TME Town Meeting and Reception: Impact of the Microenvironment in Response to Therapy

Tuesday, April 9, 2013, 6:30 p.m. - 8:30 p.m.
Grand Hyatt Hotel, Constitution Rooms A-B

Chairperson: M. Celeste Simon, Ph.D., Abramson Family Cancer Research Institute of the University of Pennsylvania, Philadelphia, PA
Chairperson-Elect: Mary Helen Barcellos-Hoff, Ph.D., New York University, New York, NY

The 203 attendees had an opportunity to hear from our colleagues in academia, government and industry about the impact of the microenvironment on therapeutic responses. Attendees learned about these and other important TME initiatives, met members of the working group and steering committee, in addition to taking advantage of the opportunity to join the TME Working Group. A networking reception followed.

Speakers included:

Kyla Driscoll Carroll, ImClone Systems, New York, NY
Targeting the Tumor Microenvironment with TGFβ Pathway Modulators

Philip J. Tofilon, National Cancer Inst., Bethesda, MD
Microenvironmental Regulation of Human Glioblastoma Radiosensitivity

Peter S. Nelson, Fred Hutchinson Cancer Research Ctr., Seattle, WA
Targeting Damage Responses in the Tumor Microenvironment to Circumvent Treatment Resistance 

Joint Cancer Immunology (CIMM)/Tumor Microenvironment (TME) Working Group
Evening Scientific Session: Innate Responses and the Tumor Microenvironment

Monday, April 8, 2013
6:00-8:00 p.m.
Grand Hyatt Hotel, Bridge Rooms

This jointly-sponsored Working Group Session was attended by 248+ individuals comprised of TME Members and other interested Annual Meeting registrants.

Chairpersons:
Elizabaeth M. Jaffee, M.D., Johns Hopkins Kimmel Comprehensive Cancer Center, Baltimore, MD
M. Celeste Simon, Ph.D., Abramson Family Cancer Research Institute of the University of Pennsylvania, Philadelphia, PA

It is now clear that the tumor microenvironment includes multiple innate and adaptive components of the immune system that, together with tumor and tissue components, regulate tumor formation, progression and metastasis. The chairpersons of the Cancer Immunology and Tumor Microenvironment Working Groups prepared this evening scientific session to hear leaders from both fields present their most current view of these important interactions.

Speakers included:

Dafna Bar-Sagi, New York University Langone Medical Center, New York, NY
Cell and Tissue Dynamics in Pancreatic Cancer 

John S. Condeelis, Sr., Albert Einstein College of Medicine, Bronx, NY
Tumor Microenvironments Supporting Interactions between Tumor Cells and Macrophases in Breast Tumors

M. Celeste Simon, Ph.D., Abramson Family Research Cancer Institute of the University of Pennsylvania, Philadelphia, PA 
HIFs, Hypoxia, and Tumor Progression

Other TME-Related Content:

Current Concepts in Organ Site Research
Tuesday, April 9, 2013, 1:00 p.m. - 3:00 p.m.; Room 144

Molecular Basis and Therapeutic Targeting of Bone Metastasis
Sunday, April 7, 2013, 1:00 p.m. - 3:00 p.m.; Room 147

Latent Metastasis (Breast Cancer, Prostate Cancer)
Monday, April 8, 2013, 1:00 p.m. - 3:00 p.m.; Room 150

Molecular and Cellular Determinants of Brain Metastasis

Educational Sessions

Tumor-Secreted Factors
Saturday, April 6, 2013, 8:00 a.m. - 10:00 a.m.; Room 152

Tumor Immunology and Immunotherapy for Non-Immunologists
Saturday, April 6, 2013, 8:00 a.m. - 10:00 a.m.; Room 202

Cancer Immunology for the Non-Immunologist - Tutorial
Saturday, April 6, 2013, 10:00 a.m. - 12:00 noon; Room 206

Immune Modulation in the Tumor Microenvironment: Tregs and Other Factors Regulating Host Response
Saturday, April 6, 2013, 10:15 a.m. - 12:15 p.m.; Room 145

The Central Role of the Microenvironment in Initiation and Progression of Tumors and Response to Chemotherapy

Hypoxia-Induced Metastasis
Saturday, April 6, 2013, 1:00 p.m. - 3:00 p.m.; Ballroom C

Forum
The Role of Stroma in Pancreatic Cancer
Tuesday, April 9, 2013, 5:00 p.m. - 6:30 p.m.; Salon A-B, East Hall

Major Symposia
Targeting the Stroma
Monday, April 8, 2013, 1:00 p.m. - 3:00 p.m.; Salon A-B, East Hall

Intrinsic and Microenvironment-Dependent Adaptive Responses that Regulate Drug Resistance
Tuesday, April 9, 2013; 8:15 a.m. - 10:15 a.m.; Ballroom C

Innate Immune Sensing in the Tumor Microenvironment
Tuesday, April 9, 2013, 10:30 a.m. - 12:30 p.m.; Room 145

Inflammation and Cancer
Wednesday, April 10, 2013, 11:00 a.m. - 1:00 p.m.; Room 207

Minisymposia
Tissue Organization, Mechanical Forces, and 3-D Modeling of the Microenvironment
Sunday, April 7, 2013, 3:15 p.m. - 5:15 p.m.; Room 204

