition of Aurora or Polo-like kinases, Shirley Markant1; Lourdes Adriana Esparza1; Jesse Sun2; Kelly Barton2; Lisa McCoig2; Gerald Grant2; John Crawford3; Mike Levy3; Paul Northcott4; Michael Taylor4; Robert Wechsler-Reya1;
  • (C101) Proliferation of breast cancer stem cells by sphingosine-1-phosphate through the Notch signaling, Yasunari Kanda; Naoya Hirata; Shigeru Yamada; Yuko Sekino;
  • (C102) Isoliquiritigenin promotes breast cancer chemosensitivity by limiting cancer stem cells targeting aberrant β-catenin signaling, Zhiyu Wang; Neng Wang; Xiao Zheng; Jianping Chen;
  • (C103) Blockade of CTGF signaling has antitumor and antifibrotic effects linking tumor progression and fibrosis, Sebastian Bickelhaupt1; Manuel Roehrich1; Peter Peschke1; Kenneth Lipson2; Peter Huber1;
  • (C104) Isolation and characterization of a novel gene as a therapeutic target for pancreatic cancer, Toru Nakamura1; Toyomasa Katagiri1; Hidewaki Nakagawa1; Takahiro Tsuchikawa2; Satoshi Hirano2; Yusuke Nakamura1;
  • (C105) PUMA mediates apoptotic responses to different classes of targeted agents in colon cancer cells, Xingnan Zheng; Kan He; Jing Sun; Matthew F. Brown; Crissy Dudgeon; Lin Zhang; Jian Yu;
  • (C106) HER2-L726F mutation promotes tumor progression and induces lapatinib resistance in human breast cancer, Delphine R. Boulbès1; Korina V. Blachno1; Nanfu Deng1; Quanri Jin1; Stefan T. Arold1; Wei-Chao Chang2; Tzu-Hsuan Huang1; Jung-Mao Hsu1; Samuel w. Brady1; John e. Ladbury1; Dihua Yu1; Mien-Chie Hung1; Francisco J. Esteva1;
  • (C107) The combination of 2-deoxyglucose and ABT-263 induces apoptosis in cancer cells under both normoxic and hypoxic conditions, Ryuji Yamaguchi1; Minoru Kobayashi2; Hiroshi Harada2; Kiichi Hirota1;
  • (C108) DSCC1 is a novel biomarker for chemo-resistant colorectal cancer, Kiyoshi Yamaguchi; Rui Yamaguchi; Masaru Shinozaki; Giichiro Tsurita; Keisuke Hata; Seiya Imoto; Satoru Miyano; Yusuke Nakamura; Yoichi Furukawa;
  • (C109) Expression of EGFR on membrane surface detected by cetuximab itself contributes to the efficacy of cetuximab in colorectal cancer cell lines, Kohei Shigeta; Tetsu Hayashida; Yoshinori Hoshino; Hirotoshi Hasegawa; Yoshiyuki Ishii; Takashi Endo; Koji Okabayashi; Yuko Kitagawa;
  • (C110) Antitumor Activity of New Proteasome Inhibitors, Tyropeptin-Boronic Acid Derivatives, Isao Momose1; Hikaru Abe2; Takumi Watanabe2; Shun-ichi Ohba1; Masatomi Iijima1; Yohko Yamazaki1; Tohru Masuda1; Akio Nomoto1;
  • (C111) Differential response of DU145 and PC3 prostate cancer cells to ionizing radiation: Role of reactive oxygen species, GSH and Nrf2 in radiosensitivity, S Jayakumar; Santosh Kumar Sandur; Ramesh Chandra Chaubey;
  • (C112) EphA3 Maintains Tumorigenicity and is a Therapeutic Target in Glioblastoma Multiforme, Bryan W. Day1; Brett W. Stringer1; Fares Al-Ejeh1; Michael J. Ting1; John Wilson2; Kathleen S. Ensbey1; Paul J. Jamieson1; Zara C. Bruce1; Yi Chieh Lim1; Carolin Offenhauser1; Sara Charmsaz1; Leanne Cooper1; Jennifer K. Ellacott1; Angus Harding2; Lucie Leveque1; Po Inglis3; Suzanne Allan3; David Walker4; Martin Lackmann5; Geoffrey Osborne2; Kum Kum Khanna1; Brent A. Reynolds6; Jason D. Lickliter1; Andrew W. Boyd1;
  • (C113) Romidepsin (FK228) and its analogs exhibit potent cytotoxicity through HDAC/PI3K dual inhibition in colorectal cancer cell lines., Ken Saijo1; Tadashi Katoh2; Jin Lee1; Hideki Shimodaira1; Akifumi Oda3; Ohgi Takahashi4; Chikashi Ishioka1;
  • (C114) Development of candidate anticancer drug targeting tumor suppressor p53, Rieko Ohki1; Miku Shimizu1; Mayuko Matsumoto2; Motoki Takagi3; Shin?ya Kazuo4; Sei-ichi Tanuma5; Hideo Namiki2;