Program

Sunday, October 16

Keynote Session

7:00 p.m.-8:30 p.m.

Sirtuins and cancer
Leonard Guarente, Massachusetts Institute of Technology, Cambridge, MA

Cancer genes: Basic and clinical implications
Bert Vogelstein, Johns Hopkins University, Baltimore, MD

Welcome Reception

Monday, October 17

Continental Breakfast

Session 1: Studying Metabolism in Model Organisms

Session Chairperson: Sally Kornbluth, Duke University School of Medicine, Durham, NC
8:00 a.m.-10:00 a.m.

The Hippo signaling pathway in development and cancer
Duojia Pan, Johns Hopkins University, Baltimore, MD

Genetic studies of growth and metabolism in Drosophila
Iswar Hariharan, University of California, Berkeley, CA

Intestinal homeostasis and Drosophila models of gastrointestinal cancer
Bruce Edgar, Center for Molecular Biology, University of Heidelberg, Heidelberg, Germany

Metabolic regulation of caspase 2-dependent cell death
Sally Kornbluth

Break

Session 2: Stress Response and Metabolism

Session Chairperson: Beth Levine, University of Texas Southwestern Medical Center, Dallas, TX
10:30 a.m.-12:30 p.m.

Lactate metabolism as a target for therapeutic intervention
Mark Dewhirst, Duke University Medical Center, Durham, NC

Autophagy and metabolic signaling: New connections
Beth Levine

HIFs, hypoxia, and metabolism
M. Celeste Simon, University of Pennsylvania, Philadelphia, PA

A novel Noxa/Mcl-1L containing macromolecular complex in leukemia cells and how it controls oxidative stress *
Ameeta Kelekar, University of Minnesota, Minneapolis, MN

Autophagy facilitates glycolysis during Ras, but not Myc, transformation *
Srirupa Roy, University of California, San Francisco, CA

Poster Session A / Lunch

12:30 p.m.-3:00 p.m.

• View titles and presenters in this session

Session 3: Signaling Pathways

Session Chairperson: Reuben Shaw, Salk Institute, La Jolla, CA
3:00 p.m.-5:30 p.m.

The regulation of metabolism by BRAF in melanoma
Richard Marais, Institute of Cancer Research, London, England

mTOR signaling in metabolism and cancer
Brendan Manning, Harvard University, Boston, MA

The LKB1/AMPK pathway coordinates growth, metabolism and autophagy
Reuben Shaw

Control of growth by the mTOR pathway
David Sabatini, Whitehead Institute for Biomedical Research, Cambridge, MA

FGFR3 stimulates de novo lipogenesis to promote bladder tumor growth *
Jing Qing, Genentech, South San Francisco, CA

Adjacent tumors cohabiting the same tissue respond differentially to dietary restriction *
Nada Kalaany, Children's Hospital Boston, Boston, MA

Evening off / Dinner on own

5:30 p.m.-

Tuesday, October 18

Continental Breakfast

7:00 a.m.-8:00 a.m.

Session 4: Metabolic Influence of Epigenetics

Session Chairperson: Shelley Berger, University of Pennsylvania, Philadelphia, PA
8:00 a.m.-10:00 a.m.

Epigenetics and metabolism: It's about time *
Paolo Sassone-Corsi, University of California, Irvine, CA

Histone covalent modifications in epigenetic regulation
Shelley Berger

Metabolic regulation of epigenetic changes in cancer
Craig Thompson, Memorial Sloan-Kettering Cancer Center, New York, NY

The role of the histone deacetylase SIRT6 in tumor metabolism *
Raul Mostoslavsky, Massachusetts General Hospital Cancer Center, Harvard Medical School, Boston, MA

Deleterious mitochondrial mutations affect early steps in colon and rectal adenocarcinoma development *
Tatianna Larman, Harvard Medical School, Boston, MA

Break

10:00 a.m.-10:30 a.m.

