Poster Session B

SCHEDULE OF POSTER PRESENTATIONS

POSTER SESSION B

Monday, January 21, 5:15 p.m.-7:15 p.m.

(In alphabetical order, not board assignment order)

A lineage-selective transcriptional pathway linking lung differentiation and cancer metastasis. William Cheung, Yale University, New Haven, CT
A micro scale 3D in vitro model of the breast cancer progression from DCIS to IDC: Deciphering the role of the stromal fibroblasts. Kyung Sung, University of Wisconsin, Madison, WI
A novel breast cancer metastasis suppressor upstream of Hippo signaling. Li Ma, The University of Texas MD Anderson Cancer Center, Houston,
A novel high content screening approach to identify inhibitors of lysosome anterograde trafficking and tumor invasion. Hazem El-Osta, Louisiana State University Health Science Center, Shreveport, LA
A Novel Role for Matrix Metalloproteinases In Regulating Mammary Stem Cell Function via the Wnt Signaling Pathway. Kai Kessenbrock, University of California, San Francisco, CA
A novel role for monocarboxylate transporter 1 as a regulator of cancer cell motility and c-Met expression, independent of transporter activity. Alana Gray, Louisiana State University Health - Shreveport, Shreveport, LA
A novel role for the secreted growth factor progranulin in angiogenesis. Huishi Toh, McGill University, Montreal, QC, Canada
Activated c-Src enhances hypoxia in human glioblastoma multiforme and promotes tumor angiogenesis. Eskil Eskilsson, University of Bergen, Bergen, Norway
ADAM8 promotes tumorigenesis, angiogenesis and spreading of circulating tumor cells in breast cancer. Mathilde Romagnoli, Tufts University School of Medicine, Boston, MA
An interspecies comparison between the structure and products of the parathyroid hormone-related peptide gene. Adam Freeman, Sir Peter MacCallum Cancer Centre, Melbourne, Australia
Analysis of the endocytic receptor MRC2 as a target for mesenchymal pancreatic cancer cells. Arkadeep Sinha, van andel institute, Grand Rapids, MI
Ang-2-VEGF-A CrossMab, a novel bispecific human IgG1 antibody blocking VEGF-A and Ang-2 functions simultaneously, mediates potent anti-tumor, anti-angiogenic, and anti-metastatic efficiency. Erica Lorenzon, Roche Diagnostics GmbH, Penzberg, Germany
Angiomodulin (AGM/IGFBP-rP1) is overexpressed in tumor vasculature and regulates adhesion of vascular endothelial cells via integrin αvβ-3: Possible roles in tumor angiogenesis. Kaoru Miyazaki, Kihara Institute for Biological Research, Yokohama City University, Yokohama, Kanagawa, Japan
Angiotensin-(1-7) attenuates the proliferation of cancer-associated fibroblasts in triple negative breast cancer. Alison Arter, Wake Forest School of Medicine, Winston-Salem, NC
Anti-angiogenic and anti-metastatic activities of cat's whiskers tea (Orthosiphon stamineus) extract against colon cancer cell line. Fouad Alsuede, Universiti Sains Malaysia, Minden, Malaysia
Anti-metastatic and apoptosis induction potential of supercritical CO2 extract ofNigella sativa seeds. Hussein Baharetha, Universiti Sains Malaysia, Penang, Malaysia
Bone marrow microenvironment of advanced breast cancer patients without bone metastasis favors the cancer cell colonization. Leandro Martinez, Experimental Medicine and Biological Institute, Buenos Aires, Argentina
Cancer cell invasion determined by cell density dependent, cytokine-mediated crosstalk. Ghada Sharif, Georgetown University, Washington, DC
CD24 affects tumor cell properties and cytokine secretion in a STAT3 dependent fashion. Niko Bretz, German Cancer Research Center DKFZ, Heidelberg, Germany
Claudin-2 is an independent negative prognostic factor in breast cancer and specifically predicts early liver recurrences. Siker Kimbung, Department of Oncology, Lund University, Lund, Sweden
Coordinate RB/PTEN tumor suppressor loss: drives aggressive invasive behavior and is strongly associated with the progression of ductal carcinoma to invasive breast cancer. Erik Knudsen, UT Southwestern, Dallas, TX
Curcumin deteriorates trabecular and cortical bone in mice bearing metastatic Lewis lung carcinoma. Lin Yan, Agricultural Research Service-USDA, Grand Forks, ND
CX3CR1, A fractalkine receptor, Can regulate peritoneal dissemination of epithelial ovarian cancer cells. Jia Xie, University of Illinois at Chicago, Chicago, IL
Decreasing ovarian cancer metastases and progression via restoration of microRNAs that target mediators of anoikis- and chemo-resistance. Diana Cittelly, University of Colorado Anschutz Medical Campus, Aurora, CO
Deficiency for endoglin in tumor vasculature weakens the endothelial barrier to metastatic dissemination. Sara Cunha, Karolinska Institute, Stockholm, Sweden
Deletion of Smad4 results in enhancement of lymphangiogenesis and node metastasis in head and neck squamous cell carcinoma. Masako Oka, University of Colorado Denver, Aurora, CO
Development of a short peptide with anti-tumor activity. Suming Wang, Children's Hospital Boston, Boston, MA
Dichotomus role of profilin in early vs late steps of breast cancer metastasis. Partha Roy, University of Pittsburgh, Pittsburgh, PA
Differential functions of splicing factors in breast-cancer initiation and metastasis. Olga Anczukow, Cold Spring Harbor Laboratory, Cold Spring Harbor, NY
ErbB2-induced Epithelium to Mesenchyme Transition (EMT) is blocked by p38α/β- signaling to restrict early dissemination in breast cancer. Kathryn Harper, Mount Sinai School of Medicine, New York, NY
Examining reciprocal temporal interactions between human prostate cancer cells and the bone microenvironment. Erin Howe, University of Chicago, Chicago, IL
Extracellular S100A4 as an inducer of a cytokine network that mediates tumor-stroma crosstalk; potential implications for metastases. Ingrid Bettum, Institute for Cancer Research, Oslo University Hospital, The Norwegian Radium Hospital, Oslo, Norway
Fibroblast dependent modulation of drug sensitivity, stemcellnes and tumor cell dormancy. Janna Paulsson, Karolinska Institutet, Stockholm, Sweden
Galectin-1 expressed in human melanoma is bound to cancer stem cells: a driver for metastatic progression and target for anti-metastatic cancer therapy. Stephen J. Ralph, School of Medical Science, Griffith Health Institute, Griffith University, Gold Coast, QLD, Australia
Gene expression profiling during EMT and MET identifies multiple transcription factors involved in the EMT transcriptional reprogramming. Alexey Ivanov, West Virginia University, Morgantown, WV
Gene-expression profiling of human metastatic non-small cell lung cancer cells enriched by repeated intracardiac injection in mice. Yongwha Moon, National Institutes of Health/National Cancer Institute, Bethesda, MD
Genomic copy number alterations associated with the early brain metastasis of non small cell lung cancer. Hye Won Lee, Samsung medican center, Seoul, Korea (Rep.)
Heparanase modulates mammary branching morphogenesis by regulating MMP-14 level. Angelica Gomes, Federal University of Rio de Janeiro, Rio De Janeiro, Brazil
Hepatocyte growth factor activator inhibitor type 1 (HAI-1) suppresses tumor growth and metastasis of pancreatic adenocarcinoma cells. Makiko Kawaguchi, Miyazaki University, Miyazaki, Japan
High angiogenic capacity of Inflammatory Neutrophils and Polarized M2 Macrophages is determined by production of MMP-9 unencumbered by its natural inhibitor TIMP-1. Ewa Zajac, The Scripps Research Institute, La Jolla, CA
Hypoxia Inducible Factor (HIF) promotes reductive carboxylation by regulating citrate levels and renders VHL-deficient and hypoxic cells sensitive to glutamine deprivation. Othon Iliopoulos, Massachusetts General Hospital Cancer Center, Charlestown, MA
Hypoxia-induced pathological angiogenesis mediates tumor cell dissemination, invasion, and metastasis in a zebrafish tumor model. Pegah Rouhi, Karolinska Institutet, Stockholm, Sweden
Hypoxia-inducible factor 1 mediates thrombosis-associated cancer progression. Colin Evans, University of Cambridge, Cambridge, England
Identification of luminal breast cancers that establish a tumor supportive macroenvironment defined by pro-angiogenic platelets and bone marrow derived cells. Timothy Marsh, Brigham & Women's Hospital, Boston,
Identification of molecular and functional differences in tumour associated macrophage subsets. Esther Arwert, Albert Einstein College of Medicine, Bronx, NY
Identifying Different Functional Mechanisms of Invasion from Mesenchymal and Proneural Subtypes of Glioblastoma. Sungwon Jung, Translational Genomics Research Institute, Phoenix, AZ
Inhibiting endothelial FAK activity blocks tumor cell extravasation. David Schlaepfer, UCSD, Moores Cancer Center, La Jolla, CA
Integrin alpha2beta1 (α2β-1) promotes prostate cancer skeletal metastasis. Christopher Hall, University of Massachusetts Medical School, Worcester, MA
Invasive breast cancer amplifies lymphangiogenic signals in tumor microenvironment through integrin beta4 expressing cancer-associated fibroblasts. Baek Gil Kim, Yonsei University College of Medicine, Seoul, Korea (Rep.)
Investigating ARID3B Regulation of Ovarian Cancer Metastasis. Katrina Gellerman, University of Notre Dame, Notre Dame, IN
IQGAP1 in the tumor microenvironment suppresses TGF-beta mediated myofibroblastic activation and ensuing tumor growth. Ningling Kang, Mayo Clinic, Rochester, MN
Loss of the keratin cytoskeleton is not sufficient to induce epithelial mesenchymal transition in a novel KRAS driven sporadic lung cancer mouse model. Lukas Heukamp, Institute of Pathology, University of Cologne, Cologne, Germany
Lymphatic endothelium promotes angiogenesis, tumor growth and metastasis in breast cancer. Esak Lee, Johns Hopkins University, Baltimore, MD
Macrophages and T cell infiltration in colorectal liver metastases according to growth pattern. Rikke Eefsen, Department of Oncology 5073 Rigshospitalet, Copenhagen, Denmark
MCT4 expression in pancreatic cancer: Association with prognosis and potential for targeting cancer metabolism. Agnieszka K. Witkiewicz, Thomas Jefferson University and Kimmel Cancer Center, Philadelphia, PA.
MDA-9/syntenin is a key regulator of glioma pathogenesis. Timothy Kegelman, Virginia Commonwealth University, Richmond, VA
Mesenchymal stem cells promote tumor-skin involvement in inflammatory breast cancer models. Lara Lacerda, UT MD Anderson Cancer Center, Houston, TX
Metadherin mediates osteosarcoma invasion and metastasis. Dennis Hughes, The University of Texas MD Anderson Cancer Center, Houston, TX
Milky spots are required for ovarian cancer metastatic colonization of peritoneal adipose depots. Robert Clark, University of Chicago, Chicago, IL
MiR-205 puts the brakes on the malignant interplay between prostate cancer cells and associated fibroblasts. Paolo Gandellini, Fondazione IRCCS Istituto Nazionale Tumori, Milan, Italy
Mitochondrial Superoxide Dismutase (Sod2) confers a survival advantage to ovarian cancer cells under stress conditions by enhancing Mitochondrial Respiratory Reserve Capacity. Nadine Hempel, College of Nanoscale Science & Engineering SUNY Albany, Albany, NY
Mouse model of primary human renal cell carcinoma metastasis to bone. Maija Valta, Stanford School of Medicine, Stanford, CA
Multikinase inhibitors for antiangiogenesis and tumor metastasis in zebrafish model. TinChung leung, North Carolina Central University, Durham, NC
New role for α-catenin family member α-catulin in squamous cell carcinoma invasion and metastasis. Agnieszka Kobielak, University of Southern California, Norris Cancer Center, Keck School of Medicine, Los Angeles, CA
NFAT regulates a gene expression program associated with invasiveness and poor prognosis in colorectal cancer. Manish Tripathi, Vanderbilt University Medical Center, Nashville, TN
Oligodendritic precursor mediates vascular remodeling within glioma microenvironment in PDGF-C dependent manner. Yujie Huang, Weill Cornell Medical College, New York, NY
Omental milky-spots serve as a niche for ovarian cancer metastatic colonization. Venkatesh Krishnan, University of Chicago, Chicago, IL
OSM-induced cathepsin D in breast cancer invasion and metastasis. Jordan Koncinsky, Boise State University, Boise, ID
p120-catenin is required for metastatic colonization, yet its loss potentiates breast cancer progression by non-cell autonomous mechanisms. Sarah Kurley, Vanderbilt University, Nashville, TN
p53 deficiency promotes breast cancer metastasis in human-in-mouse models of triple negative breast cancer. Emily Powell, Washington University, St. Louis, MO
p60 AmotL2 disrupts apical-basal polarity and promotes tumour invasion. Mahdi Mojallal, karolinska Institiute, Stockholm, Sweden
Paracrine Insulin-like Growth Factor Binding Protein 5 Promotes Castration-Resistant Prostate Cancer Progression. Mazyar Ghaffari, Vancouver Prostate Centre, Universtity of British Columbia, Vancouver, BC, Canada
Peroxisome proliferator-activated receptor gamma agonists abrogate tumor cell migration and promote TRAIL-induced apoptosis by human astrocytoma cells. Kyungsun Choi, KAIST, Daejeon, Korea (Rep.)
Porphyromonas gingivalis-induced autophagy suppresses cell proliferation through G1 arrest in oral cancer cells. Hae Ryoun Park, School of Dentistry, Pusan National University, Yang San, Korea (Rep.)
Positive and negative coordination among tetraspanins in the TM4SF5-mediated invasion. Minkyung Kang, Department of Biomedical Sciences, College of Medicine, Seoul National University, Seoul, Korea (Rep.)
Postpartum mammary gland involution drives COX-2 dependent lymphangiogenesis and lymphatic vessel invasion in a model of postpartum breast cancer. Traci Lyons, University of Colorado Anschutz Medical Campus, Aurora, CO
Potential Role of CXCR3 in Breast Cancer Bone Metastasis. Wendy Feng, Vestavia Hills High School, Vestavia Hills, AL
Promoter methylation status of tumor suppressor genes and an inflammatory-related COX-2 gene in cervical intraepithelial neoplasia. Ruei Nian Li, Kaohsiung Medical University, Kaohsiung, Taiwan
Rebastinib, a small molecule TIE2 kinase inhibitor, prevents primary tumor growth and lung metastasis in the PyMT breast cancer model. Scott Wise, Deciphera Pharmaceuticals, LLC, Lawrence, KS
Signaling by PDGF-CC in the maintenance of a pro-tumorigenic breast cancer microenvironment. Pernilla Roswall, Karolinska Institutet, Stockholm, Sweden
Single cell gene expression analysis reveals a distinct differentiation program in human breast cancer disseminated tumor cells (DTCs). Devon Lawson, University of California, San Francisco, San Francisco, CA
Soluble lung-derived factors mediate breast cancer cell migration and growth via CD44 receptor-ligand interactions. Ying Xia, London Regional Cancer Program, London Health Sciences Centre, London, Canada
Somatic copy number alterations by whole exome sequencing reveals YWHAZ and PTK2 as potential therapeutic targets in castration resistant prostate cancer. Roopika Menon, Institute of Pathology, University Hospital of Bonn, Bonn, Germany
Spatiotemporal Regulation of Epithelial-Mesenchymal Transition is Essential for Carcinoma Metastasis. Jing Yang, University of California, San Diego, La Jolla, CA
Syndecan-1 promotes breast cancer metastasis by modulating tissue stiffness. Colleen Chute, University of Wisconsin, Madison, WI
Targeting the HIF-1α/p300 complex with epidithiodiketopiperazines for antiangiogenic therapy. Kelie Reece, National Cancer Institute, Bethesda, MD
The cholesterol metabolite, 27-hydroxycholesterol, increases breast cancer tumor growth and metastasis. Erik Nelson, Duke University School of Medicine, Durham, NC
The dual effect of therapy induced IL-1β- expression on tumor progression: role of tumor associated macrophages. Tali Voloshin, Technion, Haifa, Israel
The Effect of Extracellular Matrix Proteins from Lung on the Migration of Breast Cancer Cells. Philip Carpenter, University of California, Irvine, Orange, CA
The Regulation of Matriptase Activation through PDGF D-mediated Extracellular Acidosis. Abdo Najy, The Barbara Ann Karmanos Cancer Institute/Wayne State University School of Medicine, Detroit, MI
The role of integrin switching and Deptor in metastatic breast cancer. Jenny Parvani, Case Western Reserve University, Cleveland, OH
The role of phosphodiesterase 4D and the microenvironment in prostate cancer. Ginny Powers, University of Wisconsin-Madison, Madison, WI
The role of stromal cells in supporting tumour initiating cells in serous ovarian carcinoma. Ali Hussain, University of Toronto, Toronto, ON, Canada
The Twist box domain is required for Twist1-induced metastasis of prostate cancer cells. Phuoc Tran, Johns Hopkins Medicine, Baltimore, MD
TIMP-1 expression in colorectal cancer liver metastases is associated with vascular structures. Martin Illemann, The Finsen Laboratory, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark
Tumor associated macrophages in human papillary thyroid cancer. Sun Wook Cho, Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Korea (Rep.)
Tumor-derived factors in metastatic xenograft models of human estrogen receptor negative breast cancer primary cultures. Katherine Drews-Elger, University of Miami, Miami, FL
Understanding the mechanisms underlying recurrence of malignant gliomas after anti-angiogenesis treatment. Nahir Cortes Santiago, University of Texas MD Anderson Cancer Center, Houston, TX
Unraveling the role of a novel endoplasmic reticulum protein in cancer cell migration. Nikki Evensen, Stony Brook University, Stony Brook, NY
Unveiling the mechanisms of melanoma metastasis using a chick embryo neural crest model system. Caleb Bailey, Stowers Institute for Medical Research, Kansas City, MO
uPAR expression in the microenvironment of human urothelial neoplasia of the bladder is associated with invasive behaviour and increases significantly with T-stage and grade. Line Dohn, Department of Oncology, Finsen Centre, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark
Using Species-Specific RNAseq Reveals Stromal Reprogramming in Triple Negative Breast Cancer Xenografts. Casey Frankenberger, University of Chicago, Chicago, IL
Using three-dimensional (3D) culture systems to delineate the role of RANKL in metastatic prostate cancer. Shabnam Ziaee, Cedars-Sinai Medical Center, Los Angeles, CA