This award honors an individual who has made significant fundamental contributions to cancer research, either through a single scientific discovery or a body of work.
- 2010 Janet D. Rowley
- 2009 Joseph F. Fraumeni Jr.
- 2008 Harald zur Hausen
- 2007 Donald Metcalf
- 2006 Bernard Fisher
- 2005 Alfred G. Knudson Jr.
- 2004 Emil Frei III