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View the Table of Contents for the July 1 issue of Cancer Research.
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Roesli and colleagues used comparative proteomic analysis of two closely related murine teratocarcinoma cell lines with different metastatic potentials to reveal a dramatic increase in abundance at the cell membrane for a broad variety of proteins thought to reside in intracellular compartments. These finding were confirmed by immunofluorescence analysis of the corresponding cells and in syngeneic mouse liver metastasis models. Importantly, the accessibility of selected target proteins for intravenously administered antibodies was demonstrated by microautoradiographic analysis following intravenous administration. These results suggest that the expression of intracellular proteins on the membrane of metastatic cells is more common than previously thought.
Lee et al. Page 5481 Gammaherpesviruses such as Epstein-Barr virus are associated with malignancy in immune-suppressed individuals. Lee and colleagues report that infection of IFNγ-unresponsive mice with murine gammaherpesvirus 68 resulted in uniform development of angiocentric inflammatory lesions in the lung. Long-term outcomes of these lesions varied from spontaneous regression to pulmonary lymphoma. Both early and late stages were indistinguishable between wild-type and reactivation-defective virus infection, indicating that pathology depended on latent infection, but not on virus reactivation. Significantly, this mouse model of virus-associated pulmonary B-cell lymphoma closely mimics the full spectrum of human lymphomatoid granulomatosis, an Epstein-Barr virus–associated malignancy with no effective treatment.
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Ilkovitch et al. Page 5514 Myeloid-derived suppressor cells (MDSC) are a cell population that orchestrates immunosuppression in cancer and various other chronic pathologies. Ilkovitch and colleagues investigated homing and accumulation of MDSC in tumor-bearing mice and discovered that the liver is an organ to which MDSC home, accumulate, and expand, forming nests throughout the liver parenchyma. The authors also show that, in the liver, MDSC can interact with various immune cells such as Kupffer cells, and promote immunosuppression directly and indirectly.
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