Poster Session A

SCHEDULE OF POSTER PRESENTATIONS

POSTER SESSION A

Monday, January 21, 12:45 p.m.-2:45 p.m.

(In alphabetical order, not board assignment order)

• A distinct translational regulon driven by mTOR signalling steers cancer metastasis. Andrew Hsieh, University of California, San Francisco, San Francisco, CA
• A non-biologic nanoparticle paclitaxel (NBN-Pac) formulation (IG-001) with characteristics of albumin-based formulation-(nab-Pac). Vuong Trieu, IgDraSol, Fountain Valley, CA
• A novel in vitro model to study the role of phagocytic mammary epithelial cells in postpartum breast cancer promotion. Jaime Fornetti, University of Colorado Anschutz Medical Campus, Aurora, CO
• aB-crystallin: a Novel Regulator of Breast Cancer Metastasis to the Brain. Dmitry Malin, University of Wisconsin, Madison, WI
• Activation of FGFR1 signaling in mammary tumors leads to STAT3 activation and chemoresistance. Pavlina Chuntova, University of Minnesota, Minneapolis, MN
• AID stabilizes DNMT1 expression to interfere with the anticancer activity of DNMT inhibitors in hematopoietic malignancies. Ching-Chow Chen, College of Medicine, National Taiwan University, Taipei, Taiwan
• Aligned collagen is a prognostic signature for survival in human breast carcinoma. Matthew Conklin, University of Wisconsin, Madison, WI
• An in vivo examination of the effects of ARID3B on ovarian cancer metastasis in nude mice. Lynn Roy, Indiana University School of Medicine, South Bend, IN
• Angiopoietin-2 as target for postsurgical adjuvant tumor therapy. Kshitij Srivastava, German Cancer Research Center, DKFZ, Heidelberg, BW, Germany
• Antitumor effect of metformin in breast cancer is associated with AMPK and FOXO3a activation. Eveline Fonseca, University of Sao Paulo, São Paulo, SP, Brazil
• Bone morphogenetic protein antagonist DMH1 inhibits metastasis in a mouse model of breast cancer. Philip Owens, Vanderbilt Ingram Cancer Center, Nashville, TN
• Breast cancer intrinsic subtype specific interactions with the microenvironment dictate the mechanism of tumor invasion. Tuyen Dang, UT Southwestern Medical Center, Dallas, TX
• Cancer cells form in vivo-like tumors in Gelfoam histoculture. Robert Hoffman, AntiCancer Inc., San Diego, CA
• Cancer cells invade or divide, not both. Robert Hoffman, AntiCancer Inc., San Diego, CA
• Cancer cell-secreted CXCL1 chemokine acts on neutrophils to support metastasis. Juwon Park, Cold Spring Harbor Laboratory, Cold Spring Harbor, NY
• CD146 is a novel target of CD44-signaling mediating breast tumor invasion. Augusta Fernando, University of Iowa, Iowa City, IA
• Cell autonomous and non-Autonomous activities of Heat Shock Factor 1 support tumor initiation, progression and metastasis. Ruth Scherz-Shouval, Whitehead Institute for Biomedical Research, Cambridge, MA
• Characterization of novel regulators of epithelial-mesenchymal transition in human cancer cells. Wenliang Li, University of Texas Health Science Center at Houston, Houston,
• Circulating Tumor Cells in Human Breast Cancer Exhibit Dynamic Changes in Epithelial and Mesenchymal Composition. Min Yu, Massachusetts General Hospital, Harvard Medical School, Boston, MA
• c-Met requires palmitoylation for proper stability and trafficking in cancer cells. David Coleman, Louisiana State University-Health, Shreveport, LA
• Collagen Hydroxylases are Essential for Breast Cancer Metastasis. Daniele Gilkes, Johns Hopkins University School of Medicine, Baltimore, MD
• Collective invasion in breast cancer is led by cancer cells distinguished molecularly by basal epithelial markers. Kevin Cheung, Johns Hopkins School of Medicine, Baltimore, MD