Session 5: Metabolism and Cell Death

Session Chairperson: Douglas Green, St. Jude Children's Research Hospital, Memphis, TN
10:30 a.m.-12:30 p.m.

Fueling immunity: Metabolic reprogramming in activated T-cells
Douglas Green

Metabolism and Bcl-2 family proteins
Jeffrey Rathmell, Duke University, Durham, NC

Functions of p53 in metabolism
Karen Vousden, Beatson Institute for Cancer Research, Glasgow, Scotland

Metabolic circuit disruption induces cell death in triple negative breast cancer cells *
Fionnuala Morrish, Fred Hutchinson Cancer Research Center, Seattle, WA

Telomere-mediated senescence causes impaired insulin secretion in β-cells by limiting mitochondrial function and Ca2+ signaling *
Mary Armanios, Johns Hopkins School of Medicine, Baltimore, MD

Free Time / Lunch on Own / Metabolism Methods Workshop presented by Seahorse Bioscience Inc. (Optional)

PLEASE NOTE: This optional workshop is not part of the CME activity.
12:30 p.m.-2:30 p.m.

Discovering metabolic abnormalities in cancer cells via analysis of substrate flux: Interrogating bioenergetic and biosynthetic pathways by monitoring oxygen consumption and extracellular acidification
Min Wu, Seahorse Bioscience, Inc., North Billerica, MA

Session 6: Metabolism, ER, and Mitochondria

Session Chairperson: Randal Kaufman, University of Michigan, Ann Arbor, MI
2:30 p.m.-5:00 p.m.

Overview: The unfolded protein response
Randal Kaufman, University of Michigan, Ann Arbor, MI

Unfolded protein load and metabolic control in the cancer cell
David Ron, University of Cambridge, Cambridge, England

ER stress sensors in disease
Laurie Glimcher, Harvard University, Boston, MA

Cell fate decisions of the unfolded protein response
Scott A. Oakes, University of California, San Francisco, CA

Human cancer cells with a mutation in the TCA cycle enzyme fumarate hydratase are dependent on mitochondrial metabolism and ROS for proliferation *
Lucas Sullivan, Northwestern University Medical School, Chicago, IL

Poster Session B / Reception

5:00 p.m.-7:30 p.m.

• View titles and presenters in this session

Wednesday, October 19

Continental Breakfast

7:00 a.m.-8:00 a.m.

Session 7: Drug Development and Therapeutics

Session Chairperson: Kevan Shokat, University of California, San Francisco, CA
8:00 a.m.-10:00 a.m.

Cancer-associated IDH mutations
Shin-San Michael Su, Agios Pharmaceuticals, Cambridge, MA

Chemical genetic studies of protein and lipid kinases in the growth factor pathway
Kevan Shokat

HIF-1: Upstream and downstream of cancer metabolism
Gregg L. Semenza, Johns Hopkins University School of Medicine, Baltimore, MD

A biochemical analysis of IDH1 neomorphic mutations *
Benjamin Schwartz, GlaxoSmithKline, Collegeville, PA

A systems approach to predicting cell type-specific cancer therapies through metabolic network analysis *
Edik M. Blais, University of Virginia, Charlottesville, VA

Break

10:00 a.m.-10:30 a.m.

Session 8: Metabolic Pathways

Session Chairperson: Nickolas Papadopoulos, Johns Hopkins Kimmel Cancer Center, Baltimore, MD
10:30 a.m.-12:30 p.m.

Understanding and therapeutic targeting of cancer cell metabolism
Chi Van Dang, Johns Hopkins University, Baltimore, MD

Cancer genomes and illumination of cellular processes involved in cancer development
Nickolas Papadopoulos

Metformin shifts cellular metabolism towards glucose fermentation and increases glutamine fueling of tricarboxylic acid cycle metabolites and fatty acids *
Sarah-Maria Fendt, Massachusetts Institute of Technology, Cambridge, MA

Investigation of the melanoma genetic landscape identifies the glutamate pathway as a major player in the disease *
Yardena Samuels, National Institute of Health, Bethesda, MD

Departure