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View the Table of Contents for the December 1 issue of Cancer Research.
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Standish and colleagues used Doppler optical coherence tomography (DOCT), the optical analog of high-resolution ultrasound imaging, to measure changes in microvascular blood flow during photodynamic therapy (PDT) in Dunning rat prostate tumors. A strong inverse relationship was found between the rate of PDT-induced blood flow shutdown during light administration and the resulting percent of local tumor necrosis at 24 h posttreatment. This suggests a potential role for minimally-invasive interstitial DOCT in monitoring local tumor response during PDT, with the possibility of on-line monitoring for optimizing treatment parameters in individual patients.
Sung et al. Page 9996 Tumor-microenvironment interactions are crucial in oncogenesis and cancer progression. Sung and colleagues use a 3-dimensional coculture system to show that human bone stromal cells undergo permanent cytogenetic and gene expression changes when cocultured with prostate cancer cells and that these changes are mediated by reactive oxygen species. The evolved stromal cells are highly inductive of human prostate cancer growth in mice, and express increased levels of extracellular matrix (versican and tenascin) and chemokine (BDNF, CCL5, CXCL5 and CXCL16) genes which are validated in clinical specimens. These results, combined with previous observations, suggest coevolution of cancer and stromal cells, which could ultimately accelerate cancer growth and metastasis.
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