American Association for Cancer Research

Continuing Medical Education (CME)

Cellular Heterogeneity in the Tumor Microenvironment 2014


The American Association for Cancer Research (AACR) is accredited by the Accreditation Council for Continuing Medical Education (ACCME) to provide continuing medical education activities for physicians.


The AACR has designated this live activity for a maximum of 16.75 AMA PRA Category 1 Credit(s)TM. Physicians should only claim credit commensurate with the extent of their participation in the activity.

Credit certification for individual sessions may vary, dependent upon compliance with the ACCME Accreditation Criteria. The final number of credits may vary from the maximum number indicated above.


Physicians and other health care professionals seeking AMA PRA Category 1 Credit(s)TM for this live continuing medical education activity must complete the CME Request for Credit Survey, below, by Monday, April 14, 2014. Certificates will only be issued to those who complete the survey. Your CME certificate will be sent to you via email after the completion of the activity.


The tumor microenvironment is the tissue comprised of normal cells, molecules, and blood vessels that surround and feed tumor cells. While malignant cancer cells harboring activating mutations in oncogenes or loss of tumor suppressors drive tumor growth, they are supported by a diverse array of leukocytes, fibroblasts, endothelial cells (both blood and lymphatic), and other stromal components. It has been appreciated for some time that tumor blood vessels and the extracellular matrix play a significant role in disease progression. However, there is growing appreciation of the contribution infiltrating immune cells, cancer-associated fibroblasts, macrophages, angiogenic endothelial cells, and stress responses to oxygen play in sustaining cell proliferation, evading growth suppressors, promoting survival, activating invasion and metastasis, and reprogramming energy metabolism.

Tumor microenvironment also plays a role in the cancer recurrence and resistance to chemotherapy, as recently demonstrated in ovarian cancer. Gaining a better understanding of how tumors interact with their microenvironment will allow for novel drug development and could provide the power to overcome acquired resistance to front line therapies. This AACR Special Conference will focus on stromal cell heterogeneity, stromal cell metabolism, microenvironment contributions in early events in, stress responses to oxygen and nutrient gradients, and the potential therapeutic targets in the tumor microenvironment. 

After this conference, attendees will be able to identify roles played by microenvironment in modulating responses to anti-angiogenic drugs, establish how cancer-associated inflammation might be involved in metastasis and in developing resistance. They would be able to assess how hypoxia, metabolism, macrophages and other cell interactions play a role in angiogenesis. To bridge the gap between scientists, and physicians’ professional practice, this conference will provide a platform for discussion and initiating collaborations for the discovery of novel therapeutic targets.

After participating in this CME activity, physicians should be able to:

  • Evaluate concepts of intracellular interactions in the tumor microenvironment;
  • Identify the role of microenvironment in tumor resistance to novel therapies;
  • Assess the contribution of innate and adaptive immune cells to tumor progression and growth;
  • Evaluate targets for combinatorial targeting of growth factor pathways; and
  • Explain the contribution of the tumor microenvironment in tumor metabolic adaptations.


It is the policy of the AACR that the information presented at AACR CME activities will be unbiased and based on scientific evidence. To help participants make judgments about the presence of bias, the AACR will provide information that Program Committee members and speakers have disclosed about financial relationships they have with commercial entities that produce or market products or services related to the content of this CME activity. This disclosure information will be made available in the Program/Proceedings of this conference.


This activity is supported by grants and will be disclosed at the activity.


Please contact the Office of CME at 215-440-9300 or