• Colorectal cancer stroma: tumor cells in disguise. Giuseppe Celesti, Humanitas Clinical and Research Center, Rozzano, Milan, Italy
• Combining molecular target drugs to inhibit cancer-stromal cell interaction in gastrointestinal cancer. Yasuhiko Kitadai, Hiroshima University, Hiroshima, Japan
• Comparison of a hypoxia gene signature in matched ovarian primary tumors and peritoneal metastasis. Amanda Baker, University of Arizona Cancer Center, Tucson, AZ
• Cooption of the reactive stroma by brain metastasis relies on protease inhibitors. Manuel Valiente, Memorial Sloan-Kettering Cancer Center, New York, NY
• CXCR4 drives the metastatic phenotype in breast cancer through induction of CXCR2, transactivation of HER2/EGFR, and activation of MEK and PI3K pathways. Tammy Sobolik, Vanderbilt University Medical Center, Nashville, TN
• DCQ is a hypoxia-activated quinoxaline 1,4-dioxide that reduces breast cancer metastasis. Khaled Ghattass, American University of Beirut, Beirut, Lebanon
• Developing Novel Treatment Strategies for Triple-Negative Breast Cancer Metastasis. Melissa Landis, The Methodist Hospital Research Institute, Houston, TX
• Direct visualization of changes of lymphatic function and drainage pathways in lymph node metastasis of B16F10 melanoma using near-infrared fluorescence imaging. Sunkuk Kwon, University of Texas Health Science Center - Houston, Houston, TX
• Dixdc1 links the LKB1 tumor suppressor to Snail, noncanonical Wnt signaling, and metastasis. Jonathan Goodwin, The Salk Institute for Biological Studies, La Jolla, CA
• E2F Transcription Factors Regulate Breast Cancer Metastasis. Eran Andrechek, Michigan State University, East Lansing, MI
• Ecrg4 down-regulation in glioma enables transformed cells to escape immunosurveillance by tumor associated macrophages/microglia. Jisook Lee, University of California, San Diego, CA
• Elucidating the role of E2F2 transcription factor in mediating human breast cancer metastasis. Inez Yuwanita, Michigan State University, East Lansing, MI
• Epigallocatechin-3-gallate inhibits stem-like inflammatory breast cancer cells. Nora Mineva, Tufts University School of Medicine, Boston, MA
• Epigenetic regulation of miR-193b by the microenvironment drives ovarian cancer metastatic colonization. Anirban Mitra, University of Chicago, Chicago, IL
• Expression profiling reveals characteristics of host-tumor interactions that promote liver metastasis of colorectal cancer. Yu Zhang, Department of Biological Sciences, Columbia, SC
• FGF-2 accelerates TGF-β--induced epithelial-mesenchymal transition. Masao Saitoh, University of Yamanashi, Shimokato, Chuo, Yamanashi, Japan
• Fibrillar human serum albumin suppresses ovarian cancer metastasis by targeting β1 integrin and its downstream FAK signaling pathways. Tai-An Chen, Agricultural Biotechnology Research Center, Academia Sinica, Taipei, Taiwan
• Fibulin-5 (FBLN5) initiates EMT and induces MMPs expression via β1 integrin/EGFR/ERK pathway. Yonghun Lee, Case Western Reserve University, Cleveland, OH
• Foxf1 transcription factor drives progression of benign lung adenomas to malignant adenocarcinomas. Tatiana Kalin, Cincinnati Children's Hospital, Cincinnati, OH
• Functional genomic screening reveals that multiple fibroblast secreted proteins support the tumorigenicity of basal breast carcinoma cells. Megha Shaffer, Cold Spring Harbor Laboratory, Cold Spring Harbor, NY
• Functional role of SOX2 in hypoxia-mediated metastasis-associated functions in prostate cancer. Yao Dai, University of Florida, Gainesville, FL
• Gas6 induces cancer cell migration and epithelial-mesenchymal transition through upregulation of MAPK and Slug. Yunhee Lee, Korea Advanced Institute of Science and Technology, Daejon, Korea (Rep.)
