American Association for Cancer Research

February 2007 CEBP Highlights

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Selected Articles from the February 2007 Issue

The articles referenced in this Highlights section will be available online in HTML and PDF formats to all interested users at no charge until the next issue of Cancer Epidemiology, Biomarkers & Prevention is published. Click on the article title to view the complete article.

View the Table of Contents for the February 2007 issue of Cancer Epidemiology, Biomarkers & Prevention.


Nevi Numbers Independent of Melanoma Risk

Cockburn et al.

Page 200

Californians, as a group, have a relatively high risk of melanoma. Cockburn et al. sought to determine, in this population-based setting, which risk factors nevi and melanoma have in common. The authors found that the prevalence of large nevi is most readily explained by constitutional and then by behavioral variables, rather than an individual’s opportunity for sun exposure. There appear to be independent relationships between nevi frequency and other melanoma risk factors, with the notable exceptions of skin color and red hair phenotype. If these risk factors represent a genetic propensity to develop melanoma, that risk would appear to be unrelated to the development of nevi.
 

Preventive Value of Activity Confirmed

Sprague et al.

Page 236

Numerous studies have observed reduced breast cancer risk with increasing levels of physical activity, yet these findings have been inconsistent regarding optimal time periods of activity and effect modification by other factors. Sprague et al. investigated the association between recreational and occupational physical activity and breast cancer risk in a population-based case-control study. Inverse associations were observed for physical activity early in life, in the postmenopausal years, and in the recent past, but these findings were confined to women without a family history of breast cancer. These results provide further evidence that for most women physical activity may reduce the risk of invasive breast cancer.


Higher Health Literacy Linked to Recall

Lillie et al.

Page 249

New genomic technology now allows physicians to provide women with individualized and highly accurate breast cancer recurrence risk estimates that are a key factor in post-surgical therapy decisions. Because these genomic tests are so new, little is known about how well patients understand the tests and their results. Lillie et al. found that women with lower health literacy recalled less of the information provided about the recurrence risk test than women with higher health literacy. Health literacy was not related to the amount of additional information women desired. Women with higher health literacy preferred to have a more active role in decisions about the test. Health literacy may affect women’s capacity to learn about the new genomic tests as well as their desire for informed participation in their medical care.

Women need to understand the link between human papillomavirus (HPV) and cervical cancer in order to make appropriate, evidence-based choices among existing prevention strategies (Pap test, HPV DNA test and HPV vaccine). Assessment of the public’s knowledge in nationally representative samples is a high-priority for cervical cancer control. Tiro et al. examined factors associated with American women’s awareness of HPV and knowledge about its link to cervical cancer. Awareness about HPV among American women is low. Having heard about HPV did not ensure accurate knowledge. Strategies for communicating accurate information about HPV transmission, prevention, and detection as well as risk and treatment of cervical cancer are needed. 


Metabolic Syndrome Synergistic with Vitamin D

Tuohimaa et al.

Page 302

Factors related to the metabolic syndrome (MS) and low levels of vitamin D have been implicated as risk factors for prostate cancer (PCa). Thus far, no studies have assessed their joint effects on PCa risk. Tuohimaa et al. studied the associations of vitamin D with the MS factors body mass index, systolic and diastolic blood pressure and HDL-cholesterol; and the PCa risk associated with these factors, and especially their joint effects with vitamin D on risk of PCa. Only in the presence of low levels of vitamin D do factors associated with the metabolic syndrome influence PCa risk.