American Association for Cancer Research

AACR Award for Outstanding Achievement in Chemistry in Cancer Research

Dale L. Boger, Ph.D. 
Eighth Annual Award Recipient
Dale L. Boger, Ph.D.
Chairman
Richard and Alice Cramer Professor, Department of Chemistry
The Scripps Research Institute
La Jolla, Calif.

Dr. Boger will deliver his award lecture titled Uniquely Effective Synthetic Analogs of the Complex Antitumor Natural Products Vinblastine and the Duocarmycins at the AACR Annual Meeting 2014 in San Diego, Calif. The award ceremony and lecture will be held on Tuesday, April 8, 2014, from 3 to 4 p.m. in the San Diego Convention Center. Visit the AACR Annual Meeting 2014 page for more information.

The Award and Lecture

The AACR and its Chemistry in Cancer Research Working Group established this award in 2007 to recognize the importance of chemistry to advancements in cancer research. The award will be given for outstanding, novel and significant chemistry research, which has led to important contributions to the fields of basic cancer research, translational cancer research, cancer diagnosis, the prevention of cancer or the treatment of patients with cancer. Such research may include, but is not limited to, drug discovery and design; structural biology; proteomics, metabolomics and biological mass spectrometry; chemical aspects of carcinogenesis; imaging agents and radiotherapeutics; and chemical biology.

The recipient of the Eighth Annual AACR Award for Outstanding Achievement in Chemistry in Cancer Research will give a 50-minute lecture during the AACR Annual Meeting 2014 in San Diego, Calif., USA (April 5-9, 2014), receive a commemorative award, a $10,000 honorarium, and receive support for the recipient and a guest to attend the annual meeting.

Eligibility Criteria

  • Candidacy is open to all researchers who are affiliated with any institution involved in cancer research, cancer medicine, or cancer-related biomedical science anywhere in the world. Such institutions include those in academia, industry, or government.
  • The award will be presented to an individual investigator. Two or more individuals may be selected to share the award when their investigations are closely related in subject matter and have resulted in work worthy of an award.
  • Institutions or organizations are not eligible for the award.
  • Selection of the award recipient will be made on the outstanding quality, novelty, and significance of the candidate's chemistry research and its important contributions to cancer research. No regard will be given to race, gender, nationality, geographic location, or religious or political views.
  • Prior recipients of the AACR-Bruce F. Cain Memorial Award are not eligible to be nominated for research previously recognized by the Cain Award.

Nomination Process

Nominations are closed.

Nominations may be made by any scientist, whether an AACR member or nonmember, who is now or has been affiliated with any institution involved in cancer research, cancer medicine, or cancer-related biomedical science. Candidates may not nominate themselves.

Selection

Candidates will be considered by a Selection Committee of international cancer leaders appointed by the president of the AACR. The committee will consider all nominations as they have been submitted; the committee may not combine submitted nominations, add a new candidate to a submitted nomination, or otherwise make alterations to the submitted nominations. After careful deliberations by the committee, its recommendations will be forwarded to the Executive Committee of the AACR for final consideration and decision. Selection of the award recipient will be made on the basis of the candidate's outstanding, novel, and significant chemistry research related to cancer. No regard will be given to age, race, gender, nationality, geographic location, or religious or political views.

Supporter

Generously supported by Ash Stevens Inc.

Questions?

Linda Stokes, Program Associate
awards@aacr.org

American Association for Cancer Research
615 Chestnut Street, 17th Floor
Philadelphia, PA 19106-4404 

SPOTLIGHT

Dale L. Boger, Ph.D. Eighth Annual Award Recipient
Dale L. Boger, Ph.D.
Chairman

Richard and Alice Cramer Professor, Department of Chemistry
The Scripps Research Institute
La Jolla, Calif.

 

Dr. Dale L. Boger, currently Richard and Alice Cramer professor and chair of the Department of Chemistry at The Scripps Research Institute in La Jolla, Calif., is honored for his development of elegant and highly dependable synthetic methods to construct numerous naturally occurring highly potent anticancer agents. His work is characterized by the pursuit of detailed structure-function relationships of natural or designed agents in order understand the fundamental structural bases of their anticancer properties. In these studies, Dr. Boger's group addresses the challenging problem of understanding the beautiful solutions and subtle design elements that nature has provided in the form of a natural product and endeavors to extend the solution through rational design elements to provide more selective, more efficacious, or more potent agents designed specifically for the problem or target under investigation.

Dr. Boger's group is particularly recognized for his many contributions to unravelling the complex properties of the sequence specific DNA alkylating natural products such as CC-1065, duocarmycins, bleomycin A2, sandramycin, luzopeptins, and isochrysohermidin. A number of the potent antitumor agents he has synthesized are being used in antibody-drug conjugates which are finding widespread use in cancer drug discovery.

Dr. Boger's seminal contributions to combinatorial chemistry include the use of solution-phase library synthesis. He devised liquid-liquid and liquid-solid extraction techniques to isolate and purify libraries. His work led to the founding of CombiChem, a successful combinatorial chemistry company sold to DuPont. He provided a total synthesis of distamycin A and library of its analogs through the solution-phase approach. He then developed rapid, high-throughput screens for determining relative DNA binding affinity and DNA binding sequence selectivity of the libraries that revealed novel DNA binding agents.

Dr. Boger has received numerous awards including the 1988 American Chemical Society A.C. Cope Scholar Award, 2002 Paul Janssen Prize for Creativity in Organic Synthesis, 2003 Royal Society of Chemistry Adrien Albert Medal, 2007 American Chemical Society Ernest Guenther Award in the Chemistry of Natural Products, and the 2013 American Chemical Society Hirschmann Award in Peptide Chemistry. He was elected to the American Academy of Arts and Sciences, named a fellow of the Royal Society of Chemistry (2009), and is a fellow of the American Chemical Society (2010).

Beyond Dr. Boger's specific contributions to the cancer research community, the broader scientific community has benefited. He has educated over 50 doctoral students and over 150 postdoctoral associates who now conduct important work in their own right, and he was the founder and remains the editor-in-chief of Bioorganic & Medicinal Chemistry Letters, a journal where important findings in cancer research are presented.

Dr. Boger earned his Bachelor of Science degree at the University of Kansas in 1975 and earned his doctorate in organic chemistry with E.J. Corey at Harvard in 1980. Following his doctorate, he returned to the University of Kansas in the Department of Medicinal Chemistry from 1979-1985. He then moved his research group to the chemistry department at Purdue University from 1985-1990 when he moved to The Scripps Research Institute.