• Global Gene Regulatory and Protein Interaction Networks in Breast Cancer Metastasis. Bin Zhang, Mount Sinai School of Medicine, New York, NY
• HIF1α and HIF2α independently activate SRC to promote melanoma invasion and metastases. Sara Hanna, University of North Carolina Chapel Hill, Chapel Hill, NC
• Human breast-to-brain metastases display GABAergic properties in the neural niche. Josh Neman, Beckman Research Institute and City of Hope, Duarte, CA
• Identification of p75NTR/TrkB-BDNF axis in breast cancer brain metastasis. Wenhong Chen, Wake Forest School of Medicine, Winston-Salem, NC
• Imaging the tumor microenvironment to monitor ovarian cancer metastasis. Jill Slack-Davis, University of Virginia, Charlottesville, VA
• Immune Cell Influx during Postpartum Mammary Gland Involution Reveals Immunosuppression and Tumor Promotion. Holly Martinson, University of Colorado Anschutz Medical Campus, Aurora, CO
• Immune suppressive myeloid cells induced by hypoxic mammary tumor cells persist after primary tumor resection and promote metastatic growth. Kevin Bennewith, British Columbia Cancer Agency, Vancouver, BC, Canada
• In vivo evidence of TIMPv as a potential target of CD146-signaling inhibiting breast tumor invasion. Allal Ouhtit, Sultan Qaboos University, Muscat, Seeb, Oman
• Insights into TIMP-1/CD63 interaction and their functional relationship with MT1-MMP in cancer progression. Richard Warner, The Barbara Ann Karmanos Cancer Institute/Wayne State University School of Medicine, Detroit, MI
• Integrated epigenomic profiling reveals widespread demethylation in melanoma, and reveals aberrant CSF-1 Receptor expression as a regulator of malignant growth and invasion inhibited by PLX3397. Brian West, Plexxikon Inc., Berkeley, CA
• Integrin α3β1-dependent regulation of Cox2 in human breast cancer. Sita Subbaram, Albany Medical College, Albany, NY
• Interleukin-1β- promotes brain metastasis of breast cancer by activating Notch signaling through reactive astrocytes. Fei Xing, University of Mississippi Medical Center, Jackson, MS
• Intravital imaging of metastatic liver colonization. Laila Ritsma, Hubrecht Institute, Utrecht, The Netherlands
• Intravital multiphoton imaging reveals multicellular streaming as a crucial component of in vivo cell migration in human breast tumors. Antonia Patsialou, Albert Einstein College of Medicine, Bronx, NY
• Investigating gene expression alterations in the tumor microenvironment based on receptor status in breast cancer using a microfluidic multi-culture platform. Lindsey Maccoux, University of Wisconsin, Madison, Madison, WI
• Investigation of novel therapeutic and diagnostic strategies for the management of triple-negative breast cancer. Chevaun Morrison, Cleveland Clinic Lerner College of Medicine of Case Western Reserve University, Cleveland, OH
• In-vivo cell-cell fusion transfers genes for malignancy and the donor tumors? organoid phenotype. David Goldenberg, Garden State Cancer Center, Center for Molecular Medicine and Immunology, Morris Plains, NJ
• Killing quiescent cancer cells in vitro and in vivo with tumor targeting Salmonella typhimurium A1-R. Robert Hoffman, AntiCancer Inc., San Diego, CA
• Loss of Par3 promotes metastasis of ErbB2 transformed mammary epithelial cells by inhibiting E-cadherin adhesion junction maturation. Senthil Muthuswamy, Ontario Cancer Institute/ University of Toronto, Toronto, Canada
• Lysophosphatidic acid induces ovarian cancer cell invasion through EGFR phosphorylation and proteolytic enzyme expression. Hoi Young Lee, Department of Pharmacology, College of Medicine, Konyang University, Daejeon, Korea (Rep.)
• Make a Difference and Save Lives in Human Metastatic Cancer by Attacking the ?Achilles Heel? in the Oncogenic ERBB/K-RAS Signaling Pathway. Amy Tang, Eastern Virginia Medical School, Norfolk, VA
• Microenvironment controls breast cancer cells sensitivity to doxorubicin by autophagy inhibition. Luciana Gomes, Instituto de Ciências Biomédicas, Universidade de São Paulo, São Paulo, SP, Brazil
• Microfluidic In-Vitro Platform for Imaging Metastasis: Perfusable Microvascular Networks and Cancer Cells on a Microfluidic Chip. Noo Li Jeon, Seoul National University, Seoul, Korea (Rep.)
• Micromanaging the Microenvironment: The Role of microRNA in Metastatic Mammary Tumor Associated Macrophages. Haritha Mathsyaraja, The Ohio State University, Columbus, OH
• MicroRNA-200c modulates epthelial-mesenchymal transition and increases radiosensitivity of human cancer cells with activated EGFR or HER2-associated signaling. In Ah Kim, Seoul National University, Seoul, Korea (Rep.)
• Molecular regulation of cancer cell invasion and tumor metastasis by an atypical MAPK ERK3. Weiwen Long, Baylor College of Medicine, Houston, TX
• MUC1 drives c-Met-dependent migration and scattering. Teresa Horm, University of Arizona, Tucson, AZ
• Multimodal imaging of blood-brain barrier disruption during brain metastatic progression in a relevant experimental mouse model. Frits Thorsen, Department of Biomedicine, University of Bergen, Bergen, Norway
• Nanobiocojugates of differential imaging and treatment of brain metastatic tumors. Julia Ljubimova, Cedars-Sinai Medical Center, Los Angeles, CA
• NEDD9 promotes cell invasion through modulation of ARF6 activity and endocytic recycling.?. Elena Pugacheva, Mary Babb Randolph Cancer Center, West Virginia University School of Medicine, Morgantown, WV
• Neural regulation of metastasis:  New avenues for therapeutic intervention. Erica Sloan, Monash Institute of Pharmaceutical Sciences, Melbourne, VIC, Australia
• Novel mouse models to investigate the molecular pathogenesis of metastatic osteosarcoma. Jason Yustein, Baylor College of Medicine, Houston, TX
• Opposing effects of heat shock factors 1 and 2 on prostate cancer invasion. Malin Åkerfelt, VTT Technical Research Centre of Finland, Turku, Finland
• Optical imaging model for monitoring dynamic interactions of breast cancer cells and bone tissues in ex vivo co-cultures. Bonnie King, Stanford University School of Medicine, Stanford, CA
• Prevention of bone metastasis and bone destruction from breast cancer by autocrine inhibition of the c-fms proto-oncogene. Setsuko Chambers, University of Arizona Cancer Center, Tucson, AZ
• Receptor-binding cancer antigen expressed on SiSo cells (RCAS1) induces apoptosis via ectodomain shedding mediated by a disintegrin and metalloproteinase 9. Kenzo Sonoda, Kyushu University, Fukuoka, Japan
• Regulation of EGFR:Stat3 signaling by Mig6 is required for Metastatic Outgrowth in Triple-Negative Breast Cancer. Mike Wendt, Case Western Reserve University, Cleveland, OH
• Role of PDGF signaling during the progression of breast ductal carcinoma in situ to invasive carcinoma. Carina Strell, Karolinska Institutet, Stockholm, Sweden
• ShcA is required for the TGFβ--induced repression of Chordin-like-1 in ErbB2-expressing breast cancer cells. Jason Northey, McGill University, Montreal, QC, Canada
• Signaling cross-talk between FAK activity and IL6-STAT3 signaling pathway for invasion in a TM4SF5-dependent manner. Jihye Ryu, College of Pharmacy, Seoul National University, Seoul, Korea (Rep.)
• Significant inhibition of human breast tumor growth, Metastases and disseminated tumor cells by anti-Wnt OMP-18R5 and anti-Notch 1 OMP-52M51 antibodies in murine orthotopic models. Gilbert O'Young, OncoMed, Redwood City, CA
• SIRT1 regulates Rac1-GTPase activation via the guanine nucleotide exchange factor TIAM1. Madhurima Saxena, Louisiana State University Health Shreveport, Shreveport, LA
• Small molecule Cathepsin L inhibitor KGP94 suppresses hypoxia and acidosis potentiated metastatic capacity of prostate and breast cancer cells. Dhivya Sudhan, University of Florida, Gainesville, FL
• Stromal CAIX Expression in Oral Squamous Cell Carcinoma and Corresponding Lymph Node Metastases. Nigel Brockton, Alberta Health Services - Cancer Care, Calgary, AL, Canada
• Stromal LOX Promotes TGFβ-R2 Null Breast Cancer Metastasis. Michael Pickup, Vanderbilt University, Nashville, TN
• Sulfated polysaccharides from marine brown alga alleviate pancreatic cancer metastasis. Natarajan Aravindan, Departments of Radiation Oncology, University of Oklahoma Health Sciences Center, Oklahoma City, OK
• Synaptojanin-2 And MicroRNA-31 Control Invadopodia And Metastasis By Regulating Vesicular Trafficking. Nir Ben-Chetrit, Weizmann Institute of Science, Rehovot, Israel
• TACE-regulated TGF-alpha shedding drives GRB7-dependent invasion in triple-negative breast cancer cell lines. Paraic Kenny, Albert Einstein College of Medicine, Bronx, NY
• Targeting the PH domain of TIAM1 to inhibit prostate cancer metastasis. Emmanuelle Meuillet, University of Arizona Cancer Center, Tucson, AZ
• TGF-β-2 underpins CD44-promoted breast tumor cell invasion. Rajiv Gaur, Sultan Qaboos University, Muscat, Seeb, Oman
• The impact of the inflammatory microenvironment on breast cancer metastasis and chemotherapy responsiveness. Kelly Kersten, Netherlands Cancer Institute, Amsterdam, The Netherlands
• The importance of metabolic heterogeneity and its consequences on tumor invasion, metastatic growth and treatment. Alexander Anderson, Moffitt Cancer Center, Tampa, FL
• The role of PI3-kinase signaling pathway in invadopodia formation. Hideki Yamaguchi, National Cancer Center Research Institute, Tokyo, Japan
• The role of the microenvironment  protein cathelicidin LL-37  in pancreatic ductal adenocarcinoma. Christopher Heeschen, Spanish National Cancer Research Centre (CNIO), Madrid, Spain
• Therapeutic effects of standardized Wedelia chinensis extract on prostate cancer in vivo. Pei-Wen Hsiao, National Taiwan University, Taipei, Taiwan
• Transcriptional regulation of the interleukin-11 gene by oncogenic Ras. Soon Young Shin, Department of Biomedical Science and Technology, SMART Institute of ABS, RCTC, Konkuk University, Seoul, Korea (Rep.)
• Transmembrane 4 L six family member 5 (TM4SF5) regulates FAK/c-Src signaling activity for cell migration and invasion. Jung Weon Lee, College of Pharmacy, Seoul National University, Seoul, Korea (Rep.)
• Treating trastuzumab-resistant HER2+ breast cancers with a HER3-targeted nanoparticle. Jessica Sims, Cedars-Sinai Medical Center, Los Angeles, CA
• Tumor secreted Hsp90 initiates tumor growth and the epithelial to mesenchymal transition (EMT) in prostate cancer. Jennifer Isaacs, Medical University of South Carolina, Charleston, SC
• Vimentin serves as a signaling scaffold at focal adhesion sites to regulate lung cancer cell adhesion. Adam Marcus, Emory University, Winship Cancer Institute, Atlanta, GA