Role of Microenvironment in Tumor Dormancy and Resistance Niches
Sunday, April 7, 2013, 3:15 p.m. - 5:15 p.m.; Room 152

Microenvironment Driving Tumor Initiation: Molecular Mechanisms

Novel Mediators of Tumor Angiogenesis
Monday, April 8, 2013, 3:00 p.m. - 5:00 p.m.; Room 204

New Pathways in Tumor Metastasis
Tuesday, April 9, 2013, 3:00 p.m. - 5:00 p.m.; Room 207

Pediatric Cancer 1: Genomic Landscapes, Microenvironment and Response to Therapy

Plenary Session
Cancer Evolution and Resistance (Microenvironmental contributions to cancer drug resistance)
Wednesday, April 10, 2013, 8:00 a.m. - 10:00 a.m.; Ballroom A-B

Poster Session
Monday, April 8, 2013, 1:00 p.m. - 5:00 p.m.; Hall A-C, Poster Section 5

Cancer Cell Adhesion
Sunday, April 7, 2013, 1:00 pm - 5:00 pm; Hall A-C, Poster Section 12

Metastasis-Related Technologies: Imaging, Sequencing, Profiling, and Biomarkers
Sunday, April 7, 2013, 1:00 p.m. - 5:00 p.m.; Hall A-C, Poster Section 19

Host-Tumor Interaction
Sunday, April 7, 2013, 1:00 p.m. - 5:00 p.m.; Hall A-C, Poster Section 18

Response and Resistance to Angiogenic Inhibitors
Monday, April 8, 2013, 1:00 p.m. - 5:00 p.m.; Hall A-C, Poster Section 20

Macrophages as Key Players in the Tumor Microenvironment
Monday, April 8, 2013, 1:00 p.m. - 5:00 p.m.; Hall A-C, Poster Section 17

Cytokines, Modification of the Tumor Microenvironment, and Intervention

Circulating and Disseminated Tumor Cell Quantification
Monday, April 8, 2013, 1:00 p.m. - 5:00 p.m.; Hall A-C, Poster Section 14

Tumor-Stromal Interactions
Monday, April 8, 2013, 1:00 pm - 5:00 p.m.; Hall A-C, Poster Section 21

Chemokines, Cytokines, and Tumor Microenvironment Interaction
Monday, April 8, 2013, 1:00 p.m. - 5:00 p.m.; Hall A-C; Poster Section 13

Gene Expression, Epigenetics, and Proteomics in the Tumor Microenvironment
Monday, April 8, 2013, 1:00 p.m. - 5:00 p.m.; Hall A-C, Poster Section 16

Cancer Stem Cells, Cancer Initiating Cells, and Tumor Dormancy in the Tumor Microenvironment Complex
Tuesday, April 9, 2013, 8:00 a.m. - 12:00 noon; Hall A-C, Poster Section 12

Metastasis-Promoting Pathways

The Metastatic Microenvironment 1
Tuesday, April 9, 2013, 8:00 a.m. - 12:00 noon; Hall A-C, Poster Section 20

Cell Migration and Invasion 1
Tuesday, April 9, 2013, 8:00 a.m. - 12:00 noon; Hall A-C, Poster Section 13

Cell Migration and Invasion 2
Tuesday, April 9, 2013, 1:00 p.m. - 5:00 p.m.; Hall A-C, Poster Section 14

Metastasis-Inducing and Metastasis-Suppressive Pathways

The Metastatic Microenvironment 2
Tuesday, April 9, 2013, 1:00 p.m. - 5:00 p.m.; Hall A-C, Poster Section 20

Novel Angiogenic Factors and Emerging Mechanisms
Tuesday, April 9, 2013, 1:00 p.m. - 5:00 p.m.; Hall A-C, Poster Section 18

Tumor Metastasis: Quantification and Biology

Tumor Angiogenesis Inhibitors
Wednesday, April 10, 2013, 8:00 a.m. - 12:00 noon; Hall A-C, Poster Section 21

Immunity: Cancer-Related Inflammation and Microenvironmental Crosstalk
Wednesday, April 10, 2013; 8:00 a.m. - 12:00 noon; Hall A-C, Poster Section 16

Chemotherapy and Immune Therapy Targeting the Tumor Microenvironment
Wednesday, April 10, 2013, 8:00 a.m. - 12:00 noon; Hall A-C, Poster Section 15

Proteases, Protease Inhibitors, and the Tumor Microenvironment
Wednesday, April 10, 2013, 8:00 a.m. - 12:00 noon; Hall A-C, Poster Section 20

Cell Migration and Invasion 3
Wednesday, April 10, 2013, 8:00 a.m. - 12:00 noon; Hall A-C, Poster Section 13
Wednesday, April 10, 2013, 8:00 a.m. - 12:00 noon; Hall A-C, Poster Section 22
Tuesday, April 9, 2013, 1:00 p.m. - 5:00 p.m.; Hall A-C, Poster Section 17
Tuesday, April 9, 2013; 3:00 p.m. - 5:00 p.m.; Salon C, East Hall
Monday, April 8, 2013, 3:00 p.m. - 5:00 p.m.; Room 144
Saturday, April 6, 2013, 1:00 p.m. - 3:00 p.m.; Room 143