The Translational Impact of Model Organisms in Cancer
November 5-8, 2013
Omni San Diego
San Diego, CA
Cory Abate-Shen, Columbia University Medical Center, The Herbert Irving Comprehensive Cancer Center, New York, NY
A. Thomas Look, Dana-Farber Cancer Institute, Boston, MA
Terry A. Van Dyke, National Cancer Institute-Frederick, Frederick, MD
The past decade has witnessed an enormous expansion in the variety, complexity, and sophistication of model organisms of cancer. A variety of model organisms recapitulate many important features of the cancers they are intended to emulate. These new models reflect advances in our understanding of cancer mechanisms combined with technological advances in the generation of model organisms. These new model organisms are becoming well integrated with translational efforts to identify biomarkers of disease progression and outcome, to understand mechanisms of drug action, to investigate novel drug combinations and to study mechanisms of metastases and drug resistance. This AACR Special Conference highlighted important recent advances in the use and complementarity of model organisms for translational research, as well as future directions and opportunities for successful translation from models to human clinical applications